Article
Pharmacology & Pharmacy
Xiang Zhou, Shangqian Wang, Ruhua Zhou, Tongtong Zhang, Yichun Wang, Qijie Zhang, Rong Cong, Chengjian Ji, Jiaochen Luan, Liangyu Yao, Xuan Zhou, Ninghong Song
Summary: ED is comorbid with hypospadias in rat models induced by DBP, which might be explained by penile fibrosis, testosterone deficiency, and endothelial dysfunction. These effects are likely mediated through the activation of certain pathways and the suppression of others.
Article
Biochemistry & Molecular Biology
Qing Zhang, Lichong Hao, Yu Hong
Summary: The study investigated the toxic effects of DINP on Drosophila melanogaster, revealing that high concentrations of DINP can lead to metamorphic defects and intestinal cell damage, as well as severe inhibition of larval crawling ability. In addition, DINP also causes oxidative imbalance in larvae.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Food Science & Technology
Peng Song, Biao Yan, Fan Lei, Zhuonan Qiu, Chi Zhang, Yang Wu, Shaohui Chen, Xu Yang, Dingwen Shen, Ping Ma
Summary: Exposure to both DINP and ALAN resulted in nerve cell damage in mice, leading to a decline in learning and memory abilities. The combined effects of ALAN and DINP exposure were more severe than DINP exposure alone.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Toxicology
En-Hui Li, Bai-Hui Xu, Hai-Bin Wei, Yu-Chen Bai, Qi Zhang, Wei-Wen Yu, Zhi-Hui Xu, Xiao-Long Qi, Da-Hong Zhang, Heng Wang
Summary: The purpose of this study was to determine the role of di-n-butyl phthalate (DBP) in promoting bladder cancer (BCa) and to investigate its cellular and molecular effects on BCa cells. MTT and Transwell assays were used to assess the tumorigenic actions of DBP on BCa cells. Second-generation sequencing was performed to identify changes in gene expression before and after DBP treatment. Differential gene expression was confirmed by q-PCR and bioinformatics analyses. Overexpression of FOSB, a target gene, was found to increase both proliferation and invasion in BCa cells. The findings suggest that DBP promotes BCa tumorigenesis through changes in gene expression.
TOXICOLOGY IN VITRO
(2023)
Article
Pharmacology & Pharmacy
Jian Zhang, Catherine Powell, Sunitha Meruvu, Ravi Sonkar, Mahua Choudhury
Summary: The study demonstrated that PQQ can attenuate metabolic aberrations induced by obesogens and high fat diet, especially in the presence of BBP. However, the effects of PQQ were more pronounced in male mice compared to female mice.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Engineering, Environmental
Mengyao Yao, Jingran Qian, Xiaoni Chen, Jilong Liu, Xiaoqing Yang, Peng Gao, Cheng Zhang
Summary: Agricultural films are widely used in high-intensity agriculture, but the low recovery rate leads to an accumulation of plastic mulch in agricultural soils. This study focuses on the exposure impact of BBP, a chemical introduced into soil ecosystems through the accumulation of plastic mulch, on earthworms. The study explores the effects of BBP on the digestive system, oxidative stress, and neurotoxicity in earthworms, providing insights into the molecular mechanisms underlying these effects.
Article
Engineering, Environmental
Peipei Song, Nan Jiang, Kaiqu Zhang, Xianxu Li, Na Li, Youai Zhang, Qian Wang, Jun Wang
Summary: This study used zebrafish as a model to investigate the ecotoxicological effects of DBP, revealing oxidative stress, lipid peroxidation, and DNA damage in zebrafish liver. The results suggest that DBP poses significant potential risks to aquatic organisms.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Ecology
Shuqin Li, Lei Wang, Ying Li, Fuxin Huang, Hui Yu, Ying Zhang, Rui Li, Zhaobo Chen, Ningrui Wei, Zhengzhe Yu
Summary: Plant-associated bacteria can assist host plants in coping with contaminant-induced stress responses, promoting plant growth and development, and reducing contaminant residues. This study demonstrates that inoculation with degrading strains can effectively reduce DBP residue in cucumber roots and accelerate DBP dissipation in rhizosphere soil. Overall, the application of DNB-S1 strain can alleviate DBP stress on plant roots and microbial community structure.
Article
Environmental Sciences
Huan Zhang, Bing Wang, Pan Tang, Yuting Lu, Chunyang Gao
Summary: This study investigated the degradation of dibutyl phthalate (DBP) in water through ozonation in an ultrasonic cavitation-rotational flow interaction coupled-field (UC-RF coupled-field). The results showed that the degradation rate of DBP was significantly affected by the liquid flow rate and ultrasonic power. HCO3- and Cl- had an inhibitory effect on DBP removal. Compared to conventional microporous aeration (CMA) and rotating-flow microbubble aeration (RFMA), the UC-RF coupled-field had higher ozone utilization efficiency for DBP degradation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Xuejun Wang, Hao Wu, Chuhan Dai, Xiaoyu Wang, Lvjing Wang, Jianming Xu, Zhenmei Lu
Summary: Co-contamination of organic pollutants and heavy metals is common in the natural environment. The study found that co-contamination has various impacts on microbial communities, including lower diversity, simpler network structure, and fewer ecological niches. Microbial interactions were strengthened under co-contamination, enhancing the environmental fitness of the exogenous DBP-degrading bacterium. Additionally, metabolic interactions were found between non-degrading bacteria and degrading bacteria.
ENVIRONMENTAL POLLUTION
(2022)
Article
Engineering, Chemical
Yan Yu, Hongze An, Ying Zhao, Jing Feng, Tong Wei, Shuquan Yu, Yueming Ren, Yu Chen
Summary: Magnetic and stable graphene-MnFe2O4 hybrids were synthesized for efficient degradation of DBP using catalytic ozonation. The 5-rGO-MFO-200 catalyst showed significant boost in DBP degradation and good recycling stability. The mechanism involved electron cycling between Mn2(+) and Mn3+ producing (OH)-O-center dot for DBP degradation.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Toxicology
V. Plichta, W. Voelkel, L. Fembacher, M. Woeckner, D. Nowak, H. Fromme
Summary: Phthalates and other plasticizers are found in high amounts in the indoor environment, making house dust a potential exposure source. This study investigated the oral bioavailability of phthalates and DINCH (R) in humans through ingestion of house dust. The results showed that high molecular weight phthalates, DINP, and DINCH (R) reached their maximum concentration in urine 2-19 hours after ingestion. It was also found that a daily intake of 50 mg of dust could significantly contribute to the overall plasticizer exposure, especially in toddlers.
TOXICOLOGY LETTERS
(2022)
Article
Environmental Sciences
Yu Li, Bo Xiong, Yilong Miao, Qian Gao
Summary: This study evaluated the effects of BBP on porcine oocyte meiosis and found that supplementation of 50μM silibinin effectively rescued the meiotic failure induced by BBP exposure.
ENVIRONMENTAL POLLUTION
(2023)
Article
Reproductive Biology
Arpita Bhurke, Juanmahel Davila, Jodi A. Flaws, Milan K. Bagchi, Indrani C. Bagchi
Summary: Exposure to Di-isononyl phthalate (DiNP) in pregnant mice resulted in fetal loss during the later stages of gestation. This exposure affected differentiation and angiogenesis in the uterine decidual bed, as well as trophoblast differentiation and placental organization, leading to compromised nutrient transport and placental defects.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hengtao Bu, Sensheng Tang, Guiting Liu, Chenkui Miao, Xiang Zhou, Haiwei Yang, Bianjiang Liu
Summary: Dibutyl phthalate (DBP) is a chemical substance widely used in perfumes, cosmetics, shampoos, and medical devices, posing a great threat to human health. Although several studies have reported the promoting effect of DBP on the development of lung cancer, breast cancer, hepatoma, and multiple myeloma, there is still limited research on the specific molecular mechanism and prevention methods of DBP promoting prostate cancer progression. This study aims to explore the promoting effect of DBP on prostate cancer cell proliferation through in silico, in vitro, and in vivo analysis.
Article
Green & Sustainable Science & Technology
Naveed Alam, Eve Bohnett, Muhammad Zafar, Hassan Sher, Bilal Ahmad, Mohamed Fawzy Ramadan, Mushtaq Ahmad, Zahid Ullah, Ahmad Ali, Shujaul Mulk Khan, Kashmala Syed
Summary: Effective forest conservation and management requires considering ecological factors and the susceptibility of different tree species to human activities. A phytosociological survey was conducted to assess the significance of Pakistan's tropical dry deciduous forests in relation to ecological variables and anthropogenic threats. The study revealed 140 species of woody plants belonging to 52 families, with the Dodonaea viscosa-Acacia modesta-Dulbergia sissoo community being the most dominant. Altitude, precipitation, and temperature were identified as key factors influencing the distribution and composition of these forests. Immediate management intervention and a conservation strategy are recommended for areas with high levels of human threats, along with effective management of grazing and fuelwood collection.
Article
Agronomy
Shabir Ahmad, Mushtaq Ahmad, Mohamed Fawzy Ramadan, Shazia Sultana, Alessio Papini, Fazal Ullah, Saddam Saqib, Asma Ayaz, Mansoor Ahmed Bazai, Wajid Zaman, Muhammad Zafar
Summary: This study investigated the pollen of fossil plants from the Miocene period in Pakistan, revealing its high biodiversity. The analysis of 31 samples using microscopic techniques identified 48 pollen types from 12 families. However, the preservation of floral records was found to be suboptimal.
Article
Chemistry, Applied
I. Toptanci, S. Kiralan, O. Ketenoglu
Summary: This study determined the presence of five phthalate esters in olive oils flavored with different materials and marketed in Turkey in 2020. DEHP was the most abundant phthalate, with concentrations ranging from below the limit of quantification to 1.81 mg/kg. The highest amount of DEHP was found in the oil sample flavored with bergamot. DBP was detected in 9 out of 25 samples at concentrations from 0.11 to 0.27 mg/kg.
Article
Biochemistry & Molecular Biology
Syeda Abida Ejaz, Mubashir Aziz, Mohamed Fawzy Ramadan, Ammara Fayyaz, Muhammad Sajjad Bilal
Summary: This study aims to search for energetically stable and optimized pharmacophore features of 14 curcumin derivatives to ameliorate the adverse effects of Axitinib. The findings reveal that compounds S8, S11, and S14 have potential molecular interactions against all selected protein kinases, demonstrating high inhibitory potential.
Article
Food Science & Technology
Saima Naz, Waseem Ahmed, Mohamed Fawzy Ramadan
Summary: Cannabis sativa leaf essential oil (CSEO) and its fractions (CSF) were examined for fungicidal, bactericidal, antioxidant, and cytotoxic properties. CSEO was extracted at different temperatures, and the maximum extraction yield was obtained at 110 degrees C. The main components identified in CSEO were caryophyllene, humulene, trans-alpha-bergamotene, and cis-beta-farnesene. The fractionation of CSEO was carried out using vacuum fractionation, and the total phenolic, flavonoid, and pro-anthocyanidin contents were determined. CSEO exhibited antioxidant activity and showed antibacterial, antifungal, and cytotoxic effects.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Agronomy
Maria Ameen, Muhammad Zafar, Mushtaq Ahmad, Mohamed Fawzy Ramadan, Heba F. Eid, Trobjon Makhkamov, Akramjon Yuldashev, Oybek Mamarakhimov, Maxsuda Nizomova, Rima J. Isaifan, Shaista Jabeen, Salman Majeed
Summary: The research aimed to investigate and identify the micro-morphological characteristics of selected seed-bearing crops using scanning electron microscopy. Chemical extraction via Soxhlet apparatus resulted in estimating the oil content and FFA content, with a maximum biodiesel yield of 98% achieved. Multivariate analysis using PCA revealed similarities and differences among factors/variables, and SEM examination exhibited ultra-morphological characters and distinct variation in cell-wall ornamentation.
Article
Food Science & Technology
Esra Avci, Zeynep Hazal Tekin-Cakmak, Muhammed Ozgolet, Salih Karasu, Muhammed Zahid Kasapoglu, Mohamed Fawzy Ramadan, Osman Sagdic
Summary: This study investigated the use of cold-pressed hot pepper seed oil by-product (HPOB) in low-fat salad dressing to improve its rheological properties, emulsion stability, and oxidative stability. The emulsions enriched with HPOB showed shear-thinning, viscoelastic solid-like behavior, and high emulsion stability. The salad dressing samples containing HPOB exhibited higher oxidative stability and lower formation of volatile oxidative compounds. The findings suggest that HPOB can effectively enhance the rheological characteristics and oxidative stability of low-fat salad dressing.
Article
Biotechnology & Applied Microbiology
Maria Ameen, Muhammad Zafar, Mohamed Fawzy Ramadan, Mushtaq Ahmad, Trobjon Makhkamov, Awais Bokhari, Muhammad Mubashir, Lai Fatt Chuah, Pau Loke Show
Summary: The study evaluates the potential of Bischofia javanica Blume as a non-edible seed oil for biodiesel production using green nanoparticles as a catalyst. The results show that the biodiesel obtained has high yield and meets international fuel standards. The use of green nanocatalysts and biodiesel from Bischofia javanica can be a reliable and cost-effective solution for sustainable and eco-friendly biodiesel production.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2023)
Article
Materials Science, Multidisciplinary
Ribaha Manzoor, Muhammad Zafar, Tayyaba Yaqoob, Mushtaq Ahmad, Mohamed Fawzy Ramadan, Ashwaq T. Althobaiti, Azize Demirpolat, Duygu Nur Cobanoglu, Shazia Sultana, Trobjon Makhkamov, Oybek Mamarakhimov, Akramjon Yuldashev, Dilabza Khakimova, Maxsuda Nizomova, Ulugbek Ochilov, Salman Majeed
Summary: This study examines the role of light microscopic (LM) and scanning electron microscopic (SEM) micromorphological traits of the epidermis in identifying and classifying invasive plants. The results showed that various micromorphological features are very useful for species' accurate identification. Leaf epidermal morphology contains numerous useful systematic features for accurate identifications of plant species.
MICROSCOPY AND MICROANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Ahmed S. Abdelbaky, Mohamed A. Tammam, Mohamed Yassin Ali, Marwa Sharaky, Khaled Selim, Wael M. Semida, Taia A. Abd El-Mageed, Mohamed Fawzy Ramadan, Hesham F. Oraby, Yasser M. Diab
Summary: This study investigated the effect of different date palm fruit extracts on phytochemical profiles and antioxidant and anticancer activities. The results showed that certain extracts exhibited strong antioxidant and anticancer activities, highlighting their potential as new anticancer strategies from natural resources.
Article
Multidisciplinary Sciences
Yasser Fathy Abdelaliem, Marwa Hamdy Mahmoud, Nabil Abo Elkassem, Said Mohamed Mansour, Mohamed Fawzy Ramadan, Adel Abdelrazek Abdelazim Mohdaly
Summary: The study aims to evaluate the utilization of agricultural and industrial wastes for xylanase production. The results indicate that corn cob is the preferred carbon source, followed by wheat bran and rice bran. By utilizing these inexpensive and abundant resources, the production cost of xylanase can be reduced, while addressing the environmental issues associated with agro-industrial wastes disposal.
RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI
(2023)
Article
Multidisciplinary Sciences
Tuba Oencuel Abacigil, Mustafa Kiralan, Mohamed Fawzy Ramadan
Summary: Olive pests and diseases have a negative impact on the quality of olive oil, particularly the presence of olive anthracnose. This study aimed to investigate the effects of pests and diseases on Ayvalik olive oil quality parameters, and found associations between the factors and quality indicators.
RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI
(2023)
Article
Multidisciplinary Sciences
Asmaa E. Mohammed, Laila R. Abdalhalim, Khaled Mohamed Atalla, Adel Abdelrazek Abdelazim Mohdaly, Mohamed Fawzy Ramadan, Yasser Fathy Abdelaliem
Summary: Nano-chitosan and nano-sodium alginate were prepared and tested for their morphology and effects against pathogens and microorganisms using transmission electron microscopy. Nano-chitosan showed the highest antibacterial and antifungal activities, while sodium alginate nanoparticles treated with 2% acetic acid exhibited stronger antimicrobial impact. The minimum inhibitory and lethal concentrations of nano-chitosan and nano-sodium alginate were determined for different bacteria strains. The edible coating of nano-sodium alginate showed the highest reduction in yeast and fungi in Ras cheese. These findings suggest that chitosan and sodium alginate nanoparticles' edible coating could be promising for food preservation.
RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI
(2023)
Article
Environmental Sciences
Isra Toptanci
Summary: The presence of Bisphenol A (BPA), Bisphenol A Diglycidyl Ether (BADGE), and their derivatives in seventy-nine samples of food products available in Turkish stores was determined using UPLC-MS/MS. BPA was the most detected migrant with 56.97%, followed by BADGE derivatives. Fish products had the highest level of BPA with 0.102 mg/kg, although only three fish samples exceeded the SML for BPA. BADGE derivatives, BADGE·2H(2)O and CdB, were present in 57 and 52 samples, with concentrations ranging between 0-0.354 and 0-1.056 mg/kg, respectively.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yasser Fathy Abdelaliem, Tarob Abdel-Naby Abdel-Baset, Alaa Ropy Mahmoud Sayed, Aya Ahmed Owis, Mohamed Fawzy Ramadan, Adel Abdelrazek Abdelazim Mohdaly
Summary: This study aimed to investigate the effect of Mn doping on the physical characteristics and antimicrobial activity of ZnO nanoparticles. Five Mn-doped ZnO nanoparticle samples with varying Mn content were synthesized and characterized. The results showed that Mn doping enhanced the antimicrobial activity of ZnO nanoparticles, making them more effective against various pathogenic microorganisms.
RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI
(2023)
