Review
Biochemistry & Molecular Biology
Cinzia Aurilia, Simone Donati, Gaia Palmini, Francesca Miglietta, Irene Falsetti, Teresa Iantomasi, Maria Luisa Brandi
Summary: Tumors of the parathyroid glands are common endocrine diseases characterized by parathyroid hormone hypersecretion, with a wide range of clinical presentations and typically treated through surgical removal. Recent studies have suggested that alterations to the epigenetic mechanisms could play a pivotal role in tumorigenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yufei Yang, Xuebing Yan, Xinxiang Li, Yanlei Ma, Ajay Goel
Summary: Colorectal cancer is a common malignancy with challenges in diagnosis and treatment, and recent research suggests that long non-coding RNAs play important roles in the progression of the disease.
Review
Oncology
Arash Poursheikhani, Mohammad Reza Abbaszadegan, Mohammad Amin Kerachian
Summary: Colorectal cancer is a common global cancer, and long noncoding RNAs play important roles in its tumorigenesis by affecting processes like cell proliferation, apoptosis, and migration, potentially influencing the risk of CRC development.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yali Han, Guo Zhao, Xinhang Shi, Yushan Wang, Xin Wen, Lu Zhang, Xiangqian Guo
Summary: Esophageal cancer is a common malignancy with poor prognosis. Understanding the molecular mechanisms, identifying effective biomarkers, and developing early diagnosis and treatment strategies are crucial for improving patient survival. Long non-coding RNAs (lncRNAs) play important roles in the regulation of esophageal cancer, influencing the expression of oncogenes and tumor suppressors. Targeting lncRNAs through genome editing, RNA interference, and molecular drugs holds great potential for future esophageal cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Matteo Lulli, Cristina Napoli, Ida Landini, Enrico Mini, Andrea Lapucci
Summary: Non-coding RNAs, especially long non-coding RNAs, have been shown to play critical roles in the initiation, progression, and drug resistance of colorectal cancer. They are emerging as potential therapeutic targets and predictive biomarkers for the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Zarrin Banikazemi, Mojgan Farshadi, Ali Rajabi, Mina Homayoonfal, Nasrin Sharifi, Reza Sharafati Chaleshtori
Summary: This article reviews the biological effects of miRNA and lncRNA alterations following exposure to nanoplastics, which may increase the risk of chronic diseases such as cancer.
Article
Veterinary Sciences
Zhaobo Zhang, Sishi Zhang, Guoshuai Wang, Siyu Feng, Kexin Han, Limei Han, Liping Han
Summary: Marek's disease virus (MDV) causes Marek's disease (MD), which involves highly infectious tumor lesions. Noncoding RNAs play a significant role in the pathogenesis of MD, with specific miRNAs and lncRNAs participating in various cellular processes.
RESEARCH IN VETERINARY SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Nikolay K. Shakhpazyan, Liudmila M. Mikhaleva, Arcady L. Bedzhanyan, Nikolay K. Sadykhov, Konstantin Y. Midiber, Alexandra K. Konyukova, Andrey S. Kontorschikov, Ksenia S. Maslenkina, Alexander N. Orekhov
Summary: This comprehensive review explores the intricate roles of long non-coding RNAs (lncRNAs) within the microenvironment of colorectal cancer (CRC), particularly in relation to immunity, intercellular communication, and therapeutic potential. The review highlights the significance of lncRNAs in influencing inflammation, immune evasion, and treatment response in CRC, and proposes them as potential candidates for novel therapeutic strategies and biomarkers. The review also examines the complex interplay of lncRNAs with CRC tumor subtypes, their impact on immunity and inflammation within the tumor stroma, and their transportation through extracellular vesicles, specifically exosomes. Additionally, the review delves into the intricate relationship between lncRNAs and other non-coding RNAs, such as microRNAs and circular RNAs, in mediating cell-to-cell communication within the CRC microenvironment. Finally, potential strategies to manipulate lncRNAs to enhance anti-tumor immunity are proposed, highlighting the importance of lncRNAs in innovative therapeutic interventions in CRC.
Review
Oncology
Hsiao-Mei Chao, Teh-Wei Wang, Edward Chern, Shan-hui Hsu
Summary: This review discusses the basic characteristics and physiological functions of colorectal cancer stem cells, as well as the regulatory effects of non-coding RNAs (ncRNAs) on cells. Elucidation of these ncRNAs helps us understand the pathological mechanism of colorectal cancer progression and may provide new targets for cancer treatment.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Review
Oncology
Ru Sun, Xiao-Yun He, Cheng Mei, Chun-Lin Ou
Summary: Exosomes, small extracellular vesicles ranging from 30-150 nm, are crucial in cell-to-cell communication by transferring biological information like DNA, RNA, and proteins. Recent findings indicate that exosomes can carry long non-coding RNAs (lncRNAs), impacting the progression of colorectal cancer significantly.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Review
Cell Biology
Nasrin Ahangar Davoodi, Sajad Najafi, Zari Naderi Ghale-Noie, Ashkan Piranviseh, Samaneh Mollazadeh, Sahar Ahmadi Asouri, Zatollah Asemi, Mohammadamin Morshedi, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Amirhossein Sheida, Hamed Mirzaei
Summary: Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that can have severe consequences. Non-coding RNAs (ncRNAs) play important roles in the pathogenesis and development of RB, with different ncRNAs acting as either tumor promoters or suppressors. Understanding the regulatory mechanisms of ncRNAs provides new opportunities for RB therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jiaying Li, Rundong Chai, Yinxiao Chen, Shuwu Zhao, Yuhong Bian, Xiangling Wang
Summary: Colorectal cancer is a common gastrointestinal malignancy with complex pathogenesis. Curcumin has shown potent anti-tumor and anti-inflammatory effects. Recent studies have revealed that curcumin can regulate non-coding RNA expression levels to suppress tumor development in colorectal cancer. This review provides a scientific basis for the clinical application of non-coding RNAs in colorectal cancer.
Article
Medicine, Research & Experimental
Yanan Zhang, Hanbing Yan, Yan Jiang, Tao Chen, Zhijin Ma, Fei Li, Min Lin, Yanzhi Xu, Xuemei Zhang, Jianming Zhang, Hui He
Summary: The study demonstrates that IGF2-AS plays a tumor-suppressive role in breast cancer, inhibiting the expression of IGF2 gene and influencing the PI3K/AKT/mTOR signaling pathway, with significant impact on tumor development.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Review
Biology
Massimiliano Agostini, Mara Mancini, Eleonora Candi
Summary: Metabolic reprogramming is a hallmark of cancers and long non-coding RNAs play a role in regulating cancer-specific metabolic alterations. This overview focuses on breast cancer metabolic reprogramming and the involvement of long non-coding RNAs in driving these alterations.
Article
Oncology
Saeed Ashrafizaveh, Milad Ashrafizadeh, Ali Zarrabi, Kiavash Husmandi, Amirhossein Zabolian, Md Shahinozzaman, Amir Reza Aref, Michael R. Hamblin, Noushin Nabavi, Francesco Crea, Yuzhuo Wang, Kwang Seok Ahn
Summary: Studies have shown that long non-coding RNAs play a significant role in DOX resistance, both activating resistance pathways and increasing sensitivity of cancer cells to DOX.