Contrasting contributions of TNF from distinct cellular sources in arthritis

Distinct fibroblast subsets drive inflammation and damage in arthritis

(2019) Adam P. Croft et al.   NATURE

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

Locally renewing resident synovial macrophages provide a protective barrier for the joint

(2019) Stephan Culemann et al.   NATURE

Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity

(2018) Kamar-Sulu N. Atretkhany et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zytokinneutralisierung an spezifischen zellulären Quellen

(2017) A. A. Kruglov et al.   ZEITSCHRIFT FUR RHEUMATOLOGIE

Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure

(2017) Jeffrey T. Kroetsch et al.   Nature Communications

Cell-type–restricted anti-cytokine therapy: TNF inhibition from one pathogenic source

(2016) Grigory A. Efimov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Higher risk of tuberculosis reactivation when anti-TNF is combined with immunosuppressive agents: a systematic review of randomized controlled trials

(2014) Roberto Lorenzetti et al.   ANNALS OF MEDICINE

Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF

(2014) Michaela Finsterbusch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Anti-Tumor Necrosis Factor Therapy in Rheumatoid Arthritis Inhibits Memory B Lymphocytes via Effects on Lymphoid Germinal Centers and Follicular Dendritic Cell Networks

(2014) J. H. Anolik et al.   JOURNAL OF IMMUNOLOGY

Selective Tumor Necrosis Factor Receptor I Blockade Is Antiinflammatory and Reveals Immunoregulatory Role of Tumor Necrosis Factor Receptor II in Collagen-Induced Arthritis

(2014) Fiona E. McCann et al.   Arthritis & Rheumatology

Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection

(2013) Nasiema Allie et al.   Scientific Reports

Anti-TNF-α therapy improves Treg and suppresses Teff in patients with rheumatoid arthritis

(2012) Zhuochun Huang et al.   CELLULAR IMMUNOLOGY

Treatment of arthritis by macrophage depletion and immunomodulation: Testing an apoptosis-mediated therapy in a humanized death receptor mouse model

(2011) Jun Li et al.   ARTHRITIS AND RHEUMATISM

TNFR2 on non-haematopoietic cells is required for Foxp3+Treg-cell function and disease suppression in EAE

(2011) Niki Tsakiri et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pathogenic and Protective Functions of TNF in Neuroinflammation Are Defined by Its Expression in T Lymphocytes and Myeloid Cells

(2011) A. A. Kruglov et al.   JOURNAL OF IMMUNOLOGY

Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis

(2010) Stephan Blüml et al.   ARTHRITIS AND RHEUMATISM

Cellular source and molecular form of TNF specify its distinct functions in organization of secondary lymphoid organs

(2010) A. V. Tumanov et al.   BLOOD

What have we learnt from targeted anti-TNF therapy?

(2009) M Feldmann et al.   ANNALS OF THE RHEUMATIC DISEASES

The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases

(2009) John A. Hamilton et al.   ARTHRITIS AND RHEUMATISM

Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis

(2009) Peter C. Taylor et al.   Nature Reviews Rheumatology

A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis

(2008) J. L. Eyles et al.   BLOOD

Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases

(2008) Maria Armaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells

(2008) Clare A. Notley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protocol for the induction of arthritis in C57BL/6 mice

(2008) Julia J Inglis et al.   Nature Protocols

Tumor necrosis factor antagonist mechanisms of action: A comprehensive review

(2007) Daniel Tracey et al.   PHARMACOLOGY & THERAPEUTICS