Metformin alleviates hyperuricaemia-induced serum FFA elevation and insulin resistance by inhibiting adipocyte hypertrophy and reversing suppressed white adipose tissue beiging

Uric Acid Has Direct Proinflammatory Effects on Human Macrophages by Increasing Proinflammatory Mediators and Bacterial Phagocytosis Probably via URAT1

(2020) Camilo P. Martínez-Reyes et al.   Biomolecules

Adipocyte Death Preferentially Induces Liver Injury and Inflammation Through the Activation of Chemokine (C‐C Motif) Receptor 2‐Positive Macrophages and Lipolysis

(2019) Seung‐Jin Kim et al.   HEPATOLOGY

The difficult relationship between uric acid and cardiovascular disease

(2019) Stefano Masi et al.   EUROPEAN HEART JOURNAL

Adipocytes utilize sucrose as an energy source—Effect of different carbohydrates on adipocyte differentiation

(2019) Mahesh S. Krishna et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ilexgenin A prevents early colonic carcinogenesis and reprogramed lipid metabolism through HIF1α/SREBP-1

(2019) Li Zhang et al.   PHYTOMEDICINE

The link between insulin resistance parameters and serum uric acid is mediated by adiposity

(2018) Mohsen Mazidi et al.   ATHEROSCLEROSIS

Zurampic Protects Pancreatic β-Cells from High Uric Acid Induced-Damage by Inhibiting URAT1 and Inactivating the ROS/AMPK/ERK Pathways

(2018) Ying Xin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Metabolic flexibility as an adaptation to energy resources and requirements in health and disease

(2018) Reuben L Smith et al.   ENDOCRINE REVIEWS

Small molecule inhibition of the CBFβ/RUNX interaction decreases ovarian cancer growth and migration through alterations in genes related to epithelial-to-mesenchymal transition

(2018) Anne L. Carlton et al.   GYNECOLOGIC ONCOLOGY

Comparative secretome analyses of primary murine white and brown adipocytes reveal novel adipokines

(2018) Asrar Ali Khan et al.   MOLECULAR & CELLULAR PROTEOMICS

Autophagy exacerbates electrical remodeling in atrial fibrillation by ubiquitin-dependent degradation of L-type calcium channel

(2018) Yue Yuan et al.   Cell Death & Disease

Uric Acid Is a Strong Risk Marker for Developing Hypertension From PrehypertensionNovelty and Significance

(2017) Masanari Kuwabara et al.   HYPERTENSION

CIDE Family-Mediated Unique Lipid Droplet Morphology in White Adipose Tissue and Brown Adipose Tissue Determines the Adipocyte Energy Metabolism

(2017) Yuki Nishimoto et al.   Journal of Atherosclerosis and Thrombosis

Causes and mechanisms of adipocyte enlargement and adipose expansion

(2017) F. Haczeyni et al.   Obesity Reviews

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(2017) Kirstin A. Tamucci et al.   Protein & Cell

In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters

(2016) Zancong Shen et al.   CLINICAL DRUG INVESTIGATION

AMPK Activation by Metformin Suppresses Abnormal Extracellular Matrix Remodeling in Adipose Tissue and Ameliorates Insulin Resistance in Obesity

(2016) Ting Luo et al.   DIABETES

IRF3 promotes adipose inflammation and insulin resistance and represses browning

(2016) Manju Kumari et al.   JOURNAL OF CLINICAL INVESTIGATION

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(2016) Liping Luo et al.   JOURNAL OF ENDOCRINOLOGY

The Molecular Physiology of Uric Acid Homeostasis

(2015) Asim K. Mandal et al.   Annual Review of Physiology

The cell biology of fat expansion

(2015) Joseph M. Rutkowski et al.   JOURNAL OF CELL BIOLOGY

Discovery of URAT1 SNPs and association between serum uric acid levels and URAT1

(2015) Sung Kweon Cho et al.   BMJ Open

Endogenous, Adipocyte-Derived Lipids Signal the Recruitment of Proinflammatory Immune Cells

(2014) Graeme I. Lancaster et al.   DIABETES

Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes

(2014) Yea-Jin Choi et al.   LABORATORY INVESTIGATION

Metformin Lowers Plasma Triglycerides by Promoting VLDL-Triglyceride Clearance by Brown Adipose Tissue in Mice

(2013) J. J. Geerling et al.   DIABETES

Differential regulation of AMPK activation in leptin- and creatine-deficient mice

(2013) Malte Stockebrand et al.   FASEB JOURNAL

Uric Acid Secretion from Adipose Tissue and Its Increase in Obesity

(2013) Yu Tsushima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue

(2012) Nicole H. Rogers et al.   AGING CELL

The holy grail of metabolic disease

(2012) Alexander Bartelt et al.   CURRENT OPINION IN LIPIDOLOGY

Adipose tissue: friend or foe?

(2012) Mohamed Hassan et al.   Nature Reviews Cardiology

Leptin revisited: its mechanism of action and potential for treating diabetes

(2012) Roberto Coppari et al.   NATURE REVIEWS DRUG DISCOVERY

Counteracting Roles of AMP Deaminase and AMP Kinase in the Development of Fatty Liver

(2012) Miguel A. Lanaspa et al.   PLoS One

The relationship between the regional abdominal adipose tissue distribution and the serum uric acid levels in people with type 2 diabetes mellitus

(2012) Tae Kim et al.   Diabetology & Metabolic Syndrome

Transcriptional Control of Adipose Lipid Handling by IRF4

(2011) Jun Eguchi et al.   Cell Metabolism

Hyperuricemia as a Mediator of the Proinflammatory Endocrine Imbalance in the Adipose Tissue in a Murine Model of the Metabolic Syndrome

(2011) W. Baldwin et al.   DIABETES

Racial/ethnic and sex differences in the relationship between uric acid and metabolic syndrome in adolescents: an analysis of National Health and Nutrition Survey 1999-2006

(2011) Mark D. DeBoer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective

(2010) Sam Virtue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Uric acid and the development of metabolic syndrome in women and men

(2008) Xuemei Sui et al.   METABOLISM-CLINICAL AND EXPERIMENTAL