Review
Oncology
Chandra K. Maharjan, Jiao Mo, Lei Wang, Myung-Chul Kim, Sameul Wang, Nicholas Borcherding, Praveen Vikas, Weizhou Zhang
Summary: The oncogenic role of estrogen receptor (ER) signaling in breast cancer is well-established. Aberrant estrogen signaling enhances mammary epithelial cell proliferation, survival, and angiogenesis, contributing to breast cancer initiation and progression. Estrogen has been found to have both pro- and anti-inflammatory roles, and xenoestrogens can modulate chronic inflammation and breast cancer development. Understanding the complex relationship between estrogens, inflammation, and breast cancer will inform clinical research on prevention and therapy.
Article
Environmental Sciences
Juan P. Munoz, Rocio Araya-Osorio, Raul Mera-Adasme, Gloria M. Calaf
Summary: Recent reports have questioned the safety of glyphosate, the active ingredient in several herbicide formulations, suggesting that it may act as an endocrine disruptor by promoting estrogenic activity. This study aimed to investigate the mechanism by which glyphosate induces estrogenic effects using breast cancer cell line models. The results showed that high concentrations of glyphosate mimic the effects of estrogen, leading to the activation of estrogen receptor alpha and enhanced cell proliferation.
Review
Cell Biology
Karolina Nowak, Ewa Jablonska, Wioletta Ratajczak-Wrona
Summary: This review focuses on the effects of xenoestrogens (XEs) on the NF-kappa B signaling pathway in immune cells. The findings suggest that XEs generally activate NF-kappa B and play a crucial role in the development and functioning of the immune system.
Article
Oncology
Kamila Boszkiewicz, Helena Moreira, Ewa Sawicka, Anna Szyjka, Agnieszka Piwowar
Summary: Progressive industrialization, urbanization, and consumerism have led to increased contamination of the environment with endocrine-disrupting compounds (EDCs), which play a crucial role in the rise of hormone-dependent cancers, including breast cancer. This study aimed to investigate the impact of exposure to specific xenoestrogens, commonly found in daily life (aluminum in antiperspirants and deodorants; chromium (III) in dietary supplements and drugs), on the effectiveness of hormone therapy in breast cancer treatment. In vitro tests were conducted on breast cancer cell lines exposed to xenoestrogens, drugs, and their combinations, and the results showed that such exposure can impair the efficacy of hormone therapy.
Article
Environmental Sciences
Emmanuel Stephen Odinga, Xuwen Chen, Evance Omondi Mbao, Michael Gatheru Waigi, Fredrick Owino Gudda, Xian Zhou, Wanting Ling, Bozena Czech, Patryk Oleszczuk, Dyaaaldin Abdalmegeed, Yanzheng Gao
Summary: This study investigated the contamination levels and potential ecotoxicological risks of hormone substances and xenoestrogens in livestock manure-based fertilizers collected from 71 animal farms in China. The results showed varying frequencies and concentrations of these substances across different study locations. Compared with farm level manure, manure-based fertilizers had significantly reduced quantities of micropollutants. However, 38% of the fertilizers had risk quotients that exceeded 0.1, indicating medium to high risks to terrestrial organisms. Nonetheless, manure-based fertilizers had lower estrogenic risks compared to manure. This study emphasizes the importance of proper treatment of livestock manure and designing optimal fertilization strategies to mitigate the risks posed by hormone substances and xenoestrogens to agroecosystems.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Review
Biochemistry & Molecular Biology
Adele Vivacqua
Summary: Breast cancer is a major health concern for women worldwide, with its molecular pathogenesis still unclear. GPER1 and miRNAs play vital roles in breast cancer, influencing tumor development by regulating gene expression levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Fanny Leenhardt, Frederic Fiteni, Ludovic Gauthier, Marie Alexandre, Severine Guiu, Nelly Firmin, Stephane Pouderoux, Marie Viala, Gerald Lossaint, Chloe Gautier, Caroline Mollevi, Matthieu Gracia, Celine Gongora, Litaty Mbatchi, Alexandre Evrard, William Jacot
Summary: This study confirms the importance of therapeutic drug monitoring (TDM) in managing the safe use of Palbociclib, particularly in relation to hematological toxicity. The study also highlights the significance of characterizing co-treatments to limit the risk of drug-drug interactions (DDI) with oral-targeted therapies.
Article
Pharmacology & Pharmacy
Minna Lehtisalo, Wilma Kiander, Anne M. M. Filppula, Feng Deng, Heidi Kidron, Mari Korhonen, Johanna Sinkko, Kimmo Koivula, Mikko Niemi
Summary: We report 3 cases of rhabdomyolysis diagnosed in patients 1-6 months after the concurrent use of rosuvastatin and ticagrelor. A review of the literature and the Food and Drug Administration adverse event reporting system revealed more than 40 reports of rhabdomyolysis during concomitant ticagrelor and rosuvastatin, including 3 fatal cases. In vitro studies showed that ticagrelor inhibits the transport of rosuvastatin by breast cancer resistance protein, organic anion transporting polypeptide (OATP) 1B1, 1B3, and 2B1, with inhibitory concentrations ranging from 0.36 to 7.5 μM. Our findings suggest that the concomitant use of ticagrelor and rosuvastatin may lead to an increased risk of rosuvastatin-induced rhabdomyolysis due to the inhibition of rosuvastatin transport. Further research is needed to investigate the pharmacokinetic interaction between ticagrelor and rosuvastatin in humans.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Keisuke Kiyomiya, Ryuto Tomabechi, Naoki Saito, Kenta Watai, Tappei Takada, Yoshiyuki Shirasaka, Hisanao Kishimoto, Kei Higuchi, Katsuhisa Inoue
Summary: Macrolide and ketolide antibiotics can attenuate the cytotoxicity of HER2-targeting antibody-drug conjugate T-DM1 by accumulating in the lysosomes and inhibiting the function of SLC46A3, resulting in potential drug-ADC interaction during cancer chemotherapy.
MOLECULAR PHARMACEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Karolina Hanusek, Jakub Karczmarski, Anna Litwiniuk, Katarzyna Urbanska, Filip Ambrozkiewicz, Andrzej Kwiatkowski, Lidia Martynska, Anita Domanska, Wojciech Bik, Agnieszka Paziewska
Summary: Obesity is associated with an increased risk of breast cancer through mechanisms involving inflammation, cell metabolism disorders, and hormonal metabolism disturbances. MicroRNAs may play a role in regulating these processes and could serve as potential biomarkers and targets for anti-cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Konrad Wojnarowski, Paulina Cholewinska, Dusan Palic, Malgorzata Bednarska, Magdalena Jarosz, Iga Wisniewska
Summary: Estrogen receptors play a crucial role in maintaining organism homeostasis, and both endogenous and exogenous estrogens can have negative effects on animal health and welfare. Further research is needed to understand the complex interactions between different estrogens and xenoestrogens in aquatic animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Juan P. Munoz, Gloria M. Calaf
Summary: Acetylcholine (ACh) can activate the MAPK/ERK and PI3K/Akt pathways, induce p-ERα expression and nuclear translocation in breast cancer cell lines. However, ACh and 17β-estradiol have different mechanisms of action, and ACh can enhance cell viability and induce overexpression of specific EMT markers.
Article
Medicine, Research & Experimental
Jeon-Kyung Kim, Min Sun Choi, Jae-Young Kim, Jun Sang Yu, Jeong In Seo, Hye Hyun Yoo, Dong-Hyun Kim
Summary: Treatment with Gingko biloba leaf extract (GLE) suppressed intestinal BCRP expression and increased plasma concentrations of sulfasalazine in mice, accompanied by a reduction in certain bacterial populations. There was a correlation between BCRP expression and gut microbiota composition, suggesting modulation of gut microbiota may impact drug transporter-mediated interactions.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Ashley V. Ward, Shawna B. Matthews, Lynsey M. Fettig, Duncan Riley, Jessica Finlay-Schultz, Kiran V. Paul, Matthew Jackman, Peter Kabos, Paul S. MacLean, Carol A. Sartorius
Summary: This study evaluated the impact of estrogens and progestins on breast cancer cell metabolism and found that combination hormone treatment increases glucose metabolism and fat storage, promoting tumor progression. Targeting hormone-regulated metabolism may be a potential therapeutic strategy for ER+PR+ breast cancer.
Review
Pharmacology & Pharmacy
Beata Starek-Swiechowicz, Boguslawa Budziszewska, Andrzej Starek
Summary: Breast cancer is a common female malignancy driven by hormones, particularly estrogens. This paper focuses on estrogen metabolism and the mechanisms behind the development of breast cancer.
PHARMACOLOGICAL REPORTS
(2021)
Article
Medicine, General & Internal
Beata Szymanska, Zofia Marchewka, Brygida Knysz, Agnieszka Piwowar
Summary: This study measured the levels of low molecular weight proteins in urine of HIV-infected patients and found that certain protein levels are of significance in assessing kidney damage in HIV patients during antiretroviral therapy.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Karolina Jurkowska, Beata Szymanska, Brygida Knysz, Agnieszka Piwowar
Summary: This study investigated the connection between cART and the expression of SIRT1, SIRT3, and SIRT6 in HIV-infected men. The results showed that SIRT6 had the most significant changes during HIV infection, and the type of cART also had an influence on the level of SIRT1.
Article
Multidisciplinary Sciences
Sylwia Placzkowska, Malgorzata Terpinska, Agnieszka Piwowar
Summary: This study aimed to determine reference intervals (RIs) for TSH and fT4 using the indirect Hoffman method and compare them with commonly used RIs. The results showed varying RIs in different age groups of the examined populations. The established RIs for fT4 were similar to the manufacturer and literature data, while RIs for TSH differed between age groups.
Article
Virology
Beata Szymanska, Karolina Jurkowska, Brygida Knysz, Agnieszka Piwowar
Summary: This study aimed to examine the effect of combined antiretroviral therapy (cART) on the expression of select cytokines in HIV-infected individuals. The results showed that cART significantly decreased IL-7 levels and increased IL-15 levels in HIV-infected men. Further research in this area may help confirm the role of these cytokines in the disease.
Article
Medicine, General & Internal
Karolina Jurkowska, Beata Szymanska, Brygida Knysz, Agnieszka Piwowar
Summary: This study assessed the impact of combined antiretroviral therapy (cART) on selected parameters related to metabolism, cardiovascular diseases, and inflammation in HIV-infected patients. The results indicated significant changes in the expression of these parameters during HIV infection and cART. The data may contribute to better monitoring of the infection and optimizing therapy to prevent comorbidities.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Anna Bizon, Agata Tchorz, Pawel Madej, Marcin Lesniewski, Mariusz Wojtowicz, Agnieszka Piwowar, Grzegorz Franik
Summary: This study investigated the activity of superoxide dismutase (SOD) and the levels of copper (Cu) and zinc (Zn) in women with polycystic ovary syndrome (PCOS), as well as the gene polymorphism of SOD1. The results showed lower SOD1 activity and Cu, Zn concentration in women with PCOS compared to the control group. Insulin resistance in PCOS further decreased SOD1 activity and increased Cu concentration and Cu/Zn value.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Kamila Boszkiewicz, Agnieszka Piwowar, Pawel Petryszyn
Summary: Aromatase inhibitors (AIs) are commonly used as first-line therapy for hormone-dependent breast cancer patients. However, their use is associated with increased risk of cardiovascular events and the development of insulin resistance and diabetes. This meta-analysis found that AIs are associated with a higher risk of cardiovascular events compared to tamoxifen (TAM), but no significant association was found with hypertension, dyslipidemia, hyperglycemia, or weight gain.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cell Biology
Katarzyna Lipke, Adriana Kubis-Kubiak, Agnieszka Piwowar
Summary: Free fatty acids (FFAs) play vital roles in the organism but disturbances in fatty acid homeostasis can lead to lipotoxicity, contributing to the development of diseases such as insulin resistance and diabetes. Lipotoxic effects primarily affect organs such as the pancreas, liver, skeletal muscles, cardiac muscle, and kidneys.
Article
Oncology
Kamila Boszkiewicz, Helena Moreira, Ewa Sawicka, Anna Szyjka, Agnieszka Piwowar
Summary: Progressive industrialization, urbanization, and consumerism have led to increased contamination of the environment with endocrine-disrupting compounds (EDCs), which play a crucial role in the rise of hormone-dependent cancers, including breast cancer. This study aimed to investigate the impact of exposure to specific xenoestrogens, commonly found in daily life (aluminum in antiperspirants and deodorants; chromium (III) in dietary supplements and drugs), on the effectiveness of hormone therapy in breast cancer treatment. In vitro tests were conducted on breast cancer cell lines exposed to xenoestrogens, drugs, and their combinations, and the results showed that such exposure can impair the efficacy of hormone therapy.
Article
Medicine, Research & Experimental
Monika Stepien, Natalia Swiatoniowska-Lonc, Brygida Knysz, Beata Jankowska-Polanska, Amadeusz Kuzniarski, Agnieszka Piwowar, Malgorzata Zalewska
Summary: This study aimed to evaluate the levels of anti-SARS-CoV-2 immunoglobulin G (IgG) antibodies in convalescents and individuals without a past infection, and to assess socio-clinical factors associated with participants' humoral responses. The results showed the presence of anti-SARS-CoV-2 IgG antibodies in convalescents and in some individuals without a past infection, and the antibody levels were related to the severity of the symptoms.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Kamila Boszkiewicz, Agnieszka Piwowar
Summary: One-third of breast cancer patients with diabetes have a 40% higher risk of mortality. Metalloestrogens may reduce the effectiveness of aromatase inhibitors (AIs), but high glucose conditions have a greater impact on their activity. Therefore, controlling hyperglycemia and individualized treatment regimens may have important therapeutic implications for cancer patients with diabetes.
ACTA POLONIAE PHARMACEUTICA
(2023)
Article
Public, Environmental & Occupational Health
Agnieszka Piwowar, Eddie Czwojdzinski, Zofia Marchewka, Aleksandra Adamczuk, Natalia Swiatoniowska-Lonc, Beata Jankowska-Polanska
Summary: The study found that treatment satisfaction and adherence are important factors in the pharmaceutical treatment of patients with ischemic heart disease. Factors influencing patient adherence include family history, anemia, drug side effects, and satisfaction with treatment. Increasing patient awareness of treatment should be an important goal for future educational activities.
INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Anna Bizon, Justyna Chojdak-Lukasiewicz, Slawomir Budrewicz, Anna Pokryszko-Dragan, Agnieszka Piwowar
Summary: This study aimed to investigate the alterations in the antioxidant balance in patients with RRMS and the factors influencing it. The study included 161 patients and 29 healthy individuals, and measured the activity of SOD, GPx, and CAT, as well as the concentration of IL-6, LPO, TOS, and TAS. The results showed decreased GPx activity and increased CAT activity in patients with RRMS compared to the control group, and these activities were influenced by gender and disease-modifying therapies. The findings suggest that enhancing GPx activity may be a potential therapeutic strategy for mitigating oxidative stress in RRMS.
Article
Pharmacology & Pharmacy
Anna Bizon, Agnieszka Piwowar
Summary: The expression of recombinant paraoxonase 1 (PON1) in the human embryonic kidney (HEK293F) cell line was investigated. It was demonstrated that the HEK293F platform is useful for obtaining recombinant human PON1 protein. The addition of high-density lipoprotein increased serum arylesterase and lactonase activity of PON1, while low-density lipoprotein, copper ions, and iron ions decreased PON1 activity.
ACTA POLONIAE PHARMACEUTICA
(2023)
Article
Medicine, Research & Experimental
Monika Stepien, Natalia Swiatoniowska-Lonc, Brygida Knysz, Beata Jankowska-Polanska, Amadeusz Kuzniarski, Agnieszka Piwowar, Malgorzata Zalewska
Summary: This study aimed to evaluate the levels of anti-SARS-CoV-2 IgG antibodies in convalescents and individuals not previously infected, and to assess factors associated with participants' humoral responses. The results showed the presence of antibodies in some convalescents and previously uninfected individuals, but also observed that some individuals did not have detectable antibodies despite a previous infection.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
