Overexpression of fibroblast growth factor‐21 (FGF‐21) protects mesenchymal stem cells against caspase‐dependent apoptosis induced by oxidative stress and inflammation

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Transplantation of Mesenchymal Stem Cells Overexpressing FGF21 Facilitates Cognitive Recovery and Enhances Neurogenesis in a Mouse Model of Traumatic Brain Injury

(2019) Rami Ahmad Shahror et al.   JOURNAL OF NEUROTRAUMA

FGF21 Protects the Blood–Brain Barrier by Upregulating PPARγ via FGFR1/β-klotho after Traumatic Brain Injury

(2018) Jun Chen et al.   JOURNAL OF NEUROTRAUMA

Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart

(2018) Hong Yang et al.   Cell Death & Disease

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

Fibroblast Growth Factor 21—Metabolic Role in Mice and Men

(2017) Harald Staiger et al.   ENDOCRINE REVIEWS

Endothelial microparticles prevent lipid-induced endothelial damage via Akt/eNOS signaling and reduced oxidative stress

(2017) Ayman M. Mahmoud et al.   FASEB JOURNAL

Fibroblast growth factor 21 protects rat cardiomyocytes from endoplasmic reticulum stress by promoting the fibroblast growth factor receptor 1-extracellular signal-regulated kinase 1/2 signaling pathway

(2017) Pingping Liang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Peripherally derived FGF21 promotes remyelination in the central nervous system

(2017) Mariko Kuroda et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardioprotective effects of fibroblast growth factor 21 against doxorubicin-induced toxicity via the SIRT1/LKB1/AMPK pathway

(2017) Shudong Wang et al.   Cell Death & Disease

Chronic Over-expression of Fibroblast Growth Factor 21 Increases Bile Acid Biosynthesis by Opposing FGF15/19 Action

(2017) Jun Zhang et al.   EBioMedicine

Preconditioning mesenchymal stem cells with the mood stabilizers lithium and valproic acid enhances therapeutic efficacy in a mouse model of Huntington's disease

(2016) Gabriel R. Linares et al.   EXPERIMENTAL NEUROLOGY

Valproic Acid and Other HDAC Inhibitors Upregulate FGF21 Gene Expression and Promote Process Elongation in Glia by Inhibiting HDAC2 and 3

(2016) Yan Leng et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulation

(2016) Zhifei Wang et al.   Scientific Reports

Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23

(2015) Chiara Degirolamo et al.   NATURE REVIEWS DRUG DISCOVERY

FGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizers

(2014) Y Leng et al.   MOLECULAR PSYCHIATRY

Calbindin-D28K Prevents Staurosporin-induced Bax Cleavage and Membrane Permeabilization

(2014) Won-Seok Choi et al.   Experimental Neurobiology

Role of diabetes- and obesity-related protein in the regulation of osteoblast differentiation

(2011) Gabriel R. Linares et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Genetically Engineered Mesenchymal Stem Cells as a Proposed Therapeutic for Huntington’s Disease

(2011) Scott D. Olson et al.   MOLECULAR NEUROBIOLOGY

Glutaredoxin 5 regulates osteoblast apoptosis by protecting against oxidative stress

(2009) Gabriel R. Linares et al.   BONE