Defects in mTORC1 Network and mTORC1-STAT3 Pathway Crosstalk Contributes to Non-inflammatory Hepatocellular Carcinoma

Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms

(2016) Qi Wang et al.   CANCER CELL

Interleukin-6 influences stress-signalling by reducing the expression of the mTOR-inhibitor REDD1 in a STAT3-dependent manner

(2016) Jessica Pinno et al.   CELLULAR SIGNALLING

TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication

(2016) Daniel W H Ho et al.   GUT

Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

(2016) Qi Gong et al.   HEPATOLOGY

Clinical patterns of hepatocellular carcinoma in nonalcoholic fatty liver disease: A multicenter prospective study

(2016) Fabio Piscaglia et al.   HEPATOLOGY

The Transcription Factor p8 Regulates Autophagy in Response to Palmitic Acid Stress via a Mammalian Target of Rapamycin (mTOR)-independent Signaling Pathway

(2016) Sheng-Nan Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution

(2016) Adriano Maida et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential reactivation of fetal/neonatal genes in mouse liver tumors induced in cirrhotic and non-cirrhotic conditions

(2015) Xi Chen et al.   CANCER SCIENCE

Temporal Trends of Nonalcoholic Fatty Liver Disease–Related Hepatocellular Carcinoma in the Veteran Affairs Population

(2015) Sahil Mittal et al.   Clinical Gastroenterology and Hepatology

Identification of a mitochondrial defect gene signature revealsNUPR1as a key regulator of liver cancer progression

(2015) Young-Kyoung Lee et al.   HEPATOLOGY

Characterization of hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD) patients without cirrhosis

(2015) Bashar Mohamad et al.   Hepatology International

FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia

(2015) Ayako Nogami et al.   Oncotarget

Hepatocellular carcinoma epidemiology

(2014) Cristina Bosetti et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Liver Damage, Inflammation, and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition

(2014) Atsushi Umemura et al.   Cell Metabolism

Fibroblast Growth Factor 21 Limits Lipotoxicity by Promoting Hepatic Fatty Acid Activation in Mice on Methionine and Choline-Deficient Diets

(2014) Ffolliott M. Fisher et al.   GASTROENTEROLOGY

REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling

(2014) M. D. Dennis et al.   Science Signaling

Akt and mTORC1 Have Different Roles During Liver Tumorigenesis in Mice

(2013) Heidi L. Kenerson et al.   GASTROENTEROLOGY

The mTOR pathway in hepatic malignancies

(2013) Mamatha Bhat et al.   HEPATOLOGY

Epidemiology of Hepatocellular Carcinoma

(2013) Sahil Mittal et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Hepatocellular cancer: The impact of obesity, type 2 diabetes and a multidisciplinary team

(2013) Jessica Dyson et al.   JOURNAL OF HEPATOLOGY

Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace

(2012) György Baffy et al.   JOURNAL OF HEPATOLOGY

Hepatitis B Virus X Protein Upregulates mTOR Signaling through IKKβ to Increase Cell Proliferation and VEGF Production in Hepatocellular Carcinoma

(2012) Chia-Jui Yen et al.   PLoS One

Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice

(2012) S. Menon et al.   Science Signaling

Transcriptional Control of Cellular Metabolism by mTOR Signaling

(2011) J. L. Yecies et al.   CANCER RESEARCH

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma

(2011) Kohichiroh Yasui et al.   Clinical Gastroenterology and Hepatology

High-resolution characterization of a hepatocellular carcinoma genome

(2011) Yasushi Totoki et al.   NATURE GENETICS

Expansion of Hepatic Tumor Progenitor Cells in Pten-Null Mice Requires Liver Injury and Is Reversed by Loss of AKT2

(2010) Vivian A. Galicia et al.   GASTROENTEROLOGY

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-β and STAT3 activation

(2009) Atsushi Hosui et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis

(2009) Jennifer L. Estall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-221 overexpression contributes to liver tumorigenesis

(2009) P. Pineau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA