Mechanism of Action of OnabotulinumtoxinA in Chronic Migraine: A Narrative Review

Non-trigeminal nociceptive innervation of the posterior dura: implications to occipital headache

(2019) Rodrigo Noseda et al.   JOURNAL OF NEUROSCIENCE

Central Effects of Botulinum Neurotoxin—Evidence from Human Studies

(2019) David Weise et al.   Toxins

Botulinum Neurotoxin Light Chains Expressed by Defective Herpes Simplex Virus Type-1 Vectors Cleave SNARE Proteins and Inhibit CGRP Release in Rat Sensory Neurons

(2019) Charles Joussain et al.   Toxins

CALCA and TRPV1 genes polymorphisms are related to a good outcome in female chronic migraine patients treated with OnabotulinumtoxinA

(2019) R. Moreno-Mayordomo et al.   JOURNAL OF HEADACHE AND PAIN

Early efficacy and late gain in chronic and high‐frequency episodic migraine with onabotulinumtoxinA

(2019) A. Alpuente et al.   EUROPEAN JOURNAL OF NEUROLOGY

Emerging evidence of occipital nerve compression in unremitting head and neck pain

(2019) Pamela Blake et al.   JOURNAL OF HEADACHE AND PAIN

A Phase-by-Phase Review of Migraine Pathophysiology

(2018) David W. Dodick   HEADACHE

PACAP and its receptors in cranial arteries and mast cells

(2018) Inger Jansen-Olesen et al.   JOURNAL OF HEADACHE AND PAIN

CGRP as the target of new migraine therapies — successful translation from bench to clinic

(2018) Lars Edvinsson et al.   Nature Reviews Neurology

Role of critical elements in botulinum neurotoxin complex in toxin routing across intestinal and bronchial barriers

(2018) Koyel J. Ghosal et al.   PLoS One

OnabotulinumtoxinA for the Treatment of Poststroke Distal Lower Limb Spasticity: A Randomized Trial

(2018) Theodore Wein et al.   PM&R

Tracking patients with chronic occipital headache after occipital nerve decompression surgery: A case series

(2018) Pamela Blake et al.   CEPHALALGIA

Overview of Neuropeptides: Awakening the Senses?

(2017) Andrew F. Russo   HEADACHE

Fremanezumab - a humanized monoclonal anti-CGRP antibody — inhibits thinly myelinated (Aδ) but not unmyelinated (C) meningeal nociceptors

(2017) Agustin Melo-Carrillo et al.   JOURNAL OF NEUROSCIENCE

Botulinum neurotoxin type A-cleaved SNAP25 is confined to primary motor neurons and localized on the plasma membrane following intramuscular toxin injection

(2017) Brian B. Cai et al.   NEUROSCIENCE

Migraine Treatment: Current Acute Medications and Their Potential Mechanisms of Action

(2017) Jonathan Jia Yuan Ong et al.   Neurotherapeutics

Pathophysiology of Migraine: A Disorder of Sensory Processing

(2017) Peter J. Goadsby et al.   PHYSIOLOGICAL REVIEWS

Upregulation of inflammatory gene transcripts in periosteum of chronic migraineurs: Implications for extracranial origin of headache

(2016) Carlton J. Perry et al.   ANNALS OF NEUROLOGY

Extracranial injections of botulinum neurotoxin type A inhibit intracranial meningeal nociceptors’ responses to stimulation of TRPV1 and TRPA1 channels: Are we getting closer to solving this puzzle?

(2016) XiChun Zhang et al.   CEPHALALGIA

OnabotulinumtoxinA Improves Pain in Patients With Post-Stroke Spasticity: Findings From a Randomized, Double-Blind, Placebo-Controlled Trial

(2016) Jörg Wissel et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Glycans Confer Specificity to the Recognition of Ganglioside Receptors by Botulinum Neurotoxin A

(2016) Christoffer Hamark et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Durable Efficacy and Safety of Long-Term OnabotulinumtoxinA Treatment in Patients with Overactive Bladder Syndrome: Final Results of a 3.5-Year Study

(2016) Victor W. Nitti et al.   JOURNAL OF UROLOGY

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

(2016) Guorui Yao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Practice guideline update summary: Botulinum neurotoxin for the treatment of blepharospasm, cervical dystonia, adult spasticity, and headache

(2016) David M. Simpson et al.   NEUROLOGY

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

(2016) Guorui Yao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18–1/syntaxin1/SNAP-25 mediated fusion

(2016) Jianghui Meng et al.   Scientific Reports

CGRP as a neuropeptide in migraine: lessons from mice

(2015) Andrew F. Russo   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Assessing Clinically Meaningful Treatment Effects in Controlled Trials: Chronic Migraine as an Example

(2015) David W. Dodick et al.   JOURNAL OF PAIN

OnabotulinumtoxinA decreases interictal CGRP plasma levels in patients with chronic migraine

(2015) Eva Cernuda-Morollón et al.   PAIN

Selective inhibition of meningeal nociceptors by botulinum neurotoxin type A: Therapeutic implications for migraine and other pains

(2014) Rami Burstein et al.   CEPHALALGIA

Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A

(2014) Jasmin Strotmeier et al.   FEBS LETTERS

CGRP and VIP Levels as Predictors of Efficacy of Onabotulinumtoxin Type A in Chronic Migraine

(2014) Eva Cernuda-Morollón et al.   HEADACHE

Innervation of Rat and Human Dura Mater and Pericranial Tissues in the Parieto-Temporal Region by Meningeal Afferents

(2014) Markus Schueler et al.   HEADACHE

Recruitment of septin cytoskeletal proteins by botulinum toxin A protease determines its remarkable stability

(2014) Olga Vagin et al.   JOURNAL OF CELL SCIENCE

Botulinum neurotoxins: genetic, structural and mechanistic insights

(2014) Ornella Rossetto et al.   NATURE REVIEWS MICROBIOLOGY

The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones

(2014) Cordelia Imig et al.   NEURON

Chapter 3: Molecular basis for the therapeutic effectiveness of botulinum neurotoxin type A

(2014) J. Oliver Dolly et al.   NEUROUROLOGY AND URODYNAMICS

αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors

(2014) Isabel Devesa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OnabotulinumtoxinA significantly attenuates bladder afferent nerve firing and inhibits ATP release from the urothelium

(2013) Valerie M. Collins et al.   BJU INTERNATIONAL

An Exploratory Study of Salivary Calcitonin Gene-Related Peptide Levels Relative to Acute Interventions and Preventative Treatment With OnabotulinumtoxinA in Chronic Migraine

(2013) Roger Cady et al.   HEADACHE

Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A

(2013) Roger M. Benoit et al.   NATURE

CGRP and migraine: Could PACAP play a role too?

(2013) Eric A. Kaiser et al.   NEUROPEPTIDES

Effect of botulinum toxin A on urothelial-release of ATP and expression of SNARE targets within the urothelium

(2013) Ann T. Hanna-Mitchell et al.   NEUROUROLOGY AND URODYNAMICS

Extracranial projections of meningeal afferents and their impact on meningeal nociception and headache

(2013) Markus Schueler et al.   PAIN

Identification of Fibroblast Growth Factor Receptor 3 (FGFR3) as a Protein Receptor for Botulinum Neurotoxin Serotype A (BoNT/A)

(2013) Birgitte P. S. Jacky et al.   PLoS Pathogens

OnabotulinumtoxinA: A Meta-Analysis of Duration of Effect in the Treatment of Glabellar Lines

(2012) Richard Glogau et al.   DERMATOLOGIC SURGERY

CGRP and NO in the Trigeminal System: Mechanisms and Role in Headache Generation

(2012) Karl Messlinger et al.   HEADACHE

Reduction of TRPV1 expression in the trigeminal system by botulinum neurotoxin type-A

(2012) Toshihiko Shimizu et al.   NEUROBIOLOGY OF DISEASE

Extravesicular intraneuronal migration of internalized botulinum neurotoxins without detectable inhibition of distal neurotransmission

(2011) Gary W. Lawrence et al.   BIOCHEMICAL JOURNAL

Synaptic Vesicle Exocytosis

(2011) T. C. Sudhof et al.   Cold Spring Harbor Perspectives in Biology

Method of Injection of OnabotulinumtoxinA for Chronic Migraine: A Safe, Well-Tolerated, and Effective Treatment Paradigm Based on the PREEMPT Clinical Program

(2010) Andrew Blumenfeld et al.   HEADACHE

OnabotulinumtoxinA for Treatment of Chronic Migraine: Pooled Results From the Double-Blind, Randomized, Placebo-Controlled Phases of the PREEMPT Clinical Program

(2010) David W. Dodick et al.   HEADACHE

Sensory innervation of the calvarial bones of the mouse

(2009) Bela Kosaras et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Botulinum toxin for diabetic neuropathic pain: A randomized double-blind crossover trial

(2009) R. Y. Yuan et al.   NEUROLOGY

Subcutaneous Botulinum toxin type A reduces capsaicin-induced trigeminal pain and vasomotor reactions in human skin

(2008) Parisa Gazerani et al.   PAIN

Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

(2008) Pål Stenmark et al.   PLoS Pathogens