Article
Biochemistry & Molecular Biology
Monika Chauhan, Zahid Ahmad Dhar, Varun Gorki, Sonia Sharma, Ashwani Koul, Shashi Bala, Ramandeep Kaur, Sukhbir Kaur, Manu Sharma, Neelima Dhingra
Summary: Naturally occurring pentacyclic triterpenoids and their semisynthetic analogues have attracted increasing attention for their potential as anticancer agents. This study investigated the semi-synthetic modifications of Lantadenes and their anticancer activity against A375 & A431 cancer cell lines. The results showed that some novel analogues exhibited potent antiproliferative activity, with one specific compound showing the most promising potential with a low docking score and significant reduction in tumor volume in a carcinoma model.
Article
Biochemistry & Molecular Biology
Agerdanio Andrade de Souza, Brenda Lorena Sanchez Ortiz, Swanny Ferreira Borges, Andria Vanessa Pena Pinto, Ryan da Silva Ramos, Igor Colares Pena, Rosemary de Carvalho Rocha Koga, Carla Estefani Batista, Gisele Custodio de Souza, Adriana Maciel Ferreira, Sergio Duvoisin, Jose Carlos Tavares Carvalho
Summary: The study conducted a phytochemical characterization of the hydroethanolic extract of Trattinnickia rhoifolia leaves and evaluated its acute toxicity and anti-inflammatory activity in zebrafish. The results showed a diverse chemical profile of the extract and demonstrated its low toxicity and significant anti-inflammatory potential in zebrafish.
Article
Plant Sciences
Reham S. Darwish, Alaa A. El-Banna, Doaa A. Ghareeb, Mostafa F. El-Hosseny, Mohamed G. Seadawy, Hend M. Dawood
Summary: This study investigated the inhibitory activity of different L. camara cultivars to SARSCoV-2 and identified potential biomarkers related to the activity. The results showed that flowers and leaves extracts of certain cultivars exhibited high selectivity and efficacy as inhibitors of the virus. Molecular docking analysis revealed several compounds that could serve as promising anti-COVID-19 candidates. These findings highlight the potential of L. camara as a treatment for COVID-19.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Haiyang Wang, Ying Sun, Yonghong Xie, Fusheng Liu, Liwen Han
Summary: This study identified three new anti-inflammatory components of Green prickly ash fruit (GPAF) - Toddaline, Hydroxy-α-sanshool, and Hydroxy-13-sanshool, using a transgenic zebrafish model and UHPLC-QE-Orbitrap-MS technology. These findings provide scientific evidence for quality control and health product development of GPAF.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Plant Sciences
Mariam I. Gamal El-Din, Nouran M. Fahmy, Fulin Wu, Maha M. Salem, Omar M. Khattab, Hesham R. El-Seedi, Michal Korinek, Tsong-Long Hwang, Ahmed K. Osman, Mohamed El-Shazly, Shaimaa Fayez
Summary: The methanolic extracts of Lantana camara and Lantana montevidensis leaves show potential antioxidant, anti-inflammatory, and anticancer activities, inhibiting free radicals, cancer cell proliferation, reducing metastasis, and inducing apoptosis.
Article
Multidisciplinary Sciences
Priyanka R. Sapkal, Anilkumar U. Tatiya, Sandip D. Firke, Vivek K. Redasani, Shailendra S. Gurav, Muniappan Ayyanar, Prasad G. Jamkhande, Sanjay J. Surana, Rakesh E. Mutha, Mohan G. Kalaskar
Summary: This study assessed the phytochemical composition, antioxidant activity, cytotoxicity, and anti-inflammatory activity of Ailanthus excelsa stem bark extract and its fractions. The chloroform and ethyl acetate fractions showed stronger antioxidant activity. The chloroform fraction exhibited significant cytotoxic and anti-inflammatory effects, and the GC-MS analysis identified caftaric acid as a potential lead compound. Further studies are needed to explore the exact molecular mechanisms.
Article
Chemistry, Multidisciplinary
Rahul Kumar Vishwakarma, Aaysha Negi, Devendra Singh Negi
Summary: Lantana camara has multiple medicinal uses and shows potential as an anti-inflammatory agent through COX-1/2 inhibition. The methanolic extract of the plant exhibits the highest inhibition activity against COX-2, and certain phytochemicals demonstrate selectivity for COX-2 over COX-1.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Tran Thi Phuong Thao, Thanh Q. Bui, Nguyen Thi Thanh Hai, Lam K. Huynh, Phan Tu Quy, Nguyen Chi Bao, Nguyen Thi Dung, Nguyen Linh Chi, Tran Van Loc, Irina E. Smirnova, Anastasiya Petrova, Pham Thi Ninh, Tran Van Sung, Nguyen Thi Ai Nhung
Summary: The study isolated natural dipterocarpol from Dipterocarpus alatus and semi-synthesized 20 derivatives, including 13 oxime esters and 7 lactones. Some compounds were found to inhibit diabetes-related proteins, with some being reported for the first time in this study.
Article
Biochemistry & Molecular Biology
Mandeep Kaur, Hafiz Muzzammel Rehman, Gurmeet Kaur, Amandeep Kaur, Manisha Bansal
Summary: A new series of linker-based derivatives of non-steroidal anti-inflammatory drugs were synthesized and characterized. The study focused on understanding the switch in the anti-inflammatory and anticancer activity of compounds 8 and 10 through in-silico and in-vitro studies. The molecular docking study showed the importance of hetero atoms and proper alignment in the binding pocket for bioactivity. Compound 8 exhibited better inhibitory activity against the COX-2 target site, possibly due to the presence of 1,3-dicarbonyl interactions, whereas compound 10 showed increased potency towards anticancer activity. In-vitro assays confirmed the results obtained from the in-silico study.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jian-Chun Li, Shu-Yi Li, Jian-Xian Tang, Dan Liu, Xiao-Yi Feng, Kai-Rui Rao, Xu-Dong Zhao, Hong-Mei Li, Rong-Tao Li
Summary: Six undescribed triterpenoids and two undescribed C21-steroidal glycosides, along with fifty-four known compounds, were isolated from the roots of Euphorbia kansui. The structures of these compounds were determined through spectroscopic analysis, and the absolute configuration of one compound was elucidated using ECD calculation. These compounds exhibited various biological activities, including inhibition of nitric oxide production and cytotoxicity against cancer cell lines. Importantly, a compound called euphol showed selective inhibition against human glioma stem cells.
Article
Immunology
Chang-Kwon Kim, Jayeon Yu, DucDat Le, Sanghee Han, Soojung Yu, Mina Lee
Summary: In this study, three new caffeic acid benzyl ester (CABE) analogs and eight known compounds were isolated from Ilex rotunda. Compound 2 demonstrated significant anti-inflammatory properties by suppressing the production of pro-inflammatory mediators and cytokines. Molecular docking simulations showed potential interactions between compound 2 and iNOS protein, suggesting its potential as a candidate for treating inflammatory bowel disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qianqian Xu, Yuben Qiao, Zijun Zhang, Yanfang Deng, Tianqi Chen, Li Tao, Qiaoxin Xu, Junjun Liu, Weiguang Sun, Ying Ye, Yuanyuan Lu, Changxing Qi, Yonghui Zhang
Summary: Two new polyketide compounds, asperulosins A and B, and one new prenylated small molecule, asperulosin C, along with nine known compounds were isolated from a fungus Aspergillus rugulosa. The new compounds showed potential as anti-inflammatory agents, inhibiting NO production and modulating cytokine secretion in a manner comparable to the positive control, dexamethasone.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alecsanndra L. Gonzales, Steven Kuan-Hua Huang, Ureah Thea A. Sevilla, Cheng-Yang Hsieh, Po-Wei Tsai
Summary: Crescentia cujete, a widely used medicinal plant, has shown potential as an anti-inflammatory and antioxidant. However, limited research on its pharmacological potential and bioactive compounds has hindered progress in pharmacology and new drug discovery. This study utilized in silico analysis to evaluate the potential of identified bioactive compounds in the plant for antioxidant and anti-inflammatory applications. Results showed that naringenin, pinocembrin, and eriodictyol displayed the most potential as inhibitors of target proteins involved in inflammation and oxidation pathways.
Article
Medicine, Research & Experimental
Jiaojiao Wang, Dihui Xu, Lili Shen, Jing Zhou, Xiang Lv, Hongyue Ma, Nianguang Li, Qinan Wu, Jinao Duan
Summary: Bufotenine shows great potential as a novel anti-inflammatory and analgesic agent by regulating lipid metabolism pathways, providing a systemic evidence for its actions and mechanism in reducing inflammatory pain disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Inorganic & Nuclear
Sellamuthu Kathiresan, Mookkandi Palsamy Kesavan, Jamespandi Annaraj, Lokesh Ravi
Summary: This research article presents the successful chemical synthesis of a novel thiosemicarbazone ligand and its metal complexes. Spectral and molecular docking analyses revealed that the metal complexes exhibited strong binding affinity and DNA cleavage activity. Complex 1 showed the highest binding affinity and DNA cleavage activity. Complex 2 exhibited the strongest affinity for BSA and showed potential as a protein binder. Additionally, complex 1 showed effective hydrogen atom donation and inhibition of damaging effects, while complex 2 exhibited the highest scavenging activity against H2O2. The findings contribute to the understanding of the potential of complexes 1 and 2 as DNA and protein targeting agents.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Correction
Biochemistry & Molecular Biology
Mohamed Marzouk, Shimaa M. Khalifa, Amal H. Ahmed, Ahmed M. Metwaly, Hala Sh. Mohammed, Hanan A. A. Taie
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Gerardo Andres Libreros-Zuniga, Danilo Pava e Pavao, Vinicius de Morais Barroso, Nathalya Cristina de Moraes Roso Mesquita, Saulo Fehelberg Pinto Braga, Glaucius Oliva, Rafaela Salgado Ferreira, Kelly Ishida, Marcio Vinicius Bertacine Dias
Summary: Tuberculosis is a major global cause of death, and the emergence of drug-resistant strains has increased the burden of this disease. New alternative therapies are constantly needed, and recent research has identified small molecules as potential inhibitors of Ldts in M. tuberculosis, which have antimycobacterial activity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiao-Dong Wang, Yong-Si Liu, Ming-Hao Hu
Summary: In this study, a selffolded fluorescent probe was designed to selectively illuminate G4s by unfolding its intramolecular aggregation mediated by G4 binding. This probe showed more controllable background emission and promising ability to track G4 forming dynamics compared to previous disaggregation-induced emission (DIE) probes.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Xiang, Zhuo Yuan, Qichuan Deng, Linshen Xie, Dongke Yu, Jianyou Shi
Summary: This review provides a brief description of the diagnosis, pathogenesis, and potential therapeutic inhibitors for renal fibrosis. Currently, there are no clear therapeutic targets or drugs for renal fibrosis; however, some natural products may have potential efficacy for treating renal fibrosis.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Simone Giovannuzzi, Anna Nikitjuka, Bruna Rafaela Pereira Resende, Michael Smietana, Alessio Nocentini, Claudiu T. Supuran, Jean-Yves Winum
Summary: Boron-based compounds have been extensively studied in medicinal chemistry, playing a crucial role in designing small molecule drugs for various diseases. Boron is particularly valuable in developing inhibitors for metalloenzymes carbonic anhydrases, and it can modulate ligand recognition ability and selectivity. Recent advancements have led to the discovery of novel boron-based inhibitors that can inhibit carbonic anhydrases through a Lewis acid-base mechanism. Further research is needed to fully explore the potential of boron-based inhibitors and advance their clinical applications.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinxin Liu, Lei Chen, Ze Chen
Summary: This study developed a nanostructured photosensitizer loaded with oxygen-throttling drug and demonstrated its enhanced cytotoxicity against tumor cells under hypoxic conditions. Animal experiments showed the enhanced tumor targeting capability of the photosensitizer and its inhibitory effect on tumor growth.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuai Jiang, Wen-Yan Li, Zai-Feng Yuan, Qin-Shi Zhao
Summary: This study isolated two new dimeric Lycopodium alkaloids and twelve previously undescribed Lycopodium alkaloids from Lycopodiastrum casuarinoides. The structures of these compounds were determined and their inhibitory activities on the Cav3.1 channel were evaluated.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yan Yang, Dong-Xiao Yan, Rui-Xue Rong, Bing-Ye Shi, Man Zhang, Jing Liu, Jie Xin, Tao Xu, Wen-Jie Ma, Xiao-Liu Li, Ke-Rang Wang
Summary: In this study, a series of nucleolar fluorescent probes based on naphthalimide derivatives were designed and synthesized, which could achieve clear nucleolar staining in living cells. The results showed that these probes exhibited good targeting to the cell nucleolus and could bind to RNA and enhance fluorescence. This has positive implications for the diagnosis and treatment of nucleolus-related diseases.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yongxi Dong, Fang Wang, Jinlan Wen, Yongqing Mao, Shanhui Zhang, Tiemei Long, Zhangxiang Yang, Lei Li, Jiquan Zhang, Li Dong, Gang Liu, Jianwei Xu
Summary: The hybrid molecules of Scutellarein and Tertramethylpyrazine show excellent neuroprotective and antiplatelet effects in the treatment of ischemic stroke. Compound 1e is particularly effective, enhancing cell membrane permeability and inhibiting cell uptake, as well as significantly reducing cerebral infarction volume.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Chen, Yuanyuan Ying, Jonathan Lalsiamthara, Yuheng Zhao, Saber Imani, Xin Li, Sijing Liu, Qingjing Wang
Summary: This paper examines the role and metabolic regulation of NAD+ in bacteria, highlighting its impact on physiology and virulence. It explores enzymes associated with NAD+ metabolism as potential targets for antibacterial drugs and vaccine candidates. Additionally, it scrutinizes the medical potential of NAD+ and provides insights for its application in biomedicine.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jon Macicior, Daniel Fernandez, Silvia Ortega-Gutierrez
Summary: Hutchinson-Gilford progeria syndrome (HGPS), also known as progeria, is a rare genetic disease that causes premature aging and significantly reduces life expectancy. Currently, there is only one approved drug for treating progeria, but its efficacy is limited. Progerin levels are believed to be the most important biomarker related to disease severity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Fuko Hirano, Naoya Kondo, Yusuke Murata, Aya Sudani, Takashi Temma
Summary: Fluorinated alpha-methyl 3BPA derivatives showed improved water solubility, tumor targetability, and biodistribution compared to 3BPA and BPA, resulting in significantly improved tumor-to-normal tissue ratios.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ying Shi, Jiaqin Tang, Shumeng Zhi, Ruiqi Jiang, Qing Huang, Lei Sun, Zhizhong Wang, Yanran Wu
Summary: Necroptosis is a type of cell death associated with various diseases. In this study, we identified a small molecule inhibitor, SY-1, that effectively blocks necroptosis by inhibiting the phosphorylation of RIP1/RIP3/MLKL pathway. SY-1 also showed protective effects against TNF-induced hypothermia and improved survival in mice with SIRS. These findings highlight the potential therapeutic applications of SY-1.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Andrea Bagan, Sonia Abas, Judith Pala-Pujadas, Alba Irisarri, Christian Grinan-Ferre, Merce Pallas, Itziar Muneta-Arrate, Carolina Muguruza, Luis F. Callado, Belen Perez, Elies Molins, Jose A. Morales-Garcia, Carmen Escolano
Summary: Recent studies have identified the modulation of imidazoline I-2 receptors (I-2-IR) by selective ligands as a potential strategy for treating neurodegenerative diseases. This study reports a family of bicyclic alpha-iminophosphonates that show high affinity and selectivity for I-2-IR and demonstrates their neuroprotective and anti-inflammatory effects in in vitro and in vivo models. The findings emphasize the importance of exploring structurally novel I-2-IR ligands for therapeutic strategies in neurodegeneration.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qiuping Xiang, Tianbang Wu, Cheng Zhang, Chao Wang, Hongrui Xu, Qingqing Hu, Jiankang Hu, Guolong Luo, Xiaoxi Zhuang, Xishan Wu, Yan Zhang, Yong Xu
Summary: This study reports the discovery of a 1-(indolizin-3-yl)ethan-1-one derivative as a potent and selective CBP bromodomain inhibitor for AML drug development.
BIOORGANIC CHEMISTRY
(2024)