Article
Gastroenterology & Hepatology
Hyung-Don Kim, Seongju Jeong, Seongyeol Park, Yong Joon Lee, Young Seok Ju, Danbee Kim, Gi-Won Song, Jae Hoon Lee, Sang-Yeob Kim, Jaehoon Shin, Eui-Cheol Shin, Shin Hwang, Changhoon Yoo, Su-Hyung Park
Summary: The study investigated the implications of TRM-related features of tumour-infiltrating CD8(+) T cells in ICC patients, revealing that CD69(+)CD103(+) cells exhibited a stronger response to immune checkpoint inhibitors, while CD69(-) and CD69(+)CD103(-) cells were associated with the Wnt/β-catenin and TGF-beta pathways.
LIVER INTERNATIONAL
(2021)
Article
Oncology
Yang Shen, Xiao-long Li, Yu-xian Li, Zhi-guo Shan, Yong-liang Zhao, Ping Cheng, Zhuo Zhao, Jin-yu Zhang, Weisan Chen, Yuan Zhuang, Dai-yuan Ma, Quan-ming Zou, Yuan Qiu, Liu-sheng Peng
Summary: In gastric cancer, tumor-infiltrating CD8(+)CD103(+) tissue-resident memory T cells are decreased compared to non-tumor tissues and show impaired cytolytic function. Restoring the function of these cells through PD-1 blockade and 4-1BB co-stimulation may be a promising strategy for treating gastric cancer and improving patient survival.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Review
Immunology
Rut Mora-Buch, Shannon K. Bromley
Summary: Resident memory CD8(+) T cells provide rapid local protection and control tumor growth, but dysregulation may contribute to autoimmune diseases. Intrinsic mechanisms and extrinsic stimuli regulate T-RM differentiation and response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Shahd Talhouni, Wakkas Fadhil, Nigel P. Mongan, Lara Field, Kelly Hunter, Sogand Makhsous, Alexandre Maciel-Guerra, Nayandeep Kaur, Ausrine Nestarenkaite, Arvydas Laurinavicius, Benjamin E. Willcox, Tania Dottorini, Ian Spendlove, Andrew M. Jackson, Mohammad Ilyas, Judith M. Ramage
Summary: The characterization of the tumour immune infiltrate, specifically CD8+ T-cells, has a strong predictive survival value for cancer patients. A study found that the abundance and localization of activated tumour-specific tissue resident memory CD8 T-cells (T-RM) can provide a higher-resolution route to patient stratification.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Bing Wu, Ge Zhang, Zengli Guo, Gang Wang, Xiaojiang Xu, Jian-liang Li, Jason K. Whitmire, Junnian Zheng, Yisong Y. Wan
Summary: Acute viral infection leads to illness and death, with CD103 integrin playing a critical role in immune protection. SKI proto-oncogene (SKI) interference may enhance CD103(+)CD8(+) T cell response to promote protective immunity.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
Curtis J. Pritzl, Mark A. Daniels, Emma Teixeiro
Summary: CD8 positive, tissue resident memory T cells are a specialized subset of T cells that provide critical protection against tumors and pathogen re-infection. The development and maintenance of these cells involve a myriad of signals, including tissue-derived signals and antigenic/pro-inflammatory cytokines. Recent research suggests additional roles for antigenic and pro-inflammatory signals in the establishment of resident memory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Zhengrui You, You Li, Qixia Wang, Zhibin Zhao, Yikang Li, Qiwei Qian, Bo Li, Jun Zhang, Bingyuan Huang, Jubo Liang, Ruiling Chen, Zhuwan Lyu, Yong Chen, Min Lian, Xiao Xiao, Qi Miao, Jingyuan Fang, Zhexiong Lian, M. Eric Gershwin, Ruqi Tang, Xiong Ma
Summary: CD8(+) T-RM cells are significantly increased in the liver of AIH patients and correlate with disease severity; glucocorticoids attenuate hepatic inflammation by directly inhibiting the expansion of CD8(+) T-RM cells.
Article
Oncology
Chester Lai, George Coltart, Andrew Shapanis, Conor Healy, Ahmad Alabdulkareem, Sara Selvendran, Jeffrey Theaker, Matthew Sommerlad, Matthew Rose-Zerilli, Aymen Al-Shamkhani, Eugene Healy
Summary: The study identified a significant presence of CD8+CD103+ TRMs in cutaneous squamous cell carcinomas, with their expression in the tumor being associated with poorer clinical outcomes for patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Giulia Romagnoli, Quintino Giorgio D'Alessandris, Imerio Capone, Andrea Tavilla, Irene Canini, Caterina Lapenta, Mariachiara Buccarelli, Martina Giordano, Valentina Tirelli, Massimo Sanchez, Alessandra Fragale, Stefano Giannetti, Rina Di Bonaventura, Liverana Lauretti, Mauro Biffoni, Lucia Ricci-Vitiani, Roberto Pallini, Lucia Gabriele
Summary: This study aimed to determine whether the expression of selected immune checkpoints on tissue-resident memory T cells (Trm) may predict patient outcome in glioblastoma. The results showed that low levels of Trm expressing programmed cell death protein 1 (PD1) or T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) were associated with better clinical outcome.
Article
Cell Biology
Yao Chen, Jian Shen, Moujtaba Y. Kasmani, Paytsar Topchyan, Weiguo Cui
Summary: During acute infections, different memory subpopulations of CD8(+) T cells provide long-lasting protection, with tissue-resident memory (TRM) cells offering tissue-specific protection. Heterogeneity within the TRM pool in the small intestine was identified, along with potential transcriptional regulators controlling TRM cell phenotype and function during acute infection. These findings contribute to identifying new pathways for enhancing vaccination and immunotherapeutic approaches in future studies.
Review
Cell Biology
Zhijuan Qiu, Timothy H. Chu, Brian S. Sheridan
Summary: CD8 tissue-resident memory T (T-RM) cells are a subset of memory CD8 T cells that primarily reside in nonlymphoid tissues, providing front-line protective immunity against infections and cancers. They can be divided into CD103(-) T-RM cells and CD103(+) T-RM cells. TGF-beta plays a critical role in the development and maintenance of CD103(+) CD8 T-RM cells, and the review highlights the importance of TGF-beta in regulating this unique subset of memory CD8 T cells for potential vaccine design improvements.
Article
Multidisciplinary Sciences
Nicholas N. Jarjour, Kelsey M. Wanhainen, Changwei Peng, Noah V. Gavil, Nicholas J. Maurice, Henrique Borges da Silva, Ryan J. Martinez, Talia S. Dalzell, Matthew A. Huggins, David Masopust, Sara E. Hamilton, Stephen C. Jameson
Summary: Interleukin-15 (IL-15) is a central regulator of memory CD8+ T cells and can stimulate their proliferation and expansion. IL-15 sensitivity is an important feature of memory CD8+ T cell populations, with therapeutic potential.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Young Min Son, Jie Sun
Summary: This article discusses the importance of memory CD8 T and B cells in protecting respiratory mucosa from secondary microbial invasion, with a focus on the role of tissue-resident helper T cell populations in this process.
Article
Multidisciplinary Sciences
David M. Schauder, Jian Shen, Yao Chen, Moujtaba Y. Kasmani, Matthew R. Kudek, Robert Burns, Weiguo Cui
Summary: During acute viral infections, CD8 T cells encounter various antigenic and inflammatory signals, leading to differentiation into memory cells or death. Research has shown that memory precursor effector cells maintain open enhancers for key memory genes, with a high enrichment of E2A binding sites. E2A directly regulates the accessibility of enhancers for memory-related genes, increasing the frequency of memory precursor effector cells and accelerating memory cell formation while reducing short-lived effector cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Nadine Kamenjarin, Katrin Hodapp, Felix Melchior, Gregory Harms, Ann- Kathrin Hartmann, Joschka Bartneck, Sabine Muth, Verena K. Raker, Christian Becker, Anna Brand, Bjorn E. Clausen, Markus P. Radsak, Hansjorg Schild, Hans Christian Probst
Summary: Tissue-resident memory CD8+ T cells (TRM) in the skin require epidermal Langerhans cells, which cross-present keratinocyte-derived antigens, for their reactivation to provide protection against reinfection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Natasja A. M. Kragten, Renske L. R. E. Taggenbrock, Loreto Parga Vidal, Rene A. W. van Lier, Regina Stark, Klaas P. J. M. van Gisbergen
Summary: iNKT cells have developmental potential after lineage commitment, and they differentiate into resident memory cells similar to tissue-resident memory T cells. The transcription factors Hobit and Blimp-1 play a crucial role in the development of iNKT cells, specifically in the differentiation of central memory iNKT cells into resident memory iNKT cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Review
Urology & Nephrology
Loreto Parga-Vidal, Michiel C. van Aalderen, Regina Stark, Klaas P. J. M. van Gisbergen
Summary: The discovery of tissue-resident memory T (T-RM) cells residing in peripheral tissues at key pathogen entry sites has revolutionized our understanding of T cell memory responses. These cells can promptly respond to infections without the need for migration, proliferation or differentiation. They form isolated populations in peripheral tissues and play a crucial role in combating infections and tumor growth.
NATURE REVIEWS NEPHROLOGY
(2022)
Article
Immunology
Loreto Parga-Vidal, Renske L. R. E. Taggenbrock, Ammarina Beumer-Chuwonpad, Hajar Aglmous, Natasja A. M. Kragten, Felix M. Behr, Astrid A. Bovens, Rene A. W. van Lier, Regina Stark, Klaas P. J. M. van Gisbergen
Summary: Tissue-resident memory T cells (Trm) are retained in peripheral tissues after infection for enhanced protection against secondary encounter with the same pathogen. In this study, the transcription factors Hobit and Blimp-1 were found to play important roles in the formation and tissue retention of Trm.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Iris N. Pardieck, Tetje C. van der Sluis, Esme T. van der Gracht, Dominique M. B. Veerkamp, Felix M. Behr, Suzanne van Duikeren, Guillaume Beyrend, Jasper Rip, Reza Nadafi, Elham Beyranvand Nejad, Nils Mulling, Dena J. Brasem, Marcel G. M. Camps, Sebenzile K. Myeni, Peter J. Bredenbeek, Marjolein Kikkert, Yeonsu Kim, Luka Cicin-Sain, Tamim Abdelaal, Klaas P. J. M. van Gisbergen, Kees L. M. C. Franken, Jan Wouter Drijfhout, Cornelis J. M. Melief, Gerben C. M. Zondag, Ferry Ossendorp, Ramon Arens
Summary: Repeated booster vaccinations with a three dose regimen of a synthetic peptide vaccine significantly enhance the CD8(+) T cell response, leading to protection against lethal SARS-CoV-2 infection. Understanding the mechanisms and impact of booster vaccinations is crucial for vaccine design and delivery.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Ruud H. Wijdeven, Birol Cabukusta, Felix M. Behr, Xueer Qiu, Deeba Amiri, Daniel M. Borras, Ramon Arens, Yun Liang, Jacques Neefjes
Summary: The PD-L1/2-PD-1 immune checkpoint is crucial for maintaining peripheral tolerance and preventing autoimmunity, but tumor cells can exploit it for immune evasion. This study identified three factors, GATA2, MBD6, and VGLL3, that upregulate PD-L1 expression. VGLL3 acts as a transcriptional regulator and, in conjunction with TEAD1 and RUNXI/3, drives the expression of PD-L1/2. This work reveals a new transcriptional complex controlling PD-L1/2 expression and suggests that VGLL3 can balance inflammation by upregulating the anti-inflammatory factors PD-L1 and PD-L2.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Immunology
Renske L. R. E. Taggenbrock, Klaas P. J. M. van Gisbergen
Summary: This review discusses the recent advances in the development, differentiation, and effector maturation of ILC1s, as well as the observed heterogeneity in ILC1 populations within different tissues. The study of transcriptional programs reveals the shared characteristics between ILC1s and other tissue-resident lymphocytes, aiding in the effective response of ILC1s to tissue-invading pathogens.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Editorial Material
Immunology
Klaas P. J. M. van Gisbergen, Carmen Gerlach
Summary: The expansion capacity of naive T cells is believed to be the main factor determining the magnitude of CD8 T-cell responses against intracellular pathogens. However, a study challenges this notion and reveals that the recruitment of naive T-cell clones into primary responses can be incomplete, especially when there are low-affinity interactions between the T-cell receptor and the pathogen's antigen. This research shows that the regulation of CD8 T-cell response size involves control at the level of recruitment and expansion of naive CD8 T cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Ammarina Beumer-Chuwonpad, Floris P. J. van Alphen, Natasja A. M. Kragten, Julian J. Freen-van Heeren, Maria Rodriguez Gomez, Arthur J. Verhoeven, Maartje van den Biggelaar, Klaas P. J. M. van Gisbergen
Summary: Reduced oxygen pressure alters the metabolism of CD8(+) T cells, enhancing their granzyme B and IFN-gamma production capacity, but not affecting their expansion potential. In vivo, memory CD8(+) T cells cultured under low oxygen pressure provide protection against rechallenge.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rosa A. Krimpenfort, Felix M. Behr, Marja Nieuwland, Iris de Rink, Ron Kerkhoven, Marieke von Lindern, Micha Nethe
Summary: E-cadherin is a critical regulator of cell-cell adhesion in epithelial tissues and plays a role in tumor growth and invasion. This study found that E-cadherin is not expressed in human basophils but is associated with the erythroid lineage. In contrast, in mice, E-cadherin is mainly expressed in the basophil lineage. This reveals evolutionary differences between humans and mice in terms of E-cadherin expression in hematopoiesis. The findings suggest that the mouse model is not suitable for studying the function of E-cadherin in human hematopoiesis and alternative methods are needed to study its role in human erythropoiesis.
Review
Pharmacology & Pharmacy
Cheng-Chih Hsiao, Els Vos, Klaas P. J. M. van Gisbergen, Jorg Hamann
Summary: GPR56/ADGRG1 is an adhesion G protein-coupled receptor with significant roles in brain development, haematopoiesis, male fertility, and tumorigenesis. Recent studies have shown that GPR56 is also present in human cytotoxic NK and T cells, where its expression is driven by the transcription factor HOBIT and associated with cytolytic mediators, CX(3)CR1 and CD57. It indicates a state of terminal differentiation and cellular exhaustion, and disappears upon cellular activation. Functional studies reveal that GPR56 regulates cell migration and effector functions, acting as an inhibitory immune checkpoint. This article discusses the current understanding of GPR56 in cytotoxic lymphocytes.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Immunology
Jet van den Dijssel, Ruth R. Hagen, Rivka de Jongh, Maurice Steenhuis, Theo Rispens, Dionne M. Geerdes, Juk Yee Mok, Angela H. M. Kragten, Mariel C. Duurland, Niels J. M. Verstegen, S. Marieke van Ham, Wim Je van Esch, Klaas Pjm van Gisbergen, Pleun Hombrink, Anja ten Brinke, Carolien E. van de Sandt
Summary: This study identified a range of conserved SARS-CoV-2 CD8(+)T cell epitopes and determined their immunodominance and phenotypic profiles. The findings suggest that SARS-CoV-2 infection induces a predominant CD8(+)T memory response directed against a variety of conserved SARS-CoV-2 epitopes, which likely contributes to long-term protection against severe disease.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)