Towards delineating the chain of events that cause premature senescence in the accelerated aging syndrome Hutchinson–Gilford progeria (HGPS)

Heterochromatin loss as a determinant of progerin‐induced DNA damage in Hutchinson–Gilford Progeria

(2020) Alexandre Chojnowski et al.   AGING CELL

Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria

(2020) Kohta Ikegami et al.   DEVELOPMENTAL CELL

Development of a CRISPR/Cas9-based therapy for Hutchinson–Gilford progeria syndrome

(2019) Olaya Santiago-Fernández et al.   NATURE MEDICINE

Accumulation of progerin affects the symmetry of cell division and is associated with impaired Wnt signaling and the mislocalization of nuclear envelope proteins

(2019) Agustín Sola-Carvajal et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transient introduction of human telomerase mRNA improves hallmarks of progeria cells

(2019) Yanhui Li et al.   AGING CELL

Premature aging syndromes: From patients to mechanism

(2019) Mattheus Xing Rong Foo et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome

(2019) Julio Aguado et al.   Nature Communications

Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing

(2018) Vittoria Cenni et al.   AGEING RESEARCH REVIEWS

Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome

(2018) Magda R. Hamczyk et al.   Annual Review of Physiology

A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin

(2018) Ray Kreienkamp et al.   Cell Reports

Causes and consequences of genomic instability in laminopathies: Replication stress and interferon response

(2018) Simona Graziano et al.   Nucleus

Causes and consequences of genomic instability in laminopathies: Replication stress and interferon response

(2018) Simona Graziano et al.   Nucleus

Progerin sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid syndromes

(2017) Benjamin A. Hilton et al.   FASEB JOURNAL

Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome

(2017) Keith Wheaton et al.   MOLECULAR AND CELLULAR BIOLOGY

The molecular architecture of lamins in somatic cells

(2017) Yagmur Turgay et al.   NATURE

Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

(2017) Nard Kubben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient

(2016) Andrew M. Cobb et al.   AGING CELL

Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells

(2016) Dido Carrero et al.   Disease Models & Mechanisms

Molecular insights into the premature aging disease progeria

(2016) Sandra Vidak et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence

(2016) Romina Burla et al.   Open Biology

Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling

(2016) Andrew M. Cobb et al.   Nucleus

Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling

(2016) Andrew M. Cobb et al.   Nucleus

Accelerated aging syndromes, are they relevant to normal human aging?

(2016) Oliver Dreesen et al.   Aging-US

Dynamics of Cell Generation and Turnover in the Human Heart

(2015) Olaf Bergmann et al.   CELL

Networking in the nucleus: a spotlight on LEM-domain proteins

(2015) Lacy J Barton et al.   CURRENT OPINION IN CELL BIOLOGY

Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force

(2015) Elizabeth A. Booth et al.   Soft Matter

Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria

(2015) Alexandre Chojnowski et al.   eLife

TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends

(2014) Ashley M. Wood et al.   Nature Communications

Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targeting

(2014) Di Wu et al.   Nucleus

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

When Lamins Go Bad: Nuclear Structure and Disease

(2013) Katherine H. Schreiber et al.   CELL

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Lamin A/C Depletion Enhances DNA Damage-Induced Stalled Replication Fork Arrest

(2013) Mayank Singh et al.   MOLECULAR AND CELLULAR BIOLOGY

Cardiomyocyte proliferation contributes to heart growth in young humans

(2013) Mariya Mollova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

DNA Replication Timing

(2013) N. Rhind et al.   Cold Spring Harbor Perspectives in Biology

Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome

(2012) R. P. McCord et al.   GENOME RESEARCH

The nuclear lamins: flexibility in function

(2012) Brian Burke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human Telomeres Are Tethered to the Nuclear Envelope during Postmitotic Nuclear Assembly

(2012) Laure Crabbe et al.   Cell Reports

DNA-damage accumulation and replicative arrest in Hutchinson–Gilford progeria syndrome

(2011) Phillip R. Musich et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nuclear lamina at the crossroads of the cytoplasm and nucleus

(2011) Larry Gerace et al.   JOURNAL OF STRUCTURAL BIOLOGY

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

(2011) Raffaella Di Micco et al.   NATURE CELL BIOLOGY

Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

(2011) F. G. Osorio et al.   Science Translational Medicine

A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects

(2010) Jinqiu Zhang et al.   Cell Stem Cell

Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence

(2010) E. K. Benson et al.   JOURNAL OF CELL SCIENCE

Replication Timing of Human Telomeres Is Chromosome Arm–Specific, Influenced by Subtelomeric Structures and Connected to Nuclear Localization

(2010) Nausica Arnoult et al.   PLoS Genetics

Syndromes of Telomere Shortening

(2009) Mary Armanios   Annual Review of Genomics and Human Genetics

Dyskeratosis congenita, stem cells and telomeres

(2009) Michael Kirwan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway

(2009) Ignacio Gonzalez-Suarez et al.   EMBO JOURNAL

Polycomb protein Ezh2 regulates pancreatic  -cell Ink4a/Arf expression and regeneration in diabetes mellitus

(2009) H. Chen et al.   GENES & DEVELOPMENT

Telomere length in Hutchinson-Gilford Progeria Syndrome

(2009) Michelle L. Decker et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Ageing-related chromatin defects through loss of the NURD complex

(2009) Gianluca Pegoraro et al.   NATURE CELL BIOLOGY

Evidence for Cardiomyocyte Renewal in Humans

(2009) Olaf Bergmann et al.   SCIENCE

Increased mechanosensitivity and nuclear stiffness in Hutchinson–Gilford progeria cells: effects of farnesyltransferase inhibitors

(2008) Valerie L. R. M. Verstraeten et al.   AGING CELL

Nuclear Shape, Mechanics, and Mechanotransduction

(2008) Kris Noel Dahl et al.   CIRCULATION RESEARCH

Suppression of Proliferative Defects Associated with Processing-defective Lamin A Mutants by hTERT or Inactivation of p53

(2008) Brian A. Kudlow et al.   MOLECULAR BIOLOGY OF THE CELL

Phenotype and Course of Hutchinson–Gilford Progeria Syndrome

(2008) Melissa A. Merideth et al.   NEW ENGLAND JOURNAL OF MEDICINE