Boosting the Biogenesis and Secretion of Mesenchymal Stem Cell-Derived Exosomes

Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt/β-catenin pathway

(2019) Xiaoli Rong et al.   Stem Cell Research & Therapy

Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A

(2019) Eun-Ju Im et al.   Nature Communications

Mechanisms associated with biogenesis of exosomes in cancer

(2019) Kathleen M. McAndrews et al.   Molecular Cancer

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

Carrier-Free CXCR4-Targeted Nanoplexes Designed for Polarizing Macrophages to Suppress Tumor Growth

(2019) Michael B. Deci et al.   Cellular and Molecular Bioengineering

The Phenotypic Effects of Exosomes Secreted from Distinct Cellular Sources: a Comparative Study Based on miRNA Composition

(2018) Scott Ferguson et al.   AAPS Journal

Modulating Macrophage Polarization through CCR2 Inhibition and Multivalent Engagement

(2018) Michael B. Deci et al.   MOLECULAR PHARMACEUTICS

The Impact of the CD9 Tetraspanin on Lentivirus Infectivity and Exosome Secretion

(2018) Kai O. Böker et al.   MOLECULAR THERAPY

Biogenesis and function of extracellular vesicles in cancer

(2018) Maarten P. Bebelman et al.   PHARMACOLOGY & THERAPEUTICS

Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing

(2018) Jun Ishihara et al.   Nature Communications

High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer

(2018) Amrita Datta et al.   Scientific Reports

The microRNA regulatory landscape of MSC-derived exosomes: a systems view

(2018) Scott W. Ferguson et al.   Scientific Reports

Enhanced extracellular vesicle production and ethanol-mediated vascularization bioactivity via a 3D-printed scaffold-perfusion bioreactor system

(2018) Divya B. Patel et al.   Acta Biomaterialia

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

(2018) Sophia Antimisiaris et al.   Pharmaceutics

Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases

(2017) Anne-lie Ståhl et al.   PEDIATRIC NEPHROLOGY

Hypoxia Inducible Factor-1α Potentiates Jagged 1-Mediated Angiogenesis by Mesenchymal Stem Cell-Derived Exosomes

(2017) Hernán Gonzalez-King et al.   STEM CELLS

Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way

(2017) Jinyun Zhu et al.   Artificial Cells Nanomedicine and Biotechnology

More Than Tiny Sacks

(2016) Raj Kishore et al.   CIRCULATION RESEARCH

Exosomes as therapeutics: The implications of molecular composition and exosomal heterogeneity

(2016) Scott W. Ferguson et al.   JOURNAL OF CONTROLLED RELEASE

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

(2016) Sarah R. Amend et al.   Jove-Journal of Visualized Experiments

Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy

(2015) Stella Kourembanas   Annual Review of Physiology

Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction

(2015) Kobina Essandoh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

(2015) Yoshihiro Nakamura et al.   FEBS LETTERS

Directional cell movement through tissues is controlled by exosome secretion

(2015) Bong Hwan Sung et al.   Nature Communications

Host Matrix Modulation by Tumor Exosomes Promotes Motility and Invasiveness

(2015) Wei Mu et al.   NEOPLASIA

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

(2014) Luisa Pascucci et al.   JOURNAL OF CONTROLLED RELEASE

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

(2013) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles

(2013) Takeshi Katsuda et al.   PROTEOMICS

Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells

(2013) V Severino et al.   Cell Death & Disease

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

(2011) Tian Chen et al.   Journal of Translational Medicine

Detachment of Breast Tumor Cells Induces Rapid Secretion of Exosomes Which Subsequently Mediate Cellular Adhesion and Spreading

(2011) Rainelli B. Koumangoye et al.   PLoS One

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Microphthalmia-associated Transcription Factor RegulatesRAB27AGene Expression and Controls Melanosome Transport

(2008) Christine Chiaverini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE