Article
Immunology
Anne Marie Lund, Mohammad Al-Mahdi Al-Karagholi
Summary: A 30-year-old male diagnosed with reversible cerebral vasoconstriction syndrome (RCVS) experienced a series of attacks resembling RCVS after receiving the first Pfizer COVID-19 vaccine. However, treatment with the angiotensin 2 receptor antagonist, losartan, proved effective in preventing further RCVS attacks.
Article
Microbiology
Michael P. Doyle, Joseph R. Genualdi, Adam L. Bailey, Nurgun Kose, Christopher Gainza, Jessica Rodriguez, Kristen M. Reeder, Christopher A. Nelson, Prashant N. Jethva, Rachel E. Sutton, Robin G. Bombardi, Michael L. Gross, Justin G. Julander, Daved H. Fremont, Michael S. Diamond, James E. Crowe
Summary: Yellow fever virus (YFV) is a mosquito-borne virus that occasionally causes outbreaks of severe infection in South America and sub-Saharan Africa. Effective vaccines have been developed, but recent production and distribution issues have left many people vulnerable. This study aimed to isolate an antibody from individuals who had received the YFV vaccine for future use as a biologic drug. The most powerful antiviral antibody was found to be effective in animal models of human infection. These studies provide insights into the human immune response to YFV and offer a potential therapeutic antibody candidate for inhibiting highly virulent strains of the virus.
Article
Microbiology
Sherif A. El-Kafrawy, Abby Odle, Aymn T. Abbas, Ahmed M. Hassan, Umama A. Abdel-Dayem, Arooj K. Qureshi, Lok-Yin Roy Wong, Jian Zheng, David K. Meyerholz, Stanley Perlman, Alimuddin Zumla, Esam Azhar
Summary: The use of IgY antibodies from chickens has shown prophylactic efficacy against SARS-CoV-2 in mice, reducing viral replication, morbidity, and lung pathology.
Article
Medicine, General & Internal
Huan Liu, Shu Shen, Qiuhui Wang
Summary: This case report describes a 51-year-old male patient with chronic hepatitis B virus infection who had recurrent pulmonary cryptococcosis. After treatment with fluconazole and bicyclol, the patient fully recovered and did not experience recurrence during a 2-year follow-up. This highlights the importance of recognizing opportunistic infections, particularly the potential for recurrence, in patients with chronic hepatitis B virus infection.
Article
Multidisciplinary Sciences
Naphak Modhiran, Hao Song, Lidong Liu, Cheryl Bletchly, Lou Brillault, Alberto A. Amarilla, Xiaoying Xu, Jianxun Qi, Yan Chai, Stacey T. M. Cheung, Renee Traves, Yin Xiang Setoh, Summa Bibby, Connor A. P. Scott, Morgan E. Freney, Natalee D. Newton, Alexander A. Khromykh, Keith J. Chappell, David A. Muller, Katryn J. Stacey, Michael J. Landsberg, Yi Shi, George F. Gao, Paul R. Young, Daniel Watterson
Summary: The NS1 antibody 1G5.3 can effectively block NS1-mediated cell permeability of multiple flaviviruses, reduce viremia, and improve survival in various animal models. The protective effect of 1G5.3 is independent of effector function, making it a key site for broad-spectrum antiviral development.
Article
Biochemistry & Molecular Biology
J. Maximilian Fels, Daniel P. Maurer, Andrew S. Herbert, Ariel S. Wirchnianski, Olivia Vergnolle, Robert W. Cross, Dafna M. Abelson, Crystal L. Moyer, Akaash K. Mishra, Jennifer T. Aguilan, Ana Kuehne, Noel T. Pauli, Russell R. Bakken, Elisabeth K. Nyakatura, Jan Hellert, Gregory Quevedo, Leslie Lobel, Stephen Balinandi, Julius J. Lutwama, Larry Zeitlin, Thomas W. Geisbert, Felix A. Rey, Simone Sidoli, Jason S. McLellan, Jonathan R. Lai, Zachary A. Bornholdt, John M. Dye, Laura M. Walker, Kartik Chandran
Summary: The study characterizes the human immune response to CCHFV infection, identifying neutralizing monoclonal antibodies targeting the viral glycoprotein. By mapping antigenic sites and utilizing bispecific antibody engineering, synergistic neutralization is achieved, leading to a promising therapeutic candidate for CCHFV.
Article
Biochemistry & Molecular Biology
Arthur S. Kim, Natasha M. Kafai, Emma S. Winkler, Theron C. Jr Jr Gilliland, Emily L. Cottle, James T. Earnest, Prashant N. Jethva, Paulina Kaplonek, Aadit P. Shah, Rachel H. Fong, Edgar Davidson, Ryan J. Malonis, Jose A. Quiroz, Lauren E. Williamson, Lo Vang, Matthias Mack, James E. Jr Jr Crowe, Benjamin J. Doranz, Jonathan R. Lai, Galit Alter, Michael L. Gross, William B. Klimstra, Daved H. Fremont, Michael S. Diamond
Summary: Two poorly neutralizing human monoclonal antibodies, DC2.112 and DC2.315, have been identified as pan-protective against both arthritogenic and encephalitic alphaviruses. These antibodies target a conserved epitope in the E1 protein domain II and offer protection through multiple mechanisms, including inhibiting viral egress and monocyte-dependent Fc effector functions. This finding provides potential targets for pan-alphavirus immunotherapy and vaccine design.
Article
Immunology
Shimeng Bai, Tianhan Yang, Cuisong Zhu, Meiqi Feng, Li Zhang, Ziling Zhang, Xiang Wang, Rui Yu, Xinghao Pan, Chen Zhao, Jianqing Xu, Xiaoyan Zhang
Summary: A nucleoside-modified Rabies mRNA-LNP vaccine was developed, which showed more potent immune responses and prolonged protection compared to a commercially available inactivated vaccine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemical Research Methods
Lutz Gieselmann, Christoph Kreer, Meryem Seda Ercanoglu, Nathalie Lehnen, Matthias Zehner, Philipp Schommers, Julian Potthoff, Henning Gruell, Florian Klein
Summary: The study introduces a highly efficient high-throughput protocol for isolating pathogen-specific antibodies, covering all critical steps from sample collection to antibody production within 12-14 days.
Article
Integrative & Complementary Medicine
Na Zhi, Qian Mo, Shuo Yang, Yuan-xing Qin, Hao Chen, Zeng-guang Wu, Cai-hong Lan, Jun Zhang, Yin-long Li
Summary: After one month of oral treatment with traditional Chinese medicine decoction, a 61-year-old female patient with COVID-19 showed significant improvement in lung inflammation and fibrosis, as well as quality of life, with no recurrence or deterioration observed within seven weeks of treatment and follow-up.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Immunology
Hiroshi Shimizu, Haruki Matsumoto, Tomomi Sasajima, Tomohiro Suzuki, Yoshinori Okubo, Yuya Fujita, Jumpei Temmoku, Shuhei Yoshida, Tomoyuki Asano, Hiromasa Ohira, Yutaka Ejiri, Kiyoshi Migita
Summary: This article reports a case of complicated COVID-19 presenting with skin rash, muscle weakness, and interstitial lung disease (ILD), subsequently diagnosed with dermatomyositis (DM). The case suggests a possible association between COVID-19 and the development of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Lok R. Joshi, David Knudsen, Pablo Pineyro, Santosh Dhakal, Gourapura J. Renukaradhya, Diego G. Diel
Summary: The study developed two recombinant orf viruses expressing the HA gene or the HA and NP genes of IAV-S, which induced robust virus neutralizing antibody responses in pigs. The immunization with the HA-NP virus resulted in a Th1-biased immune response and provided incremental protection against challenge infection compared to the HA group.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Christian J. Maine, Guilhem Richard, Darina S. Spasova, Shigeki J. Miyake-Stoner, Jessica Sparks, Leonard Moise, Ryan P. Sullivan, Olivia Garijo, Melissa Choz, Jenna M. Crouse, Allison Aguilar, Melanie D. Olesiuk, Katie Lyons, Katrina Salvador, Melissa Blomgren, Jason L. DeHart, Kurt I. Kamrud, Gad Berdugo, Anne S. De Groot, Nathaniel S. Wang, Parinaz Aliahmad
Summary: By combining antigen selection, construct design, and a robust vaccine platform based on SMARRT technology, effective control of tumor growth and generation of high-quality T cell responses can be achieved in both mice and non-human primates, showing promise for translational and clinical application in therapeutic oncology vaccines.
Article
Immunology
Giuseppe Barilaro, Emmanuel Coloma-Bazan, Alejandro Chacur, Carlo Della Rocca, Albert Perez-Isidro, Estibaliz Ruiz-Ortiz, Odette Vinas, Dolors Tassies Penella, Joan Carles Reverter, Alicia Molina Andujar, Ricard Cervera, Gerard Espinosa
Summary: The purpose of this study was to analyze the persistence of antiphospholipid antibodies (aPL) over time in patients with antiphospholipid syndrome (APS) and its association with clinical recurrence. The results showed that more than half of the patients maintained persistent positive aPLs over a long-term follow-up, and these patients were more prone to experience recurrence of clinical manifestations.
AUTOIMMUNITY REVIEWS
(2022)
Article
Oncology
Juyue Zhou, Zhonghai Du
Summary: Recurrence of meningiomas with multiple extracranial metastases after surgery is rare. This case report presents a patient with recurrent meningioma and multiple distant metastases. Treatment with immune checkpoint inhibitors and anti-angiogenic drugs resulted in symptom relief and stable disease. This study highlights the potential benefit of combination therapy in improving survival and quality of life for meningioma patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Jun Wang, Jixing Wu, Xianying Zhu, Jinkun Chen, Jianping Zhao, Yongjian Xu, Jungang Xie
Summary: MFG-E8 plays a crucial role in hypoxia-induced PH, and its absence can attenuate the development of PH and vascular remodeling. MFG-E8 may serve as a potential therapeutic target or biomarker for PH.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yi Wang, Lei Zhang, Guo-Rao Wu, Qing Zhou, Huihui Yue, Li-Zong Rao, Ting Yuan, Biwen Mo, Fa-Xi Wang, Long-Min Chen, Fei Sun, Jia Song, Fei Xiong, Shu Zhang, Qilin Yu, Ping Yang, Yongjian Xu, Jianping Zhao, Huilan Zhang, Weining Xiong, Cong-Yi Wang
Summary: Despite extensive studies, the mechanisms underlying PF remain poorly understood. This study found altered MBD2 expression in macrophages in lungs from different types of PF patients and mice with PF, and Mbd2 deficiency protected against BLM-induced PF. Mbd2 selectively influenced TGF-β1 production and M2 macrophage program through Ship promoter binding in macrophages.
Article
Multidisciplinary Sciences
Haidong Li, Xiuchao Zhao, Yujin Wang, Xin Lou, Shizhen Chen, He Deng, Lei Shi, Junshuai Xie, Dazhong Tang, Jianping Zhao, Louis-S Bouchard, Liming Xia, Xin Zhou
Summary: The recovery process of COVID-19 patients remains unclear, with some experiencing ongoing respiratory issues. Xe-129 MRI analysis reveals higher ventilation defects and longer gas-blood exchange time in COVID-19 patients, indicating lung function impairment during recovery.
Article
Medical Laboratory Technology
Shanshan Wang, Kun Tang, Yanjiao Lu, Zhen Tian, Zhenli Huang, Meijia Wang, Jianping Zhao, Jungang Xie
Summary: The study identified differential metabolites in asthma patients and healthy subjects, including phosphatidic acid, phosphatidylglyceml, and phosphatidylethanolamine. These metabolites showed significant relevance to diagnostic and prognostic indicators of asthma, providing potential for developing new biomarkers.
CLINICA CHIMICA ACTA
(2021)
Editorial Material
Biotechnology & Applied Microbiology
Yi Wang, Jianping Zhao, Huilan Zhang, Cong-Yi Wang
Article
Surgery
Jianping Zhao, Yao Chen, Jingjing Wang, Jian Wang, Ying Wang, Songshan Chai, Yuxin Zhang, Xiaoping Chen, Wanguang Zhang
Summary: The preoperative risk grade (PRG) integrating non-tumor-specific SIR markers like PLR and ALB was significantly associated with the overall survival of intrahepatic cholangiocarcinoma (ICC) patients, showing higher predictive accuracy compared to other systems. Incorporating PRG into a nomogram improved the predictive ability of ICC prognosis.
Article
Medicine, General & Internal
Wei Zhu, Huaqiu Zhang, Yong Li, Zeyang Ding, Zhuo Liu, Yajun Ruan, Huan Feng, Ganxun Li, Bo Liu, Fan He, Ning Zhou, Jiangang Jiang, Zhixiang Wen, Gang Xu, Jianping Zhao, Bixiang Zhang, Daowen Wang, Zhouping Tang, Hui Wang, Jihong Liu
Summary: Limited data is available on the treatment for COVID-19, with the main treatment strategies including ventilatory support, multiple organ function preservation, glucocorticoid use, renal replacement therapy, anticoagulation, and restrictive fluid management. Early recognition and intervention, multidisciplinary collaboration, multi-organ function support, and personalized treatment might be the key for reducing mortality.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Wen Zhang, Chuanwei Li, Yu Xu, Binfeng He, Mingdong Hu, Guoqiang Cao, Li Li, Shuang Wu, Xia Wang, Chun Zhang, Jianping Zhao, Jungang Xie, Zihui Xu, Qi Li, Guansong Wang
Summary: This study found that COVID-19 patients with diabetes or hyperglycemia have higher inflammatory levels and more severe illness, suggesting that hyperglycemia is a risk factor for the increased severity of COVID-19. Initial measurement of plasma glucose levels after hospitalization may help identify patients predisposed to a worse clinical course.
MEDIATORS OF INFLAMMATION
(2021)
Article
Oncology
Li Ni, Zheng Wen, Xiaowen Hu, Wei Tang, Haisheng Wang, Ling Zhou, Lujin Wu, Hong Wang, Chang Xu, Xizhen Xu, Zhichao Xiao, Zongzhe Li, Chene Li, Yujian Liu, Jialin Duan, Chen Chen, Dan Li, Runhua Zhang, Jinliang Li, Yongxiang Yi, Wei Huang, Yanyan Chen, Jianping Zhao, Jianping Zuo, Jianping Weng, Hualiang Jiang, Dao Wen Wang
Summary: The study showed that the combination of Shuanghuanglian (SHL) and standard care was safe and partially effective for treating COVID-19, with higher negative conversion rates of SARS-CoV-2 and promoted absorption of pneumonia inflammatory focus. No serious adverse events were reported in the SHL groups.
FRONTIERS OF MEDICINE
(2021)
Article
Allergy
Lingling Yi, Shuchen Zhang, Yuchen Feng, Wenliang Wu, Chenli Chang, Dian Chen, Shengchong Chen, Jianping Zhao, Guohua Zhen
Summary: Galectin-13 expression is significantly increased in asthma patients and is correlated with eosinophilic airway inflammation and Th2 signature genes. Inhaled corticosteroid treatment can reduce plasma galectin-13 levels, and galectin-13 may contribute to allergic airway eosinophilic inflammation by upregulating the expression of certain cytokines. Plasma galectin-13 levels may serve as a useful predictor for responses to ICS treatment.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Review
Immunology
Yue Yuan, Jianping Zhao, Min Chen, Huifang Liang, Xin Long, Bixiang Zhang, Xiaoping Chen, Qian Chen
Summary: Exosomes play important roles in the pathogenesis of schistosomiasis by facilitating intercellular communication and regulating the host immune response. Understanding the involvement of exosomes may offer new perspectives in diagnosing and treating this neglected disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Ting Yang, Renjie Chen, Xiaoying Gu, Jianying Xu, Lan Yang, Jianping Zhao, Xiangyan Zhang, Chunxue Bai, Jian Kang, Pixin Ran, Huahao Shen, Fuqiang Wen, Kewu Huang, Yahong Chen, Tieying Sun, Guangliang Shan, Yingxiang Lin, Sinan Wu, Jianguo Zhu, Ruiying Wang, Zhihong Shi, Yongjian Xu, Xianwei Ye, Yuanlin Song, Qiuyue Wang, Yumin Zhou, Liren Ding, Ting Yang, Wanzhen Yao, Yanfei Guo, Fei Xiao, Yong Lu, Xiaoxia Peng, Biao Zhang, Dan Xiao, Zuomin Wang, Hong Zhang, Xiaoning Bu, Xiaolei Zhang, Li An, Shu Zhang, Zhixin Cao, Qingyuan Zhan, Yuanhua Yang, Lirong Liang, Bin Cao, Huaping Dai, Aaron van Donkelaar, Randall V. Martin, Tangchun Wu, Jiang He, Haidong Kan, Chen Wang
Summary: The China Pulmonary Health study found that long-term exposure to ambient PM2.5 and some constituents, especially organic matter and nitrate, were associated with lower large- and small-airway function.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Yanjiao Lu, Jinkun Chen, Shanshan Wang, Zhen Tian, Yan Fan, Meijia Wang, Jianping Zhao, Kun Tang, Jungang Xie
Summary: This study highlighted the significant impact of aging on idiopathic pulmonary fibrosis (IPF) and bleomycin-induced pulmonary fibrosis (BIPF) through comprehensive gene expression profile analysis. Aging was found to be closely associated with changes in differentially expressed genes (DEGs) and the severity of pulmonary fibrosis development. Four aging-associated core genes (Slc2a3, Fga, Hp, and Thbs1) were identified as key players in the pathogenesis of pulmonary fibrosis.
FRONTIERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Fen Lan, Chen Zhu, Rui Jin, Lingxiao Zhou, Yue Hu, Jianping Zhao, Shuyun Xu, Yang Xia, Wen Li
Summary: This study aimed to compare the clinical features of COVID-19 patients with and without complications for treatment guidance and prognosis prediction. The top-ranking clinical characteristics varied in each subgroup, with renal function indices ranking highest in all subgroups and showing significant differences during hospitalization.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Yang Xia, Weixiang Chen, Hongyi Ren, Jianping Zhao, Lihua Wang, Rui Jin, Jiesen Zhou, Qiyuan Wang, Fugui Yan, Bin Zhang, Jian Lou, Shaobin Wang, Xiaomeng Li, Jie Zhou, Liming Xia, Cheng Jin, Jianjiang Feng, Wen Li, Huahao Shen
Summary: This study demonstrated the efficiency of a classifier combining chest X-ray and clinical features in distinguishing COVID-19 from influenza A/B pneumonia. The combined classifier showed significantly improved diagnostic efficacy compared to using clinical features or CXR alone, with high sensitivity and specificity. Additionally, the AI system exhibited superiority in turn-around time and diagnostic accuracy compared to experienced pulmonary physicians in the reader study.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)