Human Induced Pluripotent Stem Cell-Derived 3D-Neurospheres Are Suitable for Neurotoxicity Screening

Environmental neurotoxicant-induced dopaminergic neurodegeneration: a potential link to impaired neuroinflammatory mechanisms

(2019) Arthi Kanthasamy et al.   PHARMACOLOGY & THERAPEUTICS

A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine

(2019) Simon Plummer et al.   Scientific Reports

Modelling the neuropathology of lysosomal storage disorders through disease-specific human induced pluripotent stem cells

(2019) Julianna Kobolák et al.   EXPERIMENTAL CELL RESEARCH

Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone

(2018) Georgina Harris et al.   ARCHIVES OF TOXICOLOGY

Exposure of human neurons to silver nanoparticles induces similar pattern of ABC transporters gene expression as differentiation: Study on proliferating and post-mitotic LUHMES cells

(2018) M. Zuberek et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Human iPSC-derived neuronal models for in vitro neurotoxicity assessment

(2018) Anke M. Tukker et al.   NEUROTOXICOLOGY

OUP accepted manuscript

(2018)   TOXICOLOGICAL SCIENCES

Testing for developmental neurotoxicity using a battery of in vitro assays for key cellular events in neurodevelopment

(2018) Joshua A. Harrill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Development of the Adverse Outcome Pathway (AOP): Chronic binding of antagonist to N -methyl- d -aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities of children

(2018) Magdalini Sachana et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Rotenone exerts developmental neurotoxicity in a human brain spheroid model

(2018) David Pamies et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

(2018) Ellen Fritsche et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods

(2018) Anna Bal-Price et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Culture of human neurospheres in 3D scaffolds for developmental neurotoxicity testing

(2018) Christine Hellwig et al.   TOXICOLOGY IN VITRO

A high-throughput approach to identify specific neurotoxicants / developmental toxicants in human neuronal cell function assays

(2018) Johannes Delp   ALTEX-Alternatives to Animal Experimentation

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

(2018) Anna Bal-Price   ALTEX-Alternatives to Animal Experimentation

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

(2018) David Pamies   ALTEX-Alternatives to Animal Experimentation

Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC–Derived Neural 3D Cultures

(2018) Oksana Sirenko et al.   TOXICOLOGICAL SCIENCES

Vincristine Impairs Microtubules and Causes Neurotoxicity in Cerebral Organoids

(2018) Fangkun Liu et al.   NEUROSCIENCE

Nrf2 pathway activation upon rotenone treatment in human iPSC-derived neural stem cells undergoing differentiation towards neurons and astrocytes

(2017) Francesca Pistollato et al.   NEUROCHEMISTRY INTERNATIONAL

Evaluation of the rotenone-induced activation of the Nrf2 pathway in a neuronal model derived from human induced pluripotent stem cells

(2017) Dimitra Zagoura et al.   NEUROCHEMISTRY INTERNATIONAL

Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human induced pluripotent stem cells

(2017) Abinaya Chandrasekaran et al.   Stem Cell Research

Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro

(2017) Maxi Hofrichter et al.   Stem Cell Research

A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity

(2017) David Pamies   ALTEX-Alternatives to Animal Experimentation

Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells

(2017) Matthias Höllerhage et al.   Scientific Reports

Tranylcypromine Causes Neurotoxicity and Represses BHC110/LSD1 in Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids Model

(2017) Jing Huang et al.   Frontiers in Neurology

Omnisphero: a high-content image analysis (HCA) approach for phenotypic developmental neurotoxicity (DNT) screenings of organoid neurosphere cultures in vitro

(2016) Martin R. Schmuck et al.   ARCHIVES OF TOXICOLOGY

In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

(2016) Béla Z. Schmidt et al.   ARCHIVES OF TOXICOLOGY

Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes

(2016) Ying Pei et al.   BRAIN RESEARCH

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

21st Century Cell Culture for 21st Century Toxicology

(2016) David Pamies et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening

(2016) Zhi-Bin Tong et al.   JOURNAL OF APPLIED TOXICOLOGY

Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking

(2016) Shan Shan H. Wang et al.   NEURON

Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity

(2016) Kristen R. Ryan et al.   NEUROTOXICOLOGY

Is the time right for in vitro neurotoxicity testing using human iPSC-derived neurons?

(2016) Anke Tukker   ALTEX-Alternatives to Animal Experimentation

Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation

(2016) Shuling Zhou et al.   Stem Cells International

International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes

(2015) Anna Bal-Price et al.   ARCHIVES OF TOXICOLOGY

A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis

(2015) L. Smirnova et al.   ARCHIVES OF TOXICOLOGY

Comparative human and rat neurospheres reveal species differences in chemical effects on neurodevelopmental key events

(2015) Jenny Baumann et al.   ARCHIVES OF TOXICOLOGY

Cell-based assays for Parkinson's disease using differentiated human LUHMES cells

(2014) Xiao-min Zhang et al.   ACTA PHARMACOLOGICA SINICA

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Dynamics of nascent and active zone ultrastructure as synapses enlarge during long-term potentiation in mature hippocampus

(2014) Maria Elizabeth Bell et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Engineering of Midbrain Organoids Containing Long-Lived Dopaminergic Neurons

(2014) Vannary Tieng et al.   STEM CELLS AND DEVELOPMENT

Developmental neurotoxicity – Challenges in the 21st Century and In Vitro Opportunities

(2014) Lena Smirnova   ALTEX-Alternatives to Animal Experimentation

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

(2014) Natalie Alépée   ALTEX-Alternatives to Animal Experimentation

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Do we really want to REACH out to in vitro?

(2013) Remco H.S. Westerink   NEUROTOXICOLOGY

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward a 3D model of human brain development for studying gene/environment interactions

(2013) Helena T Hogberg et al.   Stem Cell Research & Therapy

Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction

(2012) Jian Ye et al.   BMC BIOINFORMATICS

Developmental neurotoxicity guideline study: Issues with methodology, evaluation and regulation*

(2012) Ryozo Tsuji et al.   CONGENITAL ANOMALIES

Developmental neurotoxicity testing: A path forward

(2012) Kevin M. Crofton et al.   CONGENITAL ANOMALIES

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

(2012) Yichen Shi et al.   Nature Protocols

The Presynaptic Active Zone

(2012) Thomas C. Südhof   NEURON

A quantitative method for detection of spliced X-box binding protein-1 (XBP1) mRNA as a measure of endoplasmic reticulum (ER) stress

(2011) Annemarie van Schadewijk et al.   CELL STRESS & CHAPERONES

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line

(2011) Diana Scholz et al.   JOURNAL OF NEUROCHEMISTRY

Neural Stem Cells: Historical Perspective and Future Prospects

(2011) Joshua J. Breunig et al.   NEURON

Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3

(2011) P. M. Rappold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

In vitro developmental neurotoxicity (DNT) testing: Relevant models and endpoints

(2009) Anna K. Bal-Price et al.   NEUROTOXICOLOGY

Application of in vitro neurotoxicity testing for regulatory purposes: Symposium III summary and research needs

(2008) Anna K. Bal-Price et al.   NEUROTOXICOLOGY

Developmental neurotoxicity testing in vitro: Models for assessing chemical effects on neurite outgrowth

(2008) Nicholas M. Radio et al.   NEUROTOXICOLOGY

Thoughts on limitations of animal models

(2008) Thomas Hartung   PARKINSONISM & RELATED DISORDERS