Review
Biochemistry & Molecular Biology
Nikita Suvorov, Viktor Pogorilyy, Ekaterina Diachkova, Yuri Vasil'ev, Andrey Mironov, Mikhail Grin
Summary: The rapid growth of drug-resistant bacteria has led to a major research challenge in finding alternative treatments, such as photodynamic therapy using photosensitizers and visible light at a certain wavelength to treat bacteria. Chlorophyll derivatives play a special role in this antimicrobial PDT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Marta Erminia Alberto, Bruna Clara De Simone, Tiziana Marino, Marirosa Toscano, Nino Russo
Summary: Thionation of carbonyl groups in known dyes has proven to enhance singlet oxygen production and shift the absorption band, suggesting a potential strategy for developing heavy-atom-free photosensitizers for photodynamic therapy (PDT). In this study, the effect of sulfur and selenium substitution for oxygen in the oxo-4-dimethylamino-1,8-naphthalimide molecule was investigated. The thio- and seleno-derivatives were found to allow for multiple intersystem crossing pathways, leading to increased singlet oxygen production. Moreover, the transition from a (1)pi pi* to a (1)n pi* state in the selenium derivative was crucial for reaching clinically useful regions of the spectrum. These findings suggest that selenium-for-oxygen substitution could be a promising strategy for developing more suitable PDT agents and advancing heavy-atom-free photosensitizers.
JOURNAL OF PHYSICAL CHEMISTRY A
(2022)
Article
Multidisciplinary Sciences
Helder Oliveira, Paula Araujo, Ana Rita Pereira, Nuno Mateus, Victor de Freitas, Joana Oliveira, Iva Fernandes
Summary: This study investigated the potential of five nature-inspired amino-based flavylium compounds as photosensitizers for photodynamic therapy. Some of the compounds demonstrated good photoactivation efficiency in inhibiting the growth of skin cells.
SCIENTIFIC REPORTS
(2021)
Article
Spectroscopy
Rodrigo C. Silva, Hilde H. Buzza, Eli S. A. Ducas, Kleber T. Oliveira, Vanderlei S. Bagnato, Guilherme R. L. Souza, Luciane M. Almeida, Pablo J. Goncalves
Summary: A supramolecular assembly of methylene blue and curcumin was synthesized and evaluated for its potential in photodynamic antiangiogenic therapy. The results demonstrated that the MB-Curc assembly exhibited a synergistic vascular effect, causing significant damage to the vascular network after irradiation.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Inorganic & Nuclear
Xuwen Da, Fei-Hu Yu, Chao Zhang, Zhanhua Wang, Yao Jian, Yuanjun Hou, Yong Chen, Xuesong Wang, Qianxiong Zhou
Summary: This work proposes a bioorthogonal assembly based on d(10)MIDLINE HORIZONTAL ELLIPSISd(10) metallophilic interactions for precise cancer cell imaging and photodynamic therapy (PDT). The assembly exhibits luminescence turn-on and singlet oxygen generation upon irradiation, demonstrating the potential of using supramolecular interaction for bioorthogonal chemistry.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Chemistry, Inorganic & Nuclear
Zhiheng Li, Zhenwu Zhou, Yarui Wang, Jie Wang, Liming Zhou, Hong-Bo Cheng, Juyoung Yoon
Summary: Due to deficiencies in specific accumulation at tumors and undesired activation in normal tissues, many photodynamic therapy (PDT) agents show off-target phototoxicity. To address this issue, activatable photodynamic nano-photosensitizers (nanoPSs) that generate reactive oxygen species (ROS) in response to tumor-associated or external stimuli have been developed. These nanoPSs are in an off-state during delivery and are only activated in targeted lesions, enhancing the accuracy and minimizing side effects. This review discusses the design, work principle, and therapeutic performance of PDT using activatable nanoPSs, categorized by different stimuli and composite materials.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Viktor Pogorilyy, Petr Ostroverkhov, Valeria Efimova, Ekaterina Plotnikova, Olga Bezborodova, Ekaterina Diachkova, Yuriy Vasil'ev, Andrei Pankratov, Mikhail Grin
Summary: The development of sulfur-containing pharmaceutical compounds is crucial in medicinal chemistry. Photosensitizers that incorporate sulfur-containing groups or atoms into their structure exhibit new properties. This study optimized the synthesis of sulfur-containing derivatives of natural chlorophyll a using Lawesson's reagent. Thiocarbonyl chlorins were found to have a significant red shift in absorption and fluorescence. The feasibility of functionalizing the thiocarbonyl group by forming a Pt(II) metal complex in cisplatin was demonstrated, and the resulting conjugate showed high cytotoxic activity against sarcoma S37 tumor cells due to the combined photodynamic and chemotherapeutic effects.
Article
Chemistry, Multidisciplinary
Daniel Obitz, Karmel S. Gkika, Marvin Heller, Tia E. Keyes, Nils Metzler-Nolte
Summary: A lanthanide(iii) complex connected to a light harvesting antenna was synthesized and tested as a potential photosensitizer in photodynamic therapy. The complex showed significant phototoxic activity on cancer cells upon irradiation, with ROS production identified as the compound's phototoxic mode of action. In cell viability assays, a 10-fold decrease in IC50 value was observed compared to the dark control.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Zilin Zhu, Li Wei, Ashish Kumar Yadav, Zhongxian Fan, Ashish Kumar, Mengzhao Miao, Samya Banerjee, Huaiyi Huang
Summary: Recently, there has been interest in developing photo catalytic anticancer drugs, mainly in the form of metal complexes. In this study, we introduce lysosome/mitochondria targeting cyanine appended bipyridine compounds as potential organic photocatalytic anticancer agents. The organocatalyst (bpyPCN) not only induces light-induced NADH oxidation but also generates intracellular ROS, showcasing its anticancer activity. This is the first example of an organic compound inducing catalytic NADH photo-oxidation in both aqueous solutions and cancer cells.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Sebastian Makuch, Mateusz Drozdz, Alicja Makarec, Piotr Ziolkowski, Marta Wozniak
Summary: Psoriasis is an immune-mediated skin disease that affects patient quality of life. Photodynamic therapy (PDT) shows promise in treating psoriatic lesions, but its clinical utilization remains limited. Further research is needed to evaluate the efficacy of a wider range of photosensitizers and the potential of nanotechnology in psoriasis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Manita Das, Archana Solanki, Ashwini Ganesh, Sonal Thakore
Summary: Recent advancements in cancer therapy have focused on utilizing reactive oxygen species mediated treatments, with biomacromolecules derived hybrid nanomaterials playing a crucial role in the development of therapeutic solutions. Photodynamic therapy (PDT) has emerged as a powerful non-invasive technique for cancer diagnosis and treatment, with a particular emphasis on oxidative stress. The interactions of these materials at the biological interface and their mechanisms in generating oxidative stress and inducing cell death have been key areas of exploration for effective cancer management.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Review
Materials Science, Biomaterials
Samara Rodrigues Alves, Italo Rodrigo Calori, Antonio Claudio Tedesco
Summary: Photodynamic therapy (PDT) combined with immunotherapy has become a promising option for treating metastatic cancer, and the use of metal-organic frameworks as fourth generation photosensitizers has shown outstanding outcomes in pre-clinical studies. These new PSs can help alleviate skin photosensitivity, improve treatment efficacy, and play a crucial role in cancer therapy.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Qiang Wang, Chunbin Li, Yuchen Song, Qiankun Shi, Heng Li, Hua Zhong, Jianguo Wang, Fang Hu
Summary: In this study, a new donor was developed to improve the overall performance of aggregation-induced emission photosensitizers. By expanding the pi extension of aromatic rings, the new photosensitizer exhibited red-shifted absorption and fluorescence peaks, enhanced photosensitization efficiency, and demonstrated excellent imaging and cancer cell ablation capabilities.
Review
Chemistry, Multidisciplinary
Yi Zhang, Xiangqian Zhang, Huocheng Yang, Le Yu, Yunjie Xu, Amit Sharma, Peng Yin, Xiangyang Li, Jong Seung Kim, Yao Sun
Summary: The article discusses the advantages and potential of photodynamic therapy and sonodynamic therapy in the treatment of deep-seated tumors, as well as imaging-guided precise SDT and recent clinical trials. It also summarizes the strategies for designing sonosensitizers based on tumor environment and structure modifications, as well as the approach of SDT combination therapy.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Shuang Chao, Ziyan Shen, Jiaming Ren, Zhilin Zhang, Xiaolin Chen, Yuxin Pei, Zhichao Pei
Summary: A three-in-one self-assembled metallo-nanophotosensitizer system (NLCD) was constructed by cooperative coordination of amphiphilic l-arginine-modified photosensitizer NBS-l-Arg and DOX in the presence of Cu(2+)via the synergy of coordination, hydrophobic, and pi-pi stacking interactions. The resulting NLCD NPs possessed uniform size, well-defined nanosphere structure, and GSH-responsive ability. In vitro studies exhibited that NLCD NPs integrating photodynamic/chemodynamic/chemo multimodal therapy achieved an enhanced therapeutic effect.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Tzu-Jung Sung, Yu-Ying Wang, Kai-Lun Liu, Chun-Hsu Chou, Ping-Shan Lai, Chang-Wei Hsieh
Article
Biochemical Research Methods
Han-Ju Chien, Syu-Ming Lai, Wei-Chen Wang, Hung-Yu Lin, Yu-Min Juang, Ping-Shan Lai, Chien-Chen Lai
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2020)
Article
Engineering, Chemical
Yi-Ling Li, Yu-Wen Huang, Min-Zi Wu, Tsung-Yen Wu, Ping-Shan Lai, Nan-Nong Sun, Chiou-Yeong Saw, Chia-Wei Li, Chi-Fai Chau
Summary: The study demonstrated that the complexation of rice with chlorogenic acid could enhance its antioxidant and antidiabetic properties by modifying its physicochemical properties, resulting in increased resistance to digestion and desirable pasting properties.
Article
Biochemistry & Molecular Biology
Martin Hsiu-Chu Lin, Ping-Shan Lai, Li-Ching Chang, Wei-Chao Huang, Ming-Hsueh Lee, Kuo-Tai Chen, Chiu-Yen Chung, Jen-Tsung Yang
Summary: The study combines PS80 PBCA NP with chitosan surface modification for the transfection-guided neural-lineage specification of mouse iPSCs. The complex exhibits high stability, low cell toxicity, and enhances BDNF expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Tzu-Yang Chen, Ching-Li Tseng, Chih-An Lin, Hua-Yang Lin, Parthiban Venkatesan, Ping-Shan Lai
Summary: In this study, HA-nimesulide conjugates showed anti-inflammatory activity and promoted goblet cell recovery and corneal epithelium regeneration when used as topical eye drops, potentially being effective for the treatment of DES.
Article
Biochemistry & Molecular Biology
Yung-Tsung Kao, Yen-Ting Chen, Hueng-Chuen Fan, Tung-Chou Tsai, Shin-Nan Cheng, Ping-Shan Lai, Jen-Kun Chen, Chuan-Mu Chen
Summary: A novel nonviral gene therapy strategy utilizing DPPC-Fe3O4 to deliver BDD-FVIII plasmid was developed and successfully improved bleeding disorder in FVIII KO mice. The results suggest the potential of this approach for treating hemophilia A patients in clinical settings, with no observed adverse effects after treatment.
Article
Materials Science, Coatings & Films
Lalani Fernando, Wei-Ting Chen, Chung-Wei Lai, Fang-Yi Ye, Ping-Shan Lai, Jiang-Jen Lin, Kiyokazu Yasuda, Tsing-Tang Song, Jenn-Ming Song
Summary: CuO nano-sized needles coated on nano silicate platelets (NSP) effectively prevent aggregation and enhance antibacterial efficiency without affecting biocompatibility. The generated hydroxyl radicals by CuO/NSP might damage bacterial cellular components and result in bacterial death.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Food Science & Technology
Shisan Xu, Huan Zhang, Cun-Zhao Li, Ping-Shan Lai, Guijiang Wang, Yu Suen Chan, Shuk Han Cheng, Xueping Chen
Summary: CBD extract accelerates fin regeneration and reduces apoptosis after amputation by modulating the inflammatory response and the IL-1 beta/Caspase 3/PARP signal pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Pharmacology & Pharmacy
Martin Hsiu-Chu Lin, Li-Ching Chang, Chiu-Yen Chung, Wei-Chao Huang, Ming-Hsueh Lee, Kuo-Tai Chen, Ping-Shan Lai, Jen-Tsung Yang
Summary: The study conducted phototherapy using the PCI technique on a human GBM cell-line, showing that the formulation Etop/PpIX-PAMAM(G5) Ns had higher cellular uptake and exhibited a synergistic effect compared to free PpIX. Furthermore, phototherapy with light illumination resulted in increased oxidative stress and apoptosis, indicating a potential therapeutic strategy for GBM treatment.
Article
Pharmacology & Pharmacy
Chih-An Lin, Hui-Min Ho, Parthiban Venkatesan, Chiung-Yi Huang, Yu-Jhen Cheng, Yu-Hsing Lin, Hua-Yang Lin, Tzu-Yang Chen, Ming-Hsi Huang, Ping-Shan Lai
Summary: The study demonstrated that the use of hyaluronic acid-glycine cholesterol conjugate as an excipient for vaccine formulation showed promising results by stabilizing the emulsion interface, enhancing immune responses, and reducing local inflammation compared to traditional adjuvants, showcasing its potential in vaccine formulations for boosting T cell-mediated immunity.
Article
Biochemistry & Molecular Biology
His Lin, Kuan-Chen Cheng, Jer-An Lin, Liang-Po Hsieh, Chun-Hsu Chou, Yu-Ying Wang, Ping-Shan Lai, Po-Cheng Chu, Chang-Wei Hsieh
Summary: Research shows that Pholiota nameko polysaccharides (PNPs) can protect against UVA-induced skin aging by reducing elastase activity, inhibiting the production of reactive oxygen species, and decreasing cell aging. PNPs also increase the protein expression of tissue inhibitor metalloproteinase 1.
Article
Pharmacology & Pharmacy
Cun-Zhao Li, Hui-Min Chang, Wei-Li Hsu, Parthiban Venkatesan, Martin Hsiu-Chu Lin, Ping-Shan Lai
Summary: Curcumin plays a vital role in inhibiting influenza infection, with self-assembled oil-free Cur-M micelles showing excellent bioactivity and stability against the virus. The solid formulation Cur-SM, developed using physical adsorption, facilitates fast release of curcumin for potential pharmaceutical applications, demonstrating improved solubility and dispersity.
Article
Biochemistry & Molecular Biology
Tzu-Yang Chen, Neng-Yu Lin, Chih-Hao Wen, Chih-An Lin, Parthiban Venkatesan, Prasanna Wijerathna, Chung-Yu Lin, Ping-Shan Lai
Summary: Hyaluronic acid conjugation is a promising strategy for the treatment of rheumatoid arthritis (RA), as it improves the specific accumulation of steroids in inflamed tissues while reducing side effects. This study demonstrates the efficiency and effectiveness of the HA/triamcinolone acetonide conjugates in animal models, indicating their potential for long-term administration against RA.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Biomaterials
Rong-Kai Lin, Parthiban Venkatesan, Chao-Hsuan Yeh, Ching-Ming Chien, Te-Shan Lin, Chi-Chen Lin, Chu-Chieh Lin, Ping-Shan Lai
Summary: Psoriasis is a chronic inflammatory skin disease that significantly impacts quality of life. Research suggests that novel NNO-tridentate vanadium (IV) complexes used in photodynamic therapy have anti-inflammatory effects in a psoriasis-like skin disease mouse model. These complexes exhibit low photocytotoxicity in the dark and significant photocytotoxicity under blue light irradiation.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
