Article
Chemistry, Applied
Khadijeh Soleimani, Hossein Derakhshankhah, Mehdi Jaymand, Hadi Samadian
Summary: Natural gums can be utilized as stimuli-responsive DDSs for cancer treatment due to their beneficial characteristics, though they may require modification to overcome certain limitations. This review article aims to compile natural gums-based stimuli-responsive DDSs and briefly highlight different types of stimuli, fundamental features of natural gums, and chemical modification approaches.
CARBOHYDRATE POLYMERS
(2021)
Article
Materials Science, Multidisciplinary
Muhammad Farooq, Elham Azadfar, Alexandru Rusu, Monica Trif, Mahmoud Kohneh Poushi, Yunyang Wang
Summary: The study showed that mastic gum as a natural coating agent significantly extended the shelf life of peeled fresh almond kernels over four months of storage, reducing moisture absorption, oxidation, yeast and mold growth, and inhibiting Aspergillus species development. Mastic gum can be a great natural preservative coating candidate with antioxidant and antimicrobial effects.
Article
Multidisciplinary Sciences
Ifra Hassan, Adil Gani, Mudasir Ahmad, Javid Banday
Summary: The valorization of new polymer sources from underutilized plants for food and nutraceutical applications is gaining attention. This study explored the use of mucilage from Althea rosea and revealed its physicochemical properties, in vitro antidiabetic and antihypertensive activity. The results showed that Althea rosea mucilage exhibited functional, hypo-lipidemic, anti-hyperglycemic, antioxidant, and anti-bacterial properties, making it a potential eco-friendly substitute for the food and nutraceutical industry.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Danmin Yang, Qun Liu, Xu Zeng, Xiaoting Chen, Meng Li, Xialing Wu, Yue Liu, Yanzhen Zheng, Jionghua Xiang, Chunchun Wang, Wuyin Weng, Yucang Zhang
Summary: In this study, pH-sensitive indicator films based on cellulose nanofibers were developed to monitor shrimp freshness. The films showed good tensile strength and color response, allowing for real-time detection of shrimp freshness.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biotechnology & Applied Microbiology
Cristian O. Illanes, Eduardo A. Takara, Martin A. Masuelli, Nelio A. Ochoa
Summary: In this study, pH-responsive tragacanth gum hydrogels were successfully obtained by crosslinking with glutaraldehyde. The crosslinking reaction led to changes in the micro- and macrostructure, resulting in improved adsorptive properties of the hydrogels. These properties make the TG-GLU hydrogels suitable for practical applications in the pharmaceutical industry related to drug delivery and water remediation.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Zhihao Zhong, Chao Liu, Yatao Xu, Weili Si, Wenjun Wang, Liping Zhong, Yongxiang Zhao, Xiaochen Dong
Summary: This study presents a new therapeutic nanoplatform for synergistic cancer therapy using photoacoustic imaging-guided chemo/chemodynamic/photothermal (CT/CDT/PTT) approaches. The synthesized nanoplatform showed selective accumulation at tumor sites and demonstrated significant synergistic therapeutic effects in vitro and in vivo.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Anees Ur Rehman Qureshi, Nasima Arshad, Atta Rasool, Muhmmad Rizwan, Tahir Rasheed
Summary: In this study, hydrogels for controlled release of diclofenac sodium were synthesized from graphene oxide-reinforced guar gum and poly (N-vinyl-2-pyrrolidone) using the Solution Casting Technique. The hydrogels were crosslinked with varying concentrations of 3-Glycidyloxypropyl trimethoxysilane (GLYMO). The characterization of hydrogels was performed using techniques such as FTIR, X-ray diffraction, thermal analysis, and SEM.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Sunita Ranote, Marta Musiol, Marek Kowalczuk, Veena Joshi, Ghanshyam S. Chauhan, Rakesh Kumar, Sandeep Chauhan, Kiran Kumar
Summary: In this study, a pH-responsive nanogel based on Moringa oleifera gum was synthesized to deliver DOX as a drug carrier, showing promising drug release performance for targeted and controlled release of anticancer drugs.
Article
Biochemistry & Molecular Biology
Pratiksha Devkar, Sopan Nangare, Laxmikant Zawar, Nitin Shirsath, Piyush Bafna, Pankaj Jain
Summary: Microwave-assisted grafting of polyacrylamide on sesbania gum (PAAM-g-SG) was used to form H-PAAM-g-SG, which was then hydrolyzed using sodium hydroxide (NaOH). Diclofenac sodium-loaded pH-sensitive interpenetrating polymeric network (IPN) microbeads were designed using H-PAAM-g-SG and sodium alginate (SA). Different spectroscopic analyses confirmed the synthesis of PAAM-g-SG and diclofenac-loaded pH-sensitive IPN H-PAAM-g-SG-SA microbeads. The release of diclofenac sodium from the microbeads was pH-sensitive and showed promising potential for drug delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Umar Aslam Khan, Iqra Iqbal, Mohamed Nainar Mohamed Ansari, Saiful Izwan Abd Razak, Mohsin Ali Raza, Amna Sajjad, Faiza Jabeen, Mohd Riduan Mohamad, Norhana Jusoh
Summary: The research focused on the fabrication of CS/PVA/GG blended hydrogels with TEOS for sustained paracetamol release. The hydrogels were characterized using various techniques to understand their physicochemical properties and drug release behavior, showing potential for controlled drug delivery and antimicrobial activity.
Article
Chemistry, Multidisciplinary
Ruyuan Zhang, Li Li, Caixia Ma, Fatima-ezzahra Ettoumi, Miral Javed, Xingyu Lin, Xingfeng Shao, Gengsheng Xiao, Zisheng Luo
Summary: In this study, zein and peach gum polysaccharide (PGP) based biopolymeric nanoparticles were fabricated to stabilize Pickering emulsions and deliver curcumin. The addition order of PGP during and after anti-solvent precipitation process affected the properties of the nanoparticles. The zein-PGP and zein/PGP nanoparticles stabilized emulsions showed improved stability and curcumin release rates compared to zein nanoparticles.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2022)
Article
Biochemistry & Molecular Biology
Antonia Carla de Jesus Oliveira, Emilliany Barbara Silva, Thaisa Cardoso de Oliveira, Fabio de Oliveira Silva Ribeiro, Daniella Nadvorny, Johny Wysllas de Freitas Oliveira, Ana Borrego-Sanchez, Klinger Antonio da Franca Rodrigues, Marcelo Sousa Silva, Pedro Jose Rolim-Neto, Cesar Viseras, Edson C. Silva-Filho, Durcilene Alves da Silva, Luise Lopes Chaves, Monica Felts de La Roca Soares, Jose Lamartine Soares-Sobrinho
Summary: Nanotechnology has led to new and creative applications of nano-medicine, and polymeric nanoparticles have become increasingly important in pharmaceutical applications. This study investigated the use of cashew phthalate gum (PCG) as a particle-forming polymer, which showed pH-sensitive behavior and control over drug release. The developed nanoparticles carrying benznidazole exhibited enhanced biological activity, reduced cytotoxicity, high anti-T. cruzi performance, and pH-responsive release.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Ghada A. Mahmoud, Hussein E. Ali, Rasha R. Radwan
Summary: A polymeric pH-sensitive nanocarrier was synthesized to deliver pyrogallol, and its anti-tumor activity against colon cancer in rats was investigated. The results showed that pyrogallol-loaded polymeric nanogel significantly reduced tumor incidence and volume. It activated apoptotic pathway and attenuated cell cycle progression. It also exhibited anti-proliferative activity and reduced pro-inflammatory cytokines. The histopathological examination confirmed the results. This formulation could be considered as a promising agent in the treatment of colon cancer.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Mingxia Wang, Tariq Muhammad, Huiling Gao, Jianzhang Liu, Hao Liang
Summary: In this study, chitosan-based nanogels were developed to enhance the antibacterial and anti-biofilm efficacy of Tanshinone IIA (TA) against Streptococcus mutans (S. mutans). The results showed that the nanogels had excellent encapsulation efficiency, uniform particle sizes, and enhanced stability of TA under harsh environments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Mhejabeen Sayed
Summary: This study investigates the supramolecular recognition behavior of protonated and neutral forms of the acridine orange dye with gamma-cyclodextrin host. The protonated form shows sequential multi-mode binding interactions with the host, forming dimeric inclusion complexes at lower host concentration and monomeric complexes at higher concentration. On the other hand, the neutral form primarily forms dimeric complexes throughout the entire host concentration range. The study provides insights into the pH-dependent interaction mechanism and potential applications in pH-controlled supramolecular assemblies.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Meher E. Abhinav, Anuraj Sundararaj, D. Jaison, Gopalakrishnan Chandrasekaran, Manikandan Krishnan, S. Arumugam, Kasmir S. Raja
APPLIED SURFACE SCIENCE
(2019)
Article
Materials Science, Multidisciplinary
Preethi Selvamuthu, Jaison Darson, Chandrasekar Ponnusamy, Gopalakrishnan Chandrasekar, Sivakumar Muthusamy, Ruckmani Kandasamy, Subramanian Natesan
MATERIALS RESEARCH EXPRESS
(2019)
Article
Chemistry, Physical
N. Angeline Little Flower, K. Mani Rahulan, R. Annie Sujatha, R. A. Sharath, Jaison Darson, C. Gopalakrishnan
APPLIED SURFACE SCIENCE
(2019)
Article
Materials Science, Multidisciplinary
D. Jaison, Meher E. Abhinav, Asnit Gangwar, Prasad Nand Kishore, Gopalakrishnan Chandrasekaran, M. Mothilal
MATERIALS RESEARCH EXPRESS
(2020)
Article
Pharmacology & Pharmacy
S. Manjunath Kamath, D. Jaison, Subha Krishna Rao, K. Sridhar, N. Kasthuri, V. Gopinath, P. Sivaperumal, Nilkantha Gupta, S. Shantanu Patil
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Chemistry, Physical
Subha Krishna Rao, A. Kalai Priya, S. Manjunath Kamath, P. Karthick, B. Renganathan, S. Anuraj, D. Sastikumar, K. Jeyadheepan, C. Gopalakrishnan
JOURNAL OF ALLOYS AND COMPOUNDS
(2020)
Article
Biochemistry & Molecular Biology
Manjunath S. Kamath, Subha Krishna Rao, D. Jaison, K. Sridhar, N. Kasthuri, V Gopinath, P. Sivaperumal, Shantanu S. Patil
PROCESS BIOCHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Nilkantha Gupta, Manjunath S. Kamath, Subha Krishna Rao, D. Jaison, Shantanu Patil, Neha Gupta, Kantha Deivi Arunachalam
Summary: Encapsulation of Kaempferol into albumin nanoparticles and electrospinning with dexamethasone in polycaprolactone solution resulted in nanofibrous mats with sustained release of both drugs for cartilage tissue engineering. The fabricated mats showed increased deposition of glycosaminoglycans and non-cytotoxicity with pro chondrogenic properties when evaluated with human chondrocytes in vitro, indicating potential benefits for cartilage regeneration.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
