Smooth Muscle Sirtuin 1 Blocks Thoracic Aortic Aneurysm/Dissection Development in Mice

Cellular Mechanisms of Aortic Aneurysm Formation

(2019) Raymundo Alain Quintana et al.   CIRCULATION RESEARCH

SPECT/CT imaging of apoptosis in aortic aneurysm with radiolabeled duramycin

(2019) Chengkai Hu et al.   APOPTOSIS

Mechanisms of aortic dissection smooth muscle cell phenotype switch

(2017) Zhao An et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel

(2017) Ajit Vikram et al.   NATURE MEDICINE

Sirtuins, Cell Senescence, and Vascular Aging

(2016) Yujiro Kida et al.   CANADIAN JOURNAL OF CARDIOLOGY

Ursodeoxycholic Acid Attenuates Acute Aortic Dissection Formation in Angiotensin II-Infused Apolipoprotein E-Deficient Mice Associated with Reduced ROS and Increased Nrf2 Levels

(2016) Wanjun Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic AneurysmNovelty and Significance

(2016) Hou-Zao Chen et al.   CIRCULATION RESEARCH

Calorie restriction protects against experimental abdominal aortic aneurysms in mice

(2016) Yue Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

(2015) James G. Ryall et al.   Cell Stem Cell

Deficiency of MMP17/MT4-MMP Proteolytic Activity Predisposes to Aortic Aneurysm in MiceNovelty and Significance

(2015) Mara Martín-Alonso et al.   CIRCULATION RESEARCH

Adventitial CXCL1/G-CSF Expression in Response to Acute Aortic Dissection Triggers Local Neutrophil Recruitment and Activation Leading to Aortic Rupture

(2015) A. Anzai et al.   CIRCULATION RESEARCH

Mechanical stretch-induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection

(2015) Li-Xin Jia et al.   JOURNAL OF PATHOLOGY

Thoracic Aortic Aneurysm and Dissection

(2014) Judith Z. Goldfinger et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetics of Thoracic Aortic Aneurysm

(2013) Elisabeth Gillis et al.   CIRCULATION RESEARCH

H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction

(2013) G. C. A. Taylor et al.   GENOME RESEARCH

Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice

(2013) Peng Gao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Medical Treatment for Thoracic Aortic Aneurysm – Much More Work To Be Done

(2013) Andrew S. Chun et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Neutrophil-Derived Matrix Metalloproteinase 9 Triggers Acute Aortic Dissection

(2012) Tomohiro Kurihara et al.   CIRCULATION

SIRT1, a Calorie Restriction Mimetic, in a New Therapeutic Approach for Type 2 Diabetes Mellitus and Diabetic Vascular Complications

(2012) Shinji Kume et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway

(2011) Shinichi Oka et al.   Cell Metabolism

SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice

(2011) Li Li et al.   CIRCULATION RESEARCH

Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction

(2011) Shuang Zhou et al.   CIRCULATION RESEARCH

Thoracic Aortic Aneurysm

(2010) John A. Elefteriades et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Epidemiology of thoracic aortic dissection

(2010) Scott A. LeMaire et al.   Nature Reviews Cardiology

SIRT1: A novel target to prevent atherosclerosis

(2009) Wei Yu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice

(2009) Brian C. Tieu et al.   JOURNAL OF CLINICAL INVESTIGATION

Biomarkers of abdominal aortic aneurysm progression. Part 2: inflammation

(2009) Femke A. M. V. I. Hellenthal et al.   Nature Reviews Cardiology

Biomarkers of AAA progression. Part 1: extracellular matrix degeneration

(2009) Femke A. M. V. I. Hellenthal et al.   Nature Reviews Cardiology

Inflammatory response is associated with aortic dissection

(2008) Fang Luo et al.   AGEING RESEARCH REVIEWS

SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells

(2008) Ryohei Miyazaki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice

(2008) Q.-j. Zhang et al.   CARDIOVASCULAR RESEARCH

Long-Term Doxycycline Is More Effective Than Atenolol to Prevent Thoracic Aortic Aneurysm in Marfan Syndrome Through the Inhibition of Matrix Metalloproteinase-2 and -9

(2008) Ada W.Y. Chung et al.   CIRCULATION RESEARCH

Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome

(2008) Wanfen Xiong et al.   JOURNAL OF VASCULAR SURGERY

Sirtuins — novel therapeutic targets to treat age-associated diseases

(2008) Siva Lavu et al.   NATURE REVIEWS DRUG DISCOVERY

Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease

(2007) Joseph D. Raffetto et al.   BIOCHEMICAL PHARMACOLOGY