Article
Materials Science, Multidisciplinary
Nara S. Soares, Luciana M. Hollanda, Conceicao M. V. Elias, Marleane M. F. Azevedo, Francisco Eroni P. Santos, Anderson O. Lobo, Fernanda R. Marciano
Summary: This study reported the antibacterial effect of electrospun blends modified with quaternary amine group, which increased the positive charge and killed more bacteria.
Article
Pharmacology & Pharmacy
Elham Khodaverdi, Mohammad Reza Abbaspour, Fatemeh Oroojalian, Negar Omidkhah, Samir Hossein-nezahd, Hossein Kamali, Farzin Hadizadeh
Summary: The triblock copolymers of PEG-PCL-PEG (PEGCL) were fabricated using ring-opening polymerization (ROP) of epsilon-caprolactone. The scaffolds with adjustable structure and morphology were constructed using the scCO(2) gas foaming method to provide controlled release of dexamethasone loaded in PEGCL.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Polymer Science
Nuttapol Risangud, Nootcharee Kunkit, Piyarat Sungkhaphan, Weerawan Hankamolsiri, Lertchai Sornchalerm, Somprasong Thongkham, Kantapat Chansaenpak
Summary: In this study, PEG(114)-b-PCLx copolymer was used to enhance the water solubility of TPO, a fashionable photoinitiator. TPO@PEG(114)-b-PCLx nanoparticles were prepared through nanoprecipitation and subsequent lyophilization. The resulting nanoparticles had different sizes and encapsulation efficiencies depending on the molecular weights of PEG(114)-b-PCLx and the TPO:PEG(114)-b-PCLx ratios. The prepared photoinitiators were then used to fabricate 3D-printed hydrogels with PEGDMA and Dex-MA. The hydrogels exhibited good mechanical properties and were noncytotoxic to cells.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Physical
Chufen Yang, Delin Wang, Wenyao Liu, Zexiong Yang, Teng He, Fang Chen, Wenjing Lin
Summary: In this study, folate (FA) modified dual pH/reduction-responsive mixed polymeric micelles were successfully assembled for high loading, controlled release, and active targeted delivery. The micelles showed excellent drug loading capacity and encapsulation efficiency, and demonstrated well-controlled release performance in neutral and acidic environments. Cytotoxicity assays further revealed the superior inhibitory effect of FA-modified micelles on cancer cells. These findings suggest that the developed micelles have great potential for anticancer drug delivery.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Evelyn Osehontue Uroro, Richard Bright, Jing Yang Quek, Krasimir Vasilev
Summary: A novel approach for drug administration using stimulus-responsive carriers is introduced in this study to minimize drug dosage and frequency, thereby reducing cytotoxicity levels. Nanocomposites loaded with rifampicin (RFP) were prepared using lipases-sensitive polycaprolactone (PCL) and showed responsive behavior and improved biocompatibility compared to the free drug.
Article
Pharmacology & Pharmacy
Minoo Ghanavi, Ali Khoshandam, Shaghayegh Aslzad, Marziyeh Fathi, Abolfazl Barzegari, Elaheh Dalir Abdolahinia, Khosro Adibkia, Jaleh Barar, Yadollah Omidi
Summary: Due to the unique structure of the human eye, ocular drug delivery faces challenges such as low bioavailability. In-situ gel-forming mucoadhesive hydrogels can improve ocular bioavailability. Chitosan has been used in the preparation of these hydrogels. Water-soluble chitosan was obtained and gel formation was accomplished using sodium beta-glycerophosphate and sodium bicarbonate. The prepared hydrogel showed sustained-release and antibacterial activity in vitro.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zhuolun Song, Jinghuan Fang, Zhenhua Wang, Renming Xiao, Xing Guo, Shaobing Zhou
Summary: In this study, rod-shaped polylactic acid polyglycolic acid nanoparticles encapsulated with piceatannol were developed to target and interfere with the interaction between neutrophils and inflamed endothelial cells in ischemic stroke. The nanoparticles with an aspect ratio of 5 exhibited enhanced internalization by neutrophils and were able to block neutrophil adherence to endothelial cells and inhibit infiltration into the blood-brain barrier. The released piceatannol within the ischemic region also inhibited neuroinflammation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Mehdi Afrouz, Farnaz Ahmadi-Nouraldinvand, Amin Amani, Hoda Zahedian, Sabry G. Elias, Fatemeh Arabnejad, Hashem Yaghoubi, Omid Farshad, Neda Farazi, Atefeh Jalali, Hadi Eskanlou
Summary: This study evaluated the gene delivery capability of different micelles in MCF-7 cells and found that FePECLEFE/DNA micelles had higher gene transfer efficiency. Additionally, the ability of these micelles to neutralize the negative charge of DNA and protect it against restriction enzymes was investigated, and it was found that they have good biocompatibility and low cytotoxicity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Nicola Di Trani, Hsuan-Chen Liu, Ruogu Qi, Dixita I. Viswanath, Xuewu Liu, Corrine Ying Xuan Chua, Alessandro Grattoni
Summary: Strict adherence to drug administration timing improves efficacy, while poor adherence leads to safety concerns. Nanofluidic technology enables long-acting drug delivery with tunable timing of drug administration.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Sepideh Khoee, Samaneh Moayeri, Mohammad A. Charsooghi
Summary: This paper synthesized functionalized nanoparticles and investigated their diffusion coefficients and velocities in different solutions, as well as the effects of an external magnetic field and NaCl concentration on their movement direction.
Article
Pharmacology & Pharmacy
Pelin Saracoglu, Senanur Dokuz, Tulin Ozbek, Murat Topuzogullari, Mehmet Murat Ozmen
Summary: Nanogels crosslinked with starch and polyethylene glycol diglycidyl ether (PEGDE) were synthesized as nanocarriers for antibacterial agents, showing excellent drug release and antibacterial activity in vitro. These nanogels possess small hydrodynamic diameters and good biodegradability, making them suitable as nanocarriers for drugs/bioactive agents.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Infectious Diseases
Chengang Ni, Yuening Zhong, Weixi Wu, Yaping Song, Pooyan Makvandi, Chengzhong Yu, Hao Song
Summary: This study successfully combined vancomycin and nano-Ag onto pollen-like silica nanoparticles to enhance bacterial killing. The silver nanoparticles were observed to be well-distributed on the surface of silica nanoparticles, with a unique spiky morphology promoting adhesion to bacterial surfaces for localized drug release to kill bacteria.
Article
Chemistry, Multidisciplinary
Mengyao Wang, Ye Lin, Jianxu Gao, Dongmei Liu
Summary: Dissipative particle dynamics (DPD) simulation was used to study the morphologies and structures of PLGA-b-PEG-b-PLGA polymeric micelles. The results showed that the micelles exhibited different structures, such as spherical, onionlike, columnar, and lamellar, under different concentrations and drug content. The drug release process under shear flow was also simulated, and it was found that the shear rate affected the micelle structure and drug release.
Article
Pharmacology & Pharmacy
Naveed Ahmad, Muhammad Masood Ahmad, Nabil K. Alruwaili, Ziyad Awadh Alrowaili, Fadhel Ahmed Alomar, Sultan Akhtar, Omar Awad Alsaidan, Nabil A. Alhakamy, Ameeduzzafar Zafar, Mohammed Elmowafy, Mohammed H. Elkomy
Summary: This study investigated the application of Arabinoxylan-gelatin blended films as wound dressings for treating chronic wound infections. The results showed that these dressings have good drug release and antibacterial properties, making them suitable for wound protection.
Article
Pharmacology & Pharmacy
Hisako Ibaraki, Naruhiro Hatakeyama, Naoki Arima, Akihiro Takeda, Yasuo Seta, Takanori Kanazawa
Summary: It was found that the delivery of siRNA using MPEG-PCL-CH2R4H2C nanomicelles has good therapeutic effects on ulcerative colitis. These nanomicelles have optimal physical properties and high siRNA compaction ability, allowing for higher accumulation of siRNA at the inflammatory site, thus improving the therapeutic effect.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Energy & Fuels
Nurizan Omar, Ezzat Chan Abdullah, Ashley Aaron Petrus, Nabisab Mujawar Mubarak, Mohammad Khalid, Elochukwu Stephen Agudosi, Arshid Numan, Siti Rahmah Aid
Summary: This study examines the preparation of coconut shell and watermelon rind biochar using binary metal oxides and a vacuum condition, and characterizes the samples using various methods. The optimal pyrolysis temperature for producing high surface area is found to be 600 degrees C. FTIR and FESEM analysis reveal changes in the samples' structure and surface. In addition, the application of biochar in electrochemical energy storage is explored.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Materials Science, Coatings & Films
Yu Yi How, Faiza Bibi, Arshid Numan, Rashmi Walvekar, Priyanka Jagadish, Mohammad Khalid, Javed Iqbal, Nabisab Mujawar Mubarak
Summary: This study aims to optimize the fabrication parameters of NiFe-P electrode for high areal capacity in supercapattery. The study uses a one-step hydrothermal synthesis method and central composite design (CCD) to optimize the performance. The optimized electrode shows high specific capacity and excellent stability.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
K. C. Bhuvan, Alian A. Alrasheedy, Peter A. Leggat, Nagashekhara Molugulu, Mohamed Izham Mohamed Ibrahim, Asmita Priyadarshini Khatiwada, Sunil Shrestha
Summary: Pharmacists at airport pharmacies offer various professional services, including the provision of medicines, health products, general health services, travel health services, and counseling. Challenges faced by pharmacists at airport pharmacies include language barriers, requests for different medicine brands by travelers, and financial issues. There is further scope for improvement in this sector to ensure a more active role in travel medicine.
INTEGRATED PHARMACY RESEARCH AND PRACTICE
(2022)
Review
Energy & Fuels
Ong Gerard, Arshid Numan, Syam Krishnan, Mohammad Khalid, Ramesh Subramaniam, Ramesh Kasi
Summary: This review discusses the progress in binder-free synthesis techniques, focusing on microwave-assisted hydrothermal synthesis for fabricating electrodes in electrochemical energy storage devices. It compares the advantages of this approach with conventional methods and critically analyzes its commercial viability and future opportunities.
JOURNAL OF ENERGY STORAGE
(2022)
Article
Energy & Fuels
Nurizan Omar, Ezzat Chan Abdullah, Arshid Numan, Nabisab Mujawar Mubarak, Mohammad Khalid, Siti Rahmah Aid, Elochukwu Stephen Agudosi
Summary: This study reports a novel binary composite material BCWR derived from watermelon rind, which can serve as an electrode for supercapacitors, and optimized the synthesis process parameters such as pyrolysis temperature, pyrolysis time, and biomass to metal oxide ratio. The experimental validation shows that BCWR has the potential to be a superior electrode material for energy storage applications.
JOURNAL OF ENERGY STORAGE
(2022)
Review
Biochemistry & Molecular Biology
Dinesh K. Chellappan, Parteek Prasher, Shakti D. Shukla, Tong W. Yee, Tiong K. Kah, Toh W. Xyan, Tang W. Kid, Teoh H. Si, Ting S. Weng, Nagashekhara Molugulu, Lakshmana P. Sakthivel, Jestin Chellian, Thiagarajan Madheswaran, Himaja Malipeddi, Yogendra Singh, Harish Dureja, Deepak N. Kapoor, Poonam Negi, Rohit Goyal, Lakshmi Thangavelu, Deepak Kumar, Piyush K. Gupta, Niraj K. Jha, Madhur D. Shastri, Ronan MacLoughlin, Sachin K. Singh, Monica Gulati, Gaurav Gupta, Kamal Dua
Summary: Respiratory diseases, such as chronic obstructive pulmonary disease, cystic fibrosis, asthma, and pneumonia, often require treatment with antibiotics and steroids. However, treatment failure and antibiotic resistance are common in managing these diseases. The demand for corticosteroids and antibiotics has been increasing due to their immunosuppressive and anti-inflammatory properties. This review explores the different applications of antibiotics, corticosteroids, and their combination in managing respiratory diseases, as well as discusses their drawbacks.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Electrochemistry
Muhammad Norhaffis Mustafa, Muhammad Amirul Aizat Mohd Abdah, Arshid Numan, Yusran Sulaiman, Rashmi Walvekar, Mohammad Khalid
Summary: In this study, nickel cobalt phosphate (NiCoP) was optimized as a positive electrode material for electrochromic energy storage applications using response surface methodology and central composite design (RSM/CCD). The NiCoP composite was prepared through electrodeposition, and four input variables (concentration of precursors, number of CV cycles, and scan rate) were simultaneously optimized for specific capacity. Statistical analysis showed that all four factors significantly influenced the specific capacity of NiCoP. The resulting quadratic model accurately predicted the specific capacity of NiCoP up to 97% with a residual standard error of 3%. The novel NiCoP electrode materials exhibited remarkable electrochromic properties and supercapacitive performance due to the synergistic effect of bimetallic oxides (NiCo) and high surface area phosphate.
ELECTROCHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Muhammad Amirul Aizat Mohd Abdah, Jayesh Cherusseri, Nurul Akmaliah Dzulkarnain, Marliyana Mokhtar, Mohd Sukor Su'ait, Yee Seng Tan, Muhammad Norhaf fis Mustafa, Mohammad Khalid, Arshid Numan, Amr Radwan
Summary: In this study, MXene hybrid electrodes were synthesized using a novel strategy to achieve a synergistic effect between the components. The AC to Ti3C2 MXene ratio was adjusted to optimize electrochemical efficiency. The hybrid AC_Ti3C2 (8:2) electrode exhibited the highest initial specific capacity and maintained good performance after consecutive cycles, indicating excellent rate capability. The work confirms the potential application of AC as an interlayer spacer in synthesizing Ti3C2 MXene hybrids for next-generation LIBs.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Mehmood Shahid, Arshid Numan, Jayesh Cherusseri, Mohammad Khalid, H. H. Somaily, Chariya Kaewsaneha
Summary: In this study, a one-step method was developed to synthesize Co(OH)2 nanoflakes intercalated into nitrogen-doped graphene oxide (NrGO). The NrGO-Co(OH)2 nanocomposite showed promising electrochemical performances and potential for energy storage devices. The specific capacity of the NRCO nanocomposite electrode reached 75.2 C/g, and the supercapattery device fabricated with NRCO nanocomposite exhibited excellent cycle life with 93.1% retention of its initial capacity after 3000 continuous charge/discharge cycles.
JOURNAL OF MATERIALS RESEARCH
(2023)
Review
Environmental Sciences
Tenzin Sonam Dongsar, Tenzin Tsering Dongsar, Nagashekhara Molugulu, Sivakumar Annadurai, Shadma Wahab, Neelima Gupta, Prashant Kesharwani
Summary: Breast carcinoma is a diverse disease and one of the most prevalent malignancies in females worldwide. Chemotherapy is widely used for its treatment, but it has limitations. Nanoparticulate systems, particularly PLGA-based nano systems, are being explored as a promising strategy for improving breast carcinoma treatment. This review focuses on the effectiveness of DOX-encapsulated PLGA nanoparticles as a feasible option for breast cancer treatment.
ENVIRONMENTAL RESEARCH
(2023)
Review
Environmental Sciences
Jyoti Chandra, Nagashekhara Molugulu, Sivakumar Annadurai, Shadma Wahab, Ritu Karwasra, Surender Singh, Rahul Shukla, Prashant Kesharwani
Summary: Cancer is a complex disease that develops in response to a combination of hereditary and environmental risk factors, resulting in genomic changes. CD44, a transmembrane glycoprotein, serves as a potential biomarker and therapeutic target for cancer stem cells. Hyaluronic acid, a polysaccharide, shows affinity for the CD44 receptor, making it a promising candidate for selectively targeting CD44-positive cancer cells.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Neha Parveen, Afsana Sheikh, Nagashekhara Molugulu, Sivakumar Annadurai, Shadma Wahab, Prashant Kesharwani
Summary: The study aimed to prepare and optimize SNEDDS loaded with azelaic acid (AzA) using a pseudo ternary phase diagram, which was then incorporated into Carbopol 940 hydrogel for treating atopic dermatitis. The composition was evaluated for various parameters, and the optimized preparation showed favorable properties. The SNEDDS hydrogel demonstrated higher permeation rate through rat skin compared to a marketed formulation, and it did not cause skin irritation.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Physical
Nikhil Agrawal, Emilio Parisini
Summary: In this study, the spontaneous binding of PAP248-286 fusogenic peptide to membrane bilayers was investigated using coarse-grained molecular dynamics simulations. The simulations revealed that PAP248-286 displayed increased binding to the membrane in the presence of anionic lipid POPG, particularly in systems containing charged histidine (His) residues. The peptide adopted a parallel orientation with the membrane, exposing its positively charged residues to the lipid bilayer. These findings provide insights into the molecular mechanisms underlying the membrane binding of PAP248-286 and its potential role in HIV fusion and infection.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Review
Engineering, Biomedical
Amir R. Afshari, Mehdi Sanati, Prashant Kesharwani, Amirhossein Sahebkar
Summary: Standard cancer chemotherapeutics often lose effectiveness and produce adverse effects due to resistance mechanisms. Curcumin, when combined with traditional chemotherapeutics, has been found to enhance cancer treatment effectiveness and reduce resistance. However, limited bioavailability requires co-delivery strategies for Cur and conventional pharmaceuticals in clinical settings.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Nikhil Agrawal, Adam A. Skelton, Emilio Parisini
Summary: Alzheimer's disease, characterized by the misfolding and aggregation of amyloid-beta (A beta) peptides, remains poorly understood in terms of its molecular mechanism of interaction with cell membranes. In this study, simulations were conducted to investigate the interaction between A beta 1-40 fibrils and different bilayers composed of DPPC and cholesterol. The results show the involvement of hydrophobic amino acid clusters, lysine residues, and C-terminal hydrophobic residues in the binding process. Furthermore, the data suggest that the binding affinity of A beta 1-40 fibrils to the membrane increases with the presence of cholesterol. These findings provide insights into potential target regions for the development of inhibitors against A beta oligomer/fibril-membrane interaction.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
