Clinical approaches towards asthma and chronic obstructive pulmonary disease based on the heterogeneity of disease pathogenesis

Genome-Wide Methylation Study Identifies an IL-13–induced Epigenetic Signature in Asthmatic Airways

(2016) Jessie Nicodemus-Johnson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Variants near the HLA complex group 22 gene (HCG22) confer increased susceptibility to late-onset asthma in Japanese populations

(2016) Yohei Yatagai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of Lung Function Genes in the Development of Asthma

(2016) Hideyasu Yamada et al.   PLoS One

Asthma–COPD Overlap. Clinical Relevance of Genomic Signatures of Type 2 Inflammation in Chronic Obstructive Pulmonary Disease

(2015) Stephanie A. Christenson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Biological clustering supports both “Dutch” and “British” hypotheses of asthma and chronic obstructive pulmonary disease

(2015) Michael A. Ghebre et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An epigenome-wide association study of total serum immunoglobulin E concentration

(2015) Liming Liang et al.   NATURE

Association of Improved Air Quality with Lung Development in Children

(2015) W. James Gauderman et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Asthma–COPD Overlap Syndrome

(2015) Dirkje S. Postma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication

(2015) Yury A. Bochkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increasing awareness of sex differences in airway diseases

(2015) Deepa Raghavan et al.   RESPIROLOGY

LAMA/LABA vs ICS/LABA in the treatment of COPD in Japan based on the disease phenotypes

(2015) Nobuyuki Hizawa   International Journal of Chronic Obstructive Pulmonary Disease

Biomarker-based detection of asthma–COPD overlap syndrome in COPD populations

(2015) Tsutomu Tamada et al.   International Journal of Chronic Obstructive Pulmonary Disease

Association of the CAT-262C>T polymorphism with asthma in smokers and the nonemphysematous phenotype of chronic obstructive pulmonary disease

(2014) Natsuko Taniguchi et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Genomewide association study identifiesHAS2as a novel susceptibility gene for adult asthma in a Japanese population

(2014) Y. Yatagai et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Human rhinovirus infection during naturally occurring COPD exacerbations

(2014) S. N. George et al.   EUROPEAN RESPIRATORY JOURNAL

Lung function trajectories from birth through puberty reflect asthma phenotypes with allergic comorbidity

(2014) Karin C. Lødrup Carlsen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prenatal and postnatal genetic influence on lung function development

(2014) Eskil Kreiner-Møller et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of airway bacterial colonization by an electronic nose in Chronic Obstructive Pulmonary Disease

(2014) Oriol Sibila et al.   RESPIRATORY MEDICINE

The genomic origins of asthma

(2014) Sunita Sharma et al.   THORAX

External validation of blood eosinophils, FENOand serum periostin as surrogates for sputum eosinophils in asthma

(2014) A H Wagener et al.   THORAX

Genetic polymorphisms and risk of recurrent wheezing in pediatric age

(2014) Susanna Esposito et al.   BMC Pulmonary Medicine

Effects of Allergic Phenotype on Respiratory Symptoms and Exacerbations in Patients with Chronic Obstructive Pulmonary Disease

(2013) Daniel B. Jamieson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exploring the Effects of Omalizumab in Allergic Asthma

(2013) Nicola A. Hanania et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The CC16 A38G polymorphism is associated with asymptomatic airway hyper-responsiveness and development of late-onset asthma

(2013) Natsuko Taniguchi et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Sex- and age-dependent DNA methylation at the 17q12-q21 locus associated with childhood asthma

(2013) Anna K. Naumova et al.   HUMAN GENETICS

Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes

(2013) Marjan Kerkhof et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genome-wide association study of lung function phenotypes in a founder population

(2013) Tsung-Chieh Yao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma and Risk of Selective IgA Deficiency or Common Variable Immunodeficiency: A Population-Based Case-Control Study

(2013) Sang-Hwa Urm et al.   MAYO CLINIC PROCEEDINGS

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

(2013) Klaus Bønnelykke et al.   NATURE GENETICS

Rhinovirus Wheezing Illness and Genetic Risk of Childhood-Onset Asthma

(2013) Minal Çalışkan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phenotypic predictors of response to oral glucocorticosteroids in severe asthma

(2013) Maciej Kupczyk et al.   RESPIRATORY MEDICINE

Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial

(2013) Guy G Brusselle et al.   THORAX

Moving from the Oslerian paradigm to the post-genomic era: are asthma and COPD outdated terms?

(2013) Lowie E G W Vanfleteren et al.   THORAX

Early lung development: lifelong effect on respiratory health and disease

(2013) Janet Stocks et al.   Lancet Respiratory Medicine

Risks of population antimicrobial resistance associated with chronic macrolide use for inflammatory airway diseases

(2013) David J Serisier   Lancet Respiratory Medicine

Genome-Wide Association Studies IdentifyCHRNA5/3andHTR4in the Development of Airflow Obstruction

(2012) Jemma B. Wilk et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Severe asthma: from characteristics to phenotypes to endotypes

(2012) S. Wenzel   CLINICAL AND EXPERIMENTAL ALLERGY

Long-term macrolide treatment for chronic respiratory disease

(2012) Paolo Spagnolo et al.   EUROPEAN RESPIRATORY JOURNAL

Bacteria in sputum of stable severe asthma and increased airway wall thickness

(2012) Qingling Zhang et al.   RESPIRATORY RESEARCH

Asthma and Chronic Obstructive Pulmonary Disease

(2011) Dirkje S. Postma et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Heterogeneity of severe asthma in childhood: Confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program

(2011) Anne M. Fitzpatrick et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population

(2011) Tomomitsu Hirota et al.   NATURE GENETICS

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

(2011) María Soler Artigas et al.   NATURE GENETICS

Exposure to Environmental Microorganisms and Childhood Asthma

(2011) Markus J. Ege et al.   NEW ENGLAND JOURNAL OF MEDICINE

Azithromycin for Prevention of Exacerbations of COPD

(2011) Richard K. Albert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

TSLP polymorphisms are associated with asthma in a sex-specific fashion

(2010) G. M. Hunninghake et al.   ALLERGY

Thymic Stromal Lymphopoietin Gene Promoter Polymorphisms Are Associated with Susceptibility to Bronchial Asthma

(2010) Michishige Harada et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Molecular cloning of two novel mucin-like genes in the disease-susceptibility locus for diffuse panbronchiolitis

(2010) Minako Hijikata et al.   HUMAN GENETICS

A functional polymorphism (−603A → G) in the tissue factor gene promoter is associated with adult-onset asthma

(2010) Akira Isada et al.   JOURNAL OF HUMAN GENETICS

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disordered Microbial Communities in Asthmatic Airways

(2010) Markus Hilty et al.   PLoS One

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Genome-wide association study identifies five loci associated with lung function

(2009) Emmanouela Repapi et al.   NATURE GENETICS

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

(2009) Dana B Hancock et al.   NATURE GENETICS

Early life origins of chronic obstructive pulmonary disease

(2009) C Svanes et al.   THORAX

A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study

(2009) Jemma B. Wilk et al.   PLoS Genetics

Chromosome 17q21 Gene Variants Are Associated with Asthma and Exacerbations but Not Atopy in Early Childhood

(2008) Hans Bisgaard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Clarithromycin Targets Neutrophilic Airway Inflammation in Refractory Asthma

(2007) Jodie L. Simpson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE