DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke

Potential microglia‐based interventions for stroke

(2020) Ling‐Zhi Li et al.   CNS Neuroscience & Therapeutics

P2Y6 receptor inhibition aggravates ischemic brain injury by reducing microglial phagocytosis

(2020) Ruo‐Xue Wen et al.   CNS Neuroscience & Therapeutics

Molecular profile of the rat peri-infarct region four days after stroke: Study with MANF

(2020) Jaakko Teppo et al.   EXPERIMENTAL NEUROLOGY

Dual Functions of Microglia in Ischemic Stroke

(2019) Chuan Qin et al.   Neuroscience Bulletin

Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury

(2019) Suvi Pöyhönen et al.   Frontiers in Physiology

Macrophages reprogram after ischemic stroke and promote efferocytosis and inflammation resolution in the mouse brain

(2019) Wenting Zhang et al.   CNS Neuroscience & Therapeutics

Effects of mesencephalic astrocyte-derived neurotrophic factor on cerebral angiogenesis in a rat model of cerebral ischemia

(2019) Baobing Gao et al.   NEUROSCIENCE LETTERS

Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection, and Neurobehavioral Recovery After Experimental Ischemic Stroke

(2018) Ludmila Belayev et al.   MOLECULAR NEUROBIOLOGY

MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke

(2018) Kuan-Yin Tseng et al.   MOLECULAR THERAPY

Poststroke delivery of MANF promotes functional recovery in rats

(2018) Kert Mätlik et al.   Science Advances

Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke

(2018) Kota Kurisu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection

(2018) Nicolas G. Bazan   MOLECULAR ASPECTS OF MEDICINE

New insights into the role of TREM2 in Alzheimer’s disease

(2018) Maud Gratuze et al.   Molecular Neurodegeneration

Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia

(2017) Xiaobao Zhang et al.   MEDIATORS OF INFLAMMATION

TREM2 protects against cerebral ischemia/reperfusion injury

(2017) Rong Wu et al.   Molecular Brain

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Involved in Inflammation by Negatively Regulating the NF-κB Pathway

(2015) Lijian Chen et al.   Scientific Reports

Neurogenesis and Inflammation after Ischemic Stroke: What is Known and Where We Go from Here

(2014) Matthew K Tobin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

(2014) Teng Jiang et al.   NEUROPSYCHOPHARMACOLOGY

TREM2 and the neuroimmunology of Alzheimer's disease

(2013) Suzanne E. Hickman et al.   BIOCHEMICAL PHARMACOLOGY

Upregulation of mesencephalic astrocyte-derived neurotrophic factor in glial cells is associated with ischemia-induced glial activation

(2012) Yujun Shen et al.   Journal of Neuroinflammation

Docosahexaenoic Acid Signaling Modulates Cell Survival in Experimental Ischemic Stroke Penumbra and Initiates Long-Term Repair in Young and Aged Rats

(2012) Tiffany N. Eady et al.   PLoS One

Docosahexaenoic Acid Signalolipidomics in Nutrition: Significance in Aging, Neuroinflammation, Macular Degeneration, Alzheimer's, and Other Neurodegenerative Diseases

(2011) Nicolas G. Bazan et al.   Annual Review of Nutrition

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Docosahexaenoic Acid Therapy of Experimental Ischemic Stroke

(2010) Ludmila Belayev et al.   Translational Stroke Research

Induction Profile of MANF/ARMET by Cerebral Ischemia and its Implication for Neuron Protection

(2009) Yong-Qiang Yu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mesencephalic astrocyte-derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats

(2009) Mikko Airavaara et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Robust Docosahexaenoic Acid–Mediated Neuroprotection in a Rat Model of Transient, Focal Cerebral Ischemia

(2009) Ludmila Belayev et al.   STROKE