The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology

Treatment with D3 Removes Amyloid Deposits, Reduces Inflammation, and Improves Cognition in Aged AβPP/PS1 Double Transgenic Mice

(2018) Thomas van Groen et al.   JOURNAL OF ALZHEIMERS DISEASE

Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species

(2016) Tamar Ziehm et al.   ACS Chemical Neuroscience

Drug treatments in Alzheimers disease

(2016) R. Briggs et al.   CLINICAL MEDICINE

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination

(2016) Antonia Nicole Klein et al.   PLoS One

Pharmacokinetic Properties of a Novel d-Peptide Developed to be Therapeutically Active Against Toxic β-Amyloid Oligomers

(2015) Leonie H. E. Leithold et al.   PHARMACEUTICAL RESEARCH

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers

(2015) Oleksandr Brener et al.   Scientific Reports

Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease

(2015) Nan Jiang et al.   PLoS One

Amyloid Aggregation Inhibitory Mechanism of Arginine-rich D-peptides

(2014) O.O. Olubiyi et al.   CURRENT MEDICINAL CHEMISTRY

Immobilization of Homogeneous Monomeric, Oligomeric and Fibrillar Aβ Species for Reliable SPR Measurements

(2014) Daniel Frenzel et al.   PLoS One

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Aβ Oligomer-Induced Synapse Degeneration in Alzheimer’s Disease

(2011) Kyle C. Wilcox et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Structural Basis for Increased Toxicity of Pathological Aβ42:Aβ40Ratios in Alzheimer Disease

(2011) Kris Pauwels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble Aβ oligomer production and toxicity

(2011) Megan E. Larson et al.   JOURNAL OF NEUROCHEMISTRY

A comparison of InVivoStat with other statistical software packages for analysis of data generated from animal experiments

(2011) Robin A Clark et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Oral Treatment with the d-Enantiomeric Peptide D3 Improves the Pathology and Behavior of Alzheimer’s Disease Transgenic Mice

(2010) Susanne Aileen Funke et al.   ACS Chemical Neuroscience

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

The Genetics of Alzheimer Disease: Back to the Future

(2010) Lars Bertram et al.   NEURON

Reduction of Alzheimer’s Disease Amyloid Plaque Load in Transgenic Mice by D3, a D-Enantiomeric Peptide Identified by Mirror Image Phage Display

(2008) Thomas van Groen et al.   ChemMedChem

In vitro and in vivo Staining Characteristics of Small, Fluorescent, Aβ42-Binding D-Enantiomeric Peptides in Transgenic AD Mouse Models

(2008) Thomas van Groen et al.   ChemMedChem