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Potent Dual BET/HDAC Inhibitors for Efficient Treatment of Pancreatic Cancer

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Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity

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SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)

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Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors

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Dual-activity PI3K–BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis

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A pathology atlas of the human cancer transcriptome

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An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer

(2017) Adrian Vallejo et al.   Nature Communications

Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors

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Targeting the cancer epigenome for therapy

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HDACs and HDAC Inhibitors in Cancer Development and Therapy

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NanoBRET—A Novel BRET Platform for the Analysis of Protein–Protein Interactions

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Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma

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Activation of SOX2 Expression by BRD4-NUT Oncogenic Fusion Drives Neoplastic Transformation in NUT Midline Carcinoma

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Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

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Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

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Super-Enhancers in the Control of Cell Identity and Disease

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Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

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Fast gapped-read alignment with Bowtie 2

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An introduction to data reduction: space-group determination, scaling and intensity statistics

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FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

The NIH Roadmap Epigenomics Mapping Consortium

(2010) Bradley E Bernstein et al.   NATURE BIOTECHNOLOGY

The Sequence Alignment/Map format and SAMtools

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