Article
Chemistry, Multidisciplinary
Andrea Sowa, Alexander Hoeing, Ulrich Dobrindt, Shirley K. Knauer, Anzhela Galstyan, Jens Voskuhl
Summary: This study describes the synthesis, characterization, and application of water-soluble zinc(II) phthalocyanines decorated with umbelliferone moieties for photodynamic therapy. These compounds exhibited excellent phototoxicity and antimicrobial activity in cells and bacteria, making them promising photosensitizers for future broad applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Medicinal
Aleksei E. Machulkin, Anastasia A. Uspenskaya, Nikolay Y. Zyk, Ekaterina A. Nimenko, Anton P. Ber, Stanislav A. Petrov, Radik R. Shafikov, Dmitry A. Skvortsov, Galina B. Smirnova, Yulia A. Borisova, Vadim S. Pokrovsky, Vasilii S. Kolmogorov, Alexander N. Vaneev, Yan A. Ivanenkov, Alexander D. Khudyakov, Sergei Kovalev, Alexander S. Erofeev, Petr Gorelkin, Elena K. Beloglazkina, Nikolay Zyk, Elena S. Khazanova, Alexander G. Majouga
Summary: The study focused on developing docetaxel conjugates for prostate cancer treatment, showing promising cytotoxicity and increased solubility compared to the drug itself. In vivo evaluation demonstrated strong inhibitory effects on tumor growth and lower toxicity compared to free docetaxel. The PSMA-targeted docetaxel conjugate is considered a good candidate for further preclinical trials due to its high antitumor activity, reduced side effects, and improved solubility.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Lei Ge, Chenyang Qiao, Yikai Tang, Xiaoke Zhang, Xiqun Jiang
Summary: COFs have been synthesized with hypoxia-responsive azo bonds containing photosensitizers and hypoxia-activated drugs for drug delivery. Upon exposure to hypoxic conditions and NIR light, the COF structure is disrupted, leading to drug release and activation of the hypoxia-activated drug, resulting in effective cancer cell killing and tumor growth inhibition.
Article
Chemistry, Multidisciplinary
Geoffrey T. Nash, Taokun Luo, Guangxu Lan, Kaiyuan Ni, Michael Kaufmann, Wenbin Lin
Summary: A new nanoscale metal-organic layer assembly, ZnOPPc@nMOL, has been designed for photodynamic therapy (PDT), which shows exceptional efficacy in inhibiting tumor growth and curing colon cancer in mouse models. The assembly efficiently sensitizes the formation of singlet oxygen by preventing aggregation-induced self-quenching of ZnOPPc excited states. With intrinsic mitochondria-targeting capability, ZnOPPc@nMOL displays strong potential for clinical applications in PDT.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
H. Yasemin Yenilmez, Nazli Farajzadeh, Gulsah Tollu, Nilguen Guler Kusculu, Dilek Bahar, Sadin Ozdemir, Zehra Altuntas Bayir
Summary: This study synthesized three silicon phthalocyanines (SiPc1-3) with different ligands attached. The effects of these ligands on the biological features of water-soluble silicon phthalocyanines were investigated. The compounds displayed antimicrobial and anti-cancer activities, with SiPcQ3 showing the highest in vitro anticancer activity against the tested cell.
Article
Chemistry, Multidisciplinary
Xue Lou, Hui Wang, Yu Liu, Yongwei Huang, Zhonghua Liu, Wei Zhang, Tie Wang
Summary: This study presents a perylene monoamide-based reactive oxygen species supergenerator that induces oxidative stress and triggers immunogenic cell death, leading to efficient tumor therapy. It also demonstrates the potential of perylene as a therapeutic platform for immunogenic photochemotherapy against hypoxic tumors.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Janas, Ewa Boniewska-Bernacka, Gabriela Dyrda, Rudolf Slota
Summary: Recent investigations on targeted phototherapy for colorectal cancer have shown promising results, with porphyrins and phthalocyanines considered attractive for inhibiting cancer cell growth. Advanced molecular systems and smart drug carriers have made photodynamic therapy a viable option for treatment.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Joanna Kurczewska
Summary: This review focuses on the progress in chitosan-based nanoparticles for targeted delivery of antitumor drugs. It discusses literature reports from the past three years on the use of chitosan nanoparticles as carriers for active substances in antitumor therapy and potential new drugs with anticancer properties. Special attention is given to different treatments applied to enhance therapeutic effectiveness and minimize side effects of specific active substances.
Review
Oncology
Haoming Xia, Ziyue Huang, Zhensheng Wang, Shuqiang Liu, Xudong Zhao, Junqi You, Yi Xu, Judy Wai Ping Yam, Yunfu Cui
Summary: Glucometabolic reprogramming plays a significant role in the development and treatment of hepatocellular carcinoma (HCC). By altering the glucose metabolism pathway, HCC cells can survive and thrive in nutrient-poor tumor microenvironments and evade immune surveillance. Targeted interventions against glucose metabolism and signaling pathways hold promising prospects for HCC therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Guoqiang Sun, Dawei Rong, Zhouxiao Li, Guangshun Sun, Fan Wu, Xiao Li, Hongyong Cao, Ye Cheng, Weiwei Tang, Yangbai Sun
Summary: Research on molecular targeted therapy of tumors is thriving, with novel targeted therapy drugs constantly emerging. Small molecule targeted compounds can be administered orally, do not elicit immune response, and are cost-effective, making them a hot topic in tumor treatment research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Rostislav A. Petrov, Sofiia R. Mefedova, Emil Yu Yamansarov, Svetlana Yu Maklakova, Dmitrii A. Grishin, Elena Lopatukhina, Olga Y. Burenina, Anton Lopukhov, Sergey Kovalev, Yury Timchenko, Evgenia E. Ondar, Yan A. Ivanenkov, Sergei A. Evteev, Alexander N. Vaneev, Roman Timoshenko, Natalia L. Klyachko, Alexander S. Erofeev, Petr Gorelkin, Elena K. Beloglazkina, Alexander G. Majouga
Summary: The study developed covalent and low molecular weight docetaxel delivery systems conjugated with N-acetyl-D-galactosamine, showing excellent affinity to ASGPR and high cytotoxicity against hepatocellular carcinoma cells. The glycoconjugates also exhibited significantly increased water solubility and prodrug lability, as well as selective toxicity against hepatoma cells compared to control cell lines. Additionally, specific ASGPR-mediated cellular uptake of the conjugates and enhanced generation of reactive oxygen species in HepG2 cells were observed, highlighting the potential of ASGPR-directed taxane drugs for selective therapy of hepatocellular carcinoma.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Lan Yang, Huijie Ma, Ye Liu, Rumeng Cao, Shaofeng Chen, Jiajia Wang, Ling Xiang, Jiumeng Zhang, Xuli Feng, Chenhui Wang
Summary: A nucleus-targeted enzyme prodrug nanocomposite, assembled from β-cyclodextrin-lysine (CL), catalase (CAT), Pt(iv) and chlorin e6 (Ce6), was developed for self-augmenting cascade photo-chemo therapy of tumors. It can effectively transport through the cytoplasm and accumulate in the nucleus, thereby significantly inhibiting tumor growth and lung metastasis.
CHEMICAL COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Edward B. Garon, Paige Brodrick
Summary: The tyrosine kinase receptor mesenchymal epithelial transition (MET) plays a role in non-small cell lung cancer (NSCLC) and abnormal activation may contribute to oncogenesis. MET overexpression, amplification, or mutation as therapeutic targets are of interest, particularly MET exon 14 skipping mutations which have shown significant responses to MET inhibitors.
Article
Biochemistry & Molecular Biology
Elaheh Mohammadnejadi, Nima Razzaghi-Asl
Summary: Non-small cell lung cancer (NSCLC) is the majority type of lung cancer, and its treatment remains a challenge. This study focused on targeting the epidermal-growth factor receptor (EGFR) to develop therapies for NSCLC. The research identified potential erlotinib analogues through computational servers and molecular docking. The aim was to find molecules that can overcome clinically frequent EGFR-TK mutants. The study provided insights into synthetically accessible small molecules with affinity for EGFR-TK mutants.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Oncology
Qianfei Cui, Peng Song, Tiancheng Ma, Zefeng Wang, Xiaojing Lu, Yongjia Shi, Fang Zhang, Guoqiang Lin, Jiajia Dong, Jiange Zhang
Summary: In this study, a novel antitumor molecule P19G1 was synthesized using modular click chemistry. P19G1 showed inhibitory effects on various tumor cells and effectively suppressed the growth and metastasis of lung adenocarcinoma.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Biochemical Research Methods
Dong-hua Wan, Xin-Yue Ma, Chen Lin, Deng-hui Zhu, Xingshu Li, Bi-Yuan Zheng, Jinyu Li, Mei-Rong Ke, Jian-Dong Huang
BIOCONJUGATE CHEMISTRY
(2020)
Article
Virology
Hongxin Guan, Youwang Wang, Vanja Perculija, Abdullah F. U. H. Saeed, Yichang Liu, Jinyu Li, Syed Sajid Jan, Yu Li, Ping Zhu, Songying Ouyang
JOURNAL OF VIROLOGY
(2020)
Article
Engineering, Chemical
Yichang Liu, Ziwei Cheng, Meiru Song, Lizhi Jiang, Gang Fu, Lin Liu, Jinyu Li
Summary: The study designed different shapes of g-C3N4 nanopores and used non-equilibrium molecular dynamics simulations to investigate their molecular mechanism for desalination processes. Results showed that the local water diffusion coefficient increased with the enlargement of nanopore sizes, suggesting the nano-effect may also play a role in water permeation.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Chemistry, Medicinal
Meiru Song, Ge Liu, Yichang Liu, Ziwei Cheng, Haili Lin, Jianyong Liu, Zaisheng Wu, Jinping Xue, Wanjin Hong, Mingdong Huang, Jinyu Li, Peng Xu
Summary: This study proposes a strategy to address the limitations of AMPs as antitumor agents by conjugating them with porphyrins, which bind to albumin and enhance the antitumor efficacy of AMPs. The conjugation also reduces the fast renal clearance and systemic toxicities of AMPs, confirming the design strategy's success.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Libin Jiang, Yunbin Jiang, Linlin Li, Ke Zheng, Shujuan Yu, Jinyu Li, Cai Yuan, Mingdong Huang
Summary: A novel matriptase targeting carrier (MTC) was designed, showed high specificity and cytotoxicity for matriptase-overexpressing cancer cells in vitro, and demonstrated potential as a highly efficient tumor targeting drug carrier for imaging and therapy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
Meiru Song, Wei Fu, Yichang Liu, Huiqiao Yao, Ke Zheng, Lin Liu, Jinping Xue, Peng Xu, Yayu Chen, Mingdong Huang, Jinyu Li
Summary: This study systematically investigated the molecular interactions of DOX with HSA at different pH levels, revealing significant effects of environmental pH on their binding. Insights gained from this study may contribute to the design of novel HSA-based microenvironment-responsive drug delivery systems for anticancer therapeutic applications.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Analytical
Yuge Hou, Xiaofei Jiang, Yuhang Gao, Ying Li, Wensi Huang, Hong Chen, Xiaoyu Tang, Makoto Tsunoda, Jinyu Li, Yingxia Zhang, Xi Xie, Rong Wang, Wenting Hu, Yanting Song, Lushuang Li
Summary: This study developed an efficient method using magnetic molecularly imprinted polymers as adsorbents for solid-phase extraction, coupled with gas chromatography-mass spectrometry, to detect type II pyrethroids in human plasma. The analytical approach showed good selectivity and sensitivity, making it suitable for monitoring type II pyrethroids in complex biological samples. The method demonstrated high adsorption capacity, good recovery rates, and low limits of detection for four pyrethroid pesticides in human plasma.
MICROCHEMICAL JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Yifan Jiang, Yichang Liu, Min Wang, Zhi Li, Lichao Su, Xin Xu, Chao Xing, Jinyu Li, Lisen Lin, Chunhua Lu, Huanghao Yang
Summary: The study introduces a carrier-free Cu-siMDR-CDDP system that combines siRNA, CDDP, and Cu2+ to deactivate and release drugs in the tumor microenvironment, targeting drug-resistant cancer cell mechanisms. This system demonstrates synergistic chemo/chemodynamic RNA interference therapy in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Hematology
Shanli Chen, Dan Chen, Yurong Liu, Yanyan Xu, Huajian Lin, Yuan Cheng, Jinyu Li, Chun Meng, Mingli Liang, Cai Yuan, Mingdong Huang
Summary: The A419Y mutation in rtPA enhances fibrinolysis activity, and tetra-alanine mutations in reteplase variants significantly reduce plasminogen activation and impair clot lysis. In a pulmonary embolism murine model, the reteplase variant with the A419Y mutation displayed a more efficient thrombolytic effect than the wild-type form.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Wei Fu, Huiqiao Yao, Mareike Buetepage, Qianqian Zhao, Bernhard Luescher, Jinyu Li
Summary: Macrodomains are evolutionarily conserved structural elements that participate in regulating physiological processes and viral replication. Targeting viral Macrodomains with inhibitors is considered a promising antiviral strategy.
DRUG DISCOVERY TODAY
(2021)
Article
Chemistry, Physical
Qianqian Zhao, Riccardo Capelli, Paolo Carloni, Bernhard Luscher, Jinyu Li, Giulia Rossetti
Summary: This study introduces an enhanced volume-based metadynamics method to address induced-fit effects in protein/ligand binding, validated in substrate/enzyme complexes of pharmacological relevance. Simulations reveal significant conformation rearrangements of active loops upon ligand binding, providing insights into the molecular basis of ADPr specificity and experimental binding affinity changes. The research contributes to the quantitative description of induced-fit events in molecular recognition.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2021)
Article
Biochemistry & Molecular Biology
Yuhua He, Wei Fu, Liyang Du, Huiqiao Yao, Zhengkang Hua, Jinyu Li, Zhonghui Lin
Summary: A novel inhibitor called GSK650394 has been found to effectively inhibit the activity of Aurora B kinase and suppress proliferation in cancer cells and Aspergillus fumigatus. This discovery may provide new insights into the combination therapy for cancer and Aspergillus fumigatus infection.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Yichang Liu, Jie Wei, Meiqin Cai, Lizhi Jiang, Lin Liu, Jinyu Li
Summary: Two-dimensional nanoporous membranes are promising for seawater desalination. This study investigates the influence of nanopore charge modification on water permeability and ions conduction. The results show that the highest water permeability is observed when the modification is approximately 0.25e. Positively charged nanopores effectively impede cation permeation and impact the diffusion behavior of anions. This work provides insights into the mechanism of saline water transport through charge-modified nanopores and emphasizes the importance of nanopore charge states for desalination.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Kunshan Huang, Huiqiao Yao, Meiqi Yan, Han Zhang, Gankun Yuan, Qilu Wang, Jinping Xue, Jinyu Li, Juanjuan Chen
Summary: TNBC is a difficult-to-treat type of breast cancer, and traditional treatments often lead to side effects and drug resistance. In this study, a novel photosensitizer BC-Pc was designed to target MCL-1 and showed significant therapeutic effects in TNBC cells with minimal toxicity to normal cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Engineering, Chemical
Lin Liu, Yichang Liu, Yingying Qi, Meiru Song, Lizhi Jiang, Gang Fu, Jinyu Li
SEPARATION AND PURIFICATION TECHNOLOGY
(2020)