Article
Immunology
Meiping Chen, Shiyi He, Phoebe Miles, Chunlin Li, Yijun Ge, Xuechan Yu, Linfeng Wang, Weina Huang, Xue Kong, Shanni Ma, Yiting Li, Qingwen Jiang, Wen Zhang, Chao Cao
Summary: Perturbation of the nasal microbiome is associated with the phenotypes and severity of chronic airways disease, including asthma and allergic rhinitis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Evy Maas, John Penders, Koen Venema
Summary: Most studies on the human gut microbiota focus on bacteria, but recent research indicates that intestinal fungi are also important for maintaining health. This study analyzed the mycobiome of healthy individuals and its interaction with the bacterial component of the microbiome. The results showed a lower diversity of fungi compared to bacteria, with significant inter-individual variation. Positive correlations were observed between certain fungi and bacteria, including those associated with alleviating inflammatory bowel disease. Further research is needed to investigate the importance of these correlations and distinguish between gut colonizers and transient species.
Article
Ecology
Xin Zhou, Jin-Ting Wang, Wei-Hua Wang, Clement K. M. Tsui, Lei Cai
Summary: The microbial community of healthy tomatoes is more stable and diverse compared to diseased tomatoes, potentially containing more potential suppressors of the Fusarium wilt pathogen. The study also found that microbial diversity is negatively correlated with the concentration of the Fusarium oxysporum f. sp. lycopersici pathogen.
Article
Microbiology
Man Kit Cheung, Jason Y. K. Chan, Martin C. S. Wong, Po Yee Wong, Pu Lei, Liuyang Cai, Linlin Lan, Wendy C. S. Ho, Apple C. M. Yeung, Paul K. S. Chan, Zigui Chen
Summary: This study characterized the oral bacterial and fungal microbiomes in a large cohort of healthy Chinese adults. The results showed that different factors shaped the diversity and structure of the oral bacterial and fungal microbiomes in healthy adults. Bacterial-fungal interactions were limited in the healthy oral microbiota.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Robin D. Wright, Thais F. Bartelli, Seyda Baydogan, James Robert White, Michael P. Kim, Manoop S. Bhutani, Florencia Mcallister
Summary: In this feasibility study, the tumor microbiome (TM) of pancreatic adenocarcinoma was characterized using Endoscopic Ultrasound-Fine Needle Aspiration (EUS-FNA) biopsy and sequencing techniques. The results showed that it is possible to characterize the TM in biopsies with proper decontamination strategies and by comparing it to non-matched tumor.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Jin Park, Nicole H. Schwardt, Jay-Hyun Jo, Zhiwei Zhang, Valentina Pillai, Sheila Phang, Sheila M. Brady, Jessica A. Portillo, Margaret A. MacGibeny, Hai Liang, Meridith Pensler, Steven J. Soldin, Jack A. Yanovski, Julia A. Segre, Heidi H. Kong
Summary: The study revealed that puberty is associated with shifts in the skin microbiome, which are influenced by sex, degree of sexual maturation, and sex hormone concentrations.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Clinical Neurology
Shao-rui Hao, Zhe Zhang, Yuan-yue Zhou, Xue Zhang, Wen-jun Sun, Zi Yang, Jian-hua Zhao, Hai-yin Jiang
Summary: The gut mycobiome is altered in children and adolescents with depression, with certain fungi being enriched and others showing decreased abundance. Furthermore, the interkingdom network between gut bacteria and fungi is significantly altered in individuals with depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Microbiology
Joanna Tannous, Casey M. Cosetta, Milton T. Drott, Tomas A. Rush, Paul E. Abraham, Richard J. Giannone, Nancy P. Keller, Benjamin E. Wolfe
Summary: Using an antibacterial Penicillium isolate and a cheese rind microbial community, this study demonstrates that a fungal specialized metabolite can regulate the diversity of bacterial communities. It reveals the role of global regulators in controlling bacterial community assembly and highlights the ecological function of fungal specialized metabolites.
Article
Dermatology
F. Vitali, R. Colucci, M. Di Paola, M. Pindo, C. De Filippo, S. Moretti, D. Cavalieri
Summary: The microbiome is increasingly recognized as playing a key role in the immune response to cancer, particularly in melanoma. Changes in gut microbiota composition in early-stage melanoma patients are associated with histopathological features, clinical course, and response to immune therapies. The presence of specific bacterial and fungal profiles in the gut correlates to the invasiveness and regression of melanoma, providing potential biomarkers for prognosis and treatment response.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Jivianne T. Lee, Carra A. Simpson, Hong-Ho Yang, Jeffrey D. Suh, Marilene B. Wang, Venu Lagishetty, Fengting Liang, Jonathan P. Jacobs
Summary: The study aims to investigate the differences in fungal and bacterial microbiomes between patients with chronic rhinosinusitis (CRSwNP and CRSsNP) and healthy controls. The results indicate significant differences in fungal diversity between CRS patients and controls, as well as significant differences in bacterial composition between different subtypes of CRS.
Article
Medicine, General & Internal
Barbara Zapala, Tomasz Stefura, Magdalena Wojcik-Pedziwiatr, Radoslaw Kabut, Marta Balajewicz-Nowak, Tomasz Milewicz, Alicja Dudek, Anastazja Stoj, Monika Rudzinska-Bar
Summary: The study compared the gut microbiota composition between patients diagnosed with Parkinson's disease and those treated only with Levodopa to healthy controls, finding that PD patients have significantly different gut microbiota profiles.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Xiaomei Liu, Xue Pan, Hao Liu, Xiaoxin Ma
Summary: This study found significant differences in the diversity and composition of gut microbiota among female patients with IM, CC, and healthy controls. Abundance of cancer-related genes was significantly increased in IM and CC patients. Prevotella_7 may serve as a potential biomarker for distinguishing IM, CC, and controls.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Charlotte M. Verburgt, Katherine A. Dunn, Mohammed Ghiboub, James D. Lewis, Eytan Wine, Rotem Sigall Boneh, Konstantinos Gerasimidis, Raanan Shamir, Susanne Penny, Devanand M. Pinto, Alejandro Cohen, Paul Bjorndahl, Vaios Svolos, Joseph P. Bielawski, Marc A. Benninga, Wouter J. de Jonge, Johan E. Van Limbergen
Summary: This study found that successful dietary therapy can correct dysbiosis in pediatric Crohn's disease (CD) patients, but 12 weeks of dieting is not enough to achieve complete correction. Composition and metabotype are important and change quickly during the early clinical response to dietary intervention. Correction of dysbiosis may be an important future treatment goal for CD.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Biology
Ming Sheng Ng, Nathaniel Soon, Ying Chang, Benjamin J. Wainwright
Summary: This study characterised the bacterial and fungal communities associated with Pteraeolidia semperi nudibranch individuals collected from four offshore islands in Singapore. The results showed no distinct spatial structuring of microbial community, richness, or diversity across sampling locations. The bacterial genera Mycoplasma and Endozoicomonas were found across all samples and islands.
Article
Medicine, General & Internal
Yi-Ju Chen, Wei-Hsiang Lee, Hsiu J. Ho, Ching-Hung Tseng, Chun-Ying Wu
Summary: The study revealed that rosacea patients had altered fecal microbial richness and composition compared to non-rosacea subjects. The distinct microbial composition in rosacea patients might be related to sulfur metabolism, cobalamin, and carbohydrate transport.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Review
Dermatology
Ruojun Wang, Shaomin Zhong, Ping Tu, Ruoyu Li, Mingyue Wang
DERMATOLOGIC THERAPY
(2019)
Review
Mycology
Ruojun Wang, Xueyan Yao, Ruoyu Li
Editorial Material
Dermatology
Ruojun Wang, Yang Wang, Zhimiao Lin
Letter
Dermatology
J. Gao, R. Wang
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Editorial Material
Medicine, General & Internal
Ming Cui, Ruojun Wang, Quan Liao
POSTGRADUATE MEDICAL JOURNAL
(2021)
Review
Dermatology
Ruojun Wang, Chen Huang, Yi Zhang, Ruoyu Li
Summary: The study found that invasive dermatophytosis often occurs in males, with common risk factors including superficial dermatophytosis and solid organ transplantation. Trichophyton rubrum is the most common pathogen causing infection, while patients with CARD9 or STAT3 gene mutations are more prone to develop mixed infections.
Editorial Material
Medicine, General & Internal
Ruojun Wang, Zhimiao Lin
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Review
Dermatology
Rong Tao, Ruoyu Li, Ruojun Wang
Summary: Seborrheic dermatitis and dandruff are common chronic inflammatory skin diseases. Microbes on the skin surface play a key role in the pathogenesis, with studies showing an increased Malassezia restricta/Malassezia globosa ratio and a reduction in the Cutibaterium/Staphylococcus ratio in patients with SD/DF. These microbes are associated with skin conditions and disease severity. Further research on their interactions can enhance our understanding of the pathogenesis of SD/DF.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
Shiqi Wang, Yinggai Song, Zhe Wan, Wei Chen, Ruojun Wang, Ruoyu Li
Summary: The nail microbiome in psoriatic patients with OM has distinct bacterial and fungal signatures, suggesting that different dysbiosis is associated with the pathogenesis of OM in psoriatic and nonpsoriatic patients.
Article
Dermatology
Rong Tao, Ruojun Wang, Zhe Wan, Yinggai Song, Yan Wu, Ruoyu Li
Summary: This study found that patients with SD had lower bacterial and fungal diversities at the lesional sites compared to healthy controls. Malassezia and Staphylococcus had increased relative abundances, while Cutibacterium had decreased relative abundance in patients with SD. Ketoconazole treatment reduced Malassezia and increased fungal diversity, which helped restore the skin microbial communities.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Shiqi Wang, Ruojun Wang, Yinggai Song, Zhe Wan, Wei Chen, Hang Li, Ruoyu Li
Summary: This study found significant changes in the bacterial and fungal microbiome of patients with nail psoriasis. The unaffected nails in psoriatic patients were associated with higher bacterial diversity and a higher relative abundance of Enhydrobacter, while nail psoriasis was correlated with a decreased relative abundance of Anaerococcus. There was a higher proportion of Malassezia in the unaffected nails of psoriatic patients and an increased proportion of Candida in psoriatic nails.
EXPERIMENTAL DERMATOLOGY
(2022)
Review
Dermatology
Rong Tao, Ruoyu Li, Ruojun Wang
Summary: Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease with increasing prevalence worldwide. The etiology and pathogenesis of AD are not fully understood, but previous studies have suggested a potential role of fungi as a triggering factor in its development. Fungal dysbiosis, characterized by decreased Malassezia and increased filamentous fungi, is observed in AD lesions, along with a positive correlation between Candida and Staphylococcus. Further research focusing on the interaction between specific skin fungi and the host can provide better insights into the role of microorganisms in AD pathogenesis.
Letter
Dermatology
Rong Tao, Ruoyu Li, Zhe Wan, Yan Wu, Ruojun Wang
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Rong Tao, Peiqiu Zhu, Yabin Zhou, Qian Li, Zhe Wan, Ruoyu Li, Ruojun Wang
Summary: The study investigates and compares the scalp bacterial and fungal microbiomes between children with tinea capitis and healthy children, as well as the differences between children and adults. The results show that children with tinea capitis have lower fungal diversity and higher bacterial diversity than healthy children. There are higher relative abundances of pathogenic fungi and significant alterations in the bacterial community in the affected areas of tinea capitis compared to healthy scalps. Compared to adults, healthy children have higher fungal diversity with lower relative abundances of Malassezia and Cutibacterium, and higher relative abundances of Candida and Streptococcus.
