Article
Clinical Neurology
Sara Poletti, Benedetta Vai, Mario Gennaro Mazza, Raffaella Zanardi, Cristina Lorenzi, Federico Calesella, Silvia Cazzetta, Igor Branchi, Cristina Colombo, Roberto Furlan, Francesco Benedetti
Summary: This study successfully predicted the differential diagnosis of MDD and BD by considering plasma levels of cytokines, chemokines, and growth factors, and found that the immune-inflammatory signature is key in distinguishing between the two disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Ji Yoon Park, Chan Woo Lee, Yoonjeong Jang, Wonyun Lee, Hyeona Yu, Joohyun Yoon, Sunghee Oh, Yun Seong Park, Hyun A. Ryoo, Jangwon Lee, Nayoung Cho, Chong Hun Lee, Yeong Chan Lee, Hong-Hee Won, Hyo Shin Kang, Tae Hyon Ha, Woojae Myung
Summary: This study aimed to investigate the relationship between childhood trauma and resilience. The results showed a significantly negative association between childhood trauma and resilience, particularly among individuals who experienced emotional abuse and emotional neglect. The negative relationship was more prominent in the comparison group than in the major depressive disorder (MDD) and bipolar II disorder (BD II) patient groups. However, the generalizability of the results may be limited due to unequal patient sample size, and the causal relationship between childhood trauma and resilience could not be examined. Therefore, it is recommended to provide close support for individuals who have experienced emotional abuse and emotional neglect to help them develop resilience. Interventions that promote resilience should be provided to individuals predisposed to psychological risks as a result of childhood trauma.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Cihad Citak, Evrim Erten
Summary: Childhood trauma is associated with lower resilience and higher attachment-related anxiety and avoidance in patients with bipolar disorder. The negative effect of childhood trauma on resilience is partly mediated by attachment-related anxiety and avoidance. Developing attachment-informed psychosocial interventions may help mitigate the detrimental impact of childhood trauma on resilience in bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Daliang Sun, Ran Zhang, Xiaowen Ma, Mst Sadia Sultana, Lianfa Jiao, Meijuan Li, Yuan Yang, Min Li, Qinghe Liu, Zezhi Li
Summary: This study investigated the relationship between childhood trauma and clinical correlates in bipolar depression. The results suggest that childhood trauma may be associated with the age of onset and physical symptoms in bipolar depression patients.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Laura Pedrini, Clarissa Ferrari, Mariangela Lanfredi, Marcella Bellani, Stefano Porcelli, Elisabetta Caletti, Michela Sala, Maria Gloria Rossetti, Sara Piccin, Nicola Dusi, Matteo Balestrieri, Cinzia Perlini, Matteo Lazzaretti, Gian Mario Mandolini, Alessandro Pigoni, Andrea Boscutti, Carolina Bonivento, Alessandro Serretti, Roberta Rossi, Paolo Brambilla
Summary: This study found that the rate of reporting childhood trauma was higher in BD patients during euthymia compared to controls, with neglect being strongly related to BD. Childhood trauma was associated with higher scores on the SCL-90-R subscales, and it had a main effect on lifetime stressful events.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Cell Biology
Michael Maes, Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Siriwan Klinchanhom, Monojit Debnath, Agnieska Basta-Kaim, Marta Kubera, Abbas F. Almulla, Atapol Sughondhabirom
Summary: Adverse childhood experiences (ACEs) aggravate inflammation and stress responses, playing a significant role in the pathogenesis of affective disorders.
Article
Clinical Neurology
Leilei Wang, Yi Yin, Qingtao Bian, Yanfang Zhou, Junchao Huang, Ping Zhang, Song Chen, Hongzhen Fan, Yimin Cui, Xingguang Luo, Shuping Tan, Zhiren Wang, Chiang-Shan R. Li, Baopeng Tian, Li Tian, L. Elliot Hong, Yunlong Tan
Summary: Childhood trauma may contribute to bipolar disorder, with patients experiencing more severe trauma than healthy controls. The relationship between childhood trauma and onset of bipolar disorder is mediated by immature defense mechanisms, with physical neglect and emotional abuse being significant factors in the diagnosis of BD-I and BD-II.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Leonardo Carvalho Oliveira, Natalia Wirowski, Pedro Borges de Souza, Andressa Schneider Lobato, Karen Jansen, Taiane de Azevedo Cardoso, Thaise Campos Mondin, Jean Pierre Oses, Flavio Kapczinski, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Fernanda Pedrotti Moreira
Summary: This study aims to compare the serum cytokine levels between controls, individuals with a current depressive episode (CDE) with childhood trauma and individuals with CDE without childhood trauma. The study found that individuals with CDE had elevated levels of certain cytokines compared to the control group, while other cytokines showed decreased levels. However, there was no significant difference in cytokine levels between individuals with CDE, with and without trauma. The findings suggest that monitoring cytokine levels may be beneficial in preventing the development of a CDE.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Tobin J. Ehrlich, Hanjoo Kim, Kelly A. Ryan, Scott A. Langenecker, Elizabeth R. Duval, Anastasia K. Yocum, Claudia Diaz-Byrd, Anna L. Wrobel, Olivia M. Dean, Sue M. Cotton, Michael Berk, Melvin G. McInnis, David F. Marshall
Summary: This study evaluated the relationship between childhood trauma and cognition in individuals diagnosed with bipolar disorder. It found that higher childhood trauma was associated with worse memory functioning in bipolar disorder patients. The study emphasizes the importance of understanding the long-term cognitive outcomes of childhood trauma in bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Immunology
Kaat Hebbrecht, Katrien Skorobogatov, Erik J. Giltay, Violette Coppens, Livia De Picker, Manuel Morrens
Summary: The TRYCAT pathway is downregulated in BD patients, with lower levels of TRP and KYN in peripheral blood compared to healthy controls, while no difference was found in cerebrospinal fluid. The quality of the studies was rated as moderate.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ricki M. de Koning, Erika Kuzminskaite, Christiaan H. Vinkers, Erik J. Giltay, Brenda W. J. H. Penninx
Summary: Childhood trauma is associated with increased levels of LPS-stimulated cytokines, showing a dose-response relationship. These findings highlight a dysregulated innate immune system capacity in adults with childhood trauma, which may contribute to an increased vulnerability for psychopathology and somatic disorders across the lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Neurosciences
Michael Maes, Joao Victor Nani, Cristiano Noto, Lucas Rizzo, Mirian A. F. Hayashi, Elisa Brietzke
Summary: The study found that bipolar disorder is associated with simultaneous activation of the immune-inflammatory response system and the compensatory immune-regulatory system, which may be related to the staging of the illness. Immune injuries and HCMV infection in BD patients contribute to dysfunctional CIRS and exaggerated IRS responses, playing a key role in inflammation and neuroaffective toxicity.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Aiste Lengvenyte, Robertas Strumila, Raoul Belzeaux, Bruno Aouizerate, Caroline Dubertret, Emmanuel Haffen, Pierre-Michel Llorca, Paul Roux, Mircea Polosan, Raymund Schwan, Michel Walter, Thierry D' Amato, Dominique Januel, Marion Leboyer, Frank Bellivier, Bruno Etain, Alvydas Navickas, Emilie Olie, Philippe Courtet
Summary: Studies suggest that inflammation is increased in some patients with depression, and peripheral inflammatory markers are associated with certain depressive symptoms. However, research on bipolar disorders mainly focuses on blood cytokines. In this study, data from a large cohort of individuals with bipolar disorder were analyzed to examine the association between peripheral blood cell counts and depression severity, symptoms, and dimensions.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Clinical Neurology
David J. Bond, Ana C. Andreazza, Ivan J. Torres, William G. Honer, Raymond W. Lam, Lakshmi N. Yatham
Summary: This study found that inflammation, measured by a composite measure of total peripheral inflammation, is associated with lower white matter volumes in the frontal and temporal lobes of patients with early-stage BD. Total inflammation is a stronger predictor of lower white matter volumes than individual cytokines.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Hartej Gill, Nelson B. Rodrigues, Rodrigo B. Mansur, CeAnn A. Marks, Joshua D. DiVincenzo, Felicia Ceban, Joshua D. Rosenblat, Bing Cao, Jonathan M. Lieberman, Roger Ho, Roger S. McIntyre
Summary: This study aimed to evaluate the antidepressant effects of adjunctive infliximab treatment in BD patients and understand its impact on cardiovascular disease (CVD) risk. The results showed no significant differences between the infliximab-treated and placebo group in terms of Framingham risk scores (FRS), mean arterial blood pressure (MAP), and total cholesterol (TC). This suggests that immune system targets have complex effects on CVD in psychiatric populations.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Michael Cronquist Christensen, Roger S. McIntyre, Ioana Florea, Henrik Loft, Andrea Fagiolini
Summary: This study analyzed the efficacy and tolerability of vortioxetine in patients with major depressive disorder. The results showed that vortioxetine 20 mg/day was more effective than 10 mg/day, with similar tolerability. In flexible-dose studies, nearly half of the patients received 20 mg/day after 1 week and two-thirds received 20 mg/day as their final dosage.
Review
Clinical Neurology
Roger S. Mcintyre, Leslie Citrome, Hannah Cummings, Mark S. Todtenkopf, Laura A. Tan, Marni White, Sarah Akerman
Summary: The endogenous opioid system plays an important role in weight and metabolism regulation. Targeting this system may help mitigate antipsychotic-induced weight gain and metabolic dysregulation.
Article
Psychiatry
Runhua Wang, Yuanyuan Cai, Weicong Lu, Ruoxi Zhang, Robin Shao, Suk-Yu Yau, Brendon Stubbs, Roger S. McIntyre, Kuan-Pin Su, Guiyun Xu, Liangwen Qi, Kwok-Fai So, Kangguang Lin
Summary: This 3-month randomized psychoeducation-controlled trial examined the effects of exercise on gut microbiota in young adolescents with subthreshold depression. The exercise intervention group showed an increase in the relative abundance of certain genera and species of gut bacteria compared to the psychoeducation-controlled group. These changes were associated with improvements in depressive symptoms and enrichment of defense and signal transduction mechanisms.
PSYCHIATRY RESEARCH
(2023)
Review
Psychiatry
Shakila Meshkat, Sipan Haikazian, Joshua D. Di Vincenzo, Farhan Fancy, Danica Johnson, David Chen-Li, Roger S. McIntyre, Rodrigo Mansur, Joshua D. Rosenblat
Summary: This systematic review evaluates the efficacy, tolerability, and safety of oral ketamine, esketamine, and r-ketamine for unipolar and bipolar depression. The results indicate significant antidepressant effects and good tolerability of oral ketamine. However, the included randomized controlled trials had a high risk of bias, and further research with larger sample sizes and longer follow-up periods is needed to determine the antisuicidal effects and efficacy in treatment-resistant depression.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Review
Clinical Neurology
Giacomo d'Andrea, Mauro Pettorruso, Giorgio Di Lorenzo, Gianluca Mancusi, Roger S. McIntyre, Giovanni Martinotti
Summary: Ketamine and esketamine have generated significant interest as potential therapeutic agents for Treatment-Resistant Depression (TRD). This article provides a comprehensive overview of their action and highlights their effectiveness on mixed features, anxiety, dysphoric mood, and bipolar traits. The complex pharmacodynamic mechanisms of action are discussed, and further research is needed to evaluate the efficacy of esketamine nasal spray in bipolar depression and the potential role of these substances as mood stabilizers.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Danica E. Johnson, Roger S. McIntyre, Rodrigo B. Mansur, Joshua D. Rosenblat
Summary: Cognitive impairment is a significant feature of bipolar disorder, affecting recovery and quality of life. While there are currently no effective treatments for cognitive impairment in bipolar disorder, various pharmacological interventions are being explored as potential options that target the underlying pathophysiology of the disorder.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Jingman Shi, Xue Han, Yuhua Liao, Hao Zhao, Beifang Fan, Huimin Zhang, Kayla M. Teopiz, Weidong Song, Lingjiang Li, Lan Guo, Ciyong Lu, Roger S. McIntyre
Summary: This study examined the association between stressful life events (SLEs) and subthreshold depressive symptoms (SDS) and major depressive disorder (MDD), with a focus on gender effects. The findings showed that individuals who experienced any SLEs were at a higher risk of SDS and MDD. The association between SLEs and SDS was stronger in females, while the association between SLEs and MDD was stronger in males.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Mi Kyoung Seo, Sehoon Jeong, Dae-Hyun Seog, Jung An Lee, Jae-Hon Lee, Yena Lee, Roger S. McIntyre, Sung Woo Park, Jung Goo Lee
Summary: This study investigated the effects of liraglutide, a GLP-1 agonist, on a depression-like phenotype in mice exposed to chronic unpredictable stress. Liraglutide treatment reduced immobility in the forced swim test and improved cognitive function in the Morris water maze test. These results suggest that GLP-1 agonists could be potential novel antidepressants.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Yanzhi Li, Lu Cheng, Lan Guo, Liwan Zhu, Hao Zhao, Caiyun Zhang, Manjun Shen, Yifeng Liu, Muhammad Youshay Jawad, Lingjiang Li, Wanxin Wang, Ciyong Lu, Roger S. McIntyre
Summary: This study explores the mediating role of personality traits in the relationship between adverse childhood experiences (ACEs) and depressive symptoms in older adults. The results suggest that maltreatment and household dysfunction induce depressive symptoms by increasing neuroticism, while poor parent-child bonding induces depressive symptoms by increasing neuroticism and reducing conscientiousness and extraversion.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Genetics & Heredity
Jiangbo Ying, Qian Hui Chew, Roger S. McIntyre, Kang Sim
Summary: Treatment-resistant schizophrenia (TRS) is difficult to treat and has a negative impact on patients' quality of life. Clozapine is effective for TRS but has side effects. This review summarizes the current genetic factors associated with TRS, clozapine resistance, and side effects. Further research is needed to identify risk genes and understand the interactions between genes and relevant clinical factors in TRS treatment.
Article
Psychiatry
Xiuwen Li, Huimin Zhang, Xue Han, Lan Guo, Felicia Ceban, Yuhua Liao, Jingman Shi, Wanxin Wang, Yifeng Liu, Weidong Song, Dongjian Zhu, Hongqiong Wang, Lingjiang Li, Beifang Fan, Ciyong Lu, Roger S. McIntyre
Summary: This study explored the association between somatic symptoms and subthreshold depression (SD) and Major Depressive Disorder (MDD), and determined the predictive potential of somatic symptoms in identifying SD and MDD in primary care. The results showed that somatic symptoms were associated with the presence of SD and MDD, and energy-related symptoms had good predictive potential.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Vincent Chin-Hung Chen, Shao-Lan Huang, Jing-Yu Huang, Tsai-Ching Hsu, Bor-Show Tzang, Roger S. Mcintyre
Summary: The combination of Nivolumab and Escitalopram oxalate was found to have synergistic effects in inhibiting the proliferation of liver cancer cells. This study highlights the potential of combined drug therapy as an alternative treatment option for liver cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Joshua D. D. Rosenblat, Froukje E. E. deVries, Zoe Doyle, Roger S. S. McIntyre, Gary Rodin, Camilla Zimmermann, Ernie Mak, Breffni Hannon, Christian Schulz-Quach, Aida Al Kindy, Zeal Patel, Madeline Li
Summary: Ketamine administered through intranasal spray has shown rapid and sustained antidepressant effects in advanced cancer patients suffering from moderate to severe depression. The treatment was well-tolerated with minimal side effects. Further larger-scale controlled trials are needed to confirm these promising findings.
Review
Pharmacology & Pharmacy
Farhan Fancy, Sipan Haikazian, Danica E. Johnson, David C. J. Chen-Li, Anastasia Levinta, Muhammad I. Husain, Rodrigo B. Mansur, Joshua D. Rosenblat
Summary: This systematic review summarizes the efficacy, safety, and tolerability of ketamine in treating bipolar depression. Preliminary evidence suggests that intravenous ketamine is safe and effective for the treatment of bipolar depression.
THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY
(2023)