Long-acting approaches for delivery of antiretroviral drugs for prevention and treatment of HIV: a review of recent research

Long-Acting Cabotegravir and Rilpivirine after Oral Induction for HIV-1 Infection

(2020) Chloe Orkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-Acting Cabotegravir and Rilpivirine for Maintenance of HIV-1 Suppression

(2020) Susan Swindells et al.   NEW ENGLAND JOURNAL OF MEDICINE

A year-long extended release nanoformulated cabotegravir prodrug

(2020) Tanmay A. Kulkarni et al.   NATURE MATERIALS

Improvement of antibody functionality by structure-guided paratope engraftment

(2019) Qingbo Liu et al.   Nature Communications

Innovation in Chemistry, Manufacturing, and Controls—A Regulatory Perspective From Industry

(2019) Nina S. Cauchon et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Advanced implantable drug delivery technologies: transforming the clinical landscape of therapeutics for chronic diseases

(2019) Fernanda P. Pons-Faudoa et al.   BIOMEDICAL MICRODEVICES

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope

(2019) Till Schoofs et al.   IMMUNITY

2-Hydroxypropyl-β-cyclodextrin-enhanced pharmacokinetics of cabotegravir from a nanofluidic implant for HIV pre-exposure prophylaxis

(2019) Fernanda P. Pons-Faudoa et al.   JOURNAL OF CONTROLLED RELEASE

Successful treatment of HIV eliminates sexual transmission

(2019) Myron S Cohen   LANCET

The Promise of Long-Acting Antiretroviral Therapies: From Need to Manufacture

(2019) Howard E. Gendelman et al.   TRENDS IN MICROBIOLOGY

Development of a Transdermal Delivery System for Tenofovir Alafenamide, a Prodrug of Tenofovir with Potent Antiviral Activity Against HIV and HBV

(2019) Ashana Puri et al.   Pharmaceutics

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

(2019) Prasanta K. Dash et al.   Nature Communications

GS-CA Compounds: First-In-Class HIV-1 Capsid Inhibitors Covering Multiple Grounds

(2019) Kamal Singh et al.   Frontiers in Microbiology

Characterization of a Reservoir-Style Implant for Sustained Release of Tenofovir Alafenamide (TAF) for HIV Pre-Exposure Prophylaxis (PrEP)

(2019) Leah M. Johnson et al.   Pharmaceutics

Synthesis and characterization of a long-acting emtricitabine prodrug nanoformulation

(2019) Ibrahim M Ibrahim et al.   International Journal of Nanomedicine

Long-acting or extended-release antiretroviral products for HIV treatment and prevention in infants, children, adolescents, and pregnant and breastfeeding women: knowledge gaps and research priorities

(2019) Sharon Nachman et al.   Lancet HIV

Synthesis of a long acting nanoformulated emtricitabine ProTide

(2019) Dhruvkumar Soni et al.   BIOMATERIALS

Creation of a long-acting rilpivirine prodrug nanoformulation

(2019) James R. Hilaire et al.   JOURNAL OF CONTROLLED RELEASE

Recent advances in microneedle composites for biomedical applications: Advanced drug delivery technologies

(2019) Sanjay Sharma et al.   Materials Science & Engineering C-Materials for Biological Applications

Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery

(2019) S. Rahima Benhabbour et al.   Nature Communications

LB8. Microarray Patch Delivery of Long-Acting HIV PrEP and Contraception

(2019) Annie Rein-Weston et al.   Open Forum Infectious Diseases

A Unified Numbering Scheme for Class C β-Lactamases

(2019) Malcolm G. P. Page   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A long acting nanoformulated lamivudine ProTide

(2019) Nathan Smith et al.   BIOMATERIALS

Broadly neutralizing antibodies and vaccine design against HIV-1 infection

(2019) Qian Wang et al.   Frontiers of Medicine

Nanoparticle-in-microparticle oral drug delivery system of a clinically relevant darunavir/ritonavir antiretroviral combination

(2018) Robin Augustine et al.   Acta Biomaterialia

Extended Duration MK-8591-Eluting Implant as a Candidate for HIV Treatment and Prevention

(2018) Stephanie E. Barrett et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles

(2018) Tian Zhou et al.   BIOMATERIALS

ProTide generated long-acting abacavir nanoformulations

(2018) Zhiyi Lin et al.   CHEMICAL COMMUNICATIONS

Improving maraviroc oral bioavailability by formation of solid drug nanoparticles

(2018) Alison C. Savage et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A Neutralizing Antibody Recognizing Primarily N -Linked Glycan Targets the Silent Face of the HIV Envelope

(2018) Tongqing Zhou et al.   IMMUNITY

Optimizing the preparation and stability of decorated antiretroviral drug nanocrystals

(2018) Tian Zhou et al.   Nanomedicine

A single injection of crystallizable fragment domain–modified antibodies elicits durable protection from SHIV infection

(2018) Rajeev Gautam et al.   NATURE MEDICINE

The expanding role of prodrugs in contemporary drug design and development

(2018) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

Randomized, placebo controlled phase I trial of safety, pharmacokinetics, pharmacodynamics and acceptability of tenofovir and tenofovir plus levonorgestrel vaginal rings in women

(2018) Andrea Ries Thurman et al.   PLoS One

Strategy for Extending Half-life in Drug Design and Its Significance

(2018) Hakan Gunaydin et al.   ACS Medicinal Chemistry Letters

Creation of a long-acting nanoformulated dolutegravir

(2018) Brady Sillman et al.   Nature Communications

Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy

(2018) Ameya R. Kirtane et al.   Nature Communications

4′-Ethynyl-2-fluoro-2′-deoxyadenosine, MK-8591

(2018) Martin Markowitz et al.   Current Opinion in HIV and AIDS

Antiretroviral implants for treatment and prevention of HIV infection

(2018) Charles Flexner   Current Opinion in HIV and AIDS

Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems

(2018) James J. Hobson et al.   RSC Advances

Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults

(2018) Martin R. Gaudinski et al.   PLOS MEDICINE

Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre-exposure prophylaxis

(2018) Corrine Ying Xuan Chua et al.   JOURNAL OF CONTROLLED RELEASE

Modulating cellular autophagy for controlled antiretroviral drug release

(2018) Midhun B Thomas et al.   Nanomedicine

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

(2018) Pilar Mendoza et al.   NATURE

Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

(2018) Yotam Bar-On et al.   NATURE MEDICINE

Pharmacokinetic testing of a first generation cabotegravir prodrug in rhesus macaques

(2018) JoEllyn McMillan et al.   AIDS

Long-Acting HIV Drugs for Treatment and Prevention

(2018) Roy M. Gulick et al.   Annual Review of Medicine

Dolutegravir monotherapy versus dolutegravir/abacavir/lamivudine for virologically suppressed people living with chronic HIV infection: the randomized non-inferiority MONCAY trial

(2018) Laurent Hocqueloux et al.   CLINICAL INFECTIOUS DISEASES

Design, formulation and evaluation of novel dissolving microarray patches containing a long-acting rilpivirine nanosuspension

(2018) Maelíosa T.C. Mc Crudden et al.   JOURNAL OF CONTROLLED RELEASE

Antibody-mediated prevention and treatment of HIV-1 infection

(2018) Henning Gruell et al.   Retrovirology

Ultra-long-acting removable drug delivery system for HIV treatment and prevention

(2018) Martina Kovarova et al.   Nature Communications

Long-acting slow effective release antiretroviral therapy

(2017) Benson Edagwa et al.   Expert Opinion on Drug Delivery

Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs

(2017) Divya Prakash Gnanadhas et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivo studies investigating biodistribution of nanoparticle-encapsulated rhodamine B delivered via dissolving microneedles

(2017) Joakim Kennedy et al.   JOURNAL OF CONTROLLED RELEASE

Long-chain triglycerides-based self-nanoemulsifying oily formulations (SNEOFs) of darunavir with improved lymphatic targeting potential

(2017) Babita Garg et al.   JOURNAL OF DRUG TARGETING

Relevance of Half-Life in Drug Design

(2017) Dennis A. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label, phase 2b, non-inferiority trial

(2017) David A Margolis et al.   LANCET

Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women

(2017) Nichole R. Klatt et al.   SCIENCE

Universal antiretroviral regimens

(2017) Jeffrey M. Jacobson et al.   Current Opinion in HIV and AIDS

Long-Acting Antiretrovirals: Where Are We now?

(2017) Amesika N Nyaku et al.   Current HIV/AIDS Reports

Safety and tolerability of long-acting cabotegravir injections in HIV-uninfected men (ECLAIR): a multicentre, double-blind, randomised, placebo-controlled, phase 2a trial

(2017) Martin Markowitz et al.   Lancet HIV

Adherence to treatment in adolescents

(2017) Danielle Taddeo et al.   Paediatrics & Child Health

Strengths, weaknesses, opportunities and challenges for long acting injectable therapies: Insights for applications in HIV therapy

(2016) Andrew Owen et al.   ADVANCED DRUG DELIVERY REVIEWS

Effectiveness and safety of oral HIV preexposure prophylaxis for all populations

(2016) Virginia A. Fonner et al.   AIDS

HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

(2016) Johannes F. Scheid et al.   NATURE

Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption

(2016) Katharine J. Bar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women

(2016) Annalene Nel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women

(2016) Jared M. Baeten et al.   NEW ENGLAND JOURNAL OF MEDICINE

Practical Synthesis of the Bicyclic Darunavir Side Chain: (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol from Monopotassium Isocitrate

(2016) Gary L. Moore et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A Tunable, Biodegradable, Thin-Film Polymer Device as a Long-Acting Implant Delivering Tenofovir Alafenamide Fumarate for HIV Pre-exposure Prophylaxis

(2016) Erica Schlesinger et al.   PHARMACEUTICAL RESEARCH

Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA)

(2016) Zhe Li Salie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

(2016) R. Kong et al.   SCIENCE

Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies

(2016) Marco Giardiello et al.   Nature Communications

The promise and pitfalls of long-acting injectable agents for HIV prevention

(2016) Raphael J. Landovitz et al.   Current Opinion in HIV and AIDS

An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability

(2016) Marit J. van Gils et al.   Nature Microbiology

Pharmacokinetics of Long-Acting Tenofovir Alafenamide (GS-7340) Subdermal Implant for HIV Prophylaxis

(2015) Manjula Gunawardana et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Oral Administration of the Nucleoside EFdA (4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine) Provides Rapid Suppression of HIV Viremia in Humanized Mice and Favorable Pharmacokinetic Properties in Mice and the Rhesus Macaque

(2015) Cheryl A. Stoddart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transdermal patches: history, development and pharmacology

(2015) Michael N Pastore et al.   BRITISH JOURNAL OF PHARMACOLOGY

Systematic Literature Review and Meta-analysis of Medication Adherence With Once-weekly Versus Once-daily Therapy

(2015) Kristy Iglay et al.   CLINICAL THERAPEUTICS

Phase 1 Safety, Pharmacokinetics, and Pharmacodynamics of Dapivirine and Maraviroc Vaginal Rings

(2015) Beatrice A. Chen et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Genital Tenofovir Concentrations Correlate With Protection Against HIV Infection in the CAPRISA 004 Trial

(2015) Angela D. M. Kashuba et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

(2015) Marina Caskey et al.   NATURE

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

(2015) Rebecca M. Lynch et al.   Science Translational Medicine

Formulation and pharmacology of long-acting cabotegravir

(2015) Christine Trezza et al.   Current Opinion in HIV and AIDS

Oral Pre-Exposure Prophylaxis (PrEP) for Prevention of HIV in Serodiscordant Heterosexual Couples in the United States: Opportunities and Challenges

(2014) James M. McMahon et al.   AIDS PATIENT CARE AND STDS

Lower Pill Burden and Once-Daily Antiretroviral Treatment Regimens for HIV Infection: A Meta-Analysis of Randomized Controlled Trials

(2014) Jean B. Nachega et al.   CLINICAL INFECTIOUS DISEASES

4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms

(2014) Eleftherios Michailidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface

(2014) Jinghe Huang et al.   NATURE

Effects of Substitutions at the 4′ and 2 Positions on the Bioactivity of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine

(2013) Karen A. Kirby et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of dapivirine vaginal ring for HIV prevention

(2013) Bríd Devlin et al.   ANTIVIRAL RESEARCH

Nano scale self-emulsifying oil based carrier system for improved oral bioavailability of camptothecin derivative by P-Glycoprotein modulation

(2013) Lalit Mohan Negi et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Long-acting injectable antiretrovirals for HIV treatment and prevention

(2013) William R. Spreen et al.   Current Opinion in HIV and AIDS

Antiretroviral Solid Drug Nanoparticles with Enhanced Oral Bioavailability: Production, Characterization, and In Vitro-In Vivo Correlation

(2013) Tom O. McDonald et al.   Advanced Healthcare Materials

Adherence to Antiretroviral Medications for HIV Pre-Exposure Prophylaxis

(2012) Linda J. Koenig et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Biphasic Elimination of Tenofovir Diphosphate and Nonlinear Pharmacokinetics of Zidovudine Triphosphate in a Microdosing Study

(2012) Jianmeng Chen et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Advances in gastro retentive drug-delivery systems

(2011) Pascal Prinderre et al.   Expert Opinion on Drug Delivery

Antiretroviral prophylaxis: a defining moment in HIV control

(2011) Salim S Abdool Karim et al.   LANCET

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

(2011) Jason S. McLellan et al.   NATURE

Broad neutralization coverage of HIV by multiple highly potent antibodies

(2011) Laura M. Walker et al.   NATURE

Prodrugs--from Serendipity to Rational Design

(2011) K. M. Huttunen et al.   PHARMACOLOGICAL REVIEWS

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

(2011) J. F. Scheid et al.   SCIENCE

Pharmacokinetic Assessment of Dapivirine Vaginal Microbicide Gel in Healthy, HIV-Negative Women

(2010) Annalene M. Nel et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Pharmacokinetics and Disposition of Rilpivirine (TMC278) Nanosuspension as a Long-Acting Injectable Antiretroviral Formulation

(2010) G. van 't Klooster et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems

(2010) Vivek K. Pawar et al.   DRUG DELIVERY

Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men

(2010) Robert M. Grant et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY