Current View on EpCAM Structural Biology

A case of severe malnutrition infant with neonatal onset intractable diarrhea

(2020) Youhong Fang et al.   BMC Pediatrics

Congenital Tufting Enteropathy-Associated Mutant of Epithelial Cell Adhesion Molecule Activates the Unfolded Protein Response in a Murine Model of the Disease

(2020) Barun Das et al.   Cells

Membrane-associated epithelial cell adhesion molecule is slowly cleaved by γ-secretase prior to efficient proteasomal degradation of its intracellular domain

(2019) Yuanchi Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM

(2019) Jessica B. Casaletto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic value of the expression of epithelial cell adhesion molecules in head and neck squamous cell carcinoma treated by definitive radiotherapy

(2019) Naoya Murakami et al.   JOURNAL OF RADIATION RESEARCH

EGF-like and Other Disulfide-rich Microdomains as Therapeutic Scaffolds

(2019) Benjamin J. Tombling et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Sequence-specific Peptide-binding Activity of the Protein Sulfide Isomerase AGR2 Directs Its Stable Binding to the Oncogenic Receptor EpCAM

(2018) M. Aiman Mohtar et al.   MOLECULAR & CELLULAR PROTEOMICS

Epithelial cell adhesion molecule overexpression regulates epithelial-mesenchymal transition, stemness and metastasis of nasopharyngeal carcinoma cells via the PTEN/AKT/mTOR pathway

(2018) Meng-He Wang et al.   Cell Death & Disease

EpCAM homo-oligomerization is not the basis for its role in cell-cell adhesion

(2018) Aljaž Gaber et al.   Scientific Reports

EpCAM ectodomain EpEX is a ligand of EGFR that counteracts EGF-mediated epithelial-mesenchymal transition through modulation of phospho-ERK1/2 in head and neck cancers

(2018) Min Pan et al.   PLOS BIOLOGY

EPCAM mutation update: Variants associated with congenital tufting enteropathy and Lynch syndrome

(2018) Sagar J. Pathak et al.   HUMAN MUTATION

Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis

(2017) Chuan-Jin Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Expansion of divergent SEA domains in cell surface proteins and nucleoporin 54

(2017) Jimin Pei et al.   PROTEIN SCIENCE

Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity

(2017) Julie Salomon et al.   Nature Communications

Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ

(2016) Marty A. Fernandez et al.   BIOCHEMISTRY

EpCAM-Regulated Transcription Exerts Influences on Nanomechanical Properties of Endometrial Cancer Cells That Promote Epithelial-to-Mesenchymal Transition

(2016) Ya-Ting Hsu et al.   CANCER RESEARCH

Novel Mutations in EPCAM Cause Congenital Tufting Enteropathy

(2016) Wenjuan Tang et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Cleavage and Cell Adhesion Properties of Human Epithelial Cell Adhesion Molecule (HEPCAM)

(2015) Thanos Tsaktanis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic analysis of Italian patients with congenital tufting enteropathy

(2015) Maria d’Apolito et al.   World Journal of Pediatrics

The cytosolic tail of the tumor marker protein Trop2 - a structural switch triggered by phosphorylation

(2015) Miha Pavšič et al.   Scientific Reports

Mutation of EpCAM leads to intestinal barrier and ion transport dysfunction

(2014) Philip A. Kozan et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The overexpression of Epithelial cell adhesion molecule (EpCAM) in glioma

(2014) Xin Chen et al.   JOURNAL OF NEURO-ONCOLOGY

Crystal structure and its bearing towards an understanding of key biological functions of EpCAM

(2014) Miha Pavšič et al.   Nature Communications

Functional consequences of EpCam mutation in mice and men

(2013) James L. Mueller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

EpCAM Controls Actomyosin Contractility and Cell Adhesion by Direct Inhibition of PKC

(2013) Nadim Maghzal et al.   DEVELOPMENTAL CELL

Epithelial cell adhesion molecule-targeted drug delivery for cancer therapy

(2013) Manuel Simon et al.   Expert Opinion on Drug Delivery

Genetic characterization of congenital tufting enteropathy: epcam associated phenotype and involvement of SPINT2 in the syndromic form

(2013) Julie Salomon et al.   HUMAN GENETICS

Absence of cell-surface EpCAM in congenital tufting enteropathy

(2013) Ulrike Schnell et al.   HUMAN MOLECULAR GENETICS

Epithelial Cell Adhesion Molecule (EpCAM) Regulates Claudin Dynamics and Tight Junctions

(2013) Chuan-Jin Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Nonsense Mutation in the EpCAM Gene in a Patient With Congenital Tufting Enteropathy

(2013) Cornelia Thoeni et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Regulated Intramembrane Proteolysis and Degradation of Murine Epithelial Cell Adhesion Molecule mEpCAM

(2013) Matthias Hachmeister et al.   PLoS One

Packing interface energetics in different crystal forms of the λ Cro dimer

(2013) Logan S. Ahlstrom et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

High-Resolution Comparative Modeling with RosettaCM

(2013) Yifan Song et al.   STRUCTURE

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

Molecular insights into the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1

(2012) Marius Sudol et al.   FEBS LETTERS

Epithelial Cell Adhesion Molecule Regulates Tumor Initiation and Tumorigenesis via Activating Reprogramming Factors and Epithelial-Mesenchymal Transition Gene Expression in Colon Cancer

(2012) Cheng-Wei Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EpCAM regulates cell cycle progression via control of cyclin D1 expression

(2012) A Chaves-Pérez et al.   ONCOGENE

mTrop1/Epcam Knockout Mice Develop Congenital Tufting Enteropathy through Dysregulation of Intestinal E-cadherin/β-catenin

(2012) Emanuela Guerra et al.   PLoS One

Putting the Pieces Together: Integrative Modeling Platform Software for Structure Determination of Macromolecular Assemblies

(2012) Daniel Russel et al.   PLOS BIOLOGY

A founder effect at the EPCAM locus in Congenital Tufting Enteropathy in the Arabic Gulf

(2011) Julie Salomon et al.   European Journal of Medical Genetics

Recurrence and variability of germline EPCAM deletions in Lynch syndrome

(2011) Roland P. Kuiper et al.   HUMAN MUTATION

Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing

(2011) Stefan F. Lichtenthaler et al.   JOURNAL OF NEUROCHEMISTRY

A non-synonymous polymorphism Thr115Met in the EpCAM gene is associated with an increased risk of breast cancer in Chinese population

(2010) Lan Jiang et al.   BREAST CANCER RESEARCH AND TREATMENT

The tumor-associated EpCAM regulates morphogenetic movements through intracellular signaling

(2010) Nadim Maghzal et al.   JOURNAL OF CELL BIOLOGY

Biochemical and Structural Characterization of β-Catenin Interactions with Nonphosphorylated and CK2-Phosphorylated Lef-1

(2010) Jinglucy Sun et al.   JOURNAL OF MOLECULAR BIOLOGY

Further evidence for EpCAM as the gene for congenital tufting enteropathy

(2009) Mamata Sivagnanam et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Deletions removing the last exon ofTACSTD1constitute a distinct class of mutations predisposing to Lynch syndrome

(2009) Marietta E. Kovacs et al.   HUMAN MUTATION

Tufting Enteropathy and Chronic Arthritis: A Newly Recognized Association With a Novel EpCAM Gene Mutation

(2009) Sulaiman M Al-Mayouf et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Claudin-7 Regulates EpCAM-Mediated Functions in Tumor Progression

(2009) T. Nubel et al.   MOLECULAR CANCER RESEARCH

Nuclear signalling by tumour-associated antigen EpCAM

(2009) Dorothea Maetzel et al.   NATURE CELL BIOLOGY

Abnormal Placental Development and Early Embryonic Lethality in EpCAM-Null Mice

(2009) Keisuke Nagao et al.   PLoS One

Structure prediction for CASP8 with all-atom refinement using Rosetta

(2009) Srivatsan Raman et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Glycosylation is crucial for stability of tumour and cancer stem cell antigen EpCAM

(2008) Markus Munz   Frontiers in Bioscience-Landmark

Identification of EpCAM as the Gene for Congenital Tufting Enteropathy

(2008) Mamata Sivagnanam et al.   GASTROENTEROLOGY

Assembly reflects evolution of protein complexes

(2008) Emmanuel D. Levy et al.   NATURE

Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1

(2008) Marjolijn J L Ligtenberg et al.   NATURE GENETICS

Two Structures of a λ Cro Variant Highlight Dimer Flexibility but Disfavor Major Dimer Distortions upon Specific Binding of Cognate DNA

(2007) Branwen M. Hall et al.   JOURNAL OF MOLECULAR BIOLOGY