Article
Microbiology
Galal Yahya, Asmaa Ebada, Eman M. Khalaf, Basem Mansour, Nehal A. Nouh, Rasha A. Mosbah, Sameh Saber, Mahmoud Moustafa, Sally Negm, Mohamed M. A. El-Sokkary, Ahmed M. El-Baz
Summary: Soil bacteria are important resources for antibiotic production and soil ecosystem maintenance. A novel antibiotic-producing bacterial strain was isolated from 55 tested soil samples, showing potential for developing new antibiotics to treat human pathogens.
Article
Ophthalmology
Camille Andre, Mohammad Mirazul Islam, Eleftherios Paschalis, Paulo J. M. Bispo
Summary: The purpose of this study was to evaluate the potential of new lipoglycopeptides as topical therapies for ocular infections. The new lipoglycopeptides showed strong antimicrobial activity against ocular staphylococci, including multidrug-resistant strains. They also exhibited less cytotoxicity on human corneal epithelial cells compared with vancomycin.
Article
Infectious Diseases
Ji Hee Kwak, Seung Won Lee, Jung Eun Lee, Eun Kyo Ha, Hey-Sung Baek, Eun Lee, Ju Hee Kim, Man Yong Han
Summary: The study aimed to assess the association between the use of antibiotics within 6 months after birth and body mass in preschool children. The findings indicated that antibiotic use was significantly associated with stunting, short stature, overweight, and obesity in preschool children.
Article
Endocrinology & Metabolism
Xin Meng, Yi Zhu, Hongkun Di, Mingye Zhang, Jing Feng, Minzhi Xu, Wenqi Xia, Qingfeng Tian, Yan He, Yong Gan, Zuxun Lu
Summary: The study aimed to investigate the dose-response relationship between early-life antibiotic exposure and the risk of subsequent overweight or obesity. The findings indicate a certain relationship between early-life antibiotic exposure and the risk of childhood overweight or obesity, highlighting the need for further studies to confirm these results.
Article
Chemistry, Multidisciplinary
Anrong Chen, Shiyin Zhao, Yang Han, Zhenghong Zhou, Bo Yang, Lan-Gui Xie, Maciej A. Walczak, Feng Zhu
Summary: C-glycosyl peptides have excellent stability and therapeutic properties, but the limited accessibility of C-glycosyl amino acids has hindered their research. This study presents a novel method for producing C-glycosyl amino acids and peptides using visible-light-driven radical conjugate addition. The method demonstrates general applicability and practicality for various sugar and peptide structures, making it useful for preparing C(sp(3))-linked sugar-based peptidomimetics.
Article
Infectious Diseases
Oguz Resat Sipahi, Deniz Akyol, Bahar Ormen, Gonul Cicek-Senturk, Sinan Mermer, Ugur Onal, Fatma Amer, Maysaa Abdallah Saed, Kevser Ozdemir, Elif Tukenmez-Tigen, Nefise Oztoprak, Ummugulsum Altin, Behice Kurtaran, Corneliu Petru Popescu, Mustafa Sakci, Bedia Mutay Suntur, Vikas Gautam, Megha Sharma, Safak Kaya, Eren Fatma Akcil, Selcuk Kaya, Tuba Turunc, Pinar Ergen, Ozlem Kandemir, Salih Cesur, Selin Bardak-Ozcem, Erkin Ozgiray, Taskin Yurtseven, Huseyin Aytac Erdem, Hilal Sipahi, Bilgin Arda, Huesnue Pullukcu, Meltem Tasbakan, Tansu Yamazhan, Sohret Aydemir, Sercan Ulusoy
Summary: This study analyzed the effectiveness of main antibiotic therapy regimens in the treatment of healthcare-associated meningitis (HCAM). The results showed that there was no significant difference in terms of clinical success and mortality among the three treatment options. All the regimens were ineffective against carbapenem-resistant bacteria. Vancomycin also had a low success rate in cases involving methicillin-resistant staphylococci or ampicillin-resistant enterococci infections.
BMC INFECTIOUS DISEASES
(2023)
Article
Medicine, Research & Experimental
Jiuzhen Tian, Honghua Liu, Hua Guo, Weiping Han, Hui Ding, Tong Chen
Summary: The study revealed that the use of antibiotics in infants and young children increases the risk of overweight and obesity at the age of 3. This risk is especially significant in children who receive antibiotics for the first time within 6 months of age and in those who are administered antibiotics five times or more.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Microbiology
Horia Todor, Nadia Herrera, Carol A. Gross
Summary: DedA family proteins are highly conserved and nearly ubiquitous integral membrane proteins found in archaea, bacteria, and eukaryotes. Recent studies have identified that eukaryotic DedA proteins are phospholipid scramblases, while some bacterial DedA proteins are undecaprenyl phosphate flippases. Our phylogenetic analysis reveals three major DedA subfamilies with distinct functions, including undecaprenyl-phosphate (UndP) flippases and putative phospholipid flippases.
Article
Microbiology
Vesa Cheng, Mohd H. Abdul-Aziz, Fay Burrows, Hergen Buscher, Young-Jae Cho, Amanda Corley, Arne Diehl, Eileen Gilder, Stephan M. Jakob, Hyung-Sook Kim, Bianca J. Levkovich, Sung Yoon Lim, Shay McGuinness, Rachael Parke, Vincent Pellegrino, Yok-Ai Que, Claire Reynolds, Sam Rudham, Steven C. Wallis, Susan A. Welch, David Zacharias, John F. Fraser, Kiran Shekar, Jason A. Roberts
Summary: This study aimed to describe the population pharmacokinetics (PK) of vancomycin in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) and recommend safe and effective dosing regimens. The results showed that the recommended dosing regimens for critically ill adult patients not on ECMO can be safely and effectively used in those on ECMO.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Engineering, Environmental
Yanhua Wang, Yanni Yang, Xia Liu, Jian Zhao, Ruihan Liu, Baoshan Xing
Summary: This research examines the interaction mechanisms of microplastics (MPs) and antibiotics (ATs) in aquatic environments, as well as the impact of MPs on the bioavailability of ATs and the abundance of antibiotic resistance genes (ARGs). It discusses the factors affecting ATs adsorption on MPs and how MPs can affect the bioaccumulation and toxicity of ATs to aquatic organisms. Furthermore, it evaluates the enrichment of ARGs by MPs and presents research challenges and perspectives for the interactions between MPs and ATs.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Physical
Haiyan Wang, Qinghua Yang, Zhaosong Li, Yuan Xie, Fanping Kong, Derui Liang, Caifeng Xia, Hanhan Huang, Jialiang Li, Zilin Meng
Summary: The removal effect of montmorillonite (Mt) on antibiotics, specifically ciprofloxacin (CIP) and erythromycin (ERY), was investigated in this study. Adsorption kinetics and isotherm experiments confirmed the effectiveness of the generalized Langmuir model in describing the adsorption process, with higher adsorption capacity observed for CIP. The intercalation and adsorption behaviors of CIP and ERY on Mt surface were analyzed using various techniques, revealing the competitive adsorption mechanism of these antibiotics. Moreover, the adsorption of antibiotics on Mt under different pH conditions was studied, and the competitive adsorption results were supported by the potential energy distribution.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biotechnology & Applied Microbiology
A. E. Kuvarina, M. L. Georgieva, E. A. Rogozhin, A. B. Kulko, I. A. Gavryushina, V. S. Sadykova
Summary: The study examined the ability of alkalophilic micromycetes Sodiomyces alkalinus to produce antimicrobial compounds, selecting a promising producer of antifungal agent. The producer showed antifungal activity against opportunistic fungi and pathogenic clinical isolates of molds and yeasts, which are pathogens of systemic mycoses.
APPLIED BIOCHEMISTRY AND MICROBIOLOGY
(2021)
Review
Endocrinology & Metabolism
Alan Pereira Chagas, Nadyellem Graciano da Silva, Carolina Martins Ribeiro, Angelica Amorim Amato
Summary: This study found that early-life exposure to antibiotics may increase the risk of overweight/obesity in children and adolescents, particularly with antenatal and early postnatal exposure. However, due to the very low certainty of evidence, further prospective studies are needed to confirm these findings.
OBESITY RESEARCH & CLINICAL PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Timm O. Koller, Martino Morici, Max Berger, Haaris A. Safdari, Deepti S. Lele, Bertrand Beckert, Kanwal J. Kaur, Daniel N. Wilson
Summary: The antimicrobial peptide drosocin, produced by Drosophila species, is O-glycosylated at threonine 11, and this glycosylation not only affects cellular uptake but also interacts with its target, the ribosome. Cryogenic electron microscopy structures reveal that glycosylated drosocin binds to the polypeptide exit tunnel of the ribosome, interfering with translation termination by trapping RF1 and inducing conformational changes. The glycosylation of drosocin enables multiple interactions with U2609 of 23S rRNA, disrupting a canonical base pair with A752. These findings provide important insights into the interaction of glycosylated drosocin with the ribosome and have implications for the development of antimicrobial drugs.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Fisheries
Feipeng Li, Jiong Huang, Mingzhu Wang, Ling Chen, Yihua Xiao
Summary: This study investigated the sources, distribution, and dynamics of 12 selected antibiotics in pond water, sediment, and shrimp muscles during a whiteleg shrimp farming cycle. The results showed the accumulation of antibiotics in these environments and their correlation with antibiotics in feeds. The study highlighted the importance of feed as a main source of antibiotic residues in aquaculture environment.