Article
Endocrinology & Metabolism
Lei Zhang, Xin-Tong Wei, Jun-Jie Niu, Zi-Xuan Lin, Qian Xu, Jing-Jing Ni, Wan-Lin Zhang, Bai-Xue Han, Shan-Shan Yan, Gui-Juan Feng, Hong Zhang, Xiao-Lin Yang, Zi-Jia Zhang, Rong Hai, Hai-Gang Ren, Feng Zhang, Yu-Fang Pei
Summary: This study identified 49 novel loci and 3 secondary signals associated with age at natural menopause through meta-analysis of three GWAS datasets, with a total of 225,200 participants. The research also revealed a causal relationship between hormone replacement therapy and age at natural menopause. These findings enhance our understanding of the etiology of female menopause and offer potential new therapies for abnormal menopause.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Lei Zhang, Xin-Tong Wei, Jun-Jie Niu, Zi-Xuan Lin, Qian Xu, Jing-Jing Ni, Wan-Lin Zhang, Bai-Xue Han, Shan-Shan Yan, Gui-Juan Feng, Hong Zhang, Xiao-Lin Yang, Zi-Jia Zhang, Rong Hai, Hai-Gang Ren, Feng Zhang, Yu-Fang Pei
Summary: By conducting a genome-wide association study (GWAS) meta-analysis, new genetic loci associated with natural menopause age (ANM) were identified, improving our understanding of the etiology of female menopause and potentially offering new therapies for abnormal menopause.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Xiao Zhang, Zhao Huangfu, Shaowei Wang
Summary: Earlier age at natural menopause (ANM) is associated with adverse outcomes such as osteoporosis, cardiovascular disease, and cancer. Mendelian randomization (MR) studies have revealed that factors such as higher body mass index, poor educational level, early age at menarche, and autoimmune thyroid disease are involved in the etiology of early ANM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Sabrina J. G. C. Welten, N. Charlotte Onland-Moret, Jolanda M. A. Boer, W. M. Monique Verschuren, Yvonne T. van der Schouw
Summary: This study found that earlier menopause is associated with increased risk of stroke in women, with a 2% lower stroke risk for each year menopause was delayed. The association with stroke risk was stronger for natural menopause.
Article
Obstetrics & Gynecology
Wenting Hao, Chunying Fu, Caiyun Dong, Chunmiao Zhou, Huizi Sun, Ziwei Xie, Dongshan Zhu
Summary: This population-based cohort study involving 160,080 women from the UK Biobank study found that earlier natural menopause (≤40 and 41-45 years) was associated with a higher risk of all-cause dementia compared to a menopause age of 46-50 years, while a U-shaped relationship was observed between age at surgical menopause and dementia risk.
HUMAN REPRODUCTION
(2023)
Letter
Medicine, General & Internal
Jessica H. Beard, Sara F. Jacoby, Zoe Maher, Beidi Dong, Elinore J. Kaufman, Amy J. Goldberg, Christopher N. Morrison
Summary: This national survey study examines trends in age at natural menopause, age at menarche, and reproductive life span among US women between 1959-1962 and 2015-2018, identifying variables associated with shorter and longer spans.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Review
Obstetrics & Gynecology
S. R. Mishra, H-F Chung, M. Waller, G. D. Mishra
Summary: This study evaluated estrogen exposure measurement and the mutual effect of age at menarche and age at menopause on the risk of cardiovascular disease events. Reproductive lifespan was the most commonly used method for estrogen exposure measurement. The findings suggest that a shorter reproductive lifespan is associated with a higher risk of cardiovascular disease events, particularly stroke.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Geriatrics & Gerontology
Mina Amiri, Maryam Rahmati, Maryam Farahmand, Fereidoun Azizi, Fahimeh Ramezani Tehrani
Summary: This study found that chronic diseases, such as metabolic disorders, cardiovascular events, and CKD, can influence the age at natural menopause in women.
Article
Public, Environmental & Occupational Health
Joanna Lankester, Jin Li, Elias Levy Itshak Salfati, Marcia L. Stefanick, Kei Hang Katie Chan, Simin Liu, Carolyn J. Crandall, Shoa L. Clarke, Themistocles L. Assimes
Summary: The study finds a causal association between a later age at natural menopause and a decreased risk of osteoporosis and fractures, as well as an increased risk of lung cancer.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Obstetrics & Gynecology
Che Xu, Xiangyan Ruan, Alfred O. Mueck
Summary: Menopause not only marks the end of reproductive life, but also has associations with diseases like hyperlipidemia, atherosclerotic cardiovascular disease, osteoporosis, and breast cancer. Traditional epidemiological studies have shown that heredity plays a significant role in determining the age of natural menopause (ANM). Advances in genomic technology have enabled researchers to conduct genome-wide association studies, revealing that defects in DNA damage repair pathways are the primary genetic mechanism. Further genetic and epidemiological studies, including research on polygenic scores and genetic mechanisms, are needed to investigate the pathogenesis and mechanisms related to menopause and its associated diseases.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Medicine, General & Internal
Zhaoxia Liang, Hao Ma, Qiying Song, Dianjianyi Sun, Tao Zhou, Yoriko Heianza, Danqing Chen, Lu Qi
Summary: The study investigated the joint associations of actual age and genetically determined age at menarche with the risk of all-cause mortality. Both actual age at menarche and genetically determined age exhibited a U-shaped association with the risk of mortality, and women with mismatched actual and genetically determined ages had the highest mortality risks.
Article
Obstetrics & Gynecology
Chen Liang, Hsin-Fang Chung, Annette J. Dobson, Janet E. Cade, Darren C. Greenwood, Kunihiko Hayashi, Rebecca Hardy, Diana Kuh, Yvonne T. van der Schouw, Sven Sandin, Elisabete Weiderpass, Gita D. Mishra
Summary: This study analyzed data from 9 observational studies and found that infertility, miscarriage, and stillbirth were associated with premature and early menopause, and the association differed between Asian and non-Asian women. Asian women had a higher risk of premature and early menopause compared to non-Asian women with the same reproductive history.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Wenguo Xing, Quanjun Lv, Yuqian Li, Chongjian Wang, Zhenxing Mao, Yan Li, Jia Li, Tianyu Yang, Linlin Li
Summary: A causal relationship was found between later age at menarche and a lower risk of developing type 2 diabetes, as well as lower levels of fasting insulin, fasting plasma glucose, and HOMA-IR. However, there was only a causal effect between age at natural menopause and HOMA-IR, with no association with type 2 diabetes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Environmental Sciences
Tongyun Qi, Yizhou Huang, Saisai Li, Qian Ying, Zhaoqiang Jiang, Linjuan Ma, Chunming Li, Peiqiong Chen, Wenxian Xu, Yibing Lan, Ketan Chu, Ling Xu, Jianlin Lou, Wenlan Yu, Jianhong Zhou
Summary: The study investigated the impact of occupation types on age at natural menopause among 17,948 female workers aged over 40. It found that specific occupations, such as legislators and health professionals, were associated with earlier age at natural menopause. Further research is needed to determine whether this association is significant.
ENVIRONMENTAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jean Shin, Kyungdo Han, Jin Hyung Jung, Hyo Jin Park, Wonsock Kim, Youn Huh, Yang Hyun Kim, Do Hoon Kim, Seon Mee Kim, Youn Seon Choi, Kyung Hwan Cho, Ga Eun Nam
Summary: This study suggests that postmenopausal women with a history of premature menopause or early menopausal age may have an increased risk of heart failure and atrial fibrillation. These reproductive factors need to be considered for preventing future risks of heart failure and atrial fibrillation.
EUROPEAN HEART JOURNAL
(2022)
Article
Neurosciences
Kazumasa Yamagishi, Koutatsu Maruyama, Ai Ikeda, Masanori Nagao, Hiroyuki Noda, Mitsumasa Umesawa, Mina Hayama-Terada, Isao Muraki, Chika Okada, Mari Tanaka, Rie Kishida, Tomomi Kihara, Tetsuya Ohira, Hironori Imano, Eric J. Brunner, Tomoko Sankai, Takeo Okada, Takeshi Tanigawa, Akihiko Kitamura, Masahiko Kiyama, Hiroyasu Iso
Summary: The study aimed to investigate the association between dietary fiber intake and the risk of disabling dementia. The results showed that higher dietary fiber intake, especially soluble fiber, was associated with a lower risk of disabling dementia requiring care.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Psychology, Clinical
Mark Weiser, Or Frenkel, Daphna Fenchel, Dorit Tzur, Sven Sandin, Magdalena Janecka, Linda Levi, Michael Davidson, Lucian Laor, Eyal Fruchter, Abraham Reichenberg
Summary: Despite the differentiation of different psychiatric disorders by ICD and DSM, these disorders often share symptoms, risk factors, and treatments. This population-based study found shared etiologies among most psychiatric disorders and low IQ.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Martina Persson, Abraham Reichenberg, Mikael Andersson Franko, Sven Sandin
Summary: This study suggests that maternal type 1 diabetes (T1D) may increase the risk of autism spectrum disorder (ASD) in offspring. It is found that this risk may be mediated by pre-term birth, which affects about one-third of pregnancies with T1D. Additionally, maternal levels of glycated haemoglobin (HbA1c) do not impact the risk of ASD beyond the T1D diagnosis itself.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Weiyao Yin, Martina Persson, Sven Sandin
Summary: This study examined the risk of type 1 diabetes mellitus (T1DM) in the offspring of parents with a psychiatric history at the birth of the child. The findings suggested a higher risk of T1DM in children of mothers with psychiatric disorders at delivery, but not in children of fathers with psychiatric disorders or those diagnosed after delivery. The association disappeared after adjusting for T1DM in parents, but remained significant in female offspring. Maternal eating disorder and obsessive-compulsive disorder were independently associated with offspring T1DM.
DIABETES & METABOLISM
(2023)
Article
Oncology
Theodore M. Brasky, Erinn M. Hade, David E. Cohn, Alison M. Newton, Stacey Petruzella, Kelli O'Connell, Kimberly A. Bertrand, Linda S. Cook, Immaculata De Vivo, Mengmeng Du, Jo L. Freudenheim, Christine M. Friedenreich, Marc T. Goodman, Jessica Gorzelitz, Torukiri I. Ibiebele, Vittorio Krogh, Linda M. Liao, Loren Lipworth, Lingeng Lu, Susan McCann, Tracy A. O'Mara, Julie R. Palmer, Jeanette Ponte, Anna Prizment, Harvey Risch, Sven Sandin, Leo J. Schouten, Veronica Wendy Setiawan, Xiao-ou Shu, Britton Trabert, Piet A. van den Brandt, Penelope M. Webb, Nicolas Wentzensen, Lynne R. Wilkens, Alicja Wolk, Herbert Yu, Marian L. Neuhouser
Summary: This study analyzed data from 12 prospective cohort studies and found that higher dietary intake of long-chain omega-3 polyunsaturated fatty acids (LCn3PUFA) may increase the risk of endometrial cancer, especially among specific subgroups characterized by body weight and tumor pathology.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Julie A. Schmidt, Inge Huybrechts, Kim Overvad, Anne Kirstine Eriksen, Anne Tjonneland, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Valeria Pala, Carlotta Sacerdote, Rosario Tumino, Bas Bueno-de-Mesquita, Maria-Jose Sanchez, Jose M. Huerta, Aurelio Barricarte, Pilar Amiano, Antonio Agudo, Anders Bjartell, Tanja Stocks, Elin Thysell, Maria Wennberg, Elisabete Weiderpass, Ruth C. Travis, Timothy J. Key, Aurora Perez-Cornago
Summary: This study investigated the associations between dietary protein intake and prostate cancer risk and mortality. The results suggest that dairy protein and yogurt protein are positively associated with prostate cancer risk, while egg protein may be positively associated with prostate cancer mortality. However, considering the weak associations and many tests conducted, these results should be interpreted with caution.
Article
Economics
Zuzana Spacirova, Stephen Kaptoge, Leticia Garcia-Mochon, Miguel Rodriguez Barranco, Maria Jose Sanchez Perez, Nicola P. Bondonno, Anne Tjonneland, Elisabete Weiderpass, Sara Grioni, Jaime Espin, Carlotta Sacerdote, Catarina Schiborn, Giovanna Masala, Sandra M. Colorado-Yohar, Lois Kim, Karel G. M. Moons, Gunnar Engstrom, Matthias B. Schulze, Lea Bresson, Concepcion Moreno-Iribas, David Epstein
Summary: The objective of this article was to assess the cost-effectiveness of screening strategies for cardiovascular diseases (CVD). The study found that one-off screening using a uniform risk threshold is cost-effective compared to no systematic screening, but the results are sensitive to assumptions about CVD incidence rates.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Oncology
S. G. Yammine, I. Huybrechts, C. Biessy, L. Dossus, S. Panico, M. J. Sanchez, V. Benetou, R. Turzanski-Fortner, V. Katzke, A. Idahl, G. Skeie, K. Standahl Olsen, A. Tjonneland, J. Halkjaer, S. Colorado-Yohar, A. K. Heath, E. Sonestedt, H. Sartor, M. B. Schulze, D. Palli, M. Crous-Bou, A. Dorronsoro, K. Overvad, A. Barricarte Gurrea, G. Severi, R. C. H. Vermeulen, T. M. Sandanger, R. C. Travis, T. Key, P. Amiano, B. Van Guelpen, M. Johansson, M. Sund, R. Tumino, N. Wareham, C. Sacerdote, V. Krogh, P. Brennan, E. Riboli, E. Weiderpass, M. J. Gunter, V. Chajes
Summary: Specific dietary fatty acids, such as gamma-linolenic acid and alpha-linolenic acid from plant sources, may be associated with lower risk of endometrial cancer.
Article
Oncology
Allini Mafra, Aude Bardot, Hadrien Charvat, Elisabete Weiderpass, Isabelle Soerjomataram, Jose Humberto Tavares Guerreiro Fregnani
Summary: This population-based study analyzes the long-term trends in cancer survival in the Barretos region, Brazil. The study finds significant differences in survival rates among different cancer types, with pancreatic and oesophageal cancers having the lowest 5-year survival rates, and prostate, thyroid, and female breast cancers having the highest rates. The study also highlights the impact of sex and clinical stage on survival rates. Overall, there has been an improvement in cancer survival in the Barretos region over the past two decades.
CANCER EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Catalina Bonet, Marta Crous-Bou, Konstantinos K. Tsilidis, Marc J. Gunter., Rudolf Kaaks., Matthias. B. Schulze, Renee T. Fortner, Christian S. Antoniussen, Christina C. Dahm, Lene Mellemkjaer, Anne Tjonneland, Pilar Amiano, Eva Ardanaz, Sandra M. Colorado-Yohar, Miguel Rodriguez-Barranco, Sandar Tin Tin, Claudia Agnoli, Giovanna Masala, Salvatore Panico, Carlotta Sacerdote, Anne M. May, Kristin Benjaminsen Borch, Charlotta Rylander, Guri Skeie, Sofia Christakoudi, Dagfinn Aune, Elisabete Weiderpass, Laure Dossus, Elio Riboli, Antonio Agudo
Summary: The study aimed to assess the association between body fatness and weight changes and overall mortality and BC-specific mortality among BC survivors. The results showed that excess body fatness is linked to poorer survival in women with BC, and substantial weight changes postdiagnosis may contribute to poorer survival.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Oncology
Fatemeh Ghasemi-Kebria, Shahryar Semnani, Abdolreza Fazel, Arash Etemadi, Taghi Amiriani, Mohammad Naeimi-Tabiei, Susan Hasanpour-Heidari, Faezeh Salamat, Nastaran Jafari-Delouie, SeyyedMehdi Sedaghat, Hamideh Sadeghzadeh, Mahnaz Akbari, Mahshid Mehrjerdian, Elisabete Weiderpass, Gholamreza Roshandel, Freddie Bray, Reza Malekzadeh
Summary: Golestan province in Iran is a high-risk area for esophageal and gastric cancers. The incidence rates of esophageal cancer have significantly decreased from 2004 to 2018, while the incidence rates of gastric cancer showed a less marked and nonsignificant decline. The decline in esophageal cancer incidence is attributed to generational changes in risk factors. However, the population in Golestan still faces a high risk of both esophageal and gastric cancers.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Michael Baumann, Julio Celis, Ulrik Ringborg, Manuel Heitor, Anton Berns, Tit Albreht, Jeliazko Arabadjiev, Michael Boutros, Mario Brandenburg, Helena Canhao, Fatima Carneiro, Christine Chomienne, Francesco De Lorenzo, Alexander M. M. Eggermont, Angel Font, Elena Garralda, Margarida Goulart, Rui Henrique, Mark Lawler, Lena Maier-Hein, Francoise Meunier, Simon Oberst, Pedro Oliveira, Maria Papatriantafyllou, Joachim Schuez, Eric Solary, Alfonso Valencia, Rosalia Vargas, Elisabete Weiderpass, Nils Wilking
Summary: European cancer research stakeholders gathered in Heidelberg, Germany, for the 5(th) Gago conference on European Cancer Policy in October 2022. The meeting focused on the current state of cancer research and care policy in Europe, identifying gaps in existing programs and proposing priorities for the future through the Heidelberg Manifesto for cancer research. The discussions in the meeting covered various aspects of cancer research, including infrastructure, digitalization, and collaboration, with an emphasis on implementation and sustainability.
MOLECULAR ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Chen Liang, Hsin-Fang Chung, Annette J. Dobson, Janet E. Cade, Darren C. Greenwood, Kunihiko Hayashi, Rebecca Hardy, Diana Kuh, Yvonne T. van der Schouw, Sven Sandin, Elisabete Weiderpass, Gita D. Mishra
Summary: This study analyzed data from 9 observational studies and found that infertility, miscarriage, and stillbirth were associated with premature and early menopause, and the association differed between Asian and non-Asian women. Asian women had a higher risk of premature and early menopause compared to non-Asian women with the same reproductive history.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Oncology
Elisabetta Casalone, Giovanni Birolo, Barbara Pardini, Alessandra Allione, Alessia Russo, Chiara Catalano, Manlio Mencoboni, Daniela Ferrante, Corrado Magnani, Marika Sculco, Irma Dianzani, Federica Grosso, Dario Mirabelli, Rosa Angela Filiberti, Ottavio Rena, Carlotta Sacerdote, Miguel Rodriguez-Barranco, Karl Smith-Byrne, Salvatore Panico, Claudia Agnoli, Theron Johnson, Rudolf Kaaks, Rosario Tumino, Jose Maria Huerta, Elio Riboli, Alicia K. Heath, Camino Trobajo-Sanmartin, Matthias B. Schulze, Calogero Saieva, Pilar Amiano, Antonio Agudo, Elisabete Weiderpass, Paolo Vineis, Giuseppe Matullo
Summary: This study identified a miRNA signature in preclinical MPM patients, which can be detected up to five years before diagnosis, providing potential non-invasive markers for early detection and intervention.
Article
Oncology
Anja M. M. Sedlmeier, Vivian Viallon, Pietro Ferrari, Laia Peruchet-Noray, Emma Fontvieille, Amina Amadou, Nazlisadat Seyed Khoei, Andrea Weber, Hansjoerg Baurecht, Alicia K. K. Heath, Kostas Tsilidis, Rudolf Kaaks, Verena Katzke, Elif Inan-Eroglu, Matthias B. B. Schulze, Kim Overvad, Catalina Bonet, Esther Ubago-Guisado, Maria-Dolores Chirlaque, Eva Ardanaz, Aurora Perez-Cornago, Valeria Pala, Rosario Tumino, Carlotta Sacerdote, Fabrizio Pasanisi, Kristin B. B. Borch, Charlotta Rylander, Elisabete Weiderpass, Marc J. J. Gunter, Beatrice Fervers, Michael F. F. Leitzmann, Heinz Freisling
Summary: This study suggests that different body shape phenotypes are positively associated with the incidence of various cancers, including overall cancer and site-specific cancers.
BRITISH JOURNAL OF CANCER
(2023)