Article
Immunology
Shao Lin, Xinlei Deng, Ian Ryan, Kai Zhang, Wangjian Zhang, Ese Oghaghare, DeeDee Bennett Gayle, Benjamin Shaw
Summary: Age, gender, and race are associated with the risk of COVID-19 death among healthcare workers. Severe clinical indicators and specific symptoms can predict COVID-19-related deaths in healthcare workers.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Pedro Augusto Sampaio Rocha-Filho, Pedro Mota Albuquerque, Larissa Clementino Leite Sa Carvalho, Mylana Dandara Pereira Gama, Joao Eudes Magalhaes
Summary: This study found that neurological symptoms and headache are common among patients with COVID-19. Headache is associated with other symptoms such as fever, sore throat, anosmia, ageusia, and myalgia, and may persist beyond the acute phase of the disease.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Immunology
Silvia Llorens, Eduardo Nava, Monica Munoz-Lopez, Alvaro Sanchez-Larsen, Tomas Segura
Summary: The COVID-19 pandemic caused by SARS-CoV-2 in 2020 has led to global outbreak, with patients experiencing respiratory, digestive, and neurological symptoms, including anosmia suggesting potential neurotropism. Research proposes an alternative pathway from gut infection involving Toll-like receptor 4 (TLR4), protease-activated receptor 2 (PAR2), and zonulin, and suggests investigation into the use of zonulin antagonists to mitigate neurological manifestations caused by SARS-CoV-19 infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Clinical Neurology
Xiangliang Chen, Sarah Laurent, Oezguer A. Onur, Nina N. Kleineberg, Gereon R. Fink, Finja Schweitzer, Clemens Warnke
Summary: The study aims to examine the frequency of neurological symptoms and complications in COVID-19 patients through a systematic review of literature. The most commonly described neurological symptoms include headache, dizziness, taste and smell dysfunctions, and impaired consciousness. Cerebrovascular events, seizures, meningoencephalitis, and immune-mediated neurological diseases have been reported in smaller studies or single cases, but are not suitable for quantitative analysis.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Rehab Magdy, Alaa Elmazny, Shaimaa H. Soliman, Eman H. Elsebaie, Sara H. Ali, Ali M. Abdel Fattah, Mahmoud Hassan, Ahmed Yassien, Noha A. Mahfouz, Radwa M. Elsayed, Wael Fathy, Hoda M. Abdel-Hamid, Jehan Mohamed, Mona Hussein
Summary: This study investigated the post-COVID-19 neuropsychiatric symptoms in migraine patients compared to a non-migraine control group. The findings suggest that migraine patients may be more vulnerable to experiencing symptoms such as fatigue, anosmia/hyposmia, anxiety, and headache after recovering from COVID-19. This highlights the importance of closely monitoring and caring for migraine patients during their recovery.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Public, Environmental & Occupational Health
Stacy E. F. Melanson, Zhen Zhao, Attila Kumanovics, Tanzy Love, Qing H. Meng, Alan H. B. Wu, Fred Apple, Caitlin R. Ondracek, Karen M. Schulz, Joseph R. Wiencek, David Koch, Robert Christenson, Y. Victoria Zhang
Summary: This study examined the side effects of COVID-19 vaccines in healthcare professionals and found that younger people, females, and those receiving the Moderna vaccine were more likely to experience side effects. Additionally, side effects were more common after the second dose of the vaccine, and the proportion of participants reporting no side effects increased with age.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Neurosciences
Aleksandra Kacprzak, Daniel Malczewski, Izabela Domitrz
Summary: The study found that headaches reported in COVID-19 patients did not meet the criteria for migraine or tension-type headache.
Review
Immunology
Yoshitaka Kase, Hideyuki Okano
Summary: Since the outbreak of COVID-19 in 2020, research reports have shown that the virus causes not only respiratory disorders, but also various neural disorders. However, there has been relatively limited research and summaries on COVID-19-related neural disorders compared to other illnesses caused by the virus.
INFLAMMATION AND REGENERATION
(2021)
Review
Biochemistry & Molecular Biology
Ghaydaa A. Shehata, Kevin C. Lord, Michaela C. Grudzinski, Mohamed Elsayed, Ramy Abdelnaby, Hatem A. Elshabrawy
Summary: COVID-19 is a severe respiratory disease caused by the newly identified human coronavirus SARS-CoV-2, which can also lead to various neurological complications. These complications include headache, dizziness, loss of taste and smell, encephalitis, and managing them remains a challenge for healthcare workers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Helena T. Hogberg, Ann Lam, Elan Ohayon, Muhammad Ali Shahbaz, Laure-Alix Clerbaux, Anna Bal-Price, Sandra Coecke, Rachel Concha, Francesca De Bernardi, Eizleayne Edrosa, Alan J. Hargreaves, Katja M. Kanninen, Amalia Munoz, Francesca Pistollato, Surat Saravanan, Natalia Garcia-Reyero, Clemens Wittwehr, Magdalini Sachana
Summary: This review organizes available knowledge on the neurobiological mechanisms of COVID-19, identifies four AOPs leading to neurological adverse outcomes, and discusses factors influencing the impact of COVID-19 on neurological AOPs. The use of the AOP framework helps visualize core pathways and shared mechanisms.
Article
Neurosciences
Gretel Sanabria-Diaz, Manina Maja Etter, Lester Melie-Garcia, Johanna M. M. Lieb, Marios-Nikos Psychogios, Gregor Hutter, Cristina Granziera
Summary: This study assessed the cortical gray matter volume, thickness, and surface area in SARS-CoV-2 infected patients with neurological symptoms. The findings suggest that viral-triggered inflammation leads to neurotoxic damage in certain cortical areas during the acute phase of the infection.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Edoardo Caronna, Alicia Alpuente, Marta Torres-Ferrus, Patricia Pozo-Rosich
Summary: Studies show that post-COVID headache encompasses various types of headaches, requiring careful evaluation and further investigation into different underlying pathophysiological mechanisms.
Article
Anesthesiology
Alicia Gonzalez-Martinez, Alvaro Planchuelo-Gomez, Angel L. Guerrero, David Garcia-Azorin, Sonia Santos-Lasaosa, Maria Pilar Navarro-Perez, Paula Odriozola-Gonzalez, Maria Jesus Irurtia, Sonia Quintas, Rodrigo de Luis-Garcia, Ana Beatriz Gago-Veiga
Summary: Approximately half of migraine patients reported worsening of their usual pain during the lockdown, which was related to changes in triggers and the emotional impact of the lockdown.
Article
Clinical Neurology
Imen Kacem, Alya Gharbi, Chahida Harizi, Emira Souissi, Mouna Safer, Amina Nasri, Hajer Letaief, Manel Akkari, Aicha Hechaichi, Saloua Mrabet, Sonia Dhaouadi, Mouna Ben Djebara, Sondes Derouiche, Amina Gargouri, Mohamed Chahed, Nissaf Ben Alaya, Riadh Gouider
Summary: Neurological symptoms in COVID-19 are common, can occur in isolation, with headache being the most prevalent symptom. Headache, when accompanied by fever, tends to be more severe and present early in the disease course.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
V. A. Blanco-Palmero, F. J. Azcarate-Diaz, M. Ruiz-Ortiz, M. I. Laespada-Garcia, P. Rabano-Suarez, A. Mendez-Guerrero, M. Aramendi-Ramos, J. L. Eguiburu, A. Perez-Rivilla, A. Marchan-Lopez, M. Rubio-Fernandez, E. Carro, J. Gonzalez de la Aleja
Summary: This study did not find evidence of increased expression of alpha-synuclein in individuals with neurological symptoms in COVID-19. Further research involving a larger group of COVID-19 patients with a wide spectrum of neurological manifestations and disease severity is needed.
JOURNAL OF NEUROLOGY
(2021)
Article
Ophthalmology
Julio Gonzalez-Martin-Moro, Jesus Porta Etessam, Belen Pilo de la Fuente, Irene Fuentes Vega, Ines Contreras
Summary: Optical coherence tomography angiography (OCTA) can be used to observe retinal vascular changes during migraine attacks. This case report demonstrates an extensive area of hypoperfusion in the macular region of the right eye using OCTA in a migraine patient. The involvement of only one eye supports the theory of selective retinal ganglion cell layer spreading depression.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Clinical Neurology
F. Ly-Yang, V. Gomez-Calleja, P. Perez-Garcia, N. Gonzalez-Gomez, J. Porta-Etessam, E. Santos-Bueso
Summary: This article presents 30 clinical cases of photophobia and reviews the literature in order to establish diagnostic criteria for this condition. The results suggest that the underlying causes of photophobia may involve the intrinsically photosensitive retinal ganglion cells as well as neurochemical factors like calcitonin-related peptide and the pituitary activating peptide cyclase. The treatment for photophobia could potentially involve the use of monoclonal antibodies targeting calcitonin-related peptide and/or pituitary activating peptide cyclase.
Article
Clinical Neurology
Maria Diez-Cirarda, Miguel Yus, Natividad Gomez-Ruiz, Carmen Polidura, Lidia Gil-Martinez, Cristina Delgado-Alonso, Manuela Jorquera, Ulises Gomez-Pinedo, Jorge Matias-Guiu, Juan Arrazola, Jordi A. Matias-Guiu
Summary: Diez-Cirarda et al. report persistent structural and functional brain alterations 11 months after acute SARS-CoV-2 infection, which are associated with cognitive dysfunction and contribute to a better understanding of the pathophysiology of the post-COVID syndrome.
Letter
Biochemistry & Molecular Biology
Maria Diez-Cirarda, Miguel Yus, Jorge Matias-Guiu, Jordi A. Matias-Guiu
MOLECULAR PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Hernan Mejia-Renteria, Alejandro Travieso, Jordi A. Matias-Guiu, Miguel Yus, Carolina Espejo-Paeres, Francesca Finocchiaro, Sara Fernandez, Carlos Ignacio Gomez-Escalonilla, Blanca Reneses-Prieto, Maria Dulcenombre Gomez-Garre, Alfonso Delgado-Alvarez, Ana Bustos, Leopoldo Perez de Isla, Jose Juan Gomez de Diego, Javier Modrego-Martin, Adriana Ortega-Hernandez, Petros Papadopoulos, Juan Arrazola-Garcia, Jorge Matias-Guiu, Javier Escaned
Summary: This study reveals the correlation between coronary microcirculatory dysfunction in patients with coronary artery disease (CAD) and cerebral small vessel disease (CSVD), as well as cognitive impairment.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Clinical Neurology
Jordi A. Matias-Guiu, Alfonso Delgado-Alvarez
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Psychiatry
Jordi A. Matias-Guiu, Elena Herrera, Maria Gonzalez-Nosti, Kamini Krishnan, Cristina Delgado-Alonso, Maria Diez-Cirarda, Miguel Yus, Alvaro Martinez-Petit, Josue Pagan, Jorge Matias-Guiu, Jose Luis Ayala, Robyn Busch, Bruce P. Hermann
Summary: The objective of this study was to develop objective criteria for cognitive dysfunction associated with the post-COVID syndrome. Four hundred and four patients with post-COVID syndrome were evaluated using comprehensive neuropsychological batteries. The developed criteria classified 41.2% and 17.3% of the sample as having at least one impaired cognitive domain using-1 and-1.5 standard deviations as cutoff points. Cognitive impairment was associated with younger age and lower education levels, but not hospitalization.
PSYCHIATRY RESEARCH
(2023)
Review
Medicine, General & Internal
Eliseo Barral, Elisa Martins Silva, David Garcia-Azorin, Michele Viana, Francesca Puledda
Summary: Migraine is a common and severe primary headache disorder characterized by pain and various non-painful symptoms, including visual phenomena. This review focuses on two visual disorders associated with migraine: visual aura and visual snow syndrome (VSS). Visual aura presents as transient positive and negative visual symptoms before, during, or outside of a migraine attack. VSS is a newly recognized phenomenon that is comorbid with migraine. The review discusses clinical features, pathophysiological mechanisms, differential diagnoses, and treatment options for these disorders, aiming to assist clinicians and researchers in recognizing these visual phenomena commonly seen in patients with underlying migraine biology.
Article
Clinical Neurology
J. Porta-Etessam, S. Santos-Lasaosa, J. Rodriguez-Vico, M. Nunez, A. Ciudad, S. Diaz-Cerezo, M. Comellas, F. J. Perez-Sadaba, L. Lizan, A. L. Guerrero-Peral
Summary: Shared decision-making (SDM) training for neurologists in migraine care does not significantly impact patients’ decisional conflict and patient-physician relationship. However, physicians reported greater satisfaction and confidence in communicating with patients after the training.
NEUROLOGY AND THERAPY
(2023)
Article
Neurosciences
Laura Hernandez-Lorenzo, Maria Jose Gil-Moreno, Isabel Ortega-Madueno, Maria Cruz Cardenas, Maria Diez-Cirarda, Alfonso Delgado-Alvarez, Marta Palacios-Sarmiento, Jorge Matias-Guiu, Silvia Corrochano, Jose L. A. Ayala, Jordi A. Matias-Guiu
Summary: This study compares the diagnostic and prognostic abilities of CSF biomarkers clustering results with their AT(N) classification. The results suggest that this data-driven three-group classification can effectively evaluate the risk of conversion to dementia.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Alfonso Delgado-Alvarez, Cristina Delgado-Alonso, Maria Valles-Salgado, Maria Jose Gil-Moreno, Lucia Fernandez-Romero, Jorge Matias-Guiu, Jordi A. Matias-Guiu
Summary: This study collected and presented normative data on three neuropsychological instruments developed from a cross-cultural perspective in a majority population sample (Spaniards living in Spain) and a minority population sample (Colombians living in Spain). The study found that these instruments have favorable cross-cultural properties and show similar influences of demographic factors in both populations.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Anesthesiology
Alicia Gonzalez-Martinez, Ancor Sanz-Garcia, David Garcia-Azorin, Jaime Rodriguez-Vico, Alex Jaimes, Andrea Gomez Garcia, Javier Casas-Limon, Javier Diaz de Teran, Maria Sastre-Real, Javier Membrilla, German Latorre, Carlos Calle de Miguel, Sendoa Gil Luque, Cristina Trevino-Peinado, Sonia Quintas, Patricia Heredia, Ana Echavarria-Iniguez, Angel Guerrero-Peral, Alvaro Sierra, Nuria Gonzalez-Garcia, Jesus Porta-Etessam, Ana Beatriz Gago-Veiga
Summary: This study evaluated the clinical characteristics, effectiveness, and tolerability of preventive anti-CGRP mAbs in the elderly. The results showed that anti-CGRP mAbs can effectively reduce the number of headaches in elderly patients with migraine, and their safety is similar to that of younger patients. In elderly patients, the diagnosis of episodic migraine and a lower baseline number of headaches were associated with a response to anti-CGRP mAbs.
Article
Clinical Neurology
Victor Obach, Fernando Velasco, Rocio Alvarez Escudero, Maria Martin Bujanda, Sonsoles Aranceta, Neus Fabregat, Teresa Marco, Aintzine Ruisanchez, Natalia Roncero, Ane Minguez-Olaondo, Marta Ruibal, Daniel Guisado-Alonso, Antia Moreira, Elisa Cuadrado-Godia, Amaya Echeverria, Izaro Kortazar Zubizarreta, Alba Lopez-Bravo, Nuria Riesco, Lucia Gonzalez-Fernandez, Nuria Pola, Paula Manera, Angel Luis Guerrero-Peral, Agustin Oterino Duran, Yesica Gonzalez-Osorio, Rosario Armand, Santiago Fernandez-Fernandez, David Garcia-Azorin, Juan Carlos Garcia-Monco
Summary: This study examines the long-term effectiveness and tolerability of galcanezumab in clinical practice for patients excluded from randomized controlled trials (RCTs). The results demonstrate that galcanezumab is effective and well-tolerated in real-world settings, with clinical outcomes comparable to those observed in RCTs.
JOURNAL OF HEADACHE AND PAIN
(2023)
Review
Clinical Neurology
Bianca Raffaelli, David Garcia-Azorin, Deirdre M. Boucherie, Faisal Mohammad Amin, Christina I. Deligianni, Raquel Gil-Gouveia, Sarah Kirsh, Christian Lampl, Simona Sacco, Derya Uluduz, Jan Versijpt, Antoinette Maassenvandenbrink, Dena Zeraatkar, Margarita Sanchez-del-Rio, Uwe Reuter
Summary: This systematic review and meta-analysis evaluated the efficacy and tolerability of topiramate in migraine prophylaxis. The results showed that topiramate significantly reduced monthly migraine days and increased the proportion of patients achieving a 50% responder rate. However, the use of topiramate was associated with an increased risk of adverse events, which may negatively impact patient satisfaction and adherence to treatment.
JOURNAL OF HEADACHE AND PAIN
(2023)
