Genetics of Atrial Fibrillation in 2020

Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

(2020) F. Kyle Satterstrom et al.   CELL

A practical view of fine-mapping and gene prioritization in the post-genome-wide association era

(2020) R. V. Broekema et al.   Open Biology

Transcriptional and Cellular Diversity of the Human Heart

(2020) Nathan R. Tucker et al.   CIRCULATION

A high-content, in vitro cardiac fibrosis assay for high-throughput, phenotypic identification of compounds with anti-fibrotic activity

(2020) G. Palano et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Epidemiology of Atrial Fibrillation in the 21st Century

(2020) Jelena Kornej et al.   CIRCULATION RESEARCH

Molecular Basis of Atrial Fibrillation Pathophysiology and Therapy

(2020) Stanley Nattel et al.   CIRCULATION RESEARCH

Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation

(2020) Antoinette F. van Ouwerkerk et al.   CIRCULATION RESEARCH

How Will Machine Learning Inform the Clinical Care of Atrial Fibrillation?

(2020) Konstantinos C. Siontis et al.   CIRCULATION RESEARCH

How Will Genetics Inform the Clinical Care of Atrial Fibrillation?

(2020) M. Benjamin Shoemaker et al.   CIRCULATION RESEARCH

Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation

(2019) Christina Ellervik et al.   JAMA Cardiology

Body composition and atrial fibrillation: a Mendelian randomization study

(2019) Emmi Tikkanen et al.   EUROPEAN HEART JOURNAL

SarcTrack: An Adaptable Software Tool for Efficient Large-Scale Analysis of Sarcomere Function in hiPSC-Cardiomyocytes

(2019) Christopher N Toepfer et al.   CIRCULATION RESEARCH

Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study

(2019) Susanna C Larsson et al.   EUROPEAN HEART JOURNAL

Analysis of polygenic risk score usage and performance in diverse human populations

(2019) L. Duncan et al.   Nature Communications

Monogenic and Polygenic Contributions to Atrial Fibrillation Risk: Results from a National Biobank

(2019) Seung Hoan Choi et al.   CIRCULATION RESEARCH

Serum albumin and atrial fibrillation: insights from epidemiological and mendelian randomization studies

(2019) Li-zhen Liao et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Identification of atrial fibrillation associated genes and functional non-coding variants

(2019) Antoinette F. van Ouwerkerk et al.   Nature Communications

Integrative Omics Approach to Identifying Genes Associated With Atrial Fibrillation

(2019) Biqi Wang et al.   CIRCULATION RESEARCH

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

(2019) Madeline H. Kowalski et al.   PLoS Genetics

The Post-GWAS Era: From Association to Function

(2018) Michael D. Gallagher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development

(2018) Jonas B. Nielsen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Multi-ethnic genome-wide association study for atrial fibrillation

(2018) Carolina Roselli et al.   NATURE GENETICS

Biobank-driven genomic discovery yields new insight into atrial fibrillation biology

(2018) Jonas B. Nielsen et al.   NATURE GENETICS

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation

(2018) Seung Hoan Choi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Screening for cardiac contractile dysfunction using an artificial intelligence–enabled electrocardiogram

(2018) Zachi I. Attia et al.   NATURE MEDICINE

Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation

(2018) Gustav Ahlberg et al.   Nature Communications

Korean atrial fibrillation network genome-wide association study for early-onset atrial fibrillation identifies novel susceptibility loci

(2017) Ji-Young Lee et al.   EUROPEAN HEART JOURNAL

Whole-genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom

(2017) Himanshu Chheda et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Common variants predict recurrence after nonfamilial atrial fibrillation ablation in Chinese Han population

(2017) Li-qun Zhao et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

PITX2 -dependent gene regulation in atrial fibrillation and rhythm control

(2017) Fahima Syeda et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Missense Variant in PLEC Increases Risk of Atrial Fibrillation

(2017) Rosa B. Thorolfsdottir et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genome-wide DNA methylation analysis in permanent atrial fibrillation

(2017) Guochang Zhao et al.   Molecular Medicine Reports

Identification of six new genetic loci associated with atrial fibrillation in the Japanese population

(2017) Siew-Kee Low et al.   NATURE GENETICS

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

(2017) Ingrid E Christophersen et al.   NATURE GENETICS

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium

(2017) Lu-Chen Weng et al.   Scientific Reports

Methylome-wide Association Study of Atrial Fibrillation in Framingham Heart Study

(2017) Honghuang Lin et al.   Scientific Reports

Heritability of Atrial FibrillationCLINICAL PERSPECTIVE

(2017) Lu-Chen Weng et al.   Circulation-Cardiovascular Genetics

Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation

(2017) Lu-Chen Weng et al.   CIRCULATION

High-throughput drug profiling with voltage- and calcium-sensitive fluorescent probes in human iPSC-derived cardiomyocytes

(2016) Stephane Bedut et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Common variation in atrial fibrillation: navigating the path from genetic association to mechanism

(2016) Nathan R. Tucker et al.   CARDIOVASCULAR RESEARCH

TBX5mutations contribute to early-onset atrial fibrillation in Chinese and Caucasians

(2016) Ji-Fang Ma et al.   CARDIOVASCULAR RESEARCH

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens

(2016) Atray Dixit et al.   CELL

Genetic Obesity and the Risk of Atrial FibrillationClinical Perspective

(2016) Neal A. Chatterjee et al.   CIRCULATION

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

(2016) Serena Nik-Zainal et al.   NATURE

Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes

(2016) Mark-Anthony Bray et al.   Nature Protocols

A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation

(2016) Nathan Orr et al.   Nature Communications

Gene-gene Interaction Analyses for Atrial Fibrillation

(2016) Honghuang Lin et al.   Scientific Reports

Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers

(2015) Carlo Sidore et al.   NATURE GENETICS

Large-scale whole-genome sequencing of the Icelandic population

(2015) Daniel F Gudbjartsson et al.   NATURE GENETICS

Integrating Genetic, Transcriptional, and Functional Analyses to Identify 5 Novel Genes for Atrial Fibrillation

(2014) Moritz F. Sinner et al.   CIRCULATION

Novel Genetic Markers Associate With Atrial Fibrillation Risk in Europeans and Japanese

(2014) Steven A. Lubitz et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population

(2014) Elaine T. Lim et al.   PLoS Genetics

Rapid Cellular Phenotyping of Human Pluripotent Stem Cell-Derived Cardiomyocytes using a Genetically Encoded Fluorescent Voltage Sensor

(2014) Jordan S. Leyton-Mange et al.   Stem Cell Reports

Worldwide Epidemiology of Atrial Fibrillation

(2013) Sumeet S. Chugh et al.   CIRCULATION

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

(2012) Patrick T Ellinor et al.   NATURE GENETICS

Absolute and Attributable Risks of Atrial Fibrillation in Relation to Optimal and Borderline Risk Factors

(2011) Rachel R. Huxley et al.   CIRCULATION

PITX2c Is Expressed in the Adult Left Atrium, and Reducing Pitx2c Expression Promotes Atrial Fibrillation Inducibility and Complex Changes in Gene Expression

(2011) Paulus Kirchhof et al.   Circulation-Cardiovascular Genetics

A rare variant in MYH6 is associated with high risk of sick sinus syndrome

(2011) Hilma Holm et al.   NATURE GENETICS

European Ancestry as a Risk Factor for Atrial Fibrillation in African Americans

(2010) Gregory M. Marcus et al.   CIRCULATION

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

(2010)   NATURE

Common variants in KCNN3 are associated with lone atrial fibrillation

(2010) Patrick T Ellinor et al.   NATURE GENETICS

Familial Aggregation of Atrial Fibrillation

(2009) Ingrid Elisabeth Christophersen et al.   Circulation-Arrhythmia and Electrophysiology

A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke

(2009) Daniel F Gudbjartsson et al.   NATURE GENETICS

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

(2009) Emelia J Benjamin et al.   NATURE GENETICS

A Gain-of-Function TBX5 Mutation Is Associated With Atypical Holt–Oram Syndrome and Paroxysmal Atrial Fibrillation

(2008) Alex V. Postma et al.   CIRCULATION RESEARCH

Atrial Natriuretic Peptide Frameshift Mutation in Familial Atrial Fibrillation

(2008) Denice M. Hodgson-Zingman et al.   NEW ENGLAND JOURNAL OF MEDICINE