Article
Chemistry, Multidisciplinary
Yize Zhang, Junjun Wang, Shen Wang, Xiaojiao Zhu, Zhipeng Yu, Zhichao Wu, Jianhua Yu, Hongping Zhou
Summary: The strategy of planarization and donor rotation was applied to design a series of D-pi-A systems, optimizing intramolecular charge transfer and non-radiative transitions to enhance photoacoustic and photothermal properties and improve ICT effect for multi-modal imaging-guided therapy in vivo.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Applied
Liucheng Mao, Hongye Huang, Danning Hu, Haijun Ma, Mei Tian, Xiaoyong Zhang, Yen Wei
Summary: A novel near-infrared aggregation-induced emission (AIE) fluorescent bioprobe TPA-diCN-F127 NPs with desirable characteristics such as near-infrared emission, large Stokes shift, good dispersibility, and biocompatibility was prepared in this study. Efficient cancer cell damage was demonstrated in vitro upon white light irradiation, indicating the potential capability of TPA-diCN-F127 NPs in imaging-guided PDT.
Article
Chemistry, Multidisciplinary
Xueqin Yang, Changhuo Xu, Xun Zhang, Pei Li, Feiyi Sun, Xinyue Liu, Xinyuan Wang, Ryan T. K. Kwok, Jinglei Yang, Jacky W. Y. Lam, Yongye Liang, Ben Zhong Tang
Summary: A facile molecular engineering strategy was developed to design photosensitizers (PSs) with aggregation induced emission (AIE) characteristics and responsive properties to the acidic tumor microenvironment (TME). Two near-infrared AIE luminogens called DBP-SPy and DBP-SPh were synthesized, which can form nanoaggregates and show different surface charge conversion properties in response to the pH of the TME. The DBP-SPy nanoaggregates demonstrated efficient photodynamic therapy on cancer cells in vitro and excellent tumor growth inhibition in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Environmental
Tianwei Li, Zhe Xu, Hong Chen, Shijie Zhen, Hua Gu, Zujin Zhao, Ben Zhong Tang
Summary: Photodynamic therapy (PDT) has many advantages including precise control, noninvasiveness, high efficiency, and spatiotemporal selectivity. However, most currently used photosensitizers have drawbacks of weak light absorption and low reactive oxygen species generation ability. By introducing highly electronegative nitrogen atom, two photostable photosensitizers are designed to have high absorption coefficient and efficient ROS generation ability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Liying Pan, Shihua Wang, Mintao Xie, Manshan Liang, Lichao Yu, Bing Du, Xiaoxia Ye, Yanshu Luo, Yun-Yun Quan, Zu-Sheng Huang
Summary: Rational design of organelle targeted therapeutic platform is an effective approach to improve treatment outcomes and minimize cytotoxicity. In this study, a photosensitizer TSPy-B was designed with biotin receptor and mitochondria dual-targeted capability, and high ROS generation efficiency for fluorescence imaging guided PDT. Cell imaging experiments demonstrated that TSPy-B could selectively target tumor cells with biotin receptor overexpression and exhibited mitochondria targeting ability. In vitro and in vivo experiments further confirmed the anticancer mechanism and therapeutic efficacy of TSPy-B.
MATERIALS & DESIGN
(2023)
Article
Chemistry, Analytical
Wendi Huang, Yujie Zhang, Xueying Tan, Nan Wang, Jinhui Wang, Menglan He, Jiejun Peng, Jingbo Hu, Yufen Zhao, Shuanghu Wang
Summary: A lysosome-targeting photosensitizer MP-TPEDCH with excellent photostability and lysosome targeting specificity has been designed in this work, showing significantly enhanced antitumor effect under NIR irradiation.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Polymer Science
Dong-Jin Lim
Summary: Methylene blue (MB) has been utilized in the textile industry and for pharmacological purposes. It has gained attention for its potential as a safe photosensitizer in photodynamic therapy (PDT), showing both anticancer and antibacterial activity. Challenges in creating MB-embedded nanoparticles or microparticles may affect the clinical efficacy of PDT.
Article
Engineering, Biomedical
Tonghui Huang, Heng Ji, Shirong Yan, Yifan Zuo, Jie Li, Jacky W. Y. Lam, Cuiping Han, Ben Zhong Tang
Summary: In this study, a tumor intracellular hypochlorite (ClO-) was used to activate fluorescence and combined with the advantages of both type I and type II photody-namic therapy (PDT) to achieve a synergistic therapeutic effect in a complex tumor environment. The developed PTZSPy functions as a type II photosensitizer with mitochondria-targeting capability, and can accurately distinguish tumor cells from normal cells and dynamically monitor the cell ablation process. This work provides an innovative strategy for imaging-guided PDT utilizing the highly abundant ClO- in tumor cells for the type I and II ROS two-pronged.
Review
Chemistry, Analytical
Hao Yu, Binjie Chen, Huiming Huang, Zhentao He, Jiangman Sun, Guan Wang, Xinggui Gu, Ben Zhong Tang
Summary: Photodynamic therapy is a non-invasive approach for tumor elimination that is gaining increasing attention. The development of aggregation-induced emission (AIE) active photosensitizers has opened up new possibilities for overcoming the limitations of traditional photodynamic therapy.
Article
Chemistry, Multidisciplinary
Miaomiao Kang, Zhijun Zhang, Wenhan Xu, Haifei Wen, Wei Zhu, Qian Wu, Hongzhuo Wu, Junyi Gong, Zhijia Wang, Dong Wang, Ben Zhong Tang
Summary: This study developed a novel approach for precise nuclear targeting PDT using photosensitizers with aggregation-induced emission characteristics. The method demonstrated efficient ROS generation and tumor growth suppression, paving the way for optimized cancer treatment strategies in translational medicine.
Article
Nanoscience & Nanotechnology
Yunhui Liao, Ruolan Wang, Shaozhen Wang, Yifan Xie, Huanhao Chen, Runjia Huang, Longquan Shao, Qiuhua Zhu, Yanshan Liu
Summary: The new AIE-active Schiff base TBTDC NPs exhibit good biocompatibility, impressive two-photon bioimaging capability, high O-1(2) generation quantum yield, specific targeting, and photostability in PDT. They also show remarkable cytotoxicity for tumor cells and potential for suppressing tumor growth in nude mice.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Zijuan Meng, Zhaojun Chen, Guangwen Lu, Xiaoqi Dong, Jun Dai, Xiaoding Lou, Fan Xia
Summary: This study prepared two short-wavelength AIE nanoparticles and customized a white-light fiber for intra-tumor irradiation. In vitro experiments showed that both nanoparticles were more efficient in producing reactive oxygen species (ROS) under white-light compared to laser. However, the level of ROS production after white-light penetrated the skin was significantly reduced. In vivo experiments demonstrated that fiber-mediated white-light photodynamic therapy (wPDT) induced tumor elimination and maximized therapeutic outcomes. Additionally, wPDT had the advantage of adapting to a wide range of photosensitizers.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Applied
Jizhong Shi, Zhencao Wang, Chaojie Shen, Tingting Pan, Longteng Xie, Mintao Xie, Lijiang Huang, Yongsheng Jiang, Jianmin Zhou, Wei Zuo, Zu-Sheng Huang
Summary: Photodynamic therapy (PDT) is a promising cancer treatment method, but it still faces challenges, such as the toxic effects of residual photosensitizers (PSs) on normal tissues. In this study, a novel PS NTPy was synthesized and successfully applied for cancer therapy. NTPy has aggregation-induced emission (AIE) characteristics, high reactive oxygen species generation efficiency, and strong fluorescence emission. Additionally, NTPy exhibits excellent mitochondria targeting capacity and the ability to detect the hypoxic microenvironment of tumors. The results show that NTPy can reduce the side effects of PS on normal tissues after effective PDT treatment, providing a new strategy for intelligent PDT treatment and increasing the biological safety of PDT.
Article
Biochemistry & Molecular Biology
Zhenxing Pan, Yakun Wang, Niping Chen, Guining Cao, Yaoxun Zeng, Jiapeng Dong, Mingzhao Liu, Zhaoyi Ye, Yushan Li, Shun Huang, Yu-jing Lu, Yan He, Xujie Liu, Kun Zhang
Summary: Photosensitizers with aggregation-induced emission (AIE) effect were designed using benzothiazole-triphenylamine (BZT-triphenylamine) as the parent nucleus for improved bioimaging and photodynamic therapy (PDT) efficacy. The synthesized compound SIN exhibited good biocompatibility, photostability, and bright emission in the near-infrared range. SIN showed significant fluorescence enhancement and high fluorescence quantum yield at high viscosity, and had lysosome targeting properties and good 1O2 generation ability under white light irradiation, especially in a weak acidic environment. These findings suggest that SIN is a promising multifunctional organic photosensitizer for bioimaging and PDT of tumors.
BIOORGANIC CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Fei Wang, Yupeng Shi, Po-Yu Ho, Engui Zhao, Chuen Kam, Qiang Zhang, Xin Zhao, Yue Pan, Sijie Chen
Summary: Photodynamic therapy is a popular method for combating bacteria. In this study, researchers have developed an aggregating-induced-emission-active bacterial inhibitor and photosensitizer called OTM, which can efficiently bind to and kill Gram-positive bacteria. OTM is also an efficient photosensitizer that enhances the production of reactive oxygen species, thereby increasing its killing effect on both Gram-positive and Gram-negative bacteria. Additionally, OTM exhibits excellent biocompatibility with normal mammalian cells and can promote the healing of bacteria-infected wounds in mice models without affecting their organs and blood parameters, making it a promising candidate for clinical applications.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Jiameng Li, Hang Xu, Zian Zhang, Yafeng Hao, Hanjie Wang, Xian Huang
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Engineering, Environmental
Yingying Zhang, Hongbin Chen, Hanjie Wang, Tiange Wang, Huizhuo Pan, Wanying Ji, Jin Chang
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Wei Ling, Jingxian Yu, Ning Ma, Ya Li, Ziyue Wu, Rong Liang, Yafeng Hao, Huizhuo Pan, Wentao Liu, Bo Fu, Kun Wang, Hanjie Wang, Lizhu Li, Xing Sheng, Hui Peng, Baoan Ning, Jiajia Yang, Xian Huang
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Han Yang, Weihang Mu, Daohe Wei, Yue Zhang, Yue Duan, Jun-xiao Gao, Xiao-qun Gong, Han-jie Wang, Xiao-li Wu, Huaying Tao, Jin Chang
Article
Neurosciences
Limin Wu, Degang Xu, Yuye Wang, Yingying Zhang, Hanjie Wang, Bin Liao, Sheng Gong, Tunan Chen, Nan Wu, Hua Feng, Jianquan Yao
Article
Chemistry, Multidisciplinary
Yingying Zhang, Xin Zhang, Hanjie Wang, Yu Tian, Huizhuo Pan, Lili Zhang, Feng Wang, Jin Chang
Summary: A magneto-luminescence microdevice (MLMD) was developed in this study to achieve optical emission through non-contact excitation using a rotating magnetic field, allowing for remote stimulation of biological tissues. This innovative approach has the potential to inspire new applications in biomedicine.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Environmental
Lu Li, Shenghui Li, Sheng Wang, Xiaoli Xing, Yating Zhang, Lin Su, Xiaoli Wu, Hanjie Wang, Jin Chang, Xiaoqun Gong
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Engineering, Environmental
Tiandi He, HanJie Wang, Tiange Wang, GaoJu Pang, YingYing Zhang, Chaonan Zhang, Peng Yu, Jin Chang
Summary: The study presents a novel approach using a sonogenetic nanosystem for cancer immunotherapy, which activates mechanosensitive ion channels to induce cell apoptosis for precise cancer treatment. This system shows potential for expanding the application of sonogenetics in cancer therapy.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Physical
Yafeng Hao, Taofeng Du, Gaoju Pang, Jiahua Li, Huizhuo Pan, Yingying Zhang, Lizhen Wang, Jin Chang, En-min Zhou, Hanjie Wang
Article
Chemistry, Multidisciplinary
Junxiao Gao, Jun Li, Daohe Wei, Han Yang, Yue Duan, Yue Zhang, Xiaoqun Gong, Hanjie Wang, Dan Ding, Xiaoli Wu, Jin Chang
SCIENCE CHINA-CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Jingxian Yu, Wei Ling, Ya Li, Ning Ma, Ziyue Wu, Rong Liang, Huizhuo Pan, Wentao Liu, Bo Fu, Kun Wang, Chenxi Li, Hanjie Wang, Hui Peng, Baoan Ning, Jiajia Yang, Xian Huang
Summary: The integration of optical fibers and flexible electronics allows for more sophisticated applications in biomedicine and biology. A multi-channel flexible device has been demonstrated in vivo with rats for optical stimulation and simultaneous monitoring of spontaneous/evoked signals using microelectrode arrays. The device's biocompatibility has been characterized, showing potential for long-term animal studies.
Review
Nanoscience & Nanotechnology
Jun Kang, Ayesha Tahir, Hanjie Wang, Jin Chang
Summary: Viruses, highly infectious pathogens, cause significant global fatalities. Nanotechnology shows promise in virus detection and tracking, but faces challenges such as clinical false positives, limitations of QDs, and the need for improved real-time tracking.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Guohui Cheng, Wei Zong, Haizhen Guo, Fuyan Li, Xu Zhang, Peng Yu, Fuxin Ren, Xinlu Zhang, Xiaoen Shi, Fei Gao, Jin Chang, Sheng Wang
Summary: The study developed a size-changeable nanotheranostic agent based on polyprodrug-modified iron oxide nanoparticles and aggregation-induced emission photosensitizer for enhanced MRI-guided chemo/photodynamic combination therapy, achieving efficient tumor accumulation, retention, and fast elimination. By forming large aggregates in acidic tumor microenvironment and re-dispersing into small-sized nanoparticles, the agent provides a promising strategy for the development of nanotheranostic agents.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Guohui Cheng, Dan Wu, Sheng Wang, Xu Zhang, Peng Yu, Jin Chang, Xiaoyuan Chen
Summary: The size of theranostic nanoagents plays a crucial role in efficient tumor accumulation, imaging, and therapy; a size-changeable strategy has been proposed to overcome the dilemma caused by size paradox; this strategy enables the adjustment of theranostic agents' size on demand, enhancing their efficacy in tumor imaging and therapy.
Article
Engineering, Environmental
Xinping Zhang, Yuxin Guo, Xiaoyang Liu, Shun-Yu Wu, Ya-Xuan Zhu, Shao-Zhe Wang, Qiu-Yi Duan, Ke-Fei Xu, Zi-Heng Li, Xiao-Yu Zhu, Guang-Yu Pan, Fu-Gen Wu
Summary: This study develops a nanotrigger HCFT for simultaneous photodynamic therapy and light-triggered ferroptosis therapy. The nanotrigger can relieve tumor hypoxia, induce enhanced photodynamic reaction, and facilitate the continuation of Fenton reaction, ultimately leading to lethal ferroptosis in tumor cells.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Olumide Bolarinwa Ayodele, Toyin Daniel Shittu, Olayinka S. Togunwa, Dan Yu, Zhen-Yu Tian
Summary: This study focused on the semihydrogenation of acetylene in an ethylene-rich stream using two alloyed Pt catalysts PtCu and PtCo. The PtCu catalyst showed higher activity and ethylene yield compared to PtCo due to its higher unoccupied Pt d-orbital density. This indicates that alloying Pt with Cu is more promising for industrial relevant SHA catalyst.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Guowei Chen, Wen-Cheng Chen, Yaozu Su, Ruicheng Wang, Jia-Ming Jin, Hui Liang, Bingxue Tan, Dehua Hu, Shaomin Ji, Hao-Li Zhang, Yanping Huo, Yuguang Ma
Summary: This study proposes an intramolecular dual-locking design for organic luminescent materials, achieving high luminescence efficiency and performance for deep-blue organic light-emitting diodes. The material also exhibits unique mechanochromic luminescence behavior and strong fatigue resistance.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Joren van Stee, Gregory Hermans, Jinu Joseph John, Koen Binnemans, Tom Van Gerven
Summary: This work presents a continuous solvent extraction method for the separation of cobalt and nickel in a millifluidic system using Cyphos IL 101 (C101) as the extractant. The optimal conditions for extraction performance and solvent properties were determined by investigating the effects of channel length, flow rate, and temperature. The performance of a developed manifold structure was compared to a single-channel system, and excellent separation results were achieved. The continuous separation process using the manifold structure resulted in high purity cobalt and nickel products.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Yan Xu, Jingai Jiang, Xinyi Lv, Hui Li, Dongliang Yang, Wenjun Wang, Yanling Hu, Longcai Liu, Xiaochen Dong, Yu Cai
Summary: A programmed gas release nanoparticle was developed to address the challenges in treating diabetic infected wounds. It effectively removes drug-resistant pathogens and remodels the wound microenvironment using NO and H2S. The nanoparticle can eliminate bacteria and promote wound healing through antibacterial and anti-inflammatory effects.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Tong Xia, Zhilin Xi, Lianquan Suo, Chen Wang
Summary: This study investigated a highly efficient coal dust suppressant with low initial viscosity and high adhesion-solidification properties. The results demonstrated that the dust suppressant formed a network of multiple hydrogen bonding cross-linking and achieved effective adhesion and solidification of coal dust through various chemical reactions.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Jinzhi Cai, Zhenshan Li
Summary: A density functional theory-based rate equation was developed to predict the gas-solid reaction kinetics of CaO carbonation with CO2 in calcium looping. The negative activation energy of CaO carbonation close to equilibrium was accurately predicted through experimental validation.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Jianxiong Chen, Fuhao Ren, Ningning Yin, Jie Mao
Summary: This study presents an economically efficient and easily implementable surface modification approach to enhance the high-temperature electrical insulation and energy storage performance of polymer dielectrics. The self-assembly of high-insulation-performance boron nitride nanosheets (BNNS) on the film surface through electrostatic interactions effectively impedes charge injection from electrodes while promoting charge dissipation and heat transfer.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Zijian Li, Zhaohui Yang, Shao Wang, Hongxia Luo, Zhimin Xue, Zhenghui Liu, Tiancheng Mu
Summary: This study reports a strategy for upgrading polyester plastics into value-added chemicals using electrocatalytic methods. By inducing the targeted transfer of *OH species, polyethylene terephthalate was successfully upgraded into potassium diformate with high purity. This work not only develops an excellent electrocatalyst, but also provides guidance for the design of medium entropy metal oxides.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Navneet Singh Shekhawat, Surendra Kumar Patra, Ashok Kumar Patra, Bamaprasad Bag
Summary: This study primarily focuses on developing a sulphur dyeing process at room temperature using bacterial Lysate, which is environmentally friendly, energy and cost effective, and sustainable. The process shows promising improvements in dye uptake and fastness properties.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Dengjia Shen, Hongyang Ma, Madani Khan, Benjamin S. Hsiao
Summary: This study developed cationic PVC nanofibrous membranes with high filtration and adsorption capability for the removal of bacteria and hexavalent chromium ions from wastewater. The membranes demonstrated remarkable performance in terms of filtration efficiency and maximum adsorption capacity. Additionally, modified nanofibrous membranes were produced using recycled materials and showed excellent retention rates in dynamic adsorption processes.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Xiaoyan Wang, Zhikun Wang, Ben Jia, Chunling Li, Shuangqing Sun, Songqing Hu
Summary: Inspired by photosystem II, self-supported Fe-doped NiCoP nanowire arrays modified with carboxylate were constructed to boost industrial-level overall water splitting by employing the concerted proton-coupled electron transfer mechanism. The introduction of Fe and carboxyl ligand led to improved catalytic activity for HER and OER, and NCFCP@NF exhibited long-term durability for overall water splitting.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Pengyao Yu, Ge Yang, Yongming Chai, Lubomira Tosheva, Chunzheng Wang, Heqing Jiang, Chenguang Liu, Hailing Guo
Summary: Thin LTA zeolite membranes were prepared through secondary growth of nano LTA seeds in a highly reactive gel, resulting in membranes with superior permeability and selectivity in gas separation applications.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Baiqin Zhou, Huiping Li, Ziyu Wang, Hui Huang, Yujun Wang, Ruichun Yang, Ranran Huo, Xiaoyan Xu, Ting Zhou, Xiaochen Dong
Summary: The use of machine learning to predict the performance of specific adsorbents in phosphate adsorption shows great promise in saving time and revealing underlying mechanisms. However, the small size of the dataset and insufficient detailed information limits the model training process and the accuracy of results. To address this, the study employs a fuzzing strategy that replaces detailed numeric information with descriptive text messages on the physiochemical properties of adsorbents. This strategy allows the recovery of discarded samples with limited information, leading to accurate prediction of adsorption amount, capacity, and kinetics. The study also finds that phosphate uptake by adsorbents is generally through physisorption, with some involvement of chemisorption. The framework established in this study provides a practical approach for quickly predicting phosphate adsorption performance in urgent scenarios, using easily accessible information.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Paula Alejandra Lamprea Pineda, Joren Bruneel, Kristof Demeestere, Lisa Deraedt, Tex Goetschalckx, Herman Van Langenhove, Christophe Walgraeve
Summary: This study evaluates the use of four esterified fatty acids and three vegetable oils as absorption liquids for hydrophobic VOCs. The experimental results show that isopropyl myristate is the most efficient liquid for absorbing the target VOCs.
CHEMICAL ENGINEERING JOURNAL
(2024)