ADP-heptose: a bacterial PAMP detected by the host sensor ALPK1

NOD-like receptors and inflammasomes: A review of their canonical and non-canonical signaling pathways

(2019) Jaye M. Platnich et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

ADP heptose, a novel pathogen-associated molecular pattern identified in Helicobacter pylori

(2019) Lennart Pfannkuch et al.   FASEB JOURNAL

Identification of promising prognostic genes for relapsed acute lymphoblastic leukemia

(2019) Chai Ji et al.   BLOOD CELLS MOLECULES AND DISEASES

Citrobacter rodentium induces rapid and unique metabolic and inflammatory responses in mice suffering from severe disease

(2019) Danielle Carson et al.   CELLULAR MICROBIOLOGY

d-Sedoheptulose-7-phosphate is a common precursor for the heptoses of septacidin and hygromycin B

(2018) Wei Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

d-Glycero-β-d-Manno-Heptose 1-Phosphate and d-Glycero-β-d-Manno-Heptose 1,7-Biphosphate Are Both Innate Immune Agonists

(2018) Itunuoluwa A. Adekoya et al.   JOURNAL OF IMMUNOLOGY

Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose

(2018) Ping Zhou et al.   NATURE

Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis

(2018) Grigory Ryzhakov et al.   Nature Communications

ALPK1 Expression Is Associated with Lymph Node Metastasis and Tumor Growth in Oral Squamous Cell Carcinoma Patients

(2018) Po-Ku Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA

(2018) Wei‐Cheng Huang et al.   CHEMBIOCHEM

ADP‐heptose is a newly identified pathogen‐associated molecular pattern of Shigella flexneri

(2018) Diego García‐Weber et al.   EMBO REPORTS

TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection

(2017) Alevtina Gall et al.   mBio

Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway

(2017) Ryan G. Gaudet et al.   Cell Reports

ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System

(2017) Stephanie Zimmermann et al.   Cell Reports

ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria

(2017) Milica Milivojevic et al.   PLoS Pathogens

Helicobacter pylori modulates host cell responses by CagT4SS-dependent translocation of an intermediate metabolite of LPS inner core heptose biosynthesis

(2017) Saskia C. Stein et al.   PLoS Pathogens

Enhanced alpha-kinase 1 accelerates multiple early nephropathies in streptozotocin-induced hyperglycemic mice

(2016) Tzer-Min Kuo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA

(2016) Tong-You Wade Wei et al.   CANCER RESEARCH

Synthesis of 5-O-oligoglucosyl extended α-(2→4)-Kdo disaccharides corresponding to inner core fragments of Moraxellaceae lipopolysaccharides

(2016) Barbara Pokorny et al.   CARBOHYDRATE RESEARCH

TIFA as a crucial mediator for NLRP3 inflammasome

(2016) Ting-Yang Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer

(2016) Juliane Strietz et al.   Oncotarget

Characterization of a biofilm-formingShigella flexneriphenotype due to deficiency in Hep biosynthesis

(2016) Dan Xu et al.   PeerJ

ALPK1 phosphorylates myosin IIA modulating TNF-α trafficking in gout flares

(2016) Chi-Pin Lee et al.   Scientific Reports

Uncovering the Mechanism of Forkhead-Associated Domain-Mediated TIFA Oligomerization That Plays a Central Role in Immune Responses

(2015) Jui-Hung Weng et al.   BIOCHEMISTRY

Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity

(2015) R. G. Gaudet et al.   SCIENCE

Bacterial spread from cell to cell: beyond actin-based motility

(2015) Carole J. Kuehl et al.   TRENDS IN MICROBIOLOGY

Tyrosine phosphorylation in Toll-like receptor signaling

(2014) Saurabh Chattopadhyay et al.   CYTOKINE & GROWTH FACTOR REVIEWS

NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

(2014) Roberta Caruso et al.   IMMUNITY

The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans

(2014) C. A. Wells et al.   JOURNAL OF IMMUNOLOGY

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Plant pattern-recognition receptors

(2014) Cyril Zipfel   TRENDS IN IMMUNOLOGY

The atypical lipopolysaccharide ofFrancisella

(2013) Nihal A. Okan et al.   CARBOHYDRATE RESEARCH

Activation of Protein Kinase PKR Requires Dimerization-inducedcis-Phosphorylation within the Activation Loop

(2013) Madhusudan Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression

(2013) R. J. Malott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation

(2012) Olivier Boulard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intermolecular Binding between TIFA-FHA and TIFA-pT Mediates Tumor Necrosis Factor Alpha Stimulation and NF- B Activation

(2012) C.-C. F. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Receptor-like kinase complexes in plant innate immunity

(2012) Christiaan Greeff et al.   Frontiers in Plant Science

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

Contribution of the Lipopolysaccharide to Resistance of Shigella flexneri 2a to Extreme Acidity

(2011) Mara Martinić et al.   PLoS One

Cell-Cell Propagation of NF-κB Transcription Factor and MAP Kinase Activation Amplifies Innate Immunity against Bacterial Infection

(2010) Christoph Alexander Kasper et al.   IMMUNITY

The alpha-kinase family: an exceptional branch on the protein kinase tree

(2009) Jeroen Middelbeek et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Shigella type III secretion effectors: how, where, when, for what purposes?

(2009) Claude Parsot   CURRENT OPINION IN MICROBIOLOGY

Cdcs1 a major colitis susceptibility locus in mice; Subcongenic analysis reveals genetic complexity

(2009) Andre Bleich et al.   INFLAMMATORY BOWEL DISEASES

TRAF-Interacting Protein with a Forkhead-Associated Domain B (TIFAB) Is a Negative Regulator of the TRAF6-Induced Cellular Functions

(2009) T. Matsumura et al.   JOURNAL OF BIOCHEMISTRY

Molecular Aspects of Moraxella catarrhalis Pathogenesis

(2009) S. P. W. de Vries et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Sensors of the innate immune system: their mode of action

(2009) Roberto Baccala et al.   Nature Reviews Rheumatology

E2 interaction and dimerization in the crystal structure of TRAF6

(2009) Qian Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY