Review
Immunology
Shasha Chen, Zhiyong Liao, Pinglong Xu
Summary: Mitochondria play versatile roles in cellular processes and have emerged as critical components in innate immunity. This review provides a comprehensive exploration of the multifaceted mechanisms underlying the interactions between mitochondria and innate immune responses. It discusses the roles of healthy mitochondria as platforms for signalosome assembly, the release of mitochondrial components as signaling messengers, and the regulation of signaling via mitophagy. Additionally, it explores the impacts of mitochondrial proteins and metabolites on modulating innate immune responses, immune cell polarization, and their implications in infectious and inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Jun Song, Xiaofang Yi, Ruolin Gao, Li Sun, Zhixuan Wu, Shuling Zhang, Letian Huang, Chengbo Han, Jietao Ma
Summary: Tumor immunotherapy has made breakthroughs in recent years, but only a subset of patients respond. The tumor microenvironment may contribute to T cell exhaustion. Studies have shown that mitochondrial dynamics play an important role in the immune surveillance of T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Bronte Manouk Verhoeven, Shenglin Mei, Thale Kristin Olsen, Karin Gustafsson, Anders Valind, Axel Lindstrom, David Gisselsson, Shahrzad Shirazi Fard, Catharina Hagerling, Peter Kharchenko, Per Kogner, John Inge Johnsen, Ninib Baryawno
Summary: Understanding the immune cell composition of human neuroblastoma is important for developing immunotherapeutics. In this study, single-cell RNA sequencing was performed on 19 neuroblastoma samples, revealing a comprehensive landscape of immune cells and identifying potential therapeutic targets and interactions.
CELL REPORTS MEDICINE
(2022)
Article
Multidisciplinary Sciences
David O. 'Sullivan, Michal A. Stanczak, Matteo Villa, Franziska M. Uhl, Mauro Corrado, Ramon I. Klein Geltink, David E. Sanin, Petya Apostolova, Nisha Rana, Joy Edwards-Hicks, Katarzyna M. Grzes, Agnieszka M. Kabat, Ryan L. Kyle, Mario Fabri, Jonathan D. Curtis, Michael D. Buck, Annette E. Patterson, Annamaria Regina, Cameron S. Field, Francesc Baixauli, Daniel J. Puleston, Edward J. Pearce, Robert Zeiser, Erika L. Pearce
Summary: Fever can enhance metabolic activity and effector functions of activated CD8* T cells, with limited effects on proliferation or activation marker expression. Exposure to 39 degrees Celsius increases mass and metabolism in T cells, with mitochondrial translation playing a crucial role in the enhanced metabolic activity and function observed.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Microbiology
Nicholas M. Maurice, Ruxana T. Sadikot
Summary: Mitochondria play a critical role in cellular processes, including energy generation. Bacterial pathogens target host cell mitochondria to disrupt host response and promote bacterial survival. This review discusses recent advancements in understanding how bacteria cause mitochondrial dysfunction, including disruptions in cell-death pathways, energy production, mitochondrial dynamics, quality control, DNA repair, and the unfolded protein response. Potential therapeutic approaches aimed at restoring host mitochondrial function to enhance the response to bacterial infection are also briefly highlighted.
Article
Oncology
Xuebing Shi, Zhixuan Li, Renqi Yao, Qingbao Cheng, Wei Li, Rui Wu, Zhihua Xie, Yanjing Zhu, Xinyao Qiu, Shuai Yang, Tao Zhou, Ji Hu, Yangqianwen Zhang, Tong Wu, Yan Zhao, Yani Zhang, Jianmin Wu, Hongyang Wang, Xiaoqing Jiang, Lei Chen
Summary: The study utilized single-cell RNA sequencing to comprehensively analyze the immune microenvironment in advanced biliary tract cancer (BTC) and identified multiple subsets of immune cells. The results showed that exhausted CD8(+) T cells, macrophages, and dendritic cells played important roles in augmenting and communicating within the tumor microenvironment. Additionally, the study revealed the involvement of XBP1 and immune checkpoint TIGIT in the remodeling of the tumor microenvironment.
NPJ PRECISION ONCOLOGY
(2022)
Article
Cell Biology
Yingping Xu, Jun Zhang, Yongfei Hu, Xuefei Li, Lihua Sun, Yu Peng, Yuzhe Sun, Bing Liu, Zhilei Bian, Zhili Rong
Summary: By single-cell RNA sequencing, the research revealed the dynamic changes of immune cells during skin development, providing detailed insight into the establishment of the immune system during embryonic development.
Review
Immunology
Jiachun Lian, Yanfang Liang, Hailiang Zhang, Minsheng Lan, Ziyu Ye, Bihua Lin, Xianxiu Qiu, Jincheng Zeng
Summary: The study of metabolism is crucial for understanding cancer cells and their treatment. Disorders in polyamine metabolism are commonly found in cancer, making it a focal point for anti-cancer strategies. Recent evidence suggests that polyamine metabolism plays an essential role in remodeling the tumor immune microenvironment, showing its potential as a new avenue for cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hella Pasmans, Magdalena A. Berkowska, Annieck M. Diks, Bas de Mooij, Rick J. Groenland, Lia de Rond, M. Alina Nicolaie, Sjoerd H. van der Burg, Jacques J. M. van Dongen, Fiona R. M. van der Klis, Anne-Marie Buisman
Summary: A study comparing immune responses in women vaccinated with bivalent and nonavalent HPV vaccines found consistent expansion of plasma cells and monocytes, but varied responses in other immune cells. Antibody levels and memory B and T-cell responses also differed between the two vaccine groups.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Meghan E. Sise, Qiyu Wang, Harish Seethapathy, Daiana Moreno, Destiny Harden, R. Neal Smith, Ivy A. Rosales, Robert B. Colvin, Sarah Chute, Lynn D. Cornell, Sandra M. Herrmann, Riley Fadden, Ryan J. Sullivan, Nancy J. Yang, Sara Barmettler, Sophia Wells, Shruti Gupta, Alexandra-Chloe Villani, Kerry L. Reynolds, Jocelyn Farmer
Summary: Non-invasive biomarkers such as elevated sIL-2R level and flow cytometric markers of B and T cell dysregulation may aid in the diagnosis of immune checkpoint inhibitor-associated acute tubulointerstitial nephritis (ICI-nephritis).
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Pablo Cruz, Ulises Ahumada-Castro, Galdo Bustos, Jordi Molgo, Daniela Sauma, Alenka Lovy, Cesar Cardenas
Summary: T-cell acute lymphoblastic leukemia is an aggressive hematological malignancy characterized by high mitochondrial respiration levels. Inhibiting InsP3R can lead to T-ALL cell death without affecting normal cells, potentially serving as an alternative therapeutic approach for T-ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Xiaohong Ma, Rong Ma, Mengzhe Zhang, Baicheng Qian, Baoliang Wang, Weijing Yang
Summary: Multiple sclerosis (MS) is an autoimmune-mediated demyelinating disease of the central nervous system. The main pathological features are inflammatory reaction, demyelination, axonal disintegration, reactive gliosis, etc. Both T cells and B cells along with their mediated immune cells have been found to be important in the pathogenesis of MS.
Article
Immunology
Baerbel Keller, Valentina Strohmeier, Ina Harder, Susanne Unger, Kathryn J. Payne, Geoffroy Andrieux, Melanie Boerries, Peter Tobias Felixberger, Jonathan J. M. Landry, Alexandra Nieters, Anne Rensing-Ehl, Ulrich Salzer, Natalie Frede, Susanne Usadel, Roland Elling, Carsten Speckmann, Ina Hainmann, Elizabeth Ralph, Kimberly Gilmour, Marjolein W. J. Wentink, Mirjam van der Burg, Hye Sun Kuehn, Sergio D. Rosenzweig, Uwe Kolsch, Horst von Bernuth, Petra Kaiser-Labusch, Florian Gothe, Sophie Hambleton, Alexandru Daniel Vlagea, Ana Garcia Garcia, Laia Alsina, Gasper Markelj, Tadej Avcin, Julia Vasconcelos, Margarida Guedes, Jing-Ya Ding, Cheng-Lung Ku, Bella Shadur, Danielle T. Avery, Nils Venhoff, Jens Thiel, Heiko Becker, Lucia Erazo-Borras, Claudia Milena Trujillo-Vargas, Jose Luis Franco, Claire Fieschi, Satoshi Okada, Paul E. Gray, Gulbu Uzel, Jean-Laurent Casanova, Manfred Fliegauf, Bodo Grimbacher, Hermann Eibel, Stephan Ehl, Reinhard E. Voll, Marta Rizzi, Polina Stepensky, Vladimir Benes, Cindy S. Ma, Claudia Bossen, Stuart G. Tangye, Klaus Warnatz
Summary: The accumulation of CD21(low) B cells in peripheral blood is a hallmark of chronic activation of the adaptive immune system in certain infections and autoimmune disorders. The transcription factor T-bet plays a prominent role in the regulation of T-bet(high)CD21(low) B cells, and essential signals such as BCR and IFN gamma R are crucial for the differentiation and expansion of these cells. Identification of important pathways provides potential targets for auto-reactive T-bet(high)CD21(low) B cells in autoimmune conditions.
SCIENCE IMMUNOLOGY
(2021)
Review
Cell Biology
Diaoyi Tan, Wei Yin, Fei Guan, Wanjiang Zeng, Pamela Lee, Fabio Candotti, Louisa K. James, Niels Olsen Saraiva Camara, S. M. Mansour Haeryfar, Yan Chen, Kamel Benlagha, Lewis Zhichang Shi, Jiahui Lei, Quan Gong, Zheng Liu, Chaohong Liu
Summary: In this article, the authors summarize the regulatory relationship between B cells and T cells, mainly focusing on T follicular regulatory cells and regulatory B cells. They introduce a new subset of regulatory T cells induced by B cells, and discuss the role of B cells in ensuring the survival of regulatory T cells. This review provides an updated overview of immunoregulatory networks and identifies potential targets for therapeutic interventions against cancer, autoimmune diseases, and allograft rejection.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Ronan Talty, Kelly Olino
Summary: Both cancer cells and immune cells rely on specific metabolic programs for survival and function, with immune cells having the capability to either enhance or suppress the antitumor immune response based on metabolic changes. The shared microenvironment within tumors affects the metabolism of immune cells and can impact the efficacy of immunotherapies, highlighting the importance of understanding the interplay between metabolism, immune response, and cancer progression.
Article
Immunology
Yichuan Xiao, Qiang Zou, Xiaoping Xie, Ting Liu, Haiyan S. Li, Zuliang Jie, Jin Jin, Hongbo Hu, Ganiraju Manyam, Li Zhang, Xuhong Cheng, Hui Wang, Isabelle Marie, David E. Levy, Stephanie S. Watowich, Shao-Cong Sun
JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Article
Multidisciplinary Sciences
Feng Xie, Ke Jin, Li Shao, Yao Fan, Yifei Tu, Yihao Li, Bin Yang, Hans van Dam, Peter ten Dijke, Honglei Weng, Steven Dooley, Shuai Wang, Junling Jia, Jin Jin, Fangfang Zhou, Long Zhang
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Zhengkui Zhang, Yao Fan, Feng Xie, Hang Zhou, Ke Jin, Li Shao, Wenhao Shi, Pengfei Fang, Bing Yang, Hans van Dam, Peter ten Dijke, Xiaofeng Zheng, Xiaohua Yan, Junling Jia, Min Zheng, Jin Jin, Chen Ding, Sheng Ye, Fangfang Zhou, Long Zhang
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Zhengjun Gao, Yiyuan Li, Fei Wang, Tao Huang, Keqi Fan, Yu Zhang, Jiangyan Zhong, Qian Cao, Tong Chao, Junling Jia, Shuo Yang, Long Zhang, Yichuan Xiao, Ji-Yong Zhou, Xin-Hua Feng, Jin Jin
NATURE COMMUNICATIONS
(2017)
Article
Immunology
Xingli Zhang, Yan Wang, Jia Yuan, Ni Li, Siyu Pei, Jing Xu, Xuan Luo, Chaoming Mao, Junli Liu, Tao Yu, Shucheng Gan, Qianqian Zheng, Yinming Liang, Weixiang Guo, Ju Qiu, Gabriela Constantin, Jin Jin, Jun Qin, Yichuan Xiao
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Immunology
Tao Huang, Zhengjun Gao, Yu Zhang, Keqi Fan, Fei Wang, Yiyuan Li, Jiangyan Zhong, Heng Y. Fan, Qian Cao, Jiyong Zhou, Yichuan Xiao, Hongbo Hu, Jin Jin
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Multidisciplinary Sciences
Junli Liu, Xinfang Huang, Shumeng Hao, Yan Wang, Manman Liu, Jing Xu, Xingli Zhang, Tao Yu, Shucheng Gan, Dongfang Dai, Xuan Luo, Qingyan Lu, Chaoming Mao, Yanyun Zhang, Nan Shen, Bin Li, Mingzhu Huang, Xiaodong Zhu, Jin Jin, Xuhong Cheng, Shao-Cong Sun, Yichuan Xiao
NATURE COMMUNICATIONS
(2018)
Article
Immunology
Keqi Fan, Fei Wang, Yiyuan Li, Lu Chen, Zhengjun Gao, Yu Zhang, Jin-yuan Duan, Tao Huang, Jiangyan Zhong, Rong-bei Liu, Xintao Mao, Hengyu Fan, Xing Guo, Jin Jin
JOURNAL OF AUTOIMMUNITY
(2019)
Article
Biochemistry & Molecular Biology
Zhengkui Zhang, Jinjin Du, Shuai Wang, Li Shao, Ke Jin, Fang Li, Bajin Wei, Wei Ding, Peifen Fu, Hans van Dam, Aijun Wang, Jin Jin, Chen Ding, Bing Yang, Min Zheng, Xin-Hua Feng, Kun-Liang Guan, Long Zhang
Article
Biochemistry & Molecular Biology
Xiaoping Xie, Jin Jin, Lele Zhu, Zuliang Jie, Yanchuan Li, Baoyu Zhao, Xuhong Cheng, Pingwei Li, Shao-Cong Sun
CELL AND BIOSCIENCE
(2019)
Article
Medicine, Research & Experimental
Yu Zhang, Rong-bei Liu, Qian Cao, Ke-qi Fan, Ling-jie Huang, Jian-shuai Yu, Zheng-jun Gao, Tao Huang, Jiang-yan Zhong, Xin-tao Mao, Fei Wang, Peng Xiao, Yuan Zhao, Xin-hua Feng, Yi-yuan Li, Jin Jin
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Biochemistry & Molecular Biology
Ke-qi Fan, Yi-yuan Li, Hao-li Wang, Xin-tao Mao, Jin-xin Guo, Fei Wang, Ling-jie Huang, Yi-ning Li, Xiang-yu Ma, Zheng-jun Gao, Wei Chen, Dan-dan Qian, Wen-jin Xue, Qian Cao, Lei Zhang, Li Shen, Long Zhang, Chao Tong, Jiang-yan Zhong, Wei Lu, Ling Lu, Ke-ming Ren, Guisheng Zhong, Yuan Wang, Mingliang Tang, Xin-hua Feng, Ren-jie Chai, Jin Jin
Review
Biochemistry & Molecular Biology
Wenping Li, Yiyuan Li, Jin Jin
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2020)
Article
Immunology
Shuai Wang, Feng Xie, Feng Chu, Zhengkui Zhang, Bing Yang, Tong Dai, Liang Gao, Lin Wang, Li Ling, Junling Jia, Hans van Dam, Jin Jin, Long Zhang, Fangfang Zhou
