The Neisseria gonorrhoeae Vaccine Candidate NHBA Elicits Antibodies That Are Bactericidal, Opsonophagocytic and That Reduce Gonococcal Adherence to Epithelial Cells

The gonococcal Neisserial Heparin Binding Antigen (NHBA) is involved in microcolony formation and contributes to serum resistance and adherence to epithelial cells

(2019) Evgeny A Semchenko et al.   JOURNAL OF INFECTIOUS DISEASES

Integrated Bioinformatic Analyses and Immune Characterization of New Neisseria gonorrhoeae Vaccine Antigens Expressed during Natural Mucosal Infection

(2019) Tianmou Zhu et al.   Vaccines

Genetic characterisation of Neisseria gonorrhoeae resistant to both ceftriaxone and azithromycin

(2018) David M Whiley et al.   LANCET INFECTIOUS DISEASES

The Bexsero Neisseria meningitidis serogroup B vaccine antigen NHBA is a high-affinity chondroitin sulfate binding protein

(2018) Tsitsi D. Mubaiwa et al.   Scientific Reports

Human Factor H Domains 6 and 7 Fused to IgG1 Fc Are Immunotherapeutic against Neisseria gonorrhoeae

(2018) Jutamas Shaughnessy et al.   JOURNAL OF IMMUNOLOGY

Structures of NHBA elucidate a broadly conserved epitope identified by a vaccine induced antibody

(2018) Martina Maritan et al.   PLoS One

The serogroup B meningococcal vaccine Bexsero elicits antibodies to Neisseria gonorrhoeae

(2018) Evgeny A Semchenko et al.   CLINICAL INFECTIOUS DISEASES

Effectiveness of a group B outer membrane vesicle meningococcal vaccine against gonorrhoea in New Zealand: a retrospective case-control study

(2017) Helen Petousis-Harris et al.   LANCET

The role of anti-NHba antibody in bactericidal activity elicited by the meningococcal serogroup B vaccine, MenB-4C

(2017) Elizabeth Partridge et al.   VACCINE

Crystal structures of human Fabs targeting the Bexsero meningococcal vaccine antigen NHBA

(2017) Martina Maritan et al.   Acta Crystallographica Section F-Structural Biology Communications

Meningococcal Antigen Typing System (MATS)-Based Neisseria meningitidis Serogroup B Coverage Prediction for the MenB-4C Vaccine in the United States

(2017) Gowrisankar Rajam et al.   mSphere

Is gonococcal disease preventable? The importance of understanding immunity and pathogenesis in vaccine development

(2016) Jennifer L. Edwards et al.   CRITICAL REVIEWS IN MICROBIOLOGY

MetQ of Neisseria gonorrhoeae Is a Surface-Expressed Antigen That Elicits Bactericidal and Functional Blocking Antibodies

(2016) Evgeny A. Semchenko et al.   INFECTION AND IMMUNITY

Neisserial Heparin Binding Antigen (NHBA) Contributes to the Adhesion of Neisseria meningitidis to Human Epithelial Cells

(2016) Irene Vacca et al.   PLoS One

Binding of Complement Factor H to PorB3 and NspA Enhances Resistance of Neisseria meningitidis to Anti-Factor H Binding Protein Bactericidal Activity

(2015) Serena Giuntini et al.   INFECTION AND IMMUNITY

Neisseria meningitidis NalP cleaves human complement C3, facilitating degradation of C3b and survival in human serum

(2013) E. Del Tordello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conservation of Meningococcal Antigens in the Genus Neisseria

(2013) A. Muzzi et al.   mBio

The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: Immunological, functional and structural characterization of the antigens

(2012) Davide Serruto et al.   VACCINE

Structure of the C-terminal Domain ofNeisseriaHeparin Binding Antigen (NHBA), One of the Main Antigens of a Novel Vaccine againstNeisseria meningitidis

(2011) Veronica Esposito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Diverse Subvariants of the Meningococcal Factor H (fH) Binding Protein for Their Ability To Bind fH, To Mediate Serum Resistance, and To Induce Bactericidal Antibodies

(2010) Kate L. Seib et al.   INFECTION AND IMMUNITY

Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans

(2010) Davide Serruto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccine-Induced Opsonophagocytic Immunity to Neisseria meningitidis Group B

(2008) J. S. Plested et al.   Clinical and Vaccine Immunology

Gonococcal Cervicitis: A Role for Biofilm in Pathogenesis

(2008) Christopher T. Steichen et al.   JOURNAL OF INFECTIOUS DISEASES

Thioredoxin Reductase Is Essential for Protection ofNeisseria gonorrhoeaeagainst Killing by Nitric Oxide and for Bacterial Growth during Interaction with Cervical Epithelial Cells

(2008) Adam J. Potter et al.   JOURNAL OF INFECTIOUS DISEASES