Towards precision medicine: Therapeutic drug monitoring–guided dosing of vancomycin and β-lactam antibiotics to maximize effectiveness and minimize toxicity

Are standard dosing regimens of ceftriaxone adapted for critically ill patients with augmented creatinine clearance? A prospective observational study.

(2019) Julien Ollivier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cefepime neurotoxicity: thresholds and risk factors. A retrospective cohort study

(2019) L. Boschung-Pasquier et al.   CLINICAL MICROBIOLOGY AND INFECTION

Therapeutic Drug Monitoring of Beta-Lactams and Other Antibiotics in the Intensive Care Unit: Which Agents, Which Patients and Which Infections?

(2018) Anouk E. Muller et al.   DRUGS

Considerable variation of trough β-lactam concentrations in older adults hospitalized with infection—a prospective observational study

(2018) Malini Hatti et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Review and Validation of Bayesian Dose‐Optimizing Software and Equations for Calculation of the Vancomycin Area Under the Curve in Critically Ill Patients

(2018) R. Brigg Turner et al.   PHARMACOTHERAPY

Too much of a good thing: a retrospective study of β-lactam concentration–toxicity relationships

(2017) Sahand Imani et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

MIC-based dose adjustment: facts and fables

(2017) Johan W Mouton et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Comprehensive Guidance for Antibiotic Dosing in Obese Adults

(2017) Lina Meng et al.   PHARMACOTHERAPY

Is Trough Concentration of Vancomycin Predictive of the Area Under the Curve? A Clinical Study in Elderly Patients

(2017) Anis Bel Kamel et al.   THERAPEUTIC DRUG MONITORING

Emerging Resistance, New Antimicrobial Agents  …  but No Tests! The Challenge of Antimicrobial Susceptibility Testing in the Current US Regulatory Landscape

(2016) R. M. Humphries et al.   CLINICAL INFECTIOUS DISEASES

The ANTIBIOPERF study: a nationwide cross-sectional survey about practices for β-lactam administration and therapeutic drug monitoring among critically ill patients in France

(2016) A. Charmillon et al.   CLINICAL MICROBIOLOGY AND INFECTION

Continuous and Prolonged Intravenous β-Lactam Dosing: Implications for the Clinical Laboratory

(2016) Mordechai Grupper et al.   CLINICAL MICROBIOLOGY REVIEWS

Population pharmacokinetics of meropenem in elderly patients: dosing simulations based on renal function

(2016) Muhammad Usman et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Effect of obesity on the pharmacokinetics of antimicrobials in critically ill patients: A structured review

(2016) Abdulaziz S. Alobaid et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Therapeutic drug monitoring in the past 40 years of the Journal of Antimicrobial Chemotherapy

(2016) David Reeves et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Augmented renal clearance in critically ill patients: etiology, definition and implications for beta-lactam dose optimization

(2015) Fekade Bruck Sime et al.   CURRENT OPINION IN PHARMACOLOGY

Assays for therapeutic drug monitoring of β-lactam antibiotics: A structured review

(2015) Mieke Carlier et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The association of elevated trough serum vancomycin concentrations with obesity

(2015) Janice Richardson et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Vancomycin Trough Concentration as a Predictor of Clinical Outcomes in Patients withStaphylococcus aureusBacteremia: A Meta-analysis of Observational Studies

(2015) John P Prybylski   PHARMACOTHERAPY

Vancomycin-Associated Nephrotoxicity: The Obesity Factor

(2015) Stephen W. Davies et al.   Surgical Infections

Innovative approaches to optimizing the delivery of vancomycin in individual patients

(2014) Manjunath P. Pai et al.   ADVANCED DRUG DELIVERY REVIEWS

Empiric Weight-Based Vancomycin in Intensive Care Unit Patients With Methicillin-Resistant Staphylococcus aureus Bacteremia

(2014) Carlos A. Alvarez et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current  -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

(2014) J. A. Roberts et al.   CLINICAL INFECTIOUS DISEASES

An international, multicentre survey of  -lactam antibiotic therapeutic drug monitoring practice in intensive care units

(2014) G. Wong et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions

(2014) Jason A Roberts et al.   LANCET INFECTIOUS DISEASES

Vancomycin AUC/MIC Ratio and 30-Day Mortality in Patients with Staphylococcus aureus Bacteremia

(2013) Natasha E. Holmes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Are Vancomycin Trough Concentrations Adequate for Optimal Dosing?

(2013) Michael N. Neely et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Empiric guideline-recommended weight-based vancomycin dosing and nephrotoxicity rates in patients with methicillin-resistant Staphylococcus aureus bacteremia: a retrospective cohort study

(2013) Ronald G Hall et al.   BMC Pharmacology & Toxicology

DALI: Defining Antibiotic Levels in Intensive care unit patients: a multi-centre point of prevalence study to determine whether contemporary antibiotic dosing for critically ill patients is therapeutic

(2012) Jason A Roberts et al.   BMC INFECTIOUS DISEASES

Continuous Infusion of Beta-Lactam Antibiotics in Severe Sepsis: A Multicenter Double-Blind, Randomized Controlled Trial

(2012) J. M. Dulhunty et al.   CLINICAL INFECTIOUS DISEASES

Vancomycin-induced nephrotoxicity: mechanism, incidence, risk factors and special populations. A literature review

(2012) Sepideh Elyasi et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Altered vancomycin pharmacokinetics in obese and morbidly obese patients: what we have learned over the past 30 years

(2012) E. Grace   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Relationship between Vancomycin Trough Concentrations and Nephrotoxicity: a Prospective Multicenter Trial

(2011) John A. Bosso et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Subtherapeutic Initial β-Lactam Concentrations in Select Critically Ill Patients

(2011) Andrew A. Udy et al.   CHEST

Health and economic burden of the projected obesity trends in the USA and the UK

(2011) Y Claire Wang et al.   LANCET

Increasing Vancomycin Serum Trough Concentrations and Incidence of Nephrotoxicity

(2010) Lindsey Pritchard et al.   AMERICAN JOURNAL OF MEDICINE

The Effects of Hypoalbuminaemia on Optimizing Antibacterial Dosing in Critically Ill Patients

(2010) Marta Ulldemolins et al.   CLINICAL PHARMACOKINETICS

Relationship between Initial Vancomycin Concentration‐Time Profile and Nephrotoxicity among Hospitalized Patients

(2009) Thomas P. Lodise et al.   CLINICAL INFECTIOUS DISEASES

Therapeutic monitoring of vancomycin in adult patients: A consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists

(2008) M. Rybak et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Larger Vancomycin Doses (at Least Four Grams per Day) Are Associated with an Increased Incidence of Nephrotoxicity

(2008) T. P. Lodise et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections

(2008) Peggy S. McKinnon et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS