Review
Neurosciences
Thiago Caetano Andrade Belo, Gabriela Xavier Santos, Bruno Eduardo Gabriel da Silva, Bruno Lopes Goncalves Rocha, Dennis William Abdala, Larissa Alves Moreira Freire, Fernanda Santos Rocha, Giovane Galdino
Summary: This review summarizes recent advances in understanding the mechanism by which IL-10/β-endorphin can reduce pain. Studies have demonstrated that IL-10 can stimulate receptors and signaling pathways, resulting in increased β-endorphin expression and secretion. Additionally, certain drugs and non-pharmacological treatments reduce pain through IL-10 mediated mechanisms, highlighting the importance of this process in pain neuroimmunology.
Article
Pharmacology & Pharmacy
Meng-Yan Deng, Khalil Ali Ahmad, Qiao-Qiao Han, Zi-Ying Wang, Rana Muhammad Shoaib, Xin-Yan Li, Yong-Xiang Wang
Summary: The study showed that thalidomide alleviates neuropathic pain by upregulating spinal microglial IL-10 and beta-endorphin expression rather than downregulating TNF alpha expression.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Neurosciences
Le Ma, Shiyu Peng, Jinbao Wei, Mengjing Zhao, Khalil Ali Ahmad, Jinghong Chen, Yong-Xiang Wang
Summary: This study investigated the regulation of pain hypersensitivity by IL-10 and GLP-1R agonist exenatide in neuropathic rats, showing that spinal microglial expression of beta-endorphin mediates the inhibitory effects.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Immunology
Khalil Ali Ahmad, Rana Muhammad Shoaib, Muhammad Zaeem Ahsan, Meng-Yan Deng, Le Ma, Evhy Apryani, Xin-Yan Li, Yong-Xiang Wang
Summary: Gabapentinoids alleviate neuropathic pain by stimulating the expression of spinal microglial IL-10 and consequent beta-endorphin.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Chemistry, Medicinal
Ying-Xiao Li, Kai-Chun Cheng, I-Min Liu, Ho-Shan Niu
Summary: Myricetin, a plant-derived flavonoid, acts as an agonist of GLP-1 receptor to improve glycemic control and interact with adropin and BER. The study demonstrates that Myricetin increases plasma adropin levels by activating GLP-1 receptor in diabetic rats, suggesting a potential therapeutic mechanism for diabetes.
Article
Pharmacology & Pharmacy
Qiao-Qiao Han, Min Yin, Zi-Ying Wang, Hao Liu, Jun-Ping Ao, Yong-Xiang Wang
Summary: The study found that cynandione A suppresses neuropathic pain through an alpha 7-nAChR-dependent IL-10/beta-endorphin signaling pathway in spinal microglia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wenbin Wu, Qingsong Xia, Yujin Guo, Hongzhan Wang, Hui Dong, Fuer Lu, Fen Yuan
Summary: This study confirmed that berberine can promote the secretion of GLP-1 in intestinal L cells and islet alpha cells through activation of the GLP-1/GLP-1R/PKA signaling pathway, thus improving the function of islet beta cells and treating T2DM.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Feng Jing, Qian Zou, Yinshuang Pu
Summary: Glucagon-like peptide-1 receptor (GLP-1R) is involved in chronic pain, but the mechanism by which GLP-1R alleviates central sensitization of chronic migraine (CM) is unclear. Treatment with GLP-1R agonist liraglutide reduced trigeminal allodynia and decreased CM-associated molecules in the trigeminal nucleus caudalis (TNC). Further analysis showed that liraglutide injection stimulated the release of IL-10 in the TNC, and IL-10 treatment also alleviated pain hyperalgesia. Our findings suggest that liraglutide may alleviate CM central sensitization by stimulating IL-10 release, revealing a novel mechanism.
NEUROSCIENCE LETTERS
(2023)
Article
Nutrition & Dietetics
Fan Yang, Xinshang Wang, Jingyu Qi, Kun Zhang, Yongli Jiang, Ban Feng, Tao Lv, Le Yang, Qi Yang, Minggao Zhao, Shuibing Liu, Xue Ma
Summary: Depression is a comorbidity frequently associated with diabetes, negatively impacting prognosis and quality of life. This study investigates the potential of the GLP-1R agonist exendin-4 (EX-4) to alleviate depression-like behaviors in diabetic mice and explores its underlying mechanism. The results show that EX-4 administration improved depressive behaviors in diabetic mice and suppressed microglial pyroptosis and neuroinflammation. GLP-1R activation by EX-4 also improved mitochondrial function and promoted mitophagy. These findings suggest that GLP-1R agonists may be a promising therapy for depression associated with diabetes.
Article
Orthopedics
C. Meurot, C. Jacques, C. Martin, L. Sudre, J. Breton, R. Rattenbach, K. Bismuth, F. Berenbaum
Summary: This article reviews the GLP-1R pathway, molecular mechanisms, and phenotypes related to the pathogenesis of osteoarthritis (OA), and discusses the translational potential of GLP-1 analogues as disease-modifying therapies for OA due to their anti-inflammatory, immunoregulatory, and differentiation properties.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Clinical Neurology
Feng Jing, Qian Zou, Yangyang Wang, Zhiyou Cai, Yong Tang
Summary: The study shows that microglial GLP-1R activation in the TNC may suppress central sensitization of chronic migraine by regulating TNC microglial activation through the PI3K/Akt pathway.
JOURNAL OF HEADACHE AND PAIN
(2021)
Review
Endocrinology & Metabolism
Amaara Marzook, Alejandra Tomas, Ben Jones
Summary: GLP-1R is a GPCR that mediates the effects of GLP-1, important in the treatment of T2D. Biased GLP-1R agonists have been discovered, showing altered trafficking profiles and selective engagement with different intracellular effectors for studying the mechanisms and physiological importance of these processes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ting-ting Liu, Yan-kun Chen, Muhammad Adil, Mazen Almehmadi, Fahad M. Alshabrmi, Mamdouh Allahyani, Ahad Amer Alsaiari, Pei Liu, Muhammad Raheel Khan, Qinghua Peng
Summary: IL-1 beta mediates inflammation and regulates immune responses, cell proliferation, and differentiation. Dysregulation of IL-1 beta is linked to inflammatory and autoimmune diseases. Elevated IL-1 beta levels are found in patients with severe COVID-19, indicating its excessive production may worsen the disease. Also, dry eye disease patients show high IL-1 beta levels in tears and conjunctival epithelium. Therefore, IL-1 beta signaling is a potential therapeutic targeting for COVID-19 and aforementioned diseases.
Article
Anatomy & Morphology
Erzsebet Farkas, Anett Szilvasy-Szabo, Yvette Ruska, Richard Sinko, Morten Gronbech Rasch, Thomas Egebjerg, Charles Pyke, Balazs Gereben, Lotte Bjerre Knudsen, Csaba Fekete
Summary: GLP-1R protein is mainly distributed in circumventricular organs and neighboring regions such as the arcuate nucleus and nucleus tractus solitarii in the rat brain. Additionally, GLP-1R protein is also present in various areas of the telencephalon, diencephalon, brainstem, and cerebellum. Ultrastructural examination reveals that GLP-1R immunoreactivity is associated with the membrane of perikarya and dendrites, and can also be found inside and on the surface of axon varicosities and terminals.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Medicine, Research & Experimental
Zhuanzhuan Wang, Xin Cui, Wenhui Yan, Na Liu, Jia Shang, Xinyao Yi, Tingli Guo, Xiaotong Wei, Yuzhuo Sun, Hao Hu, Weina Ma, Wei Cui, Lina Chen
Summary: This study aims to investigate whether small molecule GLP-1R agonists from traditional Chinese medicine can improve diabetic cognitive dysfunction. The findings suggest that mollugin can improve cognitive dysfunction in T2DM mice through activating the GLP-1R/cAMP/PKA signaling pathway.
Article
Fisheries
Haiyun Wu, Madoka Ogata, Hitoshi Ohnuki, Hideaki Endo
Summary: This study developed a biosensor that can rapidly quantify superoxide concentrations in biological samples by immobilizing cytochrome c on the surface of a gold electrode. The sensor exhibited good correlation with superoxide concentrations in the range of 0.58-9.33 μM and showed acceptable performance in Nile tilapia eyeball interstitial sclera fluid.
Article
Neurosciences
Jianqiang Song, Guoliang Du, Haiyun Wu, Xiangliang Gao, Zhen Yang, Bin Liu, Shukun Cui
Summary: The study found that quercetin can protect against TBI-induced neuroinflammation and oxidative stress by activating the cortical Nrf2/HO-1 pathway. Quercetin attenuated brain edema and microgliosis in TBI rats, reduced cortical inflammatory responses and oxidative stress. Furthermore, quercetin treatment activated the cortical Nrf2/HO-1 pathway in TBI rats.
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
(2021)
Article
Spectroscopy
Haiyun Wu, Renjie Yang, Yong Wei, Guimei Dong, Hao Jin, Yanan Zeng, Chenglong Ai
Summary: This study proposes an improved method for identifying milk adulteration using near infrared spectroscopy and discriminant analysis. The results show that the proposed method can effectively reduce the influence of milk brands on the identification models.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Environmental Sciences
Ruixue Sun, Hao Zheng, Shaojing Yin, Xin Zhang, Xiangwei You, Haiyun Wu, Fengyue Suo, Kunxu Han, Yadong Cheng, Chengsheng Zhang, Yiqiang Li
Summary: The study demonstrates the potential of biochar in enhancing peanut growth in coastal salt-affected soil, especially biochars derived from reed straw and cow manure. Biochar can increase fresh shoot weight and salt tolerance of peanuts, improve soil fertility, and promote the growth of beneficial bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Spectroscopy
Ming-Yue Huang, Ren-Jie Yang, Ze-yuan Zheng, Hai-yun Wu, Yan-rong Yang
Summary: A discrimination method for adulterated milk based on temperature-perturbed 2D infrared correlation spectroscopy and NPLS-DA is proposed. The method can accurately classify pure and adulterated milk by calculating 2D correlation spectra and building discrimination models. Compared to the conventional 3D stacked map, this method achieves higher discrimination accuracy.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
Ming-yue Huang, Jia Long, Hai-yun Wu, Ren-jie Yang, Hao Jin, Yan-rong Yang
Summary: To improve the accuracy of adulterated milk discrimination, a detection method based on temperature-perturbed generalized two-dimensional (2D) correlation characteristic slice spectra was proposed. A total of 240 samples were prepared and the infrared attenuated total reflection spectra were collected at different temperatures. Discrimination models based on 2D correlation characteristics slice spectra were established using N-way partial least squares discriminant analysis (NPLS-DA). The results showed that the proposed method effectively extracted characteristic information and improved the accuracy of discrimination.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Spectroscopy
Haiyun Wu, Renjie Yang, Mingyue Huang, Yong Wei, Guimei Dong, Hao Jin, Yanan Zeng, Yanrong Yang
Summary: The discrimination approach of adulterated milk was proposed using synchronous two-trace two-dimensional (2T2D) correlation slice spectra and multivariate method. The method was demonstrated to be useful for analyzing two common adulterants, melamine and urea. The study showed that the prediction accuracies of the slice spectral models were higher than those of the 1D whole models, indicating that the 2T2D slice spectra improved the discrimination accuracy of adulterants in milk. The complexity of the slice spectra was significantly reduced compared to the whole matrix of synchronous 2T2D correlation spectra, making it a more efficient method for adulterated milk detection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Cardiac & Cardiovascular Systems
Haiyun Wu, Ruozhu Dai, Min Wang, Chengbo Chen
Summary: Uric acid (UA) induces cardiomyocytes injury by activating NLRP3 inflammasome and ROS/TRPM2 channel/Ca2+ pathway.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Spectroscopy
Hao Jin, Gui -Mei Dong, Hai-Yun Wu, Yan-Rong Yang, Ming-Yue Huang, Meng -Yuan Wang, Ren-Jie Yang
Summary: A qualitative analysis method for melamine-adulterated milk based on two-trace two-dimensional auto-correlation spectra was proposed. Infrared spectroscopy was used to measure the spectral data of pure milk and melamine-adulterated milk. The intensity of auto-correlation peaks at specific wave numbers was selected as independent variables for modeling. The method achieved 100% accuracy for individual brands and 99.05% accuracy for all four brands combined.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Editorial Material
Chemistry, Multidisciplinary
Chuang Pan, Haiyun Wu, Yongqiang Zhao
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Applied
Kangting Sun, Chuang Pan, Shengjun Chen, Haiyun Wu, Shucheng Liu, Shuxian Hao, Hui Huang, Huan Xiang
Summary: This study evaluated the correlation between water changes and quality deterioration of Litopenaeus vannamei during partial freezing storage. The results showed significant increases in cross-sectional area and equivalent diameter, but irregular growth in roundness and longiness of the ice crystals. Bound water and immobilized water decreased significantly, while free water increased significantly during storage. Quality determination revealed a significant decrease in total sulfhydryl and Ca2+-ATPase, but a significant increase in disulfide bonds. Correlation analysis showed significant correlations between cross-sectional area and total sulfhydryl, Ca2+-ATPase, and disulfide bonds, respectively. Additionally, significant correlations were found between water distribution index and Ca2+-ATPase, disulfide bonds. Predictive models for ice crystal growth were developed based on cross-sectional area and equivalent diameter using the Arrhenius model.
Article
Agricultural Engineering
Yongcheng Jiang, Jianjun Li, Yang Li, Shide Li, Xin Song, Haiyun Wu, Shiwei Zhu
Summary: A smart control system for the precision cultivation of black fungus was designed, which utilized intelligent detection and control technology. The system included four independent environments and a remote control system, allowing for the adjustment of key parameters such as temperature, humidity, and light according to the precision cultivation stages. The test results showed that the system had high precision in temperature, humidity, and illuminance control.
INTERNATIONAL JOURNAL OF AGRICULTURAL AND BIOLOGICAL ENGINEERING
(2023)
Article
Chemistry, Analytical
Haiyun Wu, Yusuke Saito, Goro Yoshizaki, Yasutoshi Yoshiura, Hitoshi Ohnuki, Hideaki Endo
Summary: Efficient production of seedlings in aquaculture farms requires control of male and female ratios through sex distinguishing. This study aims to develop a highly sensitive biosensor system utilizing single-walled carbon nanotubes (SWCNTs) to improve the efficiency and accuracy of fish gender determination. The concentration of 11-ketotestosterone (11-KT) in plasma is utilized as an indicator. The biosensor was fabricated by immobilizing an anti-11-KT antibody onto a disk-type gold electrode surface modified with a self-assembled monolayer (SAM) and SWCNTs.
SENSING AND BIO-SENSING RESEARCH
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Shengyao Xiao, Xiaoyu Cui, Yuanqin Fan, Boyuan Lu, Haiyun Wu, Michael Christel, Shirley Saldamarco, Geoff Kaufman
Summary: The game "Blindspot" tells the story of a Chinese student facing microaggressions at an American university, with puzzle games that emphasize this topic. Players' choices in dealing with microaggressions affect the gameplay, leading to different outcomes but ultimately presenting a hopeful ending for all. The narrative and mechanics of the game aim to foster empathy with the protagonist, benefiting players in various groups.
2021 IEEE CONFERENCE ON GAMES (COG)
(2021)
Proceedings Paper
Engineering, Manufacturing
Haiyun Wu, Yanan Zeng, Yong Wei, Renjie Yang, Yaping Yu, Huiyong Shan, Xuemei Sun
Summary: An immunochromatographic test strip for quantitative detection of E.coli O157:H7 was developed using electrochemical impedance technology and the support vector regression (SVR) model, with modified antibodies and a sandwich immune complex formed to change the conductivity of the capture pad. The SVR model showed high correlation coefficients for predicting E.coli O157:H7, demonstrating the feasibility of using impedance electrical parameters and SVR technology for quantitative prediction.
2021 IEEE INTERNATIONAL CONFERENCE ON MANIPULATION, MANUFACTURING AND MEASUREMENT ON THE NANOSCALE (3M-NANO)
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
