Article
Chemistry, Applied
Zedong Jiang, Xiwen Zhang, Liyang Wu, Hebin Li, Yanhong Chen, Lijun Li, Hui Ni, Qingbiao Li, Yanbing Zhu
Summary: Immobilized AlgL17, using magnetic Fe3O4 nanoparticles, showed enhanced thermal and pH tolerance, extended storage stability, and moderate reusability. The produced AOS exhibited antioxidant and antiapoptotic activities.
CARBOHYDRATE POLYMERS
(2021)
Article
Food Science & Technology
Ho-Jeong Bang, Mok-Ryeon Ahn
Summary: This study found that pinobanksin exhibits antiangiogenic effect by inducing endothelial cell apoptosis, and it can be developed as an antiangiogenic agent. The mechanism involves inactivation of the Raf/MEK/ERK pathway and activation of apoptotic signaling such as caspase cascades.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Yannan Song, Shuo Li, Huifang Chen, Xinyi Han, Gregory J. Duns, Wubliker Dessie, Wufei Tang, Yimin Tan, Zuodong Qin, Xiaofang Luo
Summary: Novel rapid hemostatic composite sponges were developed by incorporating kaolin (K) into carboxymethyl chitosan (CMCS)/sodium alginate (SA) using ionic crosslinking, polyelectrolyte action, and freeze-drying. The CMCS/SA-K sponges had good porous structure, water absorption properties, mechanical properties, biodegradability, and biocompatibility. They showed rapid hemostatic properties in vitro and in vivo, with significantly improved hemostatic time compared to commercially available gelatin sponges.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Huijuan Jing, Xiaojing Du, Ling Mo, Hongxin Wang
Summary: Carboxymethyl chitosan (CMCS)-based self-coacervates have shown great potential in drug oral delivery due to their pH-responsive properties and stability in a wide pH range. These self-coacervates also exhibit excellent encapsulation efficiency and loading capacity for lactoferrin (LF) encapsulation, protecting LF from hydrolysis during simulated gastric digestion. Overall, CMCS self-coacervation can be utilized as a pH-responsive encapsulation and delivery strategy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Environmental Sciences
Jiajing Cui, Pingwei Wang, Shuqi Yan, Yujun Liang, Dongge Liu, Shuping Ren
Summary: The study aims to explore the role of ferroptosis in endothelial cell dysfunction and its underlying mechanisms.
Article
Biochemistry & Molecular Biology
Kejia Kan, Yifei Mu, Marielle Bouschbacher, Carsten Sticht, Natalia Kuch, Martin Sigl, Nuh Rahbari, Norbert Gretz, Prama Pallavi, Michael Keese
Summary: The study revealed a novel biphasic response of human umbilical vein endothelial cells to blue light illumination. Low fluence blue light promoted cell activities, while high fluence illumination had the opposite effect by upregulating pro-apoptotic signaling pathways. These findings provide insights into photobiomodulation by blue light and potential treatment strategies for angiogenesis-dependent diseases.
Article
Chemistry, Medicinal
Chin-Feng Hsuan, Thung-Lip Lee, Wei-Kung Tseng, Chau-Chung Wu, Chi-Chang Chang, Tsui-Ling Ko, Ya-Ling Chen, Jer-Yiing Houng
Summary: The study demonstrated that extracts from Glossogyne tenuifolia (GT) can significantly increase nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs), with the root methanol extract showing the most potent effect. The root methanol extract increased NO production by increasing eNOS expression and activating eNOS phosphorylation at serine(1177).
Article
Pharmacology & Pharmacy
Ahmed M. Omer, Maha S. Ahmed, Gehan M. El-Subruiti, Randa E. Khalifa, Abdelazeem S. Eltaweil
Summary: Alg-CMCs@AmCs dual polyelectrolyte complexes were successfully employed as a pH-sensitive drug carrier for efficient encapsulation and release of diclofenac sodium. The developed microcapsules showed excellent stability and high encapsulation efficiency under colonic conditions, suggesting great potential for practical applications.
Article
Biochemistry & Molecular Biology
Mou Zhou, Fang Lin, Wendan Li, Linying Shi, Yanhui Li, Guiqiu Shan
Summary: The novel multi-functional platform dressing exhibited excellent performance in treating bacterial infected wounds, with synergistic effect of antibacterial property and wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Yongliang Ouyang, Yizhou Zhao, Xiaoyi Zheng, Yao Zhang, Jiulong Zhao, Shige Wang, Yubei Gu
Summary: In this study, a multifunctional bio-hemostatic hydrogel (CODM) was prepared using modified alginate, polyvinylpyrrolidone (PVP), and carboxymethyl chitosan. The addition of amino group-modified montmorillonite improved the hemostatic ability of the hydrogel, making it better than commercial hemostatic materials. The CODM hydrogel also demonstrated photothermal conversion ability and antibacterial properties, making it a promising candidate for emergency hemostasis and wound management.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Wei Liu, Yanghui Ou, Yumeng Yang, Xuemei Zhang, Liqi Huang, Xiaohua Wang, Buling Wu, Mingcheng Huang
Summary: The study demonstrated that punicalagin has a protective effect on HUVECs activation through an endothelial-mediated mechanism, which may be used in the treatment of various disorders such as cancer, rheumatoid arthritis, and cardiovascular disease. This effect is achieved by reducing adhesion of monocyte cells to HUVECs, decreasing expression of ICAM-1 and VCAM-1, and inhibiting permeability, proliferation, migration, and tube formation in VEGF-induced HUVECs. Additionally, punicalagin suppresses IKK-mediated activation of NF-kappa B signaling and inhibits VEGFR2 activation and downstream p-PAK1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Regina L. Binz, Rupak Pathak
Summary: This study investigated the cytogenetic integrity of primary human umbilical vein endothelial cells (HUVECs) and found that approximately 50% of the cells have a deletion of the Xq terminal region. Additionally, a similar Xq deletion was identified in the daughter cell line generated by fusing HUVECs with A549 cells.
Article
Food Science & Technology
Yuanfei Ge, Jinyong Wu, Min Pang, Dan Hu, Zhongkui Li, Xiangqin Wang, Lijie Sun, Xiangsong Chen, Jianming Yao
Summary: In this study, CNeuAc hydrogels were developed using CMCS and NeuAc to encapsulate Pediococcus pentosaceus QK-1. The hydrogel demonstrated optimal performance at a C-NeuAc concentration of 3% (w/v), and showed excellent biocompatibility and low cytotoxicity. It also effectively protected the viability of the probiotic in simulated gastric fluid and gastrointestinal tract.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Applied
Saeedeh Hosseini, Mehdi Varidi
Summary: This study evaluated the effects of alginate, chitosan, and CaCl2 on rennet encapsulation and optimized the process using RSM. Encapsulated enzyme showed higher activity at various pH and temperature, and the release mechanism was confirmed to be Fickian.
Article
Polymer Science
Tao Lin, Dandan Chen, Yan Geng, Jiayu Li, Yanghui Ou, Zhijun Zeng, Canqiang Yin, Xudong Qian, Xiang Qiu, Gang Li, Yali Zhang, Wen Guan, Mengjie Li, Xiaojia Cai, Jiaqiang Wu, Wen-Hua Chen, Yan-Qing Guan, Hongliang Yao
Summary: In this study, a compound with anti-inflammatory activity, 3J, was synthesized and incorporated into an intelligent composite hydrogel for the treatment of oral ulcers. The hydrogel exhibited a dense honeycomb structure for effective drug loading and wound ventilation, as well as biodegradability. It showed antibacterial effects, reduced inflammatory cytokine levels, and had excellent swelling and water retention properties, making it a promising treatment for oral ulcers.
