Article
Multidisciplinary Sciences
Aziza Kantri, Jihane Ziati, Mohamed Khalis, Amal Haoudar, Karim El Aidaoui, Youssef Daoudi, Inas Chikhaoui, Khalid El Yamani, Mohammed Mouhaoui, Jalila El Bakkouri, Nezha Dini, Mohammed Mahi, Abdelhamid Naitlho, Abdelkrim Bahlaoui, Ahmed Bennana, Mustapha Noussair, Lahcen Belyamani, Chafik El Kettani
Summary: This study critically analyzed the clinical and biological characteristics of 134 patients from the North African Mediterranean region with COVID-19, finding that factors such as age, comorbidities, gender, and infection type were associated with disease progression to a severe state. Abnormalities in certain parameters were closely linked to disease deterioration.
Article
Multidisciplinary Sciences
Harpal Singh Sandhu, Joshua Lambert, Zach Steckler, Lee Park, Arnold Stromberg, Julio Ramirez, Chi-fu Jeffrey Yang
Summary: This study aimed to evaluate whether outpatient medications approved by the FDA reduce the risk of COVID-19 hospitalization. A retrospective cohort study of COVID-19 patients in the US in 2020 found that rosuvastatin, empagliflozin-metformin, metformin, and enoxaparin showed protective effects against COVID-19 hospitalization. Well-designed clinical trials are needed to assess the efficacy of these agents in therapeutic or prophylactic settings.
Article
Public, Environmental & Occupational Health
Lorenzo Guglielmetti, Irina Kontsevaya, Maria C. Leoni, Patrizia Ferrante, Elisa Fronti, Laura Gerna, Caterina Valdatta, Alessandra Donisi, Alberto Faggi, Franco Paolillo, Giovanna Ratti, Alessandro Ruggieri, Marta Scotti, Daria Sacchini, Gloria Taliani, Mauro Codeluppi
Summary: This study investigated 218 patients treated at the medical departments of Piacenza Hospital in Italy from February 21st to May 15th, 2020, and found that patients were generally older, with comorbidities, and most had acute respiratory distress syndrome and extensive lung involvement on admission. The use of antivirals and corticosteroids did not show a significant impact on survival rates.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Julia Diaz-Escobar, Nelson E. Ordonez-Guillen, Salvador Villarreal-Reyes, Alejandro Galaviz-Mosqueda, Vitaly Kober, Raul Rivera-Rodriguez, Jose E. Lozano Rizk
Summary: The study evaluates and compares deep-learning techniques for detecting COVID-19 infections from lung ultrasound imagery. The findings suggest that the InceptionV3 network provides the most promising predictive results, which can be used to further develop a viable computer-assisted screening tool for COVID-19 based on ultrasound imagery.
Article
Multidisciplinary Sciences
Tufan Arslanca, Cihan Fidan, Mine Daggez, Polat Dursun
Summary: The study found that the knowledge level of healthcare workers regarding COVID-19 was generally high, but there was a lack of competence in terms of preventive behaviors, especially among males.
Review
Microbiology
Jessica A. Plante, Brooke M. Mitchell, Kenneth S. Plante, Kari Debbink, Scott C. Weaver, Vineet D. Menachery
Summary: Despite the development of vaccines, COVID-19 caused by SARS-CoV-2 continues to be a global concern due to the emergence of new variants, raising worries about increased spread and potential impacts on immunity.
CELL HOST & MICROBE
(2021)
Article
Biochemistry & Molecular Biology
Atsuko Deguchi, Tomoko Yamamoto, Noriyuki Shibata, Yoshiro Maru
Summary: This study investigates the potential role of S100A8 in COVID-19-associated ARDS and proposes a treatment method. Pathological similarities, clinical information, and experimental results collectively support the importance of S100A8 in COVID-19.
Article
Critical Care Medicine
George L. Anesi, Adair Andrews, He Julia Bai, Pavan K. M. Bhatraju, David M. Brett-Major, M. Jana Broadhurst, Elizabeth Salvagio Campbell, J. Perren Cobb, Martin Gonzalez, Sonya D. Homami, Cameron D. Hypes, Amy J. Irwin, Christopher J. Kratochvil, Kelsey K. Krolikowski, Vishakha K. P. Kumar, Douglas P. A. Landsittel, Richard A. M. Lee, Janice M. Liebler, Karen T. Lutrick, Lucian T. M. Marts, Jarrod M. Mosier, Vikramjit Mukherjee, Radu Postelnicu, Valentina N. Rodina, Leopoldo N. E. Segal, Jonathan E. Sevransky, Christine Spainhour, Avantika M. Srivastava, Timothy M. Uyeki, Mark M. Wurfel, David Wyles, Laura Evans
Summary: This study aimed to understand the impact of the COVID-19 pandemic on hospital operations and its relationship with local viral activity. The results showed that hospitals experienced high stress in dealing with severe acute respiratory infection patients during the pandemic, and there were also some instances of care deviations. This stress was closely related to the stress in the wards and emergency departments, and it was influenced by the increase in local cases. After the peak of the Delta variant surge, the overall hospital stress persisted for a certain period of time, while the stress in the ICU and emergency departments resolved relatively earlier. Similar patterns were observed during the Omicron BA.1 subvariant surge.
CRITICAL CARE MEDICINE
(2023)
Article
Immunology
Xiaowei Deng, Juan Yang, Wei Wang, Xiling Wang, Jiaxin Zhou, Zhiyuan Chen, Jing Li, Yinzi Chen, Han Yan, Juanjuan Zhang, Yongli Zhang, Yan Wang, Qi Qiu, Hui Gong, Xianglin Wei, Lili Wang, Kaiyuan Sun, Peng Wu, Marco Ajelli, Benjamin J. Cowling, Cecile Viboud, Hongjie Yu
Summary: Our study on the case fatality risk of COVID-19 in mainland China found that the national CFR was 5.65%, with the highest in Wuhan (7.71%) and lowest in provinces outside Hubei (0.86%). Critical patients had a 3.6 times higher fatality risk compared to all patients, and the risk was between 0.8 to 10.3 times higher than that of mild-to-severe patients. Older age and being male were identified as risk factors for mortality. Additionally, time intervals from symptom onset to first healthcare consultation, to laboratory confirmation, and to hospitalization were longer for deceased patients than for those who recovered.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Pediatrics
Reza Sinaei, Sara Pezeshki, Saeedeh Parvaresh, Roya Sinaei
Summary: Research suggests that children are less frequently and severely affected by SARS-CoV-2 infection compared to adults, potentially due to factors such as a healthier respiratory system, less vigorous immune response, and other immune characteristics.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Virology
Baris Otlu, Yusuf Yakupogullari, Elif S. Tanriverdi, Yasar Bayindir
Summary: The study found that patients with a prior eCoV infection had a lower prevalence of COVID-19 and those who were infected did not exhibit severe symptoms requiring hospitalization, even with underlying conditions. These results suggest that prior eCoV infection may lead to a milder course of COVID-19, providing insights for future vaccine development studies.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Oncology
Oscar Arrieta, Luis Lara-Mejia, Elysse Bautista-Gonzalez, David Heredia, Jenny G. Turcott, Feliciano Barron, Maritza Ramos-Ramirez, Luis Cabrera-Miranda, Miguel Angel Salinas Padilla, Mercedes Aguerrebere, Andres F. Cardona, Christian Rolfo, Marisol Arroyo-Hernandez, Enrique Soto-Perez-de-Celis, Renata Baez-Saldana
Summary: The COVID-19 pandemic has had a significant impact on patients with thoracic cancer, with treatment modifications being common in Mexico. Mental health disorders may play a role in patients' adherence to the original treatment regimen.
Article
Biochemistry & Molecular Biology
Wilfredo F. Garcia-Beltran, Evan C. Lam, Michael G. Astudillo, Diane Yang, Tyler E. Miller, Jared Feldman, Blake M. Hauser, Timothy M. Caradonna, Kiera L. Clayton, Adam D. Nitido, Mandakolathur R. Murali, Galit Alter, Richelle C. Charles, Anand Dighe, John A. Branda, Jochen K. Lennerz, Daniel Lingwood, Aaron G. Schmidt, A. John Iafrate, Alejandro B. Balazs
Summary: Severe cases of COVID-19 show increased inflammatory markers, lymphopenia, pro-inflammatory cytokines, and high antibody levels. High neutralization potency is a predictor of survival. Patient sera can neutralize different strains, indicating cross-protection from reinfection.
Review
Biochemistry & Molecular Biology
Muhammad Fayyaz ur Rehman, Chaudhary Fariha, Aqsa Anwar, Naveed Shahzad, Munir Ahmad, Salma Mukhtar, Muhammad Farhan Ul Haque
Summary: COVID-19, caused by a novel coronavirus, is a global pandemic that is ongoing. Despite the repurposing of several drugs, no specific antiviral medication has been approved for treatment yet.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Multidisciplinary Sciences
Jun Wu, Boyun Liang, Cunrong Chen, Hua Wang, Yaohui Fang, Shu Shen, Xiaoli Yang, Baoju Wang, Liangkai Chen, Qi Chen, Yang Wu, Jia Liu, Xuecheng Yang, Wei Li, Bin Zhu, Wenqing Zhou, Huan Wang, Sumeng Li, Sihong Lu, Di Liu, Huadong Li, Adalbert Krawczyk, Mengji Lu, Dongliang Yang, Fei Deng, Ulf Dittmer, Mirko Trilling, Xin Zheng
Summary: The study quantified IgM and IgG antibodies recognizing SARS-CoV-2 in 349 symptomatic COVID-19 patients over 6 months, showing that IgM levels dropped after 3 months while IgG responses contracted but remained high at 6 months.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Can Li, Yanxia Chen, Yan Zhao, David Christopher Lung, Zhanhong Ye, Wenchen Song, Fei-Fei Liu, Jian-Piao Cai, Wan-Man Wong, Cyril Chik-Yan Yip, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Siddharth Sridhar, Ivan Fan-Ngai Hung, Hin Chu, Kin-Hang Kok, Dong-Yan Jin, Anna Jinxia Zhang, Kwok-Yung Yuen
Summary: Inadvertent intravenous injection of COVID-19 mRNA vaccines may induce myopericarditis in mice. Withdrawal of syringe plunger to exclude blood aspiration may reduce this risk.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Kelvin Kai-Wang To, Xin Li, David Christopher Lung, Jonathan Daniel Ip, Wan-Mui Chan, Allen Wing-Ho Chu, Cyril Chik-Yan Yip, Jonathan H. K. Chen, Rosana Wing-Shan Poon, Hoi-Wah Tsoi, Raymond Wai-Man Lai, Wing-Kin To, Lili Ren, Mingkun Li, Yunlong Cao, Xiaoliang Sunney Xie, Dong-Yan Jin, Kwok-Yung Yuen
Summary: This study reports two cases where respiratory samples were contaminated with an inactivated SARS-CoV-2 vaccine strain, likely occurring at the vaccination center. Whole genome sequencing revealed adaptive deletions on the spike protein of the vaccine strain, but without observable changes in antigenicity.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Can Li, Zhanhong Ye, Anna Jin-Xia Zhang, Jasper Fuk-Woo Chan, Wenchen Song, Feifei Liu, Yanxia Chen, Mike Yat-Wah Kwan, Andrew Chak-Yiu Lee, Yan Zhao, Bosco Ho-Yin Wong, Cyril Chik-Yan Yip, Jian-Piao Cai, David Christopher Lung, Siddharth Sridhar, Dongyan Jin, Hin Chu, Kelvin Kai-Wang To, Kwok-Yung Yuen
Summary: The study found that SARS-CoV-2 can cause acute testicular damage leading to chronic asymmetric testicular atrophy and hormonal changes in hamsters, which can be prevented by vaccination. Awareness of possible hypogonadism and subfertility is important in managing convalescent coronavirus disease 2019 in males.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Engineering, Environmental
Vincent Chi-Chung Cheng, David Christopher Lung, Shuk-Ching Wong, Albert Ka-Wing Au, Qun Wang, Hong Chen, Li Xin, Allen Wing-Ho Chu, Jonathan Daniel Ip, Wan-Mui Chan, Hoi-Wah Tsoi, Herman Tse, Ken Ho-Leung Ng, Mike Yat-Wah Kwan, Shuk-Kwan Chuang, Kelvin Kai-Wang To, Yuguo Li, Kwok-Yung Yuen
Summary: This study investigated an outbreak of the Omicron variant in a restaurant and found that enhancing indoor air dilution can reduce the risk of SARS-CoV-2 transmission in restaurants.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Environmental
Qun Wang, Yuguo Li, David Christopher Lung, Pak-To Chan, Chung-Hin Dung, Wei Jia, Te Miao, Jianxiang Huang, Wenzhao Chen, Zixuan Wang, Kai-Ming Leung, Zhang Lin, Daniel Wong, Herman Tse, Sally Cheuk Ying Wong, Garnet Kwan-Yue Choi, Jimmy Yiu-Wing Lam, Kelvin Kai-Wang To, Vincent Chi-Chung Cheng, Kwok-Yung Yuen
Summary: Studies have shown that stack aerosols generated within vertical drainage stacks in high-rise buildings may lead to outbreaks of COVID-19 and the spread of SARS-CoV-2, mainly through the chimney effect of drainage pipes. By injecting tracer gas into the drainage stacks and monitoring its distribution in different areas, researchers were able to confirm that the spread of the virus was in line with the distribution of infected cases, providing direct evidence for long-range aerosol transmission through drainage pipes.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Immunology
Timothy Lok-Hin Chiu, Daniel Leung, Koon-Wing Chan, Hok Man Yeung, Chung-Yin Wong, Huawei Mao, Jianxin He, Pandiarajan Vignesh, Weiling Liang, Woei Kang Liew, Li-Ping Jiang, Tong-Xin Chen, Xiang-Yuan Chen, Yin-Bo Tao, Yong-Bin Xu, Hsin-Hui Yu, Alta Terblanche, David Christopher Lung, Cheng-Rong Li, Jing Chen, Man Tian, Brian Eley, Xingtian Yang, Jing Yang, Wen Chin Chiang, Bee Wah Lee, Deepti Suri, Amit Rawat, Anju Gupta, Surjit Singh, Wilfred Hing Sang Wong, Gilbert T. Chua, Jaime Sou Da Rosa Duque, Kai-Ning Cheong, Patrick Chun-Yin Chong, Marco Hok-Kung Ho, Tsz-Leung Lee, Wanling Yang, Pamela P. Lee, Yu Lung Lau
Summary: This study compares the phenomic differences between XL-CGD and AR-CGD. The results show that XL-CGD patients have an earlier onset, diagnosis, and genetic diagnosis compared to AR-CGD patients, and are more commonly affected in the integument and central nervous system. Specific HPO terms such as perianal abscess, cutaneous abscess, and elevated hepatic transaminase are correlated with XL-CGD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jasper Fuk-Woo Chan, Gilman Kit-Hang Siu, Shuofeng Yuan, Jonathan Daniel Ip, Jian-Piao Cai, Allen Wing-Ho Chu, Wan-Mui Chan, Syed Muhammad Umer Abdullah, Cuiting Luo, Brian Pui-Chun Chan, Terrence Tsz-Tai Yuen, Lin-Lei Chen, Kenn Ka-Heng Chik, Ronghui Liang, Hehe Cao, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Kit-Hang Leung, Anthony Raymond Tam, Owen Tak-Yin Tsang, Jacky Man-Chun Chan, Wing-Kin To, Bosco Hoi-Shiu Lam, Lam-Kwong Lee, Hazel Wing-Hei Lo, Ivan Tak-Fai Wong, Jake Siu-Lun Leung, Evelyn Yin-Kwan Wong, Hin Chu, Cyril Chik-Yan Yip, Vincent Chi-Chung Cheng, Kwok-Hung Chan, Herman Tse, David Christopher Lung, Kenneth Ho-Leung Ng, Albert Ka-Wing Au, Ivan Fan-Ngai Hung, Kwok-Yung Yuen, Kelvin Kai-Wang To
Summary: This study investigated a pet shop-related COVID-19 outbreak in Hong Kong, revealing potential hamster-to-human transmission and highlighting the role of pet trading in the international spread of the pandemic virus.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Vincent Chi-Chung Cheng, Shuk-Ching Wong, Simon Yung-Chun So, Jonathan Hon-Kwan Chen, Pui-Hing Chau, Albert Ka-Wing Au, Kelvin Hei-Yeung Chiu, Xin Li, Patrick Ip, Vivien Wai-Man Chuang, David Christopher Lung, Cindy Wing-Sze Tse, Rodney Allan Lee, Kitty Sau-Chun Fung, Wing-Kin To, Raymond Wai-Man Lai, Tak-Lun Que, Janice Yee-Chi Lo, Kwok-Yung Yuen
Summary: Nonpharmaceutical interventions during the COVID-19 pandemic in Hong Kong have led to a reduction in wholesale antibiotic supply and a significant decrease in community-onset bacteremia caused by common bacterial species. However, no reduction was observed in hospital-onset bacteremia caused by Staphylococcus aureus or Escherichia coli.
Article
Construction & Building Technology
Vincent Chi-Chung Cheng, Shuk-Ching Wong, Albert Ka-Wing Au, Cheng Zhang, Jonathan Hon-Kwan Chen, Simon Yung-Chun So, Xin Li, Qun Wang, Kelvin Keru Lu, David Christopher Lung, Vivien Wai-Man Chuang, Eric Schuldenfrei, Gilman Kit-Hang Siu, Kelvin Kai-Wang To, Yuguo Li, Kwok-Yung Yuen
Summary: The phenomenon of vertical transmission of SARS-CoV-2 in high-rise residential buildings in Hong Kong is unique. The compulsory testing of entire buildings during the fourth and fifth waves of the COVID-19 outbreak revealed a higher prevalence of vertical transmission in the fifth wave. The analysis of viral genomes confirmed the high transmissibility of the Omicron BA.2 variant.
BUILDING AND ENVIRONMENT
(2022)
Article
Infectious Diseases
Dyna Khuon, Dhanushi Rupasinghe, Vonthanak Saphonn, Tsz-Shan Kwong, Alvina Widhani, Romanee Chaiwarith, Penh Sun Ly, Cuong Duy Do, Anchalee Avihingsanon, Suwimon Khusuwan, Tuti Parwati Merati, Kinh Van Nguyen, Nagalingeswaran Kumarasamy, Yu-Jiun Chan, Iskandar Azwa, Oon Tek Ng, Sasisopin Kiertiburanakul, Junko Tanuma, Sanjay Pujari, Rossana Ditangco, Fujie Zhang, Jun Yong Choi, Yasmin Gani, Shashikala Sangle, Jeremy Ross, Pamina M. Gorbach, Awachana Jiamsakul
Summary: This study investigated the incidence and factors associated with high fasting blood glucose among people living with HIV in the Asia-Pacific region. The study found that HIV-infected individuals with a BMI over 25 had an increased risk of high fasting blood glucose.
Article
Public, Environmental & Occupational Health
Shuk-Ching Wong, Veronica Wing-Man Chan, Christine Ho-Yan Auyeung, Jonathan Hon-Kwan Chen, Cyril Chik-Yan Yip, Simon Yung-Chun So, Xin Li, David Christopher Lung, Anita Man-Ching Tsang, Kelvin Kai-Wang To, Kwok-Yung Yuen, Vincent Chi-Chung Cheng
Summary: This study found that the air dispersal of respiratory viruses may have important implications for infection prevention and public health. The viral load of patients is closely associated with the air dispersal of viruses in isolation rooms. Patients placed in double-bed isolation rooms had a higher viral load in the air compared to singly isolated patients.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Paul Kwok-ming Poon, Ngai-sze Wong, Wai-shing Leung, Bonnie Chun-kwan Wong, Tsz-shan Kwong, Tsz-ho Kwan, Grace Chung-yan Lui, Owen Tak-yin Tsang, Man-po Lee, Ka-hing Wong, Shui-shan Lee
Summary: Early detection and prompt antiretroviral therapy have had a remarkable impact on HIV prevention, but late presentation remains a problem, particularly among heterosexual individuals.
Article
Infectious Diseases
Phillip Chan, Tommy H. C. Tang, Ruby T. S. Kwong, Lawrence Chan, Helen S. Y. Chan, K. W. Lam, W. M. Ting, S. K. Yung, Emily C. T. Lam, M. Y. Chu, Wilson Lam, T. C. Wu, Patrick Li, M. P. Lee
Summary: Syphilis does not affect the level of plasma HIV-1 RNA in virally suppressed individuals with HIV, but it does cause a decline in total lymphocyte, CD4+, and CD8+ T-cell levels, which rebound after treatment.
AIDS RESEARCH AND THERAPY
(2022)
Review
Infectious Diseases
Yi Qi Chan, Kailin Chen, Gilbert T. Chua, Peng Wu, Keith T. S. Tung, Hing Wai Tsang, David Lung, Patrick Ip, Celine S. L. Chui
Summary: This study evaluated the risk factors associated with carriage of antimicrobial-resistant bacteria in children in the Asia-Pacific region and identified significant risk factors and protective factors.
JAC-ANTIMICROBIAL RESISTANCE
(2022)
Article
Biology
Qun Wang, David Christopher Lung, Pak-To Chan, Wei Jia, Chung-Hin Dung, Te Miao, Jianxiang Huang, Wenzhao Chen, Zixuan Wang, Kai-Ming Leung, Pengcheng Xu, Zhang Lin, Daniel Wong, Herman Tse, Sally Cheuk Ying Wong, Garnet Kwan-Yue Choi, Kelvin Kai-Wang To, Vincent Chi-Chung Cheng, Kwok-Yung Yuen, Yuguo Li
Summary: This study investigated a COVID-19 outbreak in Hong Kong, revealing the association between poor housing conditions, environmental issues, and the transmission of the virus.