Article
Oncology
Yanqiong Liu, Qiulian Wu, Fuyong Zhang, Xue Qin
Summary: This study provides evidence for the first time that the NRF2 gene rs6721961 variation is a potential genetic marker for susceptibility to hepatocellular carcinoma (HCC).
CANCER CELL INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Dan-Dan Zhu, Xue-Mei Tan, Li-Qing Lu, Si-Jia Yu, Ru-Li Jian, Xin-Fang Liang, Yi-Xuan Liao, Wei Fan, Luciia Barbier-Torres, Austin Yang, He-Ping Yang, Ting Liu
Summary: COVID-19 caused by SARS-CoV-2 is a global pandemic that not only affects respiratory system but also leads to systemic inflammation and liver damage. NRF2 plays a crucial role in regulating antioxidant proteins in the context of COVID-19-induced inflammation and liver injury.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Vidyasagar Naik Bukke, Archana Moola, Gaetano Serviddio, Gianluigi Vendemiale, Francesco Bellanti
Summary: Oxidative stress is a key driver in the development and progression of various diseases, including MAFLD. NRF2, a master regulator of redox homeostasis, plays a crucial role in every step of MAFLD development. NRF2 activators regulate lipid metabolism and oxidative stress, alleviating fatty liver disease by inducing the expression of cytoprotective genes.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Wenting Jian, Huigai Ma, Dingming Wang, Peng Yang, Mengbi Jiang, Yu Zhong, Xiang Long, Jingjing Jiang, Yuan Gong
Summary: This study demonstrates that omaveloxolone exerts significant cardioprotective effects in treating sepsis-induced cardiomyopathy by activating the Nrf2 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Shuang Zhao, Tianyu Song, Yue Gu, Yihua Zhang, Siyi Cao, Qing Miao, Xiyue Zhang, Hongshan Chen, Yuanqing Gao, Lei Zhang, Yi Han, Hong Wang, Jun Pu, Liping Xie, Yong Ji
Summary: The study suggests that H2S alleviates liver damage by activating Keap1 S-sulfhydration and promoting the activation of Nrf2, leading to increased expression of antioxidant proteins, which may have potential therapeutic benefits for liver diseases.
Review
Pharmacology & Pharmacy
Daniela Maria Tanase, Alina Georgiana Apostol, Claudia Florida Costea, Claudia Cristina Tarniceriu, Ionut Tudorancea, Minela Aida Maranduca, Mariana Floria, Ionela Lacramioara Serban
Summary: Arterial hypertension is a prevalent disease characterized by increased incidence and heterogeneous pathophysiology. Oxidative stress plays an important role in its development, with excessive levels causing vascular cell damage and promoting hypertension. Transcription factors such as Nrf2 mediate antioxidant response pathways and provide protection.
Article
Biotechnology & Applied Microbiology
Huiyan Deng, Miaojian Wan, Huaping Li, Quan Chen, Runxiang Li, Bihua Liang, Huilan Zhu
Summary: The study demonstrates that curcumin can protect the skin from UV damage by regulating the Nrf2 pathway. UV irradiation leads to cell apoptosis and oxidative stress, which can be reversed by adding curcumin. Additionally, curcumin induces Nrf2 nuclear accumulation in Hacat cells to provide protection against UV exposure-induced photodamage.
Article
Environmental Sciences
Yuan-yuan Wei, Hui-ru Wang, Yi-meng Fan, Jin-hua Gu, Xiu-ying Zhang, Xu-hao Gong, Zhi-hui Hao
Summary: The study evaluated the effect and underlying mechanism of GDK aqueous extract in alleviating acute liver injury caused by CCl4. The results showed that GDK effectively inhibited liver damage and restored the structure and function of the liver. It achieved this by suppressing liver fibrosis, blocking the NFicB pathway, inhibiting hepatic inflammatory response, reducing oxidative stress, inhibiting ferroptosis, and alleviating hepatocyte injury caused by CCl4. In conclusion, this study provides insights into the potential complex mechanism of GDK against acute liver injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Medicinal
Jie-Yoon Kang, Jong-Suk Lee, In-Chan Seol, Yoon-Sik Kim, Miso S. Park, Ho-Ryong Yoo
Summary: In this study, it was found that Gami-Yukmijihwang-Tang (YJT) could alleviate neuroinflammation and oxidative stress induced by repeated lipopolysaccharide (LPS) injections. The protective effects of YJT were achieved by regulating Sirtuin 6 (Sirt6)-related pathways and normalizing the glutathione (GSH) redox cycle.
Article
Food Science & Technology
Guanglu Wang, Yong Sun, Qiankun Yang, Dapeng Dai, Le Zhang, Hui Fan, Wei Zhang, Jingquan Dong, Panpan Zhao
Summary: The present study aimed to investigate the role of liensinine in mitigating life-threatened sepsis-associated encephalopathy (SAE) in mice and the underlying mechanism. The results showed that liensinine restored cerebrum structure, improved blood-brain barrier (BBB) integrity, and reduced BBB permeability. Moreover, liensinine enhanced antioxidant enzymes activities, decreased oxidative stress and inflammation, and blocked apoptosis to restore cognitive function in SAE mice. In summary, liensinine attenuated lipopolysaccharide-induced SAE through modulation of inflammatory biomarkers and mitochondria apoptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Cell Biology
David Rysanek, Pavla Vasicova, Jayaprakash Narayana Kolla, David Sedlak, Ladislav Andera, Jiri Bartek, Zdenek Hodny
Summary: The accumulation of senescent cells in aging tissues contributes to age-associated diseases. Inhibiting the anti-apoptotic machinery of senescent cells through BCL-2 protein family inhibitors can eliminate these cells. Combination therapy with BCL-2 inhibitors shows synergistic effects in eliminating senescent cells and overcoming resistance to monotherapy.
Review
Biochemistry & Molecular Biology
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Omayma A. Eldahshan, Yasmine M. Abdelkhalek, Magdy El Dahshan, Eman A. Ahmed, Jean-Marc Sabatier, Gaber E. -S. Batiha
Summary: COVID-19 is caused by SARS-CoV-2 and results in pulmonary and extra-pulmonary manifestations due to oxidative stress and hyperinflammation. The Nrf2 pathway plays a crucial role in mitigating viral toxicity and inflammation in COVID-19, and Nrf2 activators could be a potential therapeutic strategy for managing the disease.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Review
Cell Biology
Rabab S. Hamad, Hayder M. Al-kuraishy, Athanasios Alexiou, Marios Papadakis, Eman A. Ahmed, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: COVID-19 is a recent pandemic caused by SARS-CoV-2, leading to pulmonary and extra-pulmonary manifestations. Inhibition of Nrf2 may contribute to oxidative stress and hyperinflammation in COVID-19. Nrf2 pathway suppresses pro-inflammatory cytokines, reducing pulmonary symptoms. Nrf2 activators can improve endothelial dysfunction, RAS dysregulation, immune thrombosis, and coagulopathy.
CELL STRESS & CHAPERONES
(2023)
Article
Chemistry, Medicinal
Sichen Zhang, Chunguo Qian, Hailing Li, Zhimin Zhao, Jianchun Xian, Depo Yang
Summary: The antioxidant peptide DR12 from housefly pupae showed neuroprotective effects by reducing oxidative stress, upregulating endogenous antioxidants, and activating specific signaling pathways. DR12 may have potential therapeutic applications for neurodegenerative diseases.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Integrative & Complementary Medicine
Xiaoting Lu, Xue Liu, Ershun Liang, Ruixue Yang, Yan Liu, Xiaoqiong Liu, Fangfang Yan, Yifan Xing
Summary: This study found that Panax quinquefolius saponin (PQS) can effectively inhibit vascular smooth muscle cell calcification by ameliorating oxidative stress and regulating osteogenic genes through promoting the expression of Nrf2.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Plant Sciences
Eun Hye Lee, Kwang-Il Park, Kwang-Youn Kim, Ju-Hee Lee, Eun Jeong Jang, Sae Kwang Ku, Sang Chan Kim, Ho Young Suk, Ji Young Park, Su Youn Baek, Young Woo Kim
Article
Cell & Tissue Engineering
Chang-Hyun Kim, Chi-Yeon Lim, Ju-Hee Lee, Keun Cheon Kim, Ji Yeon Ahn, Eun Ju Lee
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2019)
Article
Plant Sciences
Ju-Yeon Park, Sun-Dong Park, Young Jun Koh, Dong-Il Kim, Ju-Hee Lee
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Integrative & Complementary Medicine
Haifeng Jin, Yang Jiang, Fengxia Du, Linna Guo, Guan Wang, Sang Chan Kim, Chul Won Lee, Lei Shen, Rongjie Zhao
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Neurosciences
Hong Feng Liu, ZhengLin Zhao, Jie Zhang, Yi Yan Wu, Yu Jiao, Tong Wu, Sang Chan Kim, Bong Hyo Lee, Yu Fan, Chul Won Lee, Young Woo Kim, Chae Ha Yang, Xiao Dong Zhu, Rong Jie Zhao
NEUROSCIENCE LETTERS
(2019)
Article
Integrative & Complementary Medicine
Su Mi Park, Sang Kyu Jeon, Ok Hyeon Kim, Jung Yun Ahn, Chang-Hyun Kim, Sun-Dong Park, Ju-Hee Lee
Article
Immunology
Mi-Young Park, Young-Kug Choo, Seong Ho Jeon, Won-Gu Jang, Ju-Hee Lee, Joo-Hee Park, Chang-Hyun Kim
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Integrative & Complementary Medicine
Songhee Jeon, Quan Feng Liu, Hua Cai, Ha Jin Jeong, Su-Hyun Kim, Dong-Il Kim, Ju-Hee Lee
Article
Integrative & Complementary Medicine
Ju-Yeon Park, Young-Won Kwon, Sun-Ah Kim, Sun-Dong Park, Chang-Hyun Kim, Jin-Hee Kim, Ju-Hee Lee
Summary: The study demonstrated the anti-arthritic effects of SC-E3 in a mouse model of type-II collagen-induced arthritis, showing reduced paw swelling, bone erosion, inflammatory cell infiltration, and inflammation. SC-E3 was found to inhibit pro-inflammatory cytokines and osteoclastogenesis, indicating its potential therapeutic use for rheumatoid arthritis.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Integrative & Complementary Medicine
Seung-Nam Kim, Dae Hee Kim, Hyuek Jong Lee, Joon Seo Lim, Ju-Hee Lee, Sung Yun Park, Young Jun Koh
Summary: The study found that Rg3 has cytotoxic effects on differentiated mouse primary brown adipocytes, leading to cell death, mainly through regulation of genes related to adipocyte differentiation, adipogenesis, lipolysis, and inflammation. Further research on the potential therapeutic applications of Rg3 is warranted.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Plant Sciences
Yeon Ju Kim, Sung Yun Park, Young Jun Koh, Ju-Hee Lee
Summary: The study revealed that the extract of Fructus ligustri lucidi effectively inhibits neuroinflammation by suppressing inflammatory signaling pathways and inducing specific proteins. These findings provide a scientific basis for further exploration of this extract as a candidate for preventing or alleviating neuroinflammation.
Article
Clinical Neurology
Zhenglin Zhao, Sang Chan Kim, Yu Jiao, Yefu Wang, Bong Hyo Lee, Hee Young Kim, Chul Won Lee, Chae Ha Yang, Rongjie Zhao
Summary: The study revealed that anxiety and increased norepinephrine release induced by ethanol withdrawal are mediated by an elevation of solitary nitric oxide signaling, inhibition of nitric oxide synthase in the nucleus tractus solitarius can alleviate these effects.
BEHAVIOURAL NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Yeon Ju Kim, Sung Yun Park, Ju-Hee Lee
Summary: The study revealed that berteroin significantly inhibits lipid synthesis and lipid droplet formation, potentially mediated by AMPK activation.
Review
Biochemistry & Molecular Biology
Ju-Hee Lee, Hi-Jin You, Tae-Yul Lee, Hyo Jin Kang
Summary: Skin flaps are commonly used in plastic and reconstructive surgery, but they can cause cell necrosis and apoptosis. To prevent this, inhibiting proinflammatory cytokines, stem-cell therapies, and drug-based therapies have been suggested. Ischemic preconditioning is an effective strategy to prevent injury by inhibiting proinflammatory cytokine activity. In addition, stem cell applications and tissue-engineered flaps have been studied.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sang Kyu Jeon, Su Mi Park, Jung Yun Ahn, Ok Hyeon Kim, Young Woo Kim, Kwang-Il Park, Sun-Dong Park, Ju-Hee Lee
Summary: The study investigated the effects of JHG on human breast cancer cell lines and found that an ethanol extract of JHG suppressed the growth of cells representing four subtypes of human breast cancer. It inhibited the expression of various proteins and pathways related to cancer progression and metastasis. The JHG extract also showed potential in inhibiting the angiogenic properties of endothelial cells. These findings suggest that JHG may exert potent anticancer effects by inhibiting specific pathways and inducing apoptosis in breast cancer cells.
MOLECULAR & CELLULAR TOXICOLOGY
(2023)