Article
Clinical Neurology
Manjul Tripathi, Sahil Mehta, Raghav Singla, Chirag K. Ahuja, Naresh Tandalya, Constantin Tuleasca, Aman Batish, Sandeep Mohindra, Abhinav Agrahari, Rupinder Kaur
Summary: A 22-year-old patient with medically refractory Holmes tremor underwent stereotactic gamma knife thalamotomy, resulting in significant improvement in symptoms after 4 months and sustained neurological improvement after 1 year. This treatment modality may be considered for drug-resistant Holmes tremor patients reluctant or contraindicated for invasive surgical techniques.
ACTA NEUROCHIRURGICA
(2021)
Review
Clinical Neurology
Ming-Kai Pan, Sheng-Han Kuo
Summary: This article reviews the clinical features, pathophysiology, and various pathogenic mechanisms of essential tremor, highlighting the role of the cerebellum and the multiple abnormal brain circuitry that can contribute to action tremor.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Computer Science, Hardware & Architecture
Jigna J. Hathaliya, Hetav Modi, Rajesh Gupta, Sudeep Tanwar, Priyanka Sharma, Ravi Sharma
Summary: In this study, a classification model based on convolutional neural network and machine learning algorithms was proposed to accurately identify Parkinson's disease and essential tremor patients. Through automated feature engineering, the model outperformed traditional methods in tremor classification.
COMPUTERS & ELECTRICAL ENGINEERING
(2022)
Review
Clinical Neurology
Rodger J. Elble
Summary: Essential tremor plus (ET plus) is a new tremor classification that includes patients who meet the criteria for essential tremor but also have additional soft signs. Soft signs are not sufficient for diagnosing other tremor syndromes or movement disorders. Bayesian analysis is used to estimate the probability of alternative diagnosis in patients with possible ET. ET plus is a distinct classification and should not be considered a subtype of essential tremor. The clinical interpretation of ET plus is enhanced with the Bayesian analysis of associated soft signs.
JOURNAL OF CLINICAL NEUROLOGY
(2022)
Review
Clinical Neurology
Pattamon Panyakaew, Hyder A. Jinnah, Aasef G. Shaikh
Summary: Dystonia and tremor often coexist, either sharing biological mechanisms or as comorbid conditions. This paper compares and identifies the differences and limitations between two definitions of dystonic tremor, and discusses methods to separate tremor subtypes in dystonia based on objective measures and single neuron physiology analyses.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Review
Clinical Neurology
Florian Holtbernd, N. Jon Shah
Summary: Functional imaging studies consistently show altered functional connectivity in the cerebellum and cerebello-thalamico-cortical circuitry. Structural imaging studies are less consistent, with no clear evidence for cerebellar neurodegeneration, but diffusion tensor imaging robustly points toward microstructural cerebellar changes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Petr Holly, Tereza Duspivova, David Kemlink, Olga Ulmanova, Jan Rusz, Radim Krupicka, Robert Jech, Evzen Ruzicka
Summary: This study aimed to investigate which clinical and instrumental methods could best differentiate head tremor in patients with essential tremor (ET) and cervical dystonia (CD). The results showed that patients with head tremor had higher TETRAS and SARA scores, with no significant difference in mild head tremor subscores between the ET and CD groups. Head tremor disappeared when patients were in the supine position, and the STDT values were significantly higher in the group with head tremor.
PARKINSONISM & RELATED DISORDERS
(2023)
Review
Clinical Neurology
N. Nsengiyumva, A. Barakat, A. Macerollo, R. Pullicino, A. Bleakley, M. Bonello, R. J. B. Ellis, S. H. Alusi
Summary: Holmes Tremor (HT) is a unique and debilitating movement disorder that can result from midbrain or thalamic lesions. Clinical examination can aid in localization, with HT-m characterized by different tremor features compared to HT-t. Lesion localization can have implications for management strategies.
JOURNAL OF NEUROLOGY
(2021)
Review
Food Science & Technology
Bahman Jabbari, Samira Marie Comtesse
Summary: This review provides an up-to-date literature account on the efficacy of Botulinum toxin treatment for common motor disorders of Parkinson Disease. The reviewed disorders include tremor, focal foot dystonia, rigidity, and freezing of gait (FOG) in PD. The Yale method in the USA and Western University method in Canada offer efficacy with low incidence of side effects for Parkinson tremor. Botulinum toxin injections into toe flexors are effective in alleviating foot dystonia of PD. Improvement of Parkinson rigidity after botulinum toxin injection is suggested, but further larger clinical trials are needed for conclusive evidence. Improvement in FOG reported in open label studies needs confirmation in blinded investigations with potential adjustments in injection plan and dosage.
Article
Clinical Neurology
Pavel Filip, Kristina Burdova, Zdenek Valenta, Robert Jech, Viktoria Kokosova, Marek Balaz, Silvia Mangia, Shalom Michaeli, Martin Bares, Lubomir Vojtisek
Summary: The study found higher structural connectivity in the cerebello-thalamo-cortical network in ET patients compared to healthy controls, while tremor-dominant PD patients and PD patients without tremor showed similar results, with shared nodes with ET's tremor network. This suggests that the cerebello-thalamo-cortical network may be the dominant driver of tremor in both PD and ET, potentially explaining the different clinical features of tremor in these two disorders.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Elan D. D. Louis, Regina T. T. Martuscello, John T. T. Gionco, Whitney G. G. Hartstone, Jessica B. B. Musacchio, Marisa Portenti, Morgan McCreary, Sheng-Han Kuo, Jean-Paul G. Vonsattel, Phyllis L. L. Faust
Summary: In recent years, morphologic changes have been identified in the cerebellar cortex of essential tremor (ET) patients. However, these findings have not been fully understood in the context of other degenerative diseases. In this study, the authors compared degenerative changes in the cerebellar cortex of ET patients with other neurodegenerative disorders and control brains. They found that ET had distinct patterns of degenerative changes compared to other disorders, indicating its unique pathology.
ACTA NEUROPATHOLOGICA
(2023)
Review
Clinical Neurology
Anumeha Mishra, Sanjay Pandey
Summary: Holmes' tremor is a low-frequency tremor characterized by a combination of rest, posture, and action components. It predominantly affects male patients and is often associated with dystonia. Neuroimaging findings show involvement of various brain regions. Most patients show a positive response to levodopa.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Editorial Material
Clinical Neurology
Kristina Simonyan, Julie Barkmeier-Kraemer, Andrew Blitzer, Mark Hallett, John F. Houde, Teresa Jacobson Kimberley, Laurie J. Ozelius, Michael J. Pitman, Robert Mark Richardson, Nutan Sharma, Kristine Tanner
Summary: Research priorities for improving clinical management of laryngeal dystonia should focus on identifying disorder-specific biomarkers, elucidating critical nodes within neural networks, and fostering collaborations to facilitate rapid progress in understanding and treatment of this rare disorder.
Article
Clinical Neurology
Almudena Senchez-Gomez, Paola Camargo, Ana Cemara, Pedro Rolden, Jordi Rumia, Yaroslau Compta, Alvaro Carbayo, Maria Jose Marti, Esteban Munoz, Francesc Valldeoriola
Summary: The study evaluated the accuracy of the SureTune3 postoperative imaging software in determining the location of a deep brain stimulation electrode. The results showed a strong correlation between the SureTune3 software and clinical outcomes and adverse effects.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Andrew Dorritie, Mohammad Faysel, Angelika Gruessner, Daphne Robakis
Summary: This study found that Black patients and Hispanic patients with PD, ET, or dystonia were less likely to be treated with deep brain stimulation (DBS) compared to White patients between 2012 and 2018.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Geriatrics & Gerontology
Elisa Pelosin, Chiara Ponte, Martina Putzolu, Giovanna Lagravinese, Jeffrey M. Hausdorff, Alice Nieuwboer, Pieter Ginis, Lynn Rochester, Lisa Alcock, Bastiaan R. Bloem, Freek Nieuwhof, Andrea Cereatti, Ugo Della Croce, Anat Mirelman, Laura Avanzino
Summary: The study showed that longer TT + VR training leads to greater improvements in cognitive functions, especially those directly addressed by the virtual environment.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neuroimaging
Freek Nieuwhof, Ivan Toni, Michiel F. Dirkx, Cecile Gallea, Marie Vidailhet, Arthur W. G. Buijink, Anne-Fleur van Rootselaar, Bart P. C. van de Warrenburg, Rick C. Helmich
Summary: This study investigates the role of the cerebello-thalamo-cortical circuit and the basal ganglia in dystonic tremor syndrome, linking tremor fluctuations to cerebral activity. Tremor-related activity was found in specific brain regions, with grey matter volume changes and altered effective connectivity indicating involvement of the cerebello-thalamo-cortical circuit and pallidum in the pathophysiology of dystonic tremor syndromes. Deficient input from the cerebellum to the thalamo-cortical circuit and thalamic hypertrophy may play a key role in the generation of dystonic tremor syndrome.
NEUROIMAGE-CLINICAL
(2022)
Article
Clinical Neurology
Freek Nieuwhof, Ivan Toni, Arthur W. G. Buijink, Bart P. C. van de Warrenburg, Rick C. Helmich
Summary: This study aimed to investigate the causal role of the cerebellum and motor cortex in dystonic tremor syndromes and explore the therapeutic efficacy of phase-locked transcranial alternating current stimulation (TACS). The findings show that the cerebellum plays a causal role in the generation of (non-jerky) dystonic tremor syndrome, and tremor phenotype may guide optimal intervention targets.
CLINICAL NEUROPHYSIOLOGY
(2022)
Editorial Material
Neurosciences
Sirwan K. L. Darweesh, Nienke M. De Vries, Rick C. Helmich, Marcel M. Verbeek, Michael A. Schwarzschild, Bastiaan R. Bloem
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Health Care Sciences & Services
Maximilien Burq, Erin Rainaldi, King Chung Ho, Chen Chen, Bastiaan R. Bloem, Luc J. W. Evers, Rick C. Helmich, Lance Myers, William Marks, Ritu Kapur
Summary: Sensor-based remote monitoring using smartwatches can accurately measure motor signs of Parkinson's disease and provide reliable data. These measurements are sensitive to medication-induced changes and have good reliability, which can help reduce sample sizes in research studies.
NPJ DIGITAL MEDICINE
(2022)
Review
Clinical Neurology
Arthur W. G. Buijink, Anne-Fleur van Rootselaar, Rick C. Helmich
Summary: Understanding the pathophysiology of tremor can provide a more direct insight into the mechanism-based treatment options for this disorder, beyond just focusing on its etiology or clinical phenotype.
CURRENT OPINION IN NEUROLOGY
(2022)
Article
Clinical Neurology
Jos IJspeert, Renee Lustenhouwer, Renske M. Janssen, Jay J. Han, Maya N. Hatch, Ian Cameron, Rick C. Helmich, Baziel van Engelen, Philip van der Wees, Alexander C. H. Geurts, Nens van Alfen, Jan T. Groothuis
Summary: This study aimed to examine the ability of the Reachable Workspace (RWS) to quantitatively detect limitations in upper extremity active range of motion in patients with Neuralgic Amyotrophy (NA), and correlate these with other upper extremity functional outcome measures.
Article
Clinical Neurology
Renske M. J. Janssen, Renee Lustenhouwer, Edith H. C. Cup, Nens van Alfen, Jos Ijspeert, Rick C. Helmich, Ian G. M. Cameron, Alexander C. H. Geurts, Baziel G. M. van Engelen, Maud J. L. Graff, Jan T. Groothuis
Summary: This study compared the effects of multidisciplinary rehabilitation with usual care on the functional capability of the shoulder, arm, and hand in patients with neuralgic amyotrophy. The results showed that multidisciplinary rehabilitation was more effective in improving shoulder functional capability and reducing pain and fatigue.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Correction
Health Care Sciences & Services
Maximilien Burq, Erin Rainaldi, King Chung Ho, Chen Chen, Bastiaan R. Bloem, Luc J. W. Evers, Rick C. Helmich, Lance Myers, William J. Marks, Ritu Kapur
NPJ DIGITAL MEDICINE
(2022)
Editorial Material
Clinical Neurology
Milan Beckers, Bastiaan R. Bloem, Rick C. Helmich
JOURNAL OF MOVEMENT DISORDERS
(2023)
Review
Neurosciences
Anouk Tosserams, Bastiaan R. Bloem, Kaylena Ehgoetz A. Martens, Rick C. Helmich, Roy P. C. Kessels, James M. Shine, Natasha L. Taylor, Gabriel Wainstein, Simon J. G. Lewis, Jorik Nonnekes
Summary: In stressful situations, individuals with Parkinson's disease (PD) may experience worsening of motor symptoms, including gait impairments. However, some patients report benefits from stressful or high-arousal situations. A study with 4324 PD patients shows that they use various mental strategies to cope with gait impairments, which can either increase or decrease overall sympathetic tone. This suggests that arousal can have both detrimental and alleviating effects on gait control in PD.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Neurosciences
Martin E. Johansson, Nina M. van Lier, Roy P. C. Kessels, Bastiaan R. Bloem, Rick C. Helmich
Summary: Heterogeneity in Parkinson's disease (PD) makes it difficult to understand the disease and develop treatments. Stratifying patients into subtypes based on clinical characteristics may help overcome this challenge. A recent study classified de novo PD patients into three subtypes and found that the diffuse-malignant subtype had more severe symptoms and faster progression compared to the mild-motor predominant subtype. These findings suggest different pathophysiological mechanisms underlie distinct PD subtypes.
NPJ PARKINSONS DISEASE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Steve Bates, Serge O. Dumoulin, Paul J. M. Folkers, Elia Formisano, Rainer Goebel, Aidin Haghnejad, Rick C. Helmich, Dennis Klomp, Anja G. van der Kolk, Yi Li, Aart Nederveen, David G. Norris, Natalia Petridou, Stefan Roell, Tom W. J. Scheenen, Menno M. Schoonheim, Ingmar Voogt, Andrew Webb
Summary: We propose a vision for a 14 Tesla MR system, which includes a novel whole-body magnet design using high temperature superconductor, a console and associated electronic equipment, an optimized radiofrequency coil setup for proton measurement in the brain, and a high-performance gradient set. This system has significant applications in neuroscience and medical research, allowing for fine-grained observation of neural activity and structural abnormalities.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Article
Clinical Neurology
Renee Lustenhouwer, Ian G. M. Cameron, Nens van Alfen, Ivan Toni, Alexander C. H. Geurts, Baziel G. M. van Engelen, Jan T. Groothuis, Rick C. Helmich
Summary: This study aimed to determine whether abnormal cerebral sensorimotor representations associated with peripheral nerve damage in neuralgic amyotrophy (NA) can be changed by specialized multidisciplinary outpatient rehabilitation. The results showed that the multidisciplinary rehabilitation group demonstrated significant clinical improvement on the Shoulder Rating Questionnaire, while both groups showed improvement in task performance and increased activity in visuomotor occipito-parietal brain areas specific to the affected upper extremity. This study suggests that abnormal cerebral sensorimotor representations can recover towards normality after peripheral nerve damage.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Neuroimaging
Hanneke M. Keijzer, Puck A. M. Lange, Frederick J. A. Meijer, Bart A. R. Tonino, Michiel J. Blans, Catharina J. M. Klijn, Cornelia W. E. Hoedemaekers, Jeannette Hofmeijer, Rick C. Helmich
Summary: The study found that early MRI markers of brain network integrity after cardiac arrest can be used to predict neurological outcome six months later. Patients with good outcomes showed higher functional connectivity and mean diffusivity levels compared to those with poor outcomes.
NEUROIMAGE-CLINICAL
(2022)