Article
Biochemistry & Molecular Biology
Rong-Wei Kou, Bing Xia, Zhi-Ju Wang, Jian-Nan Li, Jun-Ren Yang, Yu-Qi Gao, Xia Yin, Jin-Ming Gao
Summary: Ganoresinoid A from Ganoderma resinaceum exhibits anti-inflammatory, antioxidative, and anti-apoptosis activities. It inhibits the release of inflammatory cytokines and reduces cell apoptosis by suppressing TLR-4/NF-κB and MAPK signaling pathways. In addition, Ganoresinoid A has antioxidant effects by activating the Akt/GSK-3β/Nrf2 signaling pathway. These findings provide a theoretical basis for using Ganoresinoid A as a nutritional intervention for neurodegenerative diseases.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Zhen-Zhu Zhao, Bao-Yu Ji, Zhen-Zhen Wang, Ying-Ying Si, Yan-Jun Sun, Hui Chen, Wei-Sheng Feng, Xiao-Ke Zheng, Ji-Kai Liu
Summary: Eight new lanostane triterpenoids and nine known ones were discovered in the fruiting bodies of Ganoderma lingzhi S.H. Wu, Y. Cao & Y.C. Dai. Their structures were determined using spectroscopic data and quantum chemical calculations. Among them, ganoderane GL-1, containing a hydrogenated tetramethylsphenanthraquinone, is the first example in the lanostane nor-triterpenoid group. In terms of biological activity, ganoderanes GL-2 and GL-3, which have a rare 1,11-epoxy moiety, showed significant inhibition against nitric oxide production induced by lipopolysaccharide in RAW264.7 macrophage cells, while ganoderanes GL-4 and GL-8 exhibited bifunctional activities of anti-proliferation and anti-inflammation.
Article
Microbiology
Xing-Rong Peng, Qian Wang, Hai-Guo Su, Lin Zhou, Wen-Yong Xiong, Ming-Hua Qiu
Summary: This study focused on the lanostane triterpenoids from Ganoderma applanatum and isolated forty highly oxygenated compounds, including sixteen new compounds. The structures of these compounds were identified and their anti-adipogenesis activities were evaluated. Some compounds exhibited stronger effects than the positive control and a key role of the A-seco-23 -> 26 lactone skeleton in anti-adipogenesis activity was established.
Article
Biochemistry & Molecular Biology
Hai-Guo Su, Qian Wang, Lin Zhou, Xing-Rong Peng, Wen-Yong Xiong, Ming -Hua Qiu
Summary: The study identified compounds in Ganoderma applanatum extract that have antiadipogenic effects, with a new compound showing potential in inhibiting adipogenesis. This suggests a new perspective for treating obesity by utilizing these compounds.
BIOORGANIC CHEMISTRY
(2021)
Article
Plant Sciences
Chien-Ming Wu, Chun-Nan Lin, Hui-Chia Chen, Shin C. Chang, Ming-Fu Chang, Kai-Wei Lin
Summary: Two undescribed lanostane triterpenoids, tsugaric acids G (1) and H (2), and a known compound, N-(3';alpha,4';beta-dihydroxy-2';beta-(hydroxymethyl)-1';beta-(cyclobutyl) palmitamide (3), were isolated and characterized from the fruiting bodies of Ganoderma tsugae. Compound 3 exhibited significant anti-HCV activity.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Arunrat Yangchum, Ryoma Fujii, Wilunda Choowong, Pranee Rachtawee, Maneerat Pobkwamsuk, Thitiya Boonpratuang, Seiji Mori, Masahiko Isaka
Summary: In the search for medicinally active compounds in Ganoderma mushrooms, eleven previously undescribed lanostane triterpenoids were isolated, including a novel chlorinated derivative. Two of these compounds exhibited moderate antimalarial activity.
Article
Biochemistry & Molecular Biology
Khadija Hassan, Blondelle Matio Kemkuignou, Marc Stadler
Summary: The study isolated two new triterpenoids and four known triterpenes from the fruiting body of Laetiporus sulphureus. Laetiporin C showed weak antifungal activity against Mucor hiemalis, and the compounds exhibited weak antiproliferative activity against mouse fibroblast cells and various human cancer cell lines.
Article
Biochemistry & Molecular Biology
Da-Wei Li, Min Liu, Yue-Qi Leng, Jin-Fang Hu, Sa Deng, Ai-Jing Leng, Xiao-Chi Ma, Ruo-Yu Wang, Jian Zhou, Chao Wang
Summary: This study investigated the bioactive phytochemicals in Ganoderma lucidum and found that its triterpenoids showed inhibitory effects on the enzyme FAAH, indicating their potential for treating neuroinflammation.
Article
Biochemistry & Molecular Biology
Qingyun Ma, Shuangshuang Zhang, Li Yang, Qingyi Xie, Haofu Dai, Zhifang Yu, Youxing Zhao
Summary: This study isolated 26 lanostane triterpenoids and 8 ergostane steroids from the fruiting bodies of Macrofungus Ganoderma luteomarginatum. Several compounds including lanostane triterpenoids 1, 2, 7, 13, 18, 22, and 24, as well as ergostane steroid 34, showed significant cytotoxicity against human cancer cell lines, suggesting their potential anti-tumor activity.
Article
Biochemistry & Molecular Biology
Li Yang, De-Xian Kong, Na Xiao, Qing-Yun Ma, Qing-Yi Xie, Jiao-Cen Guo, Chun Ying Deng, Hai-Xia Ma, Yan Hua, Hao-Fu Dai, You-Xing Zhao
Summary: Eight new lanostane triterpenoids, along with eighteen known compounds, were isolated from Ganoderma weberianum. The structures and configurations of the new compounds were determined through spectroscopic analysis, NMR chemical shifts, and ECD calculations. Some of the isolated compounds showed significant alpha-glucosidase inhibitory activity, inhibition of hepatic glucose production, and antitumor activity against HeLa cells.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ren-Fen Ma, Kun Hu, Wen-Ping Ding, Bin Wang, Tao-Bin He, Xiao-Nian Li, Han-Dong Sun, Pema-Tenzin Puno
Summary: A series of undescribed lanostane and cycloartane-type triterpenoids, Schipropins A-J, were isolated from the stems and leaves of Schisandra propinqua. Most of their structures were determined by C-3/C-4 cleavage and some were characterized by single-crystal X-ray diffraction. Schipropins E and G exhibited moderate inhibitory activity on NO production.
Article
Biochemistry & Molecular Biology
Xueqing Zhang, Xiaoxu Gao, Guoqing Long, Yongcheng Yang, Gang Chen, Guoli Hou, Xuting Huo, Jingming Jia, Anhua Wang, Gaosheng Hu
Summary: This study isolated and identified 10 undescribed lanostane triterpenoids and 21 known compounds from statically cultured mycelial mat of G. lucidum. The hepatoprotective activities of these compounds in H2O2-induced HepG2 cells were evaluated, and the structure-activity relationship was discussed.
Article
Plant Sciences
Jiang Hu, Guo-Fen Li, Feng-Ming Xu, Qiang Li, Tao Lv, Tian-Feng Peng, Si Yin, Wei Gong
Summary: This study isolated two previously undescribed lanostane triterpenoids, as well as one known compound, from the extract of Ganoderma tsugae. The structures of all compounds were determined by spectral methods. The antibacterial activities of all triterpenoids were evaluated, and one compound exhibited activity against three Gram positive bacteria.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Chemistry, Applied
Arunrat Yangchum, Pranee Rachtawee, Kitlada Srichomthong, Rattaket Choeyklin, Thitiya Boonpratuang, Chawanee Thongpanchang, Masahiko Isaka
Summary: Chemical investigation of artificially cultivated fruiting bodies of Ganoderma cf. mastoporum, strain TBRC-BCC 47851, led to the discovery of three undescribed lanostane triterpenoids (1-3) and twelve known compounds. The structures of these new compounds were determined through NMR spectroscopy and mass spectrometry. However, the new compounds showed no activity in the antimalarial and antitubercular assays.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiao-Cui Li, Fei Liu, Hai-Guo Su, Cheng Peng, Qin-Mei Zhou, Juan Liu, Yuan-Jin Huang, Li Guo, Liang Xiong
Summary: This study isolated twelve previously undescribed lanostane-type triterpene acids from Ganoderma luteomarginatum, with some compounds showing significant cytotoxicity against human cancer cells. The comparison with previous literature revealed that ganoderic alcohols have stronger cytotoxicity than ganoderic acid derivatives in the genus Ganoderma.
Article
Biochemistry & Molecular Biology
Yan-Jie Huang, Ling-Yun Zhou, Jun-Min Wang, Qiang Li, Yuan-Yuan Geng, Hai-Yang Liu, Yan Hua
Article
Chemistry, Organic
Xing-Rong Peng, Yan-Jie Huang, Shuang-Yang Lu, Jing Yang, Ming-Hua Qiu
JOURNAL OF ORGANIC CHEMISTRY
(2018)
Article
Agriculture, Multidisciplinary
Yanjie Huang, Xian Li, Xingrong Peng, Adelakun Tiwalade Adegoke, Jianchao Chen, Haiguo Su, Guilin Hu, Gang Wei, Minghua Qiu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Qiangqiang Shi, Yanjie Huang, Haiguo Su, Ya Gao, Xingrong Peng, Lin Zhou, Xiaonian Li, Minghua Qiu
Article
Food Science & Technology
Yanjie Huang, Gang Wei, Xingrong Peng, Guilin Hu, Haiguo Su, Junli Liu, Xia Chen, Minghua Qiu
FOOD RESEARCH INTERNATIONAL
(2020)
Article
Chemistry, Applied
Xing-Rong Peng, Yan-Jie Huang, Jun-Hong Liu, Ran-Ran Zhang, Zhong-Rong Li, Lin Zhou, Ming-Hua Qiu
Summary: A valid 1H qNMR method was developed and applied to quantify total macamides in different maca samples, showing a correlation between the content of total macamides and the origins and colors, with China purple maca having the highest content. Additionally, a new macamide with a unique structure was identified.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2021)
Article
Nutrition & Dietetics
Fei-Fei Mao, Shan-Shan Gao, Yan-Jie Huang, Nian Zhou, Jin-Kai Feng, Zong-Han Liu, Yu-Qing Zhang, Lu-Yun Yuan, Gang Wei, Shu-Qun Cheng
Summary: Ganoderma triterpenoids (GTs), especially Resinacein S, have been found to regulate lipid metabolism and mitochondrial biogenesis, which may have potential protective effects against nonalcoholic fatty liver disease (NAFLD).
FRONTIERS IN NUTRITION
(2023)
Correction
Biochemistry & Molecular Biology
Mohamed Marzouk, Shimaa M. Khalifa, Amal H. Ahmed, Ahmed M. Metwaly, Hala Sh. Mohammed, Hanan A. A. Taie
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Gerardo Andres Libreros-Zuniga, Danilo Pava e Pavao, Vinicius de Morais Barroso, Nathalya Cristina de Moraes Roso Mesquita, Saulo Fehelberg Pinto Braga, Glaucius Oliva, Rafaela Salgado Ferreira, Kelly Ishida, Marcio Vinicius Bertacine Dias
Summary: Tuberculosis is a major global cause of death, and the emergence of drug-resistant strains has increased the burden of this disease. New alternative therapies are constantly needed, and recent research has identified small molecules as potential inhibitors of Ldts in M. tuberculosis, which have antimycobacterial activity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiao-Dong Wang, Yong-Si Liu, Ming-Hao Hu
Summary: In this study, a selffolded fluorescent probe was designed to selectively illuminate G4s by unfolding its intramolecular aggregation mediated by G4 binding. This probe showed more controllable background emission and promising ability to track G4 forming dynamics compared to previous disaggregation-induced emission (DIE) probes.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Xiang, Zhuo Yuan, Qichuan Deng, Linshen Xie, Dongke Yu, Jianyou Shi
Summary: This review provides a brief description of the diagnosis, pathogenesis, and potential therapeutic inhibitors for renal fibrosis. Currently, there are no clear therapeutic targets or drugs for renal fibrosis; however, some natural products may have potential efficacy for treating renal fibrosis.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Simone Giovannuzzi, Anna Nikitjuka, Bruna Rafaela Pereira Resende, Michael Smietana, Alessio Nocentini, Claudiu T. Supuran, Jean-Yves Winum
Summary: Boron-based compounds have been extensively studied in medicinal chemistry, playing a crucial role in designing small molecule drugs for various diseases. Boron is particularly valuable in developing inhibitors for metalloenzymes carbonic anhydrases, and it can modulate ligand recognition ability and selectivity. Recent advancements have led to the discovery of novel boron-based inhibitors that can inhibit carbonic anhydrases through a Lewis acid-base mechanism. Further research is needed to fully explore the potential of boron-based inhibitors and advance their clinical applications.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinxin Liu, Lei Chen, Ze Chen
Summary: This study developed a nanostructured photosensitizer loaded with oxygen-throttling drug and demonstrated its enhanced cytotoxicity against tumor cells under hypoxic conditions. Animal experiments showed the enhanced tumor targeting capability of the photosensitizer and its inhibitory effect on tumor growth.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuai Jiang, Wen-Yan Li, Zai-Feng Yuan, Qin-Shi Zhao
Summary: This study isolated two new dimeric Lycopodium alkaloids and twelve previously undescribed Lycopodium alkaloids from Lycopodiastrum casuarinoides. The structures of these compounds were determined and their inhibitory activities on the Cav3.1 channel were evaluated.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yan Yang, Dong-Xiao Yan, Rui-Xue Rong, Bing-Ye Shi, Man Zhang, Jing Liu, Jie Xin, Tao Xu, Wen-Jie Ma, Xiao-Liu Li, Ke-Rang Wang
Summary: In this study, a series of nucleolar fluorescent probes based on naphthalimide derivatives were designed and synthesized, which could achieve clear nucleolar staining in living cells. The results showed that these probes exhibited good targeting to the cell nucleolus and could bind to RNA and enhance fluorescence. This has positive implications for the diagnosis and treatment of nucleolus-related diseases.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yongxi Dong, Fang Wang, Jinlan Wen, Yongqing Mao, Shanhui Zhang, Tiemei Long, Zhangxiang Yang, Lei Li, Jiquan Zhang, Li Dong, Gang Liu, Jianwei Xu
Summary: The hybrid molecules of Scutellarein and Tertramethylpyrazine show excellent neuroprotective and antiplatelet effects in the treatment of ischemic stroke. Compound 1e is particularly effective, enhancing cell membrane permeability and inhibiting cell uptake, as well as significantly reducing cerebral infarction volume.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Chen, Yuanyuan Ying, Jonathan Lalsiamthara, Yuheng Zhao, Saber Imani, Xin Li, Sijing Liu, Qingjing Wang
Summary: This paper examines the role and metabolic regulation of NAD+ in bacteria, highlighting its impact on physiology and virulence. It explores enzymes associated with NAD+ metabolism as potential targets for antibacterial drugs and vaccine candidates. Additionally, it scrutinizes the medical potential of NAD+ and provides insights for its application in biomedicine.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jon Macicior, Daniel Fernandez, Silvia Ortega-Gutierrez
Summary: Hutchinson-Gilford progeria syndrome (HGPS), also known as progeria, is a rare genetic disease that causes premature aging and significantly reduces life expectancy. Currently, there is only one approved drug for treating progeria, but its efficacy is limited. Progerin levels are believed to be the most important biomarker related to disease severity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Fuko Hirano, Naoya Kondo, Yusuke Murata, Aya Sudani, Takashi Temma
Summary: Fluorinated alpha-methyl 3BPA derivatives showed improved water solubility, tumor targetability, and biodistribution compared to 3BPA and BPA, resulting in significantly improved tumor-to-normal tissue ratios.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ying Shi, Jiaqin Tang, Shumeng Zhi, Ruiqi Jiang, Qing Huang, Lei Sun, Zhizhong Wang, Yanran Wu
Summary: Necroptosis is a type of cell death associated with various diseases. In this study, we identified a small molecule inhibitor, SY-1, that effectively blocks necroptosis by inhibiting the phosphorylation of RIP1/RIP3/MLKL pathway. SY-1 also showed protective effects against TNF-induced hypothermia and improved survival in mice with SIRS. These findings highlight the potential therapeutic applications of SY-1.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Andrea Bagan, Sonia Abas, Judith Pala-Pujadas, Alba Irisarri, Christian Grinan-Ferre, Merce Pallas, Itziar Muneta-Arrate, Carolina Muguruza, Luis F. Callado, Belen Perez, Elies Molins, Jose A. Morales-Garcia, Carmen Escolano
Summary: Recent studies have identified the modulation of imidazoline I-2 receptors (I-2-IR) by selective ligands as a potential strategy for treating neurodegenerative diseases. This study reports a family of bicyclic alpha-iminophosphonates that show high affinity and selectivity for I-2-IR and demonstrates their neuroprotective and anti-inflammatory effects in in vitro and in vivo models. The findings emphasize the importance of exploring structurally novel I-2-IR ligands for therapeutic strategies in neurodegeneration.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qiuping Xiang, Tianbang Wu, Cheng Zhang, Chao Wang, Hongrui Xu, Qingqing Hu, Jiankang Hu, Guolong Luo, Xiaoxi Zhuang, Xishan Wu, Yan Zhang, Yong Xu
Summary: This study reports the discovery of a 1-(indolizin-3-yl)ethan-1-one derivative as a potent and selective CBP bromodomain inhibitor for AML drug development.
BIOORGANIC CHEMISTRY
(2024)
