Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme

Consequences of IDH1/2 Mutations in Gliomas and an Assessment of Inhibitors Targeting Mutated IDH Proteins

(2019) Bozena Kaminska et al.   MOLECULES

Survival trends in glioblastoma and association with treating facility volume

(2019) Sonikpreet Aulakh et al.   JOURNAL OF CLINICAL NEUROSCIENCE

2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas

(2018) Pavithra Viswanath et al.   CANCER RESEARCH

Pivotal role of human stearoyl-CoA desaturases (SCD1 and 5) in breast cancer progression: oleic acid-based effect of SCD1 on cell migration and a novel pro-cell survival role for SCD5

(2018) Cristiana Angelucci et al.   Oncotarget

SCD5 restored expression favors differentiation and epithelial-mesenchymal reversion in advanced melanoma

(2018) Rossella Puglisi et al.   Oncotarget

SCD1 Confers Temozolomide Resistance to Human Glioma Cells via the Akt/GSK3β/β-Catenin Signaling Axis

(2018) Shuang Dai et al.   Frontiers in Pharmacology

The Role of Wnt Signal in Glioblastoma Development and Progression: A Possible New Pharmacological Target for the Therapy of This Tumor

(2018) Mariachiara Zuccarini et al.   Genes

Association between IDH1/2 mutations and brain glioma grade

(2018) Lei Deng et al.   Oncology Letters

Stable Isotope Labeling Highlights Enhanced Fatty Acid and Lipid Metabolism in Human Acute Myeloid Leukemia

(2018) Lucille Stuani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation

(2018) Lina Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Effect of high carbohydrate diet on elongase and desaturase activity and accompanying gene expression in rat’s liver

(2017) Jagoda Drąg et al.   Genes and Nutrition

Hydrogen peroxide induces programmed necrosis in rat nucleus pulposus cells through the RIP1/RIP3-PARP-AIF pathway

(2017) Lei Zhao et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

ω3-polyunsaturated fatty acids induce cell death through apoptosis and autophagy in glioblastoma cells: In vitro and in vivo

(2017) Soyeon Kim et al.   ONCOLOGY REPORTS

Fads3 modulates docosahexaenoic acid in liver and brain

(2017) Ji Yao Zhang et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

A pathology atlas of the human cancer transcriptome

(2017) Mathias Uhlen et al.   SCIENCE

A Study of the Differential Effects of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Gene Expression Profiles of Stimulated Thp-1 Macrophages

(2017) Bénédicte Allam-Ndoul et al.   Nutrients

Regulation of p53wt glioma cell proliferation by androgen receptor-mediated inhibition of small VCP/p97-interacting protein expression

(2017) Dejun Bao et al.   Oncotarget

Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells

(2017) Xiaoyu Yang et al.   Redox Biology

Effect of high carbohydrate diet on elongase and desaturase activity and accompanying gene expression in rat’s liver

(2017) Jagoda Drąg et al.   Genes and Nutrition

Identification of cytotoxic mediators and their putative role in the signaling pathways during docosahexaenoic acid (DHA)-induced apoptosis of cancer cells

(2016) Moitreyi Das et al.   APOPTOSIS

Recent progress in the discovery and development of stearoyl CoA desaturase inhibitors

(2016) Yoshikazu Uto   CHEMISTRY AND PHYSICS OF LIPIDS

Proliferation Index Predicts Survival after Second Craniotomy within 6 Months of Adjuvant Radiotherapy for High-grade Glioma

(2016) C. Gzell et al.   CLINICAL ONCOLOGY

Desaturase and elongase-limiting endogenous long-chain polyunsaturated fatty acid biosynthesis

(2016) Ji Yao Zhang et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

SCD1 is associated with tumor promotion, late stage and poor survival in lung adenocarcinoma

(2016) Jun Huang et al.   Oncotarget

Selective Estrogen Receptor β Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma

(2016) Gangadhara R. Sareddy et al.   Scientific Reports

Reduced Expression of FADS1 Predicts Worse Prognosis in Non-Small-Cell Lung Cancer

(2016) Dong Wang et al.   Journal of Cancer

Histological Characterization of the Tumorigenic “Peri-Necrotic Niche” Harboring Quiescent Stem-Like Tumor Cells in Glioblastoma

(2016) Aya Ishii et al.   PLoS One

High Expression of Stearoyl-CoA Desaturase 1 Predicts Poor Prognosis in Patients with Clear-Cell Renal Cell Carcinoma

(2016) Jianfeng Wang et al.   PLoS One

Decreased Expression of FADS1 Predicts a Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma

(2015) Yong Du et al.   Asian Pacific Journal of Cancer Prevention

Aberrant Lipid Metabolism in Anaplastic Thyroid Carcinoma Reveals Stearoyl CoA Desaturase 1 as a Novel Therapeutic Target

(2015) Christina A. von Roemeling et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Selection of suitable reference genes for expression analysis in human glioma using RT-qPCR

(2015) Susanne Grube et al.   JOURNAL OF NEURO-ONCOLOGY

Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment

(2015) Fares Nigim et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B

(2015) Maria Bellenghi et al.   JOURNAL OF PATHOLOGY

Influence of Serum and Hypoxia on Incorporation of [14C]-d-Glucose or [14C]-l-Glutamine into Lipids and Lactate in Murine Glioblastoma Cells

(2015) Nathan L. Ta et al.   LIPIDS

Estrogen receptor β agonist enhances temozolomide sensitivity of glioma cells by inhibiting PI3K/AKT/mTOR pathway

(2014) XIAOYANG LIU et al.   Molecular Medicine Reports

Stroke Increases Neural Stem Cells and Angiogenesis in the Neurogenic Niche of the Adult Mouse

(2014) Rui Lan Zhang et al.   PLoS One

Androgen receptor signaling regulates growth of glioblastoma multiforme in men

(2014) Xiaoming Yu et al.   TUMOR BIOLOGY

Significantly increased monounsaturated lipids relative to polyunsaturated lipids in six types of cancer microenvironment are observed by mass spectrometry imaging

(2014) Shuai Guo et al.   Scientific Reports

Stem Cell Niches in Glioblastoma: A Neuropathological View

(2014) Davide Schiffer et al.   Biomed Research International

PDGFRAAmplification is Common in Pediatric and Adult High-Grade Astrocytomas and Identifies a Poor Prognostic Group in IDH1 Mutant Glioblastoma

(2013) Joanna J. Phillips et al.   BRAIN PATHOLOGY

Trans-vaccenate is Δ13-desaturated by FADS3 in rodents

(2013) Vincent Rioux et al.   JOURNAL OF LIPID RESEARCH

Proteomic analysis of glioblastomas: What is the best brain control sample?

(2013) Jean-Michel Lemée et al.   Journal of Proteomics

Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma

(2013) Samiksha Bansal et al.   JOURNAL OF SURGICAL RESEARCH

Stearoyl-CoA desaturase enzyme 1 inhibition reduces glucose utilization for de novo fatty acid synthesis and cell proliferation in 3T3-L1 adipocytes

(2013) Jennifer K. Yee et al.   Metabolomics

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Effect of sex hormones on n-3 polyunsaturated fatty acid biosynthesis in HepG2 cells and in human primary hepatocytes

(2013) Charlene M. Sibbons et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Hydrogen peroxide-induced necrotic cell death in cardiomyocytes is independent of matrix metalloproteinase-2

(2013) Mohammad A.M. Ali et al.   TOXICOLOGY IN VITRO

Tissue-specific sex differences in docosahexaenoic acid and Δ6-desaturase in rats fed a standard chow diet

(2012) Alex P. Kitson et al.   Applied Physiology Nutrition and Metabolism

High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients

(2012) Ashley M. Holder et al.   BREAST CANCER RESEARCH AND TREATMENT

Pyrosequencing of IDH1 and IDH2 Mutations in Brain Tumors and Non-neoplastic Conditions

(2012) Matthew D. Cykowski et al.   DIAGNOSTIC MOLECULAR PATHOLOGY

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

Metabolism of [U-13C]glucose in human brain tumorsin vivo

(2012) Elizabeth A. Maher et al.   NMR IN BIOMEDICINE

StearoylCoA Desaturase-5: A Novel Regulator of Neuronal Cell Proliferation and Differentiation

(2012) Debora I. Sinner et al.   PLoS One

Inhibiting Delta-6 Desaturase Activity Suppresses Tumor Growth in Mice

(2012) Chengwei He et al.   PLoS One

Stearoyl-CoA desaturase: rogue or innocent bystander?

(2012) Leanne Hodson et al.   PROGRESS IN LIPID RESEARCH

The evolutionary history of the stearoyl-CoA desaturase gene family in vertebrates

(2011) L Filipe C Castro et al.   BMC EVOLUTIONARY BIOLOGY

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

(2011) Rasheduzzaman Chowdhury et al.   EMBO REPORTS

IDH1 and IDH2 mutations, immunohistochemistry and associations in a series of brain tumors

(2011) Marta Mellai et al.   JOURNAL OF NEURO-ONCOLOGY

Cancer Cell Dependence on Unsaturated Fatty Acids Implicates Stearoyl-CoA Desaturase as a Target for Cancer Therapy

(2011) U. V. Roongta et al.   MOLECULAR CANCER RESEARCH

FADS2 Function Loss at the Cancer Hotspot 11q13 Locus Diverts Lipid Signaling Precursor Synthesis to Unusual Eicosanoid Fatty Acids

(2011) Woo Jung Park et al.   PLoS One

Stearoyl-CoA desaturase and insulin signaling — What is the molecular switch?

(2010) Pawel Dobrzyn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Hormonal and nutritional regulation of SCD1 gene expression

(2010) Daniel Mauvoisin et al.   BIOCHIMIE

Reduced expression of fatty acid biosynthesis genes in the prefrontal cortex of patients with major depressive disorder

(2010) Robert K. McNamara et al.   JOURNAL OF AFFECTIVE DISORDERS

Identification of valid endogenous control genes for determining gene expression in human glioma

(2010) S. Kreth et al.   NEURO-ONCOLOGY

Gender affects liver desaturase expression in a rat model of n−3 fatty acid repletion☆

(2009) Audrey Extier et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Differential effects of steroids on the synthesis of polyunsaturated fatty acids by human neuroblastoma cells

(2009) Audrey Extier et al.   NEUROCHEMISTRY INTERNATIONAL

Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: Relationship with fatty acid composition

(2009) Yanhong Liu et al.   SCHIZOPHRENIA RESEARCH

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

(2009) D. Guo et al.   Science Signaling

Oncogenic EGFR Signaling Networks in Glioma

(2009) P. H. Huang et al.   Science Signaling

Biochemical and physiological function of stearoyl-CoA desaturase

(2008) Chad M. Paton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM