Glyco-engineering strategies for the development of therapeutic enzymes with improved efficacy for the treatment of lysosomal storage diseases

Enzymes Approved for Human Therapy: Indications, Mechanisms and Adverse Effects

(2015) Brian A. Baldo   BIODRUGS

Increased mannosylphosphorylation of N-glycans by heterologous expression of YlMPO1 in glyco-engineered Saccharomyces cerevisiae for mannose-6-phosphate modification

(2015) Jin Young Gil et al.   JOURNAL OF BIOTECHNOLOGY

Pressure for drug development in lysosomal storage disorders – a quantitative analysis thirty years beyond the US orphan drug act

(2015) Konstantin Mechler et al.   Orphanet Journal of Rare Diseases

Comparative study on mannose 6-phosphate residue contents of recombinant lysosomal enzymes

(2014) Tadayasu Togawa et al.   MOLECULAR GENETICS AND METABOLISM

Taliglucerase alfa: An enzyme replacement therapy using plant cell expression technology

(2014) Gregory A. Grabowski et al.   MOLECULAR GENETICS AND METABOLISM

Glycan Structure Determinants for Cation-Independent Mannose 6-Phosphate Receptor Binding and Cellular Uptake of a Recombinant Protein

(2013) Qun Zhou et al.   BIOCONJUGATE CHEMISTRY

Enhanced sialylation and in vivo efficacy of recombinant human α-galactosidase through in vitro glycosylation

(2013) Youngsoo Sohn et al.   BMB Reports

The uptake of recombinant glucocerebrosidases by blood monocytes from type 1 Gaucher disease patients is variable

(2012) Juliette Berger et al.   BRITISH JOURNAL OF HAEMATOLOGY

A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes

(2012) Petra Tiels et al.   NATURE BIOTECHNOLOGY

Strategies for Neoglycan Conjugation to Human Acid α-Glucosidase

(2011) Qun Zhou et al.   BIOCONJUGATE CHEMISTRY

Enhanced efficacy of enzyme replacement therapy in Pompe disease through mannose-6-phosphate receptor expression in skeletal muscle

(2011) Dwight D. Koeberl et al.   MOLECULAR GENETICS AND METABOLISM

Mannose-6-phosphate pathway: A review on its role in lysosomal function and dysfunction

(2011) Maria Francisca Coutinho et al.   MOLECULAR GENETICS AND METABOLISM

Carbohydrate recognition by the mannose-6-phosphate receptors

(2009) Jung-Ja P Kim et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Production of human  -hexosaminidase A with highly phosphorylated N-glycans by the overexpression of the Ogataea minuta MNN4 gene

(2009) H. Akeboshi et al.   GLYCOBIOLOGY

Functions of the α, β, and γ Subunits of UDP-GlcNAc:Lysosomal EnzymeN-Acetylglucosamine-1-phosphotransferase

(2009) Yi Qian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycoengineered Acid α-Glucosidase With Improved Efficacy at Correcting the Metabolic Aberrations and Motor Function Deficits in a Mouse Model of Pompe Disease

(2009) Yunxiang Zhu et al.   MOLECULAR THERAPY

Sorting of lysosomal proteins

(2008) Thomas Braulke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Biochemical and pharmacological characterization of different recombinant acid α-glucosidase preparations evaluated for the treatment of Pompe disease

(2008) A.J. McVie-Wylie et al.   MOLECULAR GENETICS AND METABOLISM