Review
Pharmacology & Pharmacy
Melgious Jin Yan Ang, Siew Yin Chan, Yi-Yiing Goh, Zichao Luo, Jun Wei Lau, Xiaogang Liu
Summary: The review focuses on recent developments of advanced nanomaterials and nanotheranostics in cancer treatment, particularly in the areas of stimulus-responsive nanomaterials and nanocarriers targeting the tumor microenvironment. The review also discusses the potential cytotoxicity and future prospects of next-generation nanomaterials for clinical implementation.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Haijing Qu, Longmeng Li, Han Chen, Menghuan Tang, Wei Cheng, Tzu-yin Lin, Lingyan Li, Bin Li, Xiangdong Xue
Summary: In this study, researchers developed nanoparticles with strong photo/immune therapeutic effects by integrating a photosensitizer and a Toll-like receptor 7/8 agonist. These nanoparticles can directly inhibit tumor growth, promote the immune response, and reverse the suppressive tumor immune microenvironment. They have the potential to enhance the effectiveness of immunotherapy and phototherapy in cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Physical
Zhongyuan Guo, Audrey T. Zhu, Ronnie H. Fang, Liangfang Zhang
Summary: Phototherapy is a promising cancer treatment approach that utilizes light irradiation to induce local hyperthermia and reactive oxygen species production for eradicating cancer cells. Nanoparticles, with their small size and tunable properties, have been widely used as carriers to enhance the biocompatibility and tumor-targeted delivery of phototherapeutic agents. Recent developments have focused on using nanoparticle-based phototherapy to achieve durable and systemic antitumor responses through immune modulation.
Review
Biotechnology & Applied Microbiology
Mohammad Doroudian, Saba Zanganeh, Elham Abbasgholinejad, Seamas C. Donnelly
Summary: Lung cancer is a leading cause of cancer death globally. Nanoparticles have great potential and challenges in lung cancer immunotherapy, as they can precisely target and regulate immune responses.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Polymer Science
Shreyas Mukherjee, Samrat Mukherjee, Mohammed A. S. Abourehab, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Dendrimers, as a novel drug delivery system, play an important role in cancer immunotherapy. They have various properties and functions, forming high-specificity bonds with different functional groups. However, the increasing toxicity of newer generations of dendrimers can be mitigated through the attachment of anionic or neutral ligand groups.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Shaojun Peng, Fengfeng Xiao, Meiwan Chen, Huile Gao
Summary: Cancer immunotherapy has made great progress in the past decades, but challenges such as low patient response rates and potential immune-related adverse events persist. Tumor-microenvironment (TME)-responsive nanomedicine has shown promise in amplifying immune responses in a specific and localized manner within tumor tissue, leading to increased patient response rates and reduced immune-related side effects.
Article
Chemistry, Multidisciplinary
Dong Cen, Qiwei Ge, Congkun Xie, Qiang Zheng, Jiansheng Guo, Yuqi Zhang, Yifan Wang, Xiang Li, Zhen Gu, Xiujun Cai
Summary: This study demonstrated that ZnS@BSA nanoclusters, synthesized through a self-assembly approach, significantly enhance cGAS/STING signals by releasing zinc ions in the acidic tumor microenvironment, leading to improved immunotherapy efficacy against hepatocellular carcinoma.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Jing Liu, Si Si Liew, Jun Wang, Kanyi Pu
Summary: Cancer vaccines aim to stimulate tumor-specific immune responses while sparing normal tissues, with bioinspired materials and technologies playing a role in reshaping the field of cancer nanomedicine. By mimicking desirable properties in nature, bioinspired engineering of cancer vaccine delivery platforms can enhance therapeutic efficacy and safety profiles for clinical translation.
ADVANCED MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Pengwen Chen, West Kristian Dizon Paraiso, Horacio Cabral
Summary: Cytokines have the potential for treating infections, autoimmune diseases, and cancers, but their clinical application is limited due to poor pharmacokinetics, toxicity, and efficacy. To overcome these limitations, innovative delivery strategies, such as gene and protein delivery systems targeting cytokines or encoding cytokines, can be used to improve their safety and anticancer performance. This review focuses on these delivery strategies, summarizing key approaches and examining their potential and challenges for clinical translation.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Oncology
Nour K. Younis, Rami Roumieh, Emmanuel P. Bassil, Joseph A. Ghoubaira, Firas Kobeissy, Ali H. Eid
Summary: This article introduces the role and potential of nanoparticles in diagnosing and treating colorectal cancer. Nanomedicine, as a new treatment modality, has the ability to overcome the limitations of traditional treatments and has been widely studied in clinical research. The article describes the therapeutic effects of several types of nanoparticles and their significance in targeted drug delivery, while also emphasizing the importance of nanomedicine in managing colorectal cancer and other diseases.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ana Luiza C. de S. L. Oliveira, Timo Schomann, Lioe-Fee de Geus-Oei, Ellen Kapiteijn, Luis J. Cruz, Raimundo Fernandes de Araujo Junior
Summary: Nanotechnology is a promising tool for the treatment of cancer, aiming to reduce the side effects of chemotherapy and increase treatment efficiency through drug delivery systems. However, nanomedicines face challenges and hurdles in overcoming biological barriers to effectively treat tumors.
Article
Materials Science, Multidisciplinary
Nishant Kumar, Sajid Fazal, Eijiro Miyako, Kazuaki Matsumura, Robin Rajan
Summary: Cancer is a leading cause of death globally, causing physical, emotional, and financial strain on individuals, families, and healthcare systems. The development of nanoparticle-based drug delivery systems and synthetic biodegradable polypeptides and polymers offers new hope for cancer treatment, overcoming challenges such as harmful side effects and drug resistance. Additionally, immunotherapies and bacteria-based therapies show promising selectivity and efficacy in treating various cancers.
Review
Engineering, Biomedical
Dongdong Li, Doudou Hu, Hongxia Xu, Hirak K. Patra, Xiangrui Liu, Zhuxian Zhou, Jianbin Tang, Nigel Slater, Youqing Shen
Summary: Transdermal drug delivery is promising, especially through superficial routes. Microneedles can overcome limitations and deliver drugs into the dermal layer efficiently. They have been tested for pre-clinical chemotherapy, photothermal therapy, photodynamic therapy, and immunotherapy.
Review
Chemistry, Multidisciplinary
Rita Lima-Sousa, Bruna L. Melo, Catia G. Alves, Andre F. Moreira, Antonio G. Mendonca, Ilidio J. Correia, Duarte de Melo-Diogo
Summary: The combination of nanomaterial-mediated photothermal-photodynamic therapy with ICIs shows potential in targeting metastatic cancer by generating heat and reactive oxygen species within the tumor, modulating T cell populations, and inducing an anti-metastatic effect. This approach may also lead to the development of immune memory to prevent tumor recurrence.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Biomedical
Xiangdong Xue, Haijing Qu, Ruonan Bo, Dalin Zhang, Zheng Zhu, Bai Xiang, Longmeng Li, Marina Ricci, Chong-Xian Pan, Tzu-Yin Lin, Yuanpei Li
Summary: We developed a size/charge dually transformable nanoplatform (PDR NP) with multiple therapeutic and immunostimulatory properties to effectively treat advanced cancers. The PDR NPs exhibit three different therapeutic modalities (chemotherapy, phototherapy, and immunotherapy) and can effectively treat primary and distant tumors, as well as reduce recurrent tumors. The immunotherapy is activated by three major pathways, effectively suppressing tumor development in combination with an immune checkpoint inhibitor. The size and charge responsive transformability of PDR NPs in the tumor microenvironment allows efficient delivery of payloads into tumor cells.
Article
Chemistry, Multidisciplinary
Zhen Xu, Li Zhang, Min Pan, Qunying Jiang, Yunjie Huang, Fuan Wang, Xiaoqing Liu
Summary: Nanozymes have great potential in nanomedicine, but their clinical translation is limited by biotoxicity. A new type of bionanozyme with ultrahigh and light-controlled catalytic activity has been developed through self-assembly and in situ polymerization, showing potential for tumor-specific therapy with minimal biotoxicity.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Analytical
Yeqing Wan, Gaiping Li, Lina Zou, Hong Wang, Qing Wang, Kaiyue Tan, Xiaoqing Liu, Fuan Wang
Summary: A self-catalytic DNA assembly (SDA) machine was developed for programmable assembly of functional DNA nanostructures in living cells, enabling sensitive detection of cancer biomarkers such as miR-21. The system combines catalytic self-assembly (CSA) and DNAzyme amplification modules to achieve a self-catalytic amplification reaction, leading to precise intracellular imaging and potential for early cancer diagnosis.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Shuang Li, Qunying Jiang, Yahua Liu, Wenxiao Wang, Wenqian Yu, Fuan Wang, Xiaoqing Liu
Summary: Accurate diagnosis and targeted therapy are important for precision theranostics. This study presents an activatable DNA nanosphere for specific sensing of cancer biomarker FEN1 and modulating drug release, showing good stability, sensitivity, and specificity, providing a reliable method for FEN1 imaging and suggesting a powerful strategy for precision medicine.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Junlin Sun, Feng Liu, Wenqian Yu, Dandan Fu, Qunying Jiang, Fengye Mo, Xiuyuan Wang, Tianhui Shi, Fuan Wang, Dai-Wen Pang, Xiaoqing Liu
Summary: Quantum dot nanomaterials can monitor vaccine dynamics, enhance immune response, and enable spatial and temporal tracking of vaccine transportation, providing a powerful strategy for studying immune response and evaluating vaccine efficacy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
Xue Gong, Haizhou Wang, Ruomeng Li, Kaiyue Tan, Jie Wei, Jing Wang, Chen Hong, Jinhua Shang, Xiaoqing Liu, Jing Liu, Fuan Wang
Summary: The study introduces a novel approach to achieving tumorous biomarker-activated RNAi therapy through the design of RNAi prodrugs in extracellular vesicles. This system shows promise for personalized therapy with reduced off-target effects and enhanced cancer-specific activation.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Wenqian Yu, Junlin Sun, Xiuyuan Wang, Shuyi Yu, Mingzhu Yan, Fuan Wang, Xiaoqing Liu
Summary: This study reports a convenient tumor-specific A2AR inhibition strategy to improve antitumor immune responses using a photo-modulated nanoreactor for spatiotemporally controlled oxygen supply. This nanoreactor not only relieves A2AR-mediated immunosuppression, but also enhances antitumor immunity through photothermal ablation of the tumor and immunogenic cell deaths.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Huimin Wang, Yuqiu He, Jie Wei, Hong Wang, Kang Ma, Yangjie Zhou, Xiaoqing Liu, Xiang Zhou, Fuan Wang
Summary: This study developed a versatile autocatalytic DNA circuit for high-performance in vivo bioanalysis. The circuit showed sensitive and selective detection of analytes, and enabled robust miRNA imaging in living cells and mice. These findings expand the toolbox for accurate diagnosis and programmable therapeutics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biophysics
Yunzhe Cao, Fengye Mo, Yahua Liu, Yu Liu, Gaiping Li, Wenqian Yu, Xiaoqing Liu
Summary: We constructed a portable and sensitive platform that can detect non-glucose target by combining enzyme-encapsulated zeolitic imidazole framework-90 (ZIF-90) with personal glucose meter. This method determined ATP with a remarkably sensitivity of 233 nM and effective recovery in real serum samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Jie Wei, Jinhua Shang, Shizhen He, Yu Ouyang, Itamar Willner, Fuan Wang
Summary: In this study, a simple yet versatile enthalpy-driven autocatalytic hybridization chain reaction (AHCR) machinery was constructed for accurate intracellular microRNA imaging in live cells. By introducing two differently designed HCR modules, autonomous cross-invasion and assembly of hyperbranched dsDNA nanostructures were achieved, enabling precise signal localization. The AHCR machinery can be extended for analyzing diverse biomarkers, providing a powerful tool for clinical diagnosis and therapeutic assessment.
Article
Engineering, Environmental
Jialing Hu, Zhiqiao Zou, Fengye Mo, Xue Lin, Yun Zhao, Tianhui Shi, Fuan Wang, Xiaoqing Liu
Summary: A DNA prodrug-laden metallo-nanoassembly has been developed for sensitive activation of DNAzymes to regulate disease genes, with enhanced gene cleavage activity and improved drug stability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Chen Hong, Qing Wang, Yingying Chen, Yuhui Gao, Jinhua Shang, Xiaocheng Weng, Xiaoqing Liu, Fuan Wang
Summary: The article introduces a novel method for accurate intracellular imaging of metal ions by utilizing an epigenetic demethylation-regulating DNAzyme system, which repairs and activates DNAzyme to achieve accurate imaging of metal ions.
Article
Chemistry, Multidisciplinary
Wenxiao Wang, Yu Shen, Fuan Wang, Ying Liu, Xiaoqing Liu
Summary: A versatile approach for fine control of DNA-based hierarchical assembly is developed using dual stimuli and two assembly strategies. By designing functional thrombin aptamer structures on the DNA nanoassembly, precise regulation of thrombin activity can be achieved.
CHEMICAL COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Jialing Hu, Qunying Jiang, Tianhui Shi, Xue Lin, Yun Zhao, Xiuyuan Wang, Xiaoqing Liu
Summary: A targeted metallo-nanodrug for breast cancer metastasis treatment was developed to generate oxidative stress and block metastatic pathways with high tumor specificity. The study demonstrated significant inhibition of tumor growth and reduction of metastatic lung nodules in murine breast carcinoma models, indicating the potential of the strategy for precision nanomedicine in metastatic breast cancer.
ADVANCED THERAPEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Yahua Liu, Fengye Mo, Jialing Hu, Qunying Jiang, Xiuyuan Wang, Zhiqiao Zou, Xian-Zheng Zhang, Dai-Wen Pang, Xiaoqing Liu
Summary: This study developed a tumor microenvironment-activated photothermal and photoacoustic agent for precise cancer diagnosis and treatment. Controllable plasmonic heating enables therapy and imaging in tumor tissues while avoiding damage to normal tissues.
Article
Chemistry, Multidisciplinary
Qunying Jiang, Min Pan, Jialing Hu, Junlin Sun, Lei Fan, Zhiqiao Zou, Jianshuang Wei, Xiaoquan Yang, Xiaoqing Liu
Summary: The article discusses a highly effective phototherapy method that inhibits tumor growth and metastasis by regulating redox homeostasis using a biocompatible and versatile nanotherapeutic. By eliminating the endogenous ROS scavenging system, the phototherapy is amplified, leading to effective suppression of tumor growth both in vitro and in vivo. This innovative approach may offer a clinically relevant method for cancer treatment.
