Munc13 activates the Munc18‐1/syntaxin‐1 complex and enables Munc18‐1 to prime SNARE assembly

Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly

(2019) Shen Wang et al.   Nature Communications

The pre-synaptic fusion machinery

(2019) Axel T Brunger et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties

(2019) Alex J. B. Kreutzberger et al.   Nature Communications

Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP

(2019) Karolina P. Stepien et al.   Nature Communications

Munc13-1 MUN domain and Munc18-1 cooperatively chaperone SNARE assembly through a tetrameric complex

(2019) Tong Shu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins

(2018) Haijia Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association

(2018) Junyi Jiao et al.   eLife

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 inCaenorhabditis elegans

(2017) Seungmee Park et al.   JOURNAL OF NEUROSCIENCE

Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18

(2017) Ying Lai et al.   NEURON

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

(2017) Enqi He et al.   Nature Communications

Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion

(2017) Ewa Sitarska et al.   eLife

Extension of Helix 12 in Munc18-1 Induces Vesicle Priming

(2016) A. S. Munch et al.   JOURNAL OF NEUROSCIENCE

Chaperoning SNARE assembly and disassembly

(2016) Richard W. Baker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Synaptic Vesicle Release Machinery

(2015) Josep Rizo et al.   Annual Review of Biophysics

SEC-uring membrane fusion: a sneak peek at SNARE-complex assembly driven by Sec1–Munc18 proteins

(2015) Brett M Collins et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

(2015) Xiaoyu Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly

(2015) R. W. Baker et al.   SCIENCE

SEC-uring membrane fusion: a sneak peek at SNARE-complex assembly driven by Sec1–Munc18 proteins

(2015) Brett M Collins et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

(2015) Xiaoyu Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis

(2015) Lu Ma et al.   eLife

An Extended Helical Conformation in Domain 3a of Munc18-1 Provides a Template for SNARE (SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Complex Assembly

(2014) Daniel Parisotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Pivotal Role for Pro-335 in Balancing the Dual Functions of Munc18-1 Domain-3a in Regulated Exocytosis

(2014) Gayoung Anna Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones

(2014) Cordelia Imig et al.   NEURON

The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane

(2013) S. Martin et al.   JOURNAL OF CELL SCIENCE

Domain 3a of Munc18-1 plays a crucial role at the priming stage of exocytosis

(2013) G. A. Han et al.   JOURNAL OF CELL SCIENCE

Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16*

(2013) Richard W. Baker et al.   PLoS One

Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation

(2013) K. N. Colbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CAPS and Munc13: CATCHRs that SNARE Vesicles

(2013) Declan J. James et al.   Frontiers in Endocrinology

The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?

(2012) Josep Rizo et al.   Annual Review of Cell and Developmental Biology

Molecular machines governing exocytosis of synaptic vesicles

(2012) Reinhard Jahn et al.   NATURE

A single vesicle-vesicle fusion assay for in vitro studies of SNAREs and accessory proteins

(2012) Jiajie Diao et al.   Nature Protocols

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

(2012) C. Ma et al.   SCIENCE

Munc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membrane

(2011) Gayoung A. Han et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1

(2011) Francesca Morgera et al.   MOLECULAR BIOLOGY OF THE CELL

Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex

(2011) Cong Ma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synaptic Vesicle Exocytosis

(2011) T. C. Sudhof et al.   Cold Spring Harbor Perspectives in Biology

Dynamic Conformational Changes in MUNC18 Prevent Syntaxin Binding

(2011) Dana Bar-On et al.   PLoS Computational Biology

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Membrane Fusion: Five Lipids, Four SNAREs, Three Chaperones, Two Nucleotides, and a Rab, All Dancing in a Ring on Yeast Vacuoles

(2010) William Wickner   Annual Review of Cell and Developmental Biology

Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation

(2010) S.-H. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing

(2009) Orly Laufman et al.   EMBO JOURNAL

Rescue of Munc18-1 and -2 Double Knockdown Reveals the Essential Functions of Interaction between Munc18 and Closed Syntaxin in PC12 Cells

(2009) Liping Han et al.   MOLECULAR BIOLOGY OF THE CELL

Helical extension of the neuronal SNARE complex into the membrane

(2009) Alexander Stein et al.   NATURE

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Membrane traffic in the secretory pathway

(2008) J. Malsam et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide

(2008) Pawel Burkhardt et al.   EMBO JOURNAL

Munc18a Scaffolds SNARE Assembly to Promote Membrane Fusion

(2008) Travis L. Rodkey et al.   MOLECULAR BIOLOGY OF THE CELL

SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes

(2008) D. Tareste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion

(2008) Stefan H. Gerber et al.   SCIENCE

Munc18-1 Is Critical for Plasma Membrane Localization of Syntaxin1 but Not of SNAP-25 in PC12 Cells

(2007) Lakshmanan Arunachalam et al.   MOLECULAR BIOLOGY OF THE CELL