Article
Neurosciences
Yao Wang, Yuting Gao, Min Zhao, Xin Hu, Jing Wang, Yu Han, Qinghui Wang, Xinxing Fu, Zongrui Dai, Funxin Ren, Muwei Li, Fei Gao
Summary: Presbycusis is associated with altered functional connectivity between gray matter and white matter, with disrupted connectivity between the body of the corpus callosum and ventral anterior cingulate cortex being linked to attention impairment, and enhanced connectivity between the internal capsule and the ventral auditory processing stream being associated with cognitive impairment in various domains.
Article
Anatomy & Morphology
Yuan Jiang, Pan Wang, Jiaping Wen, Jianlin Wang, Hongyi Li, Bharat B. Biswal
Summary: This study utilized functional connectivity analysis to investigate abnormal brain connections between white matter and gray matter in patients with MCI. The results showed that compared to healthy controls, MCI patients exhibited specific dysconnectivity in certain brain regions, particularly in the connections between the hippocampus and the temporal pole. These findings are important for understanding the mechanisms of memory decline in MCI and the progression of Alzheimer's disease.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Pan Wang, Zedong Wang, Jianlin Wang, Yuan Jiang, Hong Zhang, Hongyi Li, Bharat B. Biswal
Summary: By combining functional magnetic resonance imaging with diffusion tensor imaging, the study identified significant alterations in functional connectivity between gray matter and white matter in patients with Alzheimer's disease, with specific white matter-functional network changes related to cognitive abilities and pathological characteristics.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neuroimaging
Hua Lin, Muwei Li, Yang Zhan, Li Lin, Kun Yang, Shimin Hu, Ying Han
Summary: The study investigated the impact of APOE ε4 on specific white matter functional connectivity in aMCI patients, revealing decreased functional connectivity in specific regions in APOE ε4 carriers, which differed from regions of aMCI-related changes. The findings suggest that APOE ε4 genotype exerts a negative impact on neural activity in both gray and white matter, potentially contributing to functional disconnection and memory decline in aMCI.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Neurosciences
Wenhao Zhu, Hao Huang, Shiqi Yang, Xiang Luo, Wenzhen Zhu, Shabei Xu, Qi Meng, Chengchao Zuo, Yong Liu, Wei Wang
Summary: The study found that gray matter atrophy in white matter hyperintensities patients may lead to cognitive decline, especially in those with mild cognitive impairment. The reduction in gray matter volume in the thalamus and fronto-insular cortices is associated with cognitive decline, and these results were further validated.
NEUROSCIENCE BULLETIN
(2021)
Article
Clinical Neurology
Chintan Shah, Dhivya Srinivasan, Guray Erus, James E. Schmitt, Adhish Agarwal, Monique E. Cho, Alan J. Lerner, William E. Haley, Manjula Kurella Tamura, Christos Davatzikos, Robert N. Bryan, Yong Fan, Ilya M. Nasrallah
Summary: In hypertensive patients, greater white matter lesion (WML) volume is associated with lower functional connectivity (FC) of the default mode network (DMN), which in turn is related to poorer cognitive test performance. Other functional networks also demonstrated correlations with WML, but did not show an association with cognition.
Article
Neuroimaging
Juanwei Ma, Feng Liu, Yang Wang, Lin Ma, Yali Niu, Jing Wang, Zhaoxiang Ye, Jing Zhang
Summary: This study investigates the functional abnormalities in white matter (WM) associated with cognitive impairment in vascular cognitive impairment (VCI) patients. Using resting-state functional MRI, the researchers identify changes in functional connectivity and amplitude of WM networks in VCI patients. They find significant decreases in connectivity and amplitude in multiple brain regions in VCI patients, which are positively correlated with cognitive performances.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Huahong Zhu, Ruomeng Qin, Yue Cheng, Lili Huang, Pengfei Shao, Hengheng Xu, Yun Xu, Qing Ye
Summary: There is considerable variation in the cognitive performance of individuals with white matter hyperintensities (WMH). This study found that individuals with cognitive impairment (CI) had lower voxel-mirrored homotopic connectivity (VMHC) in the bilateral cuneus and calcarine and higher VMHC in the lentiform nucleus and caudate nucleus (LNCN) compared to those without CI. Furthermore, increased VMHC in the LNCN was negatively associated with global function and memory function in WMH subjects.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Tae Kim, Howard J. Aizenstein, Beth E. Snitz, Yu Cheng, Yue-Fang Chang, Rebecca E. Roush, Theodore J. Huppert, Annie Cohen, Jack Doman, James T. Becker
Summary: This study found that white matter hyperintensities (WMHs) are associated with cognitive decline, and the relationships between WM microstructural changes and structural and functional connectivity are important for understanding the pathophysiological processes of cognitive impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Xuefei Zhang, Yu Shi, Tao Fan, Kangling Wang, Hongrui Zhan, Wen Wu
Summary: This study used graph theory to analyze structural networks and explored the structural connectivity-functional connectivity coupling of multi-scale brain networks in patients with post-stroke depression (PSD). The results showed that the structural network in PSD was characterized by reduced clustering, increased path length, and lower modularity.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Cell Biology
Ashwati Vipin, Benjamin Yi Xin Wong, Dilip Kumar, Audrey Low, Kok Pin Ng, Nagaendran Kandiah
Summary: This study investigated the relationship between small-vessel cerebrovascular disease and grey matter volume (GMV) alterations in Alzheimer's disease patients. The results showed differential effects of WMH burden on GMV in Mild Cognitive Impairment (MCI), with both negative and positive associations observed at different WMH loads. Additionally, the association between WMH and cognitive functions such as memory and executive function was moderated by regional GMV in MCI patients.
Article
Neurosciences
Haifeng Chen, Jingxian Xu, Weiping Lv, Zheqi Hu, Zhihong Ke, Ruomeng Qin, Ying Chen, Yun Xu
Summary: This study examines the neuroimaging mechanisms of white matter hyperintensities (WMH) and its association with cognitive impairment. The results show altered morphological networks in WMH individuals with mild cognitive impairment, particularly in the default mode network (DMN) and limbic network (LN). These findings suggest the potential use of single-subject morphological networks as an early imaging diagnostic tool for WMH-related cognitive impairment.
BRAIN RESEARCH BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Paola Ortelli, Angelica Quercia, Antonio Cerasa, Sabrina Dezi, Davide Ferrazzoli, Luca Sebastianelli, Leopold Saltuari, Viviana Versace, Angelo Quartarone, Marco Marino
Summary: This study investigates the brain source activity in post-COVID-19 syndrome (PCS) patients and finds that PCS patients exhibit alterations in neurocognitive symptoms and fatigue. The results suggest a dysfunction in the neuronal networks involved in executive functions in PCS patients, which may contribute to their complaints of fatigue and cognitive impairment.
Article
Medicine, General & Internal
Milena Dimitrova, Yoanna Marinova, Dancho Dilkov
Summary: This study investigates cognitive impairment in patients hospitalized for COVID-19 in Bulgaria. Among 120 recovered patients, 23 (19.17%) experienced cognitive dysfunction, with only 7 showing evidence of cortical atrophy on neuroimaging examinations.
Article
Behavioral Sciences
Haichao Zhao, Jian Cheng, Jiyang Jiang, Lijun Zuo, Wanlin Zhu, Wei Wen, Perminder Sachdev, Yongjun Wang, Tao Liu, Zixiao Li
Summary: Subcortical ischemic stroke leads to significant microstructural changes in the white matter fiber orientation, especially in patients with post-stroke cognitive impairment (PSCI). These microstructural changes impact the functional connectivity in projective cerebral regions, indicating a complex relationship between white matter damage, functional connectivity, and cognitive impairment in post-stroke patients.
Letter
Biochemistry & Molecular Biology
Maria Diez-Cirarda, Miguel Yus, Jorge Matias-Guiu, Jordi A. Matias-Guiu
MOLECULAR PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Hernan Mejia-Renteria, Alejandro Travieso, Jordi A. Matias-Guiu, Miguel Yus, Carolina Espejo-Paeres, Francesca Finocchiaro, Sara Fernandez, Carlos Ignacio Gomez-Escalonilla, Blanca Reneses-Prieto, Maria Dulcenombre Gomez-Garre, Alfonso Delgado-Alvarez, Ana Bustos, Leopoldo Perez de Isla, Jose Juan Gomez de Diego, Javier Modrego-Martin, Adriana Ortega-Hernandez, Petros Papadopoulos, Juan Arrazola-Garcia, Jorge Matias-Guiu, Javier Escaned
Summary: This study reveals the correlation between coronary microcirculatory dysfunction in patients with coronary artery disease (CAD) and cerebral small vessel disease (CSVD), as well as cognitive impairment.
EUROPEAN HEART JOURNAL
(2023)
Article
Neurosciences
Alfonso Delgado-Alvarez, Maria Diez-Cirarda, Cristina Delgado-Alonso, Laura Hernandez-Lorenzo, Constanza Cuevas, Maria Valles-Salgado, Paloma Montero-Escribano, Maria Jose Gil-Moreno, Jorge Matias-Guiu, Rocio Garcia-Ramos, Jordi A. Matias-Guiu
Summary: The study validated the effectiveness of the Rowland Universal Dementia Assessment Scale (RUDAS) in patients with Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). The results showed that RUDAS performed well in diagnosing cognitive impairment associated with AD, PD, and MS, with minimal influence from education and cultural biases.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Maria Diez-Cirarda, Alberto Cabrera-Zubizarreta, Ane Murueta-Goyena, Antonio P. Strafella, Rocio Del Pino, Marian Acera, Olaia Lucas-Jimenez, Naroa Ibarretxe-Bilbao, Beatriz Tijero, Juan Carlos Gomez-Esteban, Inigo Gabilondo
Summary: Visual hallucinations (VH) are present in up to 75% of Parkinson's disease (PD) patients. However, their neural bases and participation of the visual system in VH are not well-understood in PD. This study found specific functional and structural abnormalities within the visual system in PD patients with VH, which could potentially serve as biomarkers for VH in PD.
JOURNAL OF NEUROLOGY
(2023)
Correction
Clinical Neurology
Maria Diez-Cirarda, Alberto Cabrera-Zubizarreta, Ane Murueta-Goyena, Antonio P. Strafella, Rocio Del Pino, Marian Acera, Olaia Lucas-Jimenez, Naroa Ibarretxe-Bilbao, Beatriz Tijero, Juan Carlos Gomez-Esteban, Inigo Gabilondo
JOURNAL OF NEUROLOGY
(2023)
Editorial Material
Geriatrics & Gerontology
Yuzhen Xu, Ulises Gomez-Pinedo, Jun Liu, Daojun Hong, Jun Xu
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Cell Biology
Ulises Gomez-Pinedo, Jordi A. Matias-Guiu, Denise Ojeda-Hernandez, Sarah de la Fuente-Martin, Ola Mohamed-Fathy Kamal, Maria Soledad Benito-Martin, Belen Selma-Calvo, Paloma Montero-Escribano, Jorge Matias-Guiu
Summary: The implantation of oligodendrocyte precursor cells is a potential therapeutic strategy for remyelination. However, it is unclear how these cells behave after implantation and if they retain the ability to proliferate and differentiate into myelin-forming oligodendrocytes. This study evaluates the impact of corticosteroids on cell proliferation, differentiation, and survival, finding that corticosteroids reduce these capacities and do not support remyelination.
Article
Clinical Neurology
Silvia Oliver-Mas, Cristina Delgado-Alonso, Alfonso Delgado-Alvarez, Maria Diez-Cirarda, Constanza Cuevas, Lucia Fernandez-Romero, Andreu Matias-Guiu, Maria Valles-Salgado, Lidia Gil-Martinez, Maria Jose Gil-Moreno, Miguel Yus, Jorge Matias-Guiu, Jordi A. Matias-Guiu
Summary: In a study, Oliver-Mas et al. found that anodal transcranial direct current stimulation on the left prefrontal dorsolateral cortex improved physical fatigue in patients with post-COVID syndrome. The treatment had no adverse effects and showed a statistically significant improvement in physical fatigue compared to the sham stimulation. However, no significant effect was observed on cognitive fatigue or quality of life. Further studies are needed to confirm these findings and optimize stimulation protocols.
BRAIN COMMUNICATIONS
(2023)
Article
Clinical Neurology
Cristina Delgado-Alonso, Maria Diez-Cirarda, Josue Pagan, Carlos Perez-Izquierdo, Silvia Oliver-Mas, Lucia Fernandez-Romero, Alvaro Martinez-Petit, Maria Valles-Salgado, Maria Jose Gil-Moreno, Miguel Yus, Jorge Matias-Guiu, Jose Luis Ayala, Jordi A. Matias-Guiu
Summary: Brain fog associated with COVID-19 is characterized by attention and episodic memory symptoms, and fatigue serves as the main mediator between objective and subjective cognition. Our findings contribute to understanding the pathophysiology of brain fog and underline the importance of unraveling the main mechanisms underlying brain fog, taking into account multiple aspects.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Maria Diez-Cirarda, Miguel Yus-Fuertes, Rafael Sanchez-Sanchez, Javier J. Gonzalez-Rosa, Gabriel Gonzalez-Escamilla, Lidia Gil-Martinez, Cristina Delgado-Alonso, Maria Jose Gil-Moreno, Maria Valles-Salgado, Fatima Cano-Cano, Denise Ojeda-Hernandez, Natividad Gomez-Ruiz, Silvia Oliver-Mas, Maria Soledad Benito-Martin, Manuela Jorquera, Sarah de la Fuente, Carmen Polidura, Belen Selma-Calvo, Juan Arrazola, Jorge Matias-Guiu, Ulises Gomez-Pinedo, Jordi A. Matias-Guiu
Summary: Cognitive deficits are a major symptom in both COVID-19 patients and post-COVID syndrome (PCS). The hippocampus, a key region for cognition, shows vulnerability to SARS-CoV-2 infection. In PCS patients, hippocampal grey matter atrophy, altered microstructural integrity, hypoperfusion, and functional connectivity changes are observed. Blood biomarkers, such as GFAP, MOG, CCL11, and NfL, show alterations in PCS and are associated with hippocampal volume changes.