CGRP and NO in the Trigeminal System: Mechanisms and Role in Headache Generation

Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level

(2012) Sajedeh Eftekhari et al.   BMC NEUROSCIENCE

Calcitonin gene-related peptide receptors in rat trigeminal ganglion do not control spinal trigeminal activity

(2012) Oana Covasala et al.   JOURNAL OF NEUROPHYSIOLOGY

1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors

(2011) Shawn Maddaford et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New Agents for Acute Treatment of Migraine: CGRP Receptor Antagonists, iNOS Inhibitors

(2011) Jan Hoffmann et al.   Current Treatment Options in Neurology

Design, Synthesis, and Biological Evaluation of 3,4-Dihydroquinolin-2(1H)-one and 1,2,3,4-Tetrahydroquinoline-Based Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors

(2011) Jailall Ramnauth et al.   JOURNAL OF MEDICINAL CHEMISTRY

New frontiers in headache therapy

(2011) A. Rapoport   NEUROLOGICAL SCIENCES

Evidence for CGRP re-uptake in rat dura mater encephali

(2010) Saurabh Gupta et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lack of efficacy of the selective iNOS inhibitor GW274150 in prophylaxis of migraine headache

(2010) Hans Olav Høivik et al.   CEPHALALGIA

CGRP receptor antagonist olcegepant (BIBN4096BS) does not prevent glyceryl trinitrate-induced migraine

(2010) JF Tvedskov et al.   CEPHALALGIA

Increase in CGRP- and nNOS-immunoreactive neurons in the rat trigeminal ganglion after infusion of an NO donor

(2010) Anne Dieterle et al.   CEPHALALGIA

Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura

(2010) Jakob Møller Hansen et al.   CEPHALALGIA

The General Anesthetic Propofol Excites Nociceptors by Activating TRPV1 and TRPA1 Rather than GABAAReceptors

(2010) Michael J. M. Fischer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measurement of meningeal blood vessel diameter in vivo with a plug-in for ImageJ

(2010) Michael J.M. Fischer et al.   MICROVASCULAR RESEARCH

Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion

(2010) S. Eftekhari et al.   NEUROSCIENCE

TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation

(2010) Phillip Edward Kunkler et al.   PAIN

Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus

(2009) Marie-Luise Sixt et al.   BRAIN

Increase in NADPH-Diaphorase-Positive and Neuronal NO Synthase Immunoreactive Neurons in the Rat Spinal Trigeminal Nucleus Following Infusion of a NO Donor—Evidence for a Feed-Forward Process in NO Production Involved in Trigeminal Nociception

(2009) PM Schlechtweg et al.   CEPHALALGIA

Does the Unfavorable Pharmacokinetic and Pharmacodynamic Profile of the iNOS Inhibitor GW273629 Lead to Inefficacy in Acute Migraine?

(2009) B. J. Van der Schueren et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Activation of TRPV1 Mediates Calcitonin Gene-Related Peptide Release, Which Excites Trigeminal Sensory Neurons and Is Attenuated by a Retargeted Botulinum Toxin with Anti-Nociceptive Potential

(2009) J. Meng et al.   JOURNAL OF NEUROSCIENCE

Randomized, controlled trial of telcagepant for the acute treatment of migraine

(2009) K. M. Connor et al.   NEUROLOGY

Glyceroltrinitrate facilitates stimulated CGRP release but not gene expression of CGRP or its receptor components in rat trigeminal ganglia

(2009) Mirjam Eberhardt et al.   NEUROPEPTIDES

The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs

(2009) Carlos M. Villalón et al.   PHARMACOLOGY & THERAPEUTICS

TRPV1 and TRPA1 Mediate Peripheral Nitric Oxide-Induced Nociception in Mice

(2009) Takashi Miyamoto et al.   PLoS One

Calcitonin gene-related peptide stimulation of nitric oxide synthesis and release from trigeminal ganglion glial cells

(2008) Jing Li et al.   BRAIN RESEARCH

CGRP blockers in migraine therapy: where do they act?

(2008) L Edvinsson   BRITISH JOURNAL OF PHARMACOLOGY

Calcitonin Gene-Related Peptide Receptor Inhibition Reduces Neuronal Activity Induced by Prolonged Increase in Nitric Oxide in the Rat Spinal Trigeminal Nucleus

(2008) S Kulchitsky et al.   CEPHALALGIA

Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution

(2008) Jochen K. Lennerz et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial

(2008) Tony W Ho et al.   LANCET

Calcitonin gene-related peptide release from intact isolated dorsal root and trigeminal ganglia

(2008) Mirjam Eberhardt et al.   NEUROPEPTIDES

Inhibition of stimulated meningeal blood flow by a calcitonin gene-related peptide binding mirror-image RNA oligonucleotide

(2006) Thomas Denekas et al.   BRITISH JOURNAL OF PHARMACOLOGY