Synergic complement‐mediated bactericidal activity of monoclonal antibodies with distinct specificity

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering

(2019) Simone C. Oostindie et al.   HAEMATOLOGICA

Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp

(2018) Jacinto López-Sagaseta et al.   Nature Communications

Human protective response induced by meningococcus B vaccine is mediated by the synergy of multiple bactericidal epitopes

(2018) M. Giuliani et al.   Scientific Reports

C1q: A fresh look upon an old molecule

(2017) Nicole M. Thielens et al.   MOLECULAR IMMUNOLOGY

The role of anti-NHba antibody in bactericidal activity elicited by the meningococcal serogroup B vaccine, MenB-4C

(2017) Elizabeth Partridge et al.   VACCINE

Crystal structures of human Fabs targeting the Bexsero meningococcal vaccine antigen NHBA

(2017) Martina Maritan et al.   Acta Crystallographica Section F-Structural Biology Communications

Neisseria meningitidis factor H-binding protein bound to monoclonal antibody JAR5: implications for antibody synergy

(2016) E. Malito et al.   BIOCHEMICAL JOURNAL

Meningococcal Factor H Binding Protein Vaccine Antigens with Increased Thermal Stability and Decreased Binding of Human Factor H

(2016) Raffaella Rossi et al.   INFECTION AND IMMUNITY

Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined

(2016) Massimiliano Biagini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neisseria meningitidisfactor H-binding protein fHbp: a key virulence factor and vaccine antigen

(2015) Kate L Seib et al.   Expert Review of Vaccines

MATS: Global coverage estimates for 4CMenB, a novel multicomponent meningococcal B vaccine

(2015) Duccio Medini et al.   VACCINE

Serum bactericidal antibody assays – The role of complement in infection and immunity

(2015) E.D.G. McIntosh et al.   VACCINE

Complementary and synergistic activities of anti-V3, CD4bs and CD4i antibodies derived from a single individual can cover a wide range of HIV-1 strains

(2015) Kristel Paola Ramirez Valdez et al.   VIROLOGY

Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein

(2015) Peter T. Beernink et al.   mBio

Monoclonal Antibody Combinations that Present Synergistic Neutralizing Activity: A Platform for Next-Generation Anti-Toxin Drugs

(2015) Eran Diamant et al.   Toxins

Robust Antitumor Effects of Combined Anti-CD4-Depleting Antibody and Anti-PD-1/PD-L1 Immune Checkpoint Antibody Treatment in Mice

(2015) S. Ueha et al.   Cancer Immunology Research

Synergy in monoclonal antibody neutralization of HIV-1 pseudoviruses and infectious molecular clones

(2014) Riccardo Miglietta et al.   Journal of Translational Medicine

HIV-1 Vaccine-Induced C1 and V2 Env-Specific Antibodies Synergize for Increased Antiviral Activities

(2014) Justin Pollara et al.   JOURNAL OF VIROLOGY

Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach

(2014) Steven A. Carr et al.   MOLECULAR & CELLULAR PROTEOMICS

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

(2013) Hui Wei et al.   DRUG DISCOVERY TODAY

A Multi-Component Meningococcal Serogroup B Vaccine (4CMenB): The Clinical Development Program

(2013) Miguel O’Ryan et al.   DRUGS

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties

(2013) Agnese Faleri et al.   FASEB JOURNAL

An Analysis of the Sequence Variability of Meningococcal fHbp, NadA and NHBA over a 50-Year Period in the Netherlands

(2013) Stefania Bambini et al.   PLoS One

Humoral Pattern Recognition and the Complement System

(2013) S. E. Degn et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Conservation of Meningococcal Antigens in the Genus Neisseria

(2013) A. Muzzi et al.   mBio

Structural Insight into the Mechanism of DNA-Binding Attenuation of the Neisserial Adhesin Repressor NadR by the Small Natural Ligand 4-Hydroxyphenylacetic Acid

(2012) Sébastien Brier et al.   BIOCHEMISTRY

Analysis of Defined Combinations of Monoclonal Antibodies in Anthrax Toxin Neutralization Assays and Their Synergistic Action

(2012) Miriam M. Ngundi et al.   Clinical and Vaccine Immunology

The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: Immunological, functional and structural characterization of the antigens

(2012) Davide Serruto et al.   VACCINE

A Broadly Cross-Reactive Monoclonal Antibody Against an Epitope on the N-terminus of Meningococcal fHbp

(2012) David M. Vu et al.   Scientific Reports

Structure of the uncomplexedNeisseria meningitidisfactor H-binding protein fHbp (rLP2086)

(2011) Laura Cendron et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

(2011) S.-R. Woo et al.   CANCER RESEARCH

Combined Roles of Human IgG Subclass, Alternative Complement Pathway Activation, and Epitope Density in the Bactericidal Activity of Antibodies to Meningococcal Factor H Binding Protein

(2011) Serena Giuntini et al.   INFECTION AND IMMUNITY

Complement and non-complement activating functions of C1q: A prototypical innate immune molecule

(2011) Annapurna Nayak et al.   Innate Immunity

Structure of the C-terminal Domain ofNeisseriaHeparin Binding Antigen (NHBA), One of the Main Antigens of a Novel Vaccine againstNeisseria meningitidis

(2011) Veronica Esposito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative serum bactericidal activity between human antibodies to meningococcal factor H binding protein and Neisserial heparin binding antigen

(2011) David M. Vu et al.   VACCINE

The effect of antibody isotype and antigenic epitope density on the complement-fixing activity of immune complexes: a systematic study using chimaeric anti-NIP antibodies with human Fc regions

(2010) Y. M. LUCISANO VALIM et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Characterization of Diverse Subvariants of the Meningococcal Factor H (fH) Binding Protein for Their Ability To Bind fH, To Mediate Serum Resistance, and To Induce Bactericidal Antibodies

(2010) Kate L. Seib et al.   INFECTION AND IMMUNITY

Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans

(2010) Davide Serruto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Qualitative and quantitative assessment of meningococcal antigens to evaluate the potential strain coverage of protein-based vaccines

(2010) J. Donnelly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Measuring antigen-specific bactericidal responses to a multicomponent vaccine against serogroup B meningococcus

(2010) Marzia M. Giuliani et al.   VACCINE

Development and reproducibility of a novel high-performance liquid-chromatography monolithic column method for the detection and quantification oftrans-indolyl-3-acryloylglycine in human urine

(2009) Kevin Carr et al.   BIOMEDICAL CHROMATOGRAPHY

Ex Vivo Model of Meningococcal Bacteremia Using Human Blood for Measuring Vaccine-Induced Serum Passive Protective Activity

(2009) J. S. Plested et al.   Clinical and Vaccine Immunology

Novel Chimpanzee/Human Monoclonal Antibodies That Neutralize Anthrax Lethal Factor, and Evidence for Possible Synergy with Anti-Protective Antigen Antibody

(2009) Z. Chen et al.   INFECTION AND IMMUNITY

Solution Structure of the Factor H-binding Protein, a Survival Factor and Protective Antigen ofNeisseria meningitidis

(2009) Francesca Cantini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A region of the N-terminal domain of meningococcal factor H-binding protein that elicits bactericidal antibody across antigenic variant groups

(2009) Peter T. Beernink et al.   MOLECULAR IMMUNOLOGY

Fine Antigenic Specificity and Cooperative Bactericidal Activity of Monoclonal Antibodies Directed at the Meningococcal Vaccine Candidate Factor H-Binding Protein

(2008) P. T. Beernink et al.   INFECTION AND IMMUNITY