Article
Chemistry, Medicinal
Malvi Surti, Mitesh Patel, Alya Redhwan, Lamya Ahmed Al-Keridis, Mohd Adnan, Nawaf Alshammari, Mandadi Narsimha Reddy
Summary: This study investigated the mechanism of action of IQ on HCT-116 cells. The results demonstrate that IQ significantly suppresses cell viability in a dose-dependent manner and triggers apoptosis through the mitochondrial-mediated pathway.
Article
Pharmacology & Pharmacy
Zhaojuan Guo, Pin Li, Chunguo Wang, Qianjun Kang, Can Tu, Bingqian Jiang, Jingxuan Zhang, Weiling Wang, Ting Wang
Summary: This study found that the ethanol extraction process aggravated the hepatotoxicity of Psoraleae Fructus, with bavachin, psoralidin, bavachinin, neobavaisoflavone, and bakuchiol identified as the main toxic ingredients. These constituents induced cell apoptosis, increased lipid accumulation and reactive oxygen species levels, while decreasing mitochondrial membrane potential. The mechanism may be associated with oxidative stress and mitochondrial damage-mediated apoptosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Xifeng Shan, Ling Liu, Gang Li, Kexin Xu, Bingyan Liu, Wei Jiang
Summary: In this study, the cytotoxic effects of PM2.5, BC, and Kaolin were investigated using human bronchial epithelial cells. BC and Kaolin mainly induced cell necrosis, while PM2.5 caused both apoptosis and necrosis. Excess ROS production was involved in organelle damage and cell death, with ROS playing a more significant role in BC-induced cytotoxicity compared to Kaolin. Removal of ROS partially mitigated PM2.5-induced apoptosis and necrosis, suggesting the existence of ROS-dependent and ROS-independent mechanisms in PM2.5 toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biology
Abdullah A. Alkahtane, Hamzah A. Alghamdi, Alanoud T. Aljasham, Saad Alkahtani
Summary: This study aimed to enhance the pharmacological value of Fe3O4 for colorectal cancer diagnosis by developing chitosan-coated Fe3O4. The results demonstrated that the nanohybrid exhibited enhanced ROS activity and effective cell death in colorectal carcinoma cell lines, offering a promising MRI contrasting agent for colorectal cancer diagnosis.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qian Gao, Zhong-Yuan Zhou, Ya-Ning He, Ming-Hui Dong, Zhao-Ning Wang, Hong-Mei Chen
Summary: This study evaluated the toxicity of BDE-47 towards RAW264.7 mouse macrophage cells and found that it caused a decrease in cell viability, an increase in apoptosis, and inhibition of phagocytosis. The mechanisms involved mitochondrial pathway-induced cell apoptosis and oxidative damage. Treatment with an antioxidant reversed the effects, while treatment with a ROS-inducer exacerbated them. These findings highlight the critical role of oxidative damage in BDE-47-induced suppression of immune function.
Article
Pharmacology & Pharmacy
Chao Zhang, Hong-Ying Yang, Long Gao, Ming-Zhen Bai, Wen-Kang Fu, Chong-Fei Huang, Ning-Ning Mi, Hai-Dong Ma, Ya-Wen Lu, Ning-Zu Jiang, Liang Tian, Teng Cai, Yan-Yan Lin, Xing-Xing Zheng, Kun Gao, Jian-Jun Chen, Wen-Bo Meng
Summary: In this study, five cardiac glycosides were extracted from natural plants, and Lan C was identified as the most potent anti-cholangiocarcinoma compound. Lan C inhibited the growth and induced apoptosis of cholangiocarcinoma cells, without toxic effects on normal cells. Mechanistically, Lan C downregulated the expression of STAT3, leading to apoptosis. Therefore, Lan C may serve as a promising candidate for the treatment of cholangiocarcinoma.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
James H. Schofield, Zachary T. Schafer
Summary: The relationship between mitophagy and ROS production is complex and not fully understood. This review discusses mtROS generation and their detrimental effects on cellular viability, along with the cellular defense mechanisms against oxidative stress. Furthermore, the prominent mechanisms governing mitophagy induction that bear on oxidative stress are explored.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Anberitha T. Matthews, Hitesh Soni, Katherine E. Robinson-Freeman, Theresa A. John, Randal K. Buddington, Adebowale Adebiyi
Summary: Doxorubicin (DOX), a chemotherapeutic agent, can induce fetal nephrotoxicity by inhibiting proliferation and inducing death of fetal pig glomerular mesangial cells (GMCs). DOX treatment reduces TRPC6 protein expression, leading to mitochondrial ROS generation and cell death in GMCs. The DOX-induced fetal pig GMC apoptosis is independent of TRPC6 upregulation but requires mtROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jianrong Zheng, Liao Zeng, Mingqing Tang, Hongjun Lin, Chao Pi, Ruian Xu, Xiuling Cui
Summary: Compound 1 exhibited potent anti-HCC activity by inducing cell cycle arrest and apoptosis through mitochondrial pathway, suggesting it as a promising candidate for HCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Lei Wang, Xiaoqin Bie, Suresh Mickymaray, Abdulaziz S. Alothaim, Yan Pei, Huaping Gong
Summary: The cynaropicrin extract showed anti-cancer potential against colon cancer in HCT-116 cell lines, inducing apoptosis through the mitochondria-mediated pathway.
PHARMACOGNOSY MAGAZINE
(2023)
Article
Toxicology
Imen Ayed-Boussema, Karima Rijiba-Touati, Hiba Hamdi, Hanen Chaabani, Salwa Abid-Essefi
Summary: The study found that FEN can induce apoptosis in human colon carcinoma cells by inhibiting mitochondrial electron transport. Additionally, FEN was shown to cause oxidative stress damage, while the antioxidant NAC could alleviate FEN-induced cell toxicity.
TOXICOLOGY IN VITRO
(2023)
Review
Biochemistry & Molecular Biology
Chenbin Bian, Zhuangzhuang Zheng, Jing Su, Huanhuan Wang, Sitong Chang, Ying Xin, Xin Jiang
Summary: Radiotherapy failure and poor tumor prognosis are mainly caused by radioresistance. The relationship and mechanisms between mitochondrial metabolism and cancer radioresistance are not fully understood. However, mitochondria play a crucial role in regulating various biological reactions and influencing the radiation effects of malignancies. Therefore, targeting mitochondrial signaling pathways for the development of novel anticancer drugs holds promise.
Article
Engineering, Environmental
Guoliang Chen, Mingxing Wang, Panpan Zhu, Guixue Wang, Tingzhang Hu
Summary: Pyraoxystrobin (SYP-3343), a newly-invented strobilurin fungicide, exhibits high toxicity to aquatic organisms, particularly in zebrafish embryos, through affecting cell cycle, mitochondrial membrane potential, and reactive oxygen species generation. This toxicity is dose- and time-dependent, inducing apoptosis in zebrafish embryos.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Hulya Gizem Ozkan, Vanrajsinh Thakor, Hong-Gui Xu, Galyna Bila, Rostyslav Bilyy, Daria Bida, Martin Boettcher, Dimitrios Mougiakakos, Rainer Tietze, Andriy Mokhir
Summary: Elevated levels of reactive oxygen species (ROS) and deficient mitochondria are weak points of cancer cells. Designing highly potent anticancer drugs that target both ROS and mitochondria is a valid therapeutic strategy. However, limiting the drug effects to cancer cells without affecting normal ones remains a challenge. In this study, we developed novel aminoferrocene derivatives that are chemically stable in the presence of ROS, generate mitochondrial ROS in cancer cells but not normal cells, and exhibit anticancer effects in vivo.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Immunology
Miranda D. Chavez, Hubert M. Tse
Summary: Mitochondrial dysfunction and oxidative stress are associated with T cell-mediated autoimmune diseases, and targeting metabolic pathways can inhibit autoreactive T cell activation. Increasing the requirements of Tregs for ROS and oxidative phosphorylation can promote self-tolerance and inhibit the activity of autoreactive T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nabil A. Alhakamy, Shaimaa M. Badr-Eldin, Osama A. A. Ahmed, Hibah M. Aldawsari, Solomon Z. Okbazghi, Mohamed A. Alfaleh, Wesam H. Abdulaal, Thikryat Neamatallah, Omar D. Al-hejaili, Usama A. Fahmy
Summary: The study demonstrates that a nanoemulsion formulation of costunolide (CTD) could be a potential therapeutic approach for lung cancer treatment. The optimized CTD nanoemulsion inhibited cell proliferation and promoted apoptosis in lung cancer cells. Additionally, the formulation reduced inflammatory responses, suggesting its significance in lung cancer therapy.
Article
Pharmacology & Pharmacy
Nabil A. Alhakamy, Gamal A. Mohamed, Usama A. Fahmy, Basma G. Eid, Mohammed W. Al-Rabia, Amgad I. M. Khedr, Mohammed Z. Nasrullah, Sabrin R. M. Ibrahim, Ashraf B. Abdel-Naim, Osama A. A. Ahmed, Shadab Md
Summary: This study aimed to design a hydrogel formula loaded with thioctamer, a nanoconjugate of thioctic acid (TA) and glatiramer acetate (GA), and evaluate its efficacy in expedited wound healing in a rat model of diabetic wound. The results demonstrated that thioctamer significantly enhanced wound healing and inhibited inflammation markers, showing its potential as a promising treatment for diabetic wounds.
Article
Pharmacology & Pharmacy
Basma G. Eid, Nadia M. Sokkar
Summary: This study investigates the phytochemical and biological properties of Rumex cyprius, a valuable plant widely grown in Saudi Arabia. The results show that R. cyprius contains various phenolic compounds with potential bioactivity, and exhibits a good hepatoprotective effect.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Hani Z. Asfour, Nabil A. Alhakamy, Usama A. Fahmy, Osama A. A. Ahmed, Waleed Y. Rizg, Raed Felimban, Ashraf B. Abdel-Naim, Mohammad A. S. Abourehab, Rasha A. Mansouri, Ulfat M. Omar, Shaimaa M. Badr-Eldin
Summary: This study developed a nanosphere formula to improve the bioavailability of Icariin (ICA) using nanotechnology. By optimizing the formulation of the nanospheres, the desired particle size, zeta potential, and drug entrapment efficiency were achieved. Animal experiments showed that the optimized nanospheres significantly enhanced sexual behavior. The results suggest that ICA-tocozeinolate nanospheres have the potential to improve drug delivery and efficacy.
Article
Pharmacology & Pharmacy
Wesam H. Abdulaal, Khaled M. Hosny, Nabil A. Alhakamy, Rana B. Bakhaidar, Yasir Almuhanna, Fahad Y. Sabei, Mohammed Alissa, Mohammed Majrashi, Jawaher Abdullah Alamoudi, Mohannad S. Hazzazi, Ayman Jafer, Rasha A. Khallaf
Summary: The aim of this study was to prevent bone resorption in rats by using a combination of a phospholipid-based phase separation in-situ gel (PPSG) and an alendronate sodium nanoemulsion (ALS-NE). The optimal nanoemulsion formulation had a droplet size of 90 +/- 2.0 nm and a stability index of 85 +/- 1.9%. Compared to the ALS solution-loaded in-situ gel, the ALS-NE-loaded PPSG achieved sustained and regulated release of ALS, resulting in a higher percentage of ALS remaining in rats' muscles after 30 days.
Article
Pharmacology & Pharmacy
Amina M. Bagher, Lenah S. Binmahfouz, Rasheed A. Shaik, Basma G. Eid
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy, and there is currently no effective pharmacological treatment available. Activating the CB1 receptor has shown promise in alleviating CIPN-related pain and neuroinflammation. This study investigated the potential benefits of a newly synthesized CB1 positive allosteric modulator, GAT229, in alleviating neuropathic pain and slowing CIPN progression.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Ritesh Fule, Mohammed Kaleem, Turky Omar Asar, Md Abdur Rashid, Rasheed A. Shaik, Basma G. Eid, Mohammed Z. Nasrullah, Aftab Ahmad, Imran Kazmi
Summary: Innovative drug delivery systems based on iron oxide nanoparticles (INPs) have attracted significant interest globally for their potential benefits in anticancer therapy. However, issues such as stability, absorption, and toxicity have been reported with the administration of INPs due to surface oxidation and agglomeration. To address this, trehalose-coated stabilized iron oxide nanoparticles (TINPs) were synthesized and loaded with the anticancer drug cytarabine, resulting in engineered CY-TINPs with improved stability, prevention of protein binding, and increased absorption. CY-TINPs showed remarkable enhancement in pharmacokinetic parameters and demonstrated effective delayed release, improved bioavailability, and enhanced cytotoxic activity against tumors compared to traditional drug delivery.
Article
Pharmacology & Pharmacy
Waleed S. Alharbi, Rawan H. Hareeri, Mohammed Bazuhair, Mohamed A. Alfaleh, Nabil A. Alhakamy, Usama A. Fahmy, Abdullah A. Alamoudi, Shaimaa M. Badr-Eldin, Osama A. Ahmed, Shareefa A. AlGhamdi, Marianne J. Naguib
Summary: This study aimed to develop an intranasal formulation of flibanserin using nanotechnology to overcome the limitations of oral administration. The optimized formulation showed improved bioavailability and brain delivery compared to the raw drug.
Article
Pharmacology & Pharmacy
Thikryat Neamatallah, Azizah M. M. Malebari, Abdulmohsin J. J. Alamoudi, Syed Nazreen, Mohammad Mahboob Alam, Hawazen H. H. Bin-Melaih, Osama A. A. Abuzinadah, Shaimaa M. M. Badr-Eldin, Gharam Alhassani, Lamar Makki, Mohammed Z. Z. Nasrullah
Summary: In this study, an optimized AG-PTMs formulation was prepared, which significantly inhibited the proliferation of liver cancer cells HepG2 through enhanced cellular uptake, cell cycle arrest and mitochondrial-dependent apoptosis.
Retraction
Nanoscience & Nanotechnology
N. K. Alruwaili, A. Zafar, S. S. Imam
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Shadab Md, Hatoon Abdul Rahman Mahrous, Nabil A. Alhakamy, Rasheed A. Shaik, Basma G. Eid
Summary: Icariin (ICR) is a flavonoid with various therapeutic properties. In this study, ICR nanoemulsions (ICR-NE) were developed and found to exhibit superior cardioprotective effects against doxorubicin-induced cardiotoxicity. The improved solubility, antioxidant, anti-inflammatory, and anti-apoptotic activity of ICR-NE contribute to its therapeutic efficacy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Heba A. El-Dash, Nehal E. Yousef, Abeer A. Aboelazm, Zuhier A. Awan, Galal Yahya, Amira M. El-Ganiny
Summary: A large amount of plastics are introduced into the ecosystem worldwide, causing environmental pollution. This study aims to isolate plastic-biodegrading fungi and explore optimum conditions for their action. Results showed that 10 isolates were able to degrade polyvinyl chloride (PVC) polymer, and three isolates displayed superior PVC-biodegrading activity under specific temperature and pH conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Hibah Mubarak Aldawsari, Sabna Kotta, Hani Z. Asfour, Sajith Vattamkandathil, Mahmoud Abdelkhalek Elfaky, Lubna Y. Ashri, Shaimaa M. Badr-Eldin
Summary: This study successfully formulated a quercetin-loaded bentonite-reinforced starch-gelatin based bioplastic with excellent mechanical properties and antimicrobial activity, which can be used for eco-friendly active food packaging and pharmaceutical applications.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Neurosciences
Abdulhadi Bima, Basmah Eldakhakhny, Aliaa A. Alamoudi, Zuhier Awan, Abrar Alnami, Salwa Mohamed Abo-Elkhair, Hussein Sakr, Fatma Mohamed Ghoneim, Ayman Elsamanoudy
Summary: This study investigates the relationship between brain insulin resistance and metabolic syndrome (MetS) and examines the protective effects of a low-carbohydrate, high-fat (LCHF) diet. The results suggest that MetS is associated with dysregulated gene expression in the brain, while the LCHF diet shows a protective effect against these abnormalities.
Article
Medicine, Research & Experimental
Basma G. Eid, Thikryat Neamatallah, Lenah S. Binmahfouz, Amina M. Bagher, Abdulmohsin J. Alamoudi, Hibah Mubarak Aldawsari, Abeer Hanafy, Atif Hasan, Hany M. El-Bassossy, Ashraf B. Abdel-Naim, Kiran Vemuri, Alexandros Makriyannis
Summary: This study found that CB1 antagonists AM6545 and AM4113 can protect against MetS-induced BPH through their anti-proliferative, antioxidant, and anti-inflammatory effects.
BIOMOLECULES AND BIOMEDICINE
(2023)
